Search Results - "Eda, K"

RNA-Based Vaccines in Cancer Immunotherapy by McNamara, Megan A., Holl, Eda K., Nair, Smita K.

“…RNA vaccines traditionally consist of messenger RNA synthesized by in vitro transcription using a bacteriophage RNA polymerase and template DNA that encodes…”
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Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen-specific CTLs by Brown, Michael C, Holl, Eda K, Boczkowski, David, Dobrikova, Elena, Mosaheb, Mubeen, Chandramohan, Vidya, Bigner, Darell D, Gromeier, Matthias, Nair, Smita K

“…Tumors thrive in an immunosuppressive microenvironment that impedes antitumor innate and adaptive immune responses. Thus, approaches that can overcome…”
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The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer by Allen, Irving C, TeKippe, Erin McElvania, Woodford, Rita-Marie T, Uronis, Joshua M, Holl, Eda K, Rogers, Arlin B, Herfarth, Hans H, Jobin, Christian, Ting, Jenny P-Y

“…Colitis-associated cancer (CAC) is a major complication of inflammatory bowel diseases. We show that components of the inflammasome are protective during acute…”
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The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA by Allen, Irving C., Scull, Margaret A., Moore, Chris B., Holl, Eda K., McElvania-TeKippe, Erin, Taxman, Debra J., Guthrie, Elizabeth H., Pickles, Raymond J., Ting, Jenny P.-Y.

“…The nucleotide-binding domain and leucine-rich-repeat-containing (NLR) family of pattern-recognition molecules mediate host immunity to various pathogenic…”
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Controlling cancer-induced inflammation with a nucleic acid scavenger prevents lung metastasis in murine models of breast cancer by Holl, Eda K., Frazier, Victoria, Landa, Karenia, Boczkowski, David, Sullenger, Bruce, Nair, Smita K.

“…Tumor cells release nucleic acid-containing proinflammatory complexes, termed nucleic acid-containing damage-associated molecular patterns (NA DAMPs),…”
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Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling by Brown, Michael C., Mosaheb, Mubeen M., Mohme, Malte, McKay, Zachary P., Holl, Eda K., Kastan, Jonathan P., Yang, Yuanfan, Beasley, Georgia M., Hwang, E. Shelley, Ashley, David M., Bigner, Darell D., Nair, Smita K., Gromeier, Matthias

“…Activating intra-tumor innate immunity might enhance tumor immune surveillance. Virotherapy is proposed to achieve tumor cell killing, while indirectly…”
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Examining Peripheral and Tumor Cellular Immunome in Patients With Cancer by Holl, Eda K, Frazier, Victoria N, Landa, Karenia, Beasley, Georgia M, Hwang, E Shelley, Nair, Smita K

“…Immunotherapies are rapidly being integrated into standard of care (SOC) therapy in conjunction with surgery, chemotherapy, and radiotherapy for many cancers…”
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The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB by Schneider, Monika, Zimmermann, Albert G, Roberts, Reid A, Zhang, Lu, Swanson, Karen V, Wen, Haitao, Davis, Beckley K, Allen, Irving C, Holl, Eda K, Ye, Zhengmao, Rahman, Adeeb H, Conti, Brian J, Eitas, Timothy K, Koller, Beverly H, Ting, Jenny P-Y

“…Sensors of the NLR family generally activate innate immunity. Ting et al ., however, demonstrate that the little-known NLRC3 negatively regulates Toll-like…”
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Nucleic acid scavengers inhibit thrombosis without increasing bleeding by Jain, Shashank, Pitoc, George A, Holl, Eda K, Zhang, Ying, Borst, Luke, Leong, Kam W, Lee, Jaewoo, Sullenger, Bruce A

“…Development of effective, yet safe, antithrombotic agents has been challenging because such agents increase the propensity of patients to bleed. Recently,…”
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Tandem Mass Tag LC-MS/MS of Aqueous Humor From Individuals With Type 2 Diabetes Without Retinopathy Reveals Early Dysregulation of Synaptic Proteins by Sachdeva, Mira M, Lee, Yoonjung, Unlu, Eda K, Koseoglu, Neslihan D, Cha, Eumee, Wang, Jiangxia, Prescott, Christina R, Eghrari, Allen O, Na, Chan Hyun

“…An early neurodegenerative component of diabetic retinal disease (DRD) that precedes the vascular findings of clinically diagnosed diabetic retinopathy (DR) is…”
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Generation of bone marrow and fetal liver chimeric mice by Holl, Eda K

“…The creation of bone marrow and fetal liver chimeric mice has proven to be a valuable tool in the field of immunology. Chimeric mice are used to study the…”
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Scavenging nucleic acid debris to combat autoimmunity and infectious disease by Holl, Eda K., Shumansky, Kara L., Borst, Luke B., Burnette, Angela D., Sample, Christopher J., Ramsburg, Elizabeth A., Sullenger, Bruce A.

