Search Results - "Edbauer, Dieter"

Good guy or bad guy: the opposing roles of microRNA 125b in cancer by Banzhaf-Strathmann, Julia, Edbauer, Dieter

“…MicroRNAs (miRNAs) are a class of non-coding RNAs that post-transcriptionally silence target mRNAs. Dysregulation of miRNAs is a frequent event in several…”
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MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease by Banzhaf-Strathmann, Julia, Benito, Eva, May, Stephanie, Arzberger, Thomas, Tahirovic, Sabina, Kretzschmar, Hans, Fischer, André, Edbauer, Dieter

“…Sporadic Alzheimer's disease (AD) is the most prevalent form of dementia, but no clear disease‐initiating mechanism is known. Aβ deposits and neuronal tangles…”
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In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment by Guo, Qiang, Lehmer, Carina, Martínez-Sánchez, Antonio, Rudack, Till, Beck, Florian, Hartmann, Hannelore, Pérez-Berlanga, Manuela, Frottin, Frédéric, Hipp, Mark S., Hartl, F. Ulrich, Edbauer, Dieter, Baumeister, Wolfgang, Fernández-Busnadiego, Rubén

“…Protein aggregation and dysfunction of the ubiquitin-proteasome system are hallmarks of many neurodegenerative diseases. Here, we address the elusive link…”
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Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE by Parhizkar, Samira, Arzberger, Thomas, Brendel, Matthias, Kleinberger, Gernot, Deussing, Maximilian, Focke, Carola, Nuscher, Brigitte, Xiong, Monica, Ghasemigharagoz, Alireza, Katzmarski, Natalie, Krasemann, Susanne, Lichtenthaler, Stefan F., Müller, Stephan A., Colombo, Alessio, Monasor, Laura Sebastian, Tahirovic, Sabina, Herms, Jochen, Willem, Michael, Pettkus, Nadine, Butovsky, Oleg, Bartenstein, Peter, Edbauer, Dieter, Rominger, Axel, Ertürk, Ali, Grathwohl, Stefan A., Neher, Jonas J., Holtzman, David M., Meyer-Luehmann, Melanie, Haass, Christian

“…Coding variants in the triggering receptor expressed on myeloid cells 2 ( TREM2 ) are associated with late-onset Alzheimer’s disease (AD). We demonstrate that…”
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ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import by Dormann, Dorothee, Rodde, Ramona, Edbauer, Dieter, Bentmann, Eva, Fischer, Ingeborg, Hruscha, Alexander, Than, Manuel E, Mackenzie, Ian R A, Capell, Anja, Schmid, Bettina, Neumann, Manuela, Haass, Christian

“…Mutations in fused in sarcoma ( FUS ) are a cause of familial amyotrophic lateral sclerosis (fALS). Patients carrying point mutations in the C‐terminus of FUS…”
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Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations by Mackenzie, Ian R., Arzberger, Thomas, Kremmer, Elisabeth, Troost, Dirk, Lorenzl, Stefan, Mori, Kohji, Weng, Shih-Ming, Haass, Christian, Kretzschmar, Hans A., Edbauer, Dieter, Neumann, Manuela

“…Hexanucleotide repeat expansion in C9ORF72 is the most common genetic cause of frontotemporal dementia and motor neuron disease. Recently, unconventional…”
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C9orf72 FTLD/ALS-associated Gly-Ala dipeptide repeat proteins cause neuronal toxicity and Unc119 sequestration by May, Stephanie, Hornburg, Daniel, Schludi, Martin H., Arzberger, Thomas, Rentzsch, Kristin, Schwenk, Benjamin M., Grässer, Friedrich A., Mori, Kohji, Kremmer, Elisabeth, Banzhaf-Strathmann, Julia, Mann, Matthias, Meissner, Felix, Edbauer, Dieter

“…Hexanucleotide repeat expansion in C9orf72 is the most common pathogenic mutation in patients with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar…”
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FUS-mediated alternative splicing in the nervous system: consequences for ALS and FTLD by Orozco, Denise, Edbauer, Dieter

“…Mutations in fused in sarcoma (FUS) in a subset of patients with amyotrophic lateral sclerosis (ALS) linked this DNA/RNA-binding protein to neurodegeneration…”
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Clinico-genetic findings in 509 frontotemporal dementia patients by Wagner, Matias, Lorenz, Georg, Volk, Alexander E., Brunet, Theresa, Edbauer, Dieter, Berutti, Riccardo, Zhao, Chen, Anderl-Straub, Sarah, Bertram, Lars, Danek, Adrian, Deschauer, Marcus, Dill, Veronika, Fassbender, Klaus, Fliessbach, Klaus, Götze, Katharina S., Jahn, Holger, Kornhuber, Johannes, Landwehrmeyer, Bernhard, Lauer, Martin, Obrig, Hellmuth, Prudlo, Johannes, Schneider, Anja, Schroeter, Matthias L., Uttner, Ingo, Vukovich, Ruth, Wiltfang, Jens, Winkler, Andrea S., Zhou, Qihui, Ludolph, Albert C., Oexle, Konrad, Otto, Markus, Diehl-Schmid, Janine, Winkelmann, Juliane

“…Frontotemporal dementia (FTD) is a clinically and genetically heterogeneous disorder. To which extent genetic aberrations dictate clinical presentation remains…”
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RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment by Benito, Eva, Kerimoglu, Cemil, Ramachandran, Binu, Pena-Centeno, Tonatiuh, Jain, Gaurav, Stilling, Roman Manuel, Islam, Md Rezaul, Capece, Vincenzo, Zhou, Qihui, Edbauer, Dieter, Dean, Camin, Fischer, André

“…Physical exercise in combination with cognitive training is known to enhance synaptic plasticity, learning, and memory and lower the risk for various complex…”
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Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132 by Edbauer, Dieter, Neilson, Joel R., Foster, Kelly A., Wang, Chi-Fong, Seeburg, Daniel P., Batterton, Matthew N., Tada, Tomoko, Dolan, Bridget M., Sharp, Phillip A., Sheng, Morgan

“…MicroRNAs (miRNAs) are noncoding RNAs that suppress translation of specific mRNAs. The miRNA machinery interacts with fragile X mental retardation protein…”
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Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions by COOPER-KNOCK, Johnathan, WALSH, Matthew J, HAUTBERGUE, Guillaume M, SHAW, Pamela J, HIGGINBOTTOM, Adrian, HIGHLEY, J. Robin, DICKMAN, Mark J, EDBAUER, Dieter, INCE, Paul G, WHARTON, Stephen B, WILSON, Stuart A, KIRBY, Janine

“…GGGGCC repeat expansions of C9orf72 represent the most common genetic variant of amyotrophic lateral sclerosis and frontotemporal degeneration, but the…”
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Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers by Mackenzie, Ian R. A., Frick, Petra, Grässer, Friedrich A., Gendron, Tania F., Petrucelli, Leonard, Cashman, Neil R., Edbauer, Dieter, Kremmer, Elisabeth, Prudlo, Johannes, Troost, Dirk, Neumann, Manuela

“…Hexanucleotide repeat expansion in C9ORF72 is the most common genetic cause of frontotemporal dementia and motor neuron disease. One consequence of the…”
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Gel‐like inclusions of C‐terminal fragments of TDP‐43 sequester stalled proteasomes in neurons by Riemenschneider, Henrick, Guo, Qiang, Bader, Jakob, Frottin, Frédéric, Farny, Daniel, Kleinberger, Gernot, Haass, Christian, Mann, Matthias, Hartl, F. Ulrich, Baumeister, Wolfgang, Hipp, Mark S, Meissner, Felix, Fernández‐Busnadiego, Rubén, Edbauer, Dieter

“…Aggregation of the multifunctional RNA‐binding protein TDP‐43 defines large subgroups of amyotrophic lateral sclerosis and frontotemporal dementia and…”
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Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS by LaClair, Katherine D., Zhou, Qihui, Michaelsen, Meike, Wefers, Benedikt, Brill, Monika S., Janjic, Aleksandar, Rathkolb, Birgit, Farny, Daniel, Cygan, Mikolaj, de Angelis, Martin Hrabe, Wurst, Wolfgang, Neumann, Manuela, Enard, Wolfgang, Misgeld, Thomas, Arzberger, Thomas, Edbauer, Dieter

“…Expansion of a (G 4 C 2 ) n repeat in C9orf72 causes amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the link of the five…”
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Poly-glycine–alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3 by Nihei, Yoshihiro, Mori, Kohji, Werner, Georg, Arzberger, Thomas, Zhou, Qihui, Khosravi, Barham, Japtok, Julia, Hermann, Andreas, Sommacal, Andreas, Weber, Markus, Kamp, Frits, Nuscher, Brigitte, Edbauer, Dieter, Haass, Christian

“…Repeat expansion in C9orf72 causes amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Expanded sense and antisense repeat RNA transcripts in…”
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Distribution of dipeptide repeat proteins in cellular models and C9orf72 mutation cases suggests link to transcriptional silencing by Schludi, Martin H., May, Stephanie, Grässer, Friedrich A., Rentzsch, Kristin, Kremmer, Elisabeth, Küpper, Clemens, Klopstock, Thomas, Arzberger, Thomas, Edbauer, Dieter

“…A massive expansion of a GGGGCC repeat upstream of the C9orf72 coding region is the most common known cause of amyotrophic lateral sclerosis and frontotemporal…”
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MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function by Miller, Brooke H., Zeier, Zane, Xi, Li, Lanz, Thomas A., Deng, Shibing, Strathmann, Julia, Willoughby, David, Kenny, Paul J., Elsworth, John D., Lawrence, Matthew S., Roth, Robert H., Edbauer, Dieter, Kleiman, Robin J., Wahlestedt, Claes

“…Schizophrenia is characterized by affective, cognitive, neuromorphological, and molecular abnormalities that may have a neurodevelopmental origin. MicroRNAs…”
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Distinct Roles of NR2A and NR2B Cytoplasmic Tails in Long-Term Potentiation by Foster, Kelly A, McLaughlin, Nathan, Edbauer, Dieter, Phillips, Marnie, Bolton, Andrew, Constantine-Paton, Martha, Sheng, Morgan

“…NMDA receptors (NMDARs) are critical mediators of activity-dependent synaptic plasticity, but the differential roles of NR2A- versus NR2B-containing NMDARs…”
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The porphyrin TMPyP4 inhibits elongation during the noncanonical translation of the FTLD/ALS-associated GGGGCC repeat in the C9orf72 gene by Mori, Kohji, Gotoh, Shiho, Yamashita, Tomoko, Uozumi, Ryota, Kawabe, Yuya, Tagami, Shinji, Kamp, Frits, Nuscher, Brigitte, Edbauer, Dieter, Haass, Christian, Nagai, Yoshitaka, Ikeda, Manabu

“…GGGGCC (G4C2) repeat expansion in the C9orf72 gene has been shown to cause frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Dipeptide…”
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