“…Nucleic acid-containing debris released from dead and dying cells can be recognized as damage-associated molecular patterns (DAMPs) or pattern-associated…”
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Functional reprogramming of peripheral blood monocytes by soluble mediators in patients with pancreatic cancer and intraductal papillary mucinous neoplasms by Eckhoff, Austin M, Brown, Michael C, Landa, Karenia, Naqvi, Ibtehaj, Holl, Eda K, Boczkowski, David, Fletcher, Ashley, Rhodin, Kristen E, Giang, Minh Huy, Sullenger, Bruce, Beasley, Georgia M, Allen, Peter J, Nair, Smita K

“…Monocytes and monocyte-derived tumor infiltrating cells have been implicated in the immunosuppression and immune evasion associated with pancreatic…”
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Spatial biology analysis reveals B cell follicles in secondary lymphoid structures may regulate anti-tumor responses at initial melanoma diagnosis by Therien, Aaron D, Beasley, Georgia M, Rhodin, Kristen E, Farrow, Norma E, Tyler, Douglas S, Boczkowski, David, Al-Rohil, Rami N, Holl, Eda K, Nair, Smita K

“…B cells are key regulators of immune responses in melanoma. We aimed to explore differences in the histologic location and activation status of B cell…”
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Characterization of Sentinel Lymph Node Immune Signatures and Implications for Risk Stratification for Adjuvant Therapy in Melanoma by Farrow, Norma E., Holl, Eda K., Jung, Jeanne, Gao, Junheng, Jung, Sin-Ho, Al-Rohil, Rami N., Selim, Maria A., Mosca, Paul J., Ollila, David W., Antonia, Scott J., Tyler, Douglas S., Nair, Smita K., Beasley, Georgia M.

“…Background Although sentinel lymph node (SLN) biopsy is a standard procedure used to identify patients at risk for melanoma recurrence, it fails to…”
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Immune Expression in Children With Vesicoureteral Reflux: A Pilot Study by Johnston, Ashley W., Routh, Jonathan C., Purves, J. Todd, Wiener, John S., Sinani, Angela, Holl, Eda K.

“…To perform an exploratory, descriptive pilot study of the systemic and local immune environment in patients with vesicoureteral reflux (VUR) and bladder-bowel…”
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Recombinant oncolytic poliovirus, PVSRIPO, has potent cytotoxic and innate inflammatory effects, mediating therapy in human breast and prostate cancer xenograft models by Holl, Eda K, Brown, Michael C, Boczkowski, David, McNamara, Megan A, George, Daniel J, Bigner, Darell D, Gromeier, Matthias, Nair, Smita K

“…Intratumoral inoculation of viruses with tumor-selective cytotoxicity may induce cancer cell death and, thereby, shrink neoplastic lesions. It is unlikely,…”
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Plexin-B2 and Plexin-D1 in dendritic cells: expression and IL-12/IL-23p40 production by Holl, Eda K, Roney, Kelly E, Allen, Irving C, Steinbach, Erin, Arthur, Janelle C, Buntzman, Adam, Plevy, Scott, Frelinger, Jeffrey, Ting, Jenny P-Y

“…Plexins are a family of genes (A,B,C, and D) that are expressed in many organ systems. Plexins expressed in the immune system have been implicated in cell…”
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Nucleic acid scavenging polymers inhibit extracellular DNA-mediated innate immune activation without inhibiting anti-viral responses by Holl, Eda K, Shumansky, Kara L, Pitoc, George, Ramsburg, Elizabeth, Sullenger, Bruce A

“…Toll-like receptor (TLR) family members, 3, 7 and 9 are key components in initiation and progression of autoimmune disorders such as systemic lupus…”
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Implementation of flow cytometry testing on rare matrix samples: Special considerations and best practices when the sample is unique or difficult to obtain by Devitt, Katherine A, Kern, Wolfgang, Kajstura, Malgorzata A, Holl, Eda K, Hays, Amanda L, Hedley, Benjamin D, Gonneau, Christèle, Jellison, Evan R, McCloskey, Thomas W, Mishra, Shruti, Rebeles, Jennifer, Ouseph, Madhu M

“…The publication of Clinical and Laboratory Standards Institute's guideline H62 has provided the flow cytometry community with much-needed guidance on…”
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