Search Results - "Economides, Kyriakos D."

ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance by Jang, Su Chul, Economides, Kyriakos D., Moniz, Raymond J., Sia, Chang Ling, Lewis, Nuruddeen, McCoy, Christine, Zi, Tong, Zhang, Kelvin, Harrison, Rane A., Lim, Joanne, Dey, Joyoti, Grenley, Marc, Kirwin, Katherine, Ross, Nikki L., Bourdeau, Raymond, Villiger-Oberbek, Agata, Estes, Scott, Xu, Ke, Sanchez-Salazar, Jorge, Dooley, Kevin, Dahlberg, William K., Williams, Douglas E., Sathyanarayanan, Sriram

“…Cyclic dinucleotide (CDN) agonists of the STimulator of InterferoN Genes (STING) pathway have shown immune activation and tumor clearance in pre-clinical…”
Get full text

Hoxb13 is required for normal differentiation and secretory function of the ventral prostate by Economides, Kyriakos D, Capecchi, Mario R

“…The murine prostate is a structure that is made up of four distinct lobes; the dorsal and lateral prostates (often grouped together as the dorsolateral…”
Get full text

Reduction of liver fibrosis by rationally designed macromolecular telmisartan prodrugs by Golder, Matthew R., Liu, Jenny, Andersen, Jannik N., Shipitsin, Michail V., Vohidov, Farrukh, Nguyen, Hung V.-T., Ehrlich, Deborah C., Huh, Sung Jin, Vangamudi, Bhavatarini, Economides, Kyriakos D., Neenan, Allison M., Ackley, James C., Baddour, Joelle, Paramasivan, Sattanathan, Brady, Samantha W., Held, Eric J., Reiter, Lawrence A., Saucier-Sawyer, Jennifer K., Kopesky, Paul W., Chickering, Donald E., Blume-Jensen, Peter, Johnson, Jeremiah A.

“…At present there are no drugs for the treatment of chronic liver fibrosis that have been approved by the Food and Drug Administration of the United States…”
Get full text

Hoxb13 mutations cause overgrowth of caudal spinal cordand tail vertebrae by Economides, Kyriakos D, Zeltser, Lori, Capecchi, Mario R

“…To address the expression and function of Hoxb13, the 5′ most Hox gene in the HoxB cluster, we have generated mice with loss-of-function and β- galactosidase…”
Get full text

PIAS1 confers DNA-binding specificity on the Msx1 homeoprotein by Lee, Hansol, Quinn, John C, Prasanth, Kannanganattu V, Swiss, Victoria A, Economides, Kyriakos D, Camacho, Marie M, Spector, David L, Abate-Shen, Cory

“…The mechanisms by which homeoproteins bind selectively to target genes in vivo have long remained unresolved. Here we report that PIAS1 confers DNA-binding…”
Get full text

A versatile platform for generating engineered extracellular vesicles with defined therapeutic properties by Dooley, Kevin, McConnell, Russell E., Xu, Ke, Lewis, Nuruddeen D., Haupt, Sonya, Youniss, Madeleine R., Martin, Shelly, Sia, Chang Ling, McCoy, Christine, Moniz, Raymond J., Burenkova, Olga, Sanchez-Salazar, Jorge, Jang, Su Chul, Choi, Bryan, Harrison, Rane A., Houde, Damian, Burzyn, Dalia, Leng, Charan, Kirwin, Katherine, Ross, Nikki L., Finn, Jonathan D., Gaidukov, Leonid, Economides, Kyriakos D., Estes, Scott, Thornton, James E., Kulman, John D., Sathyanarayanan, Sriram, Williams, Douglas E.

“…Extracellular vesicles (EVs) are an important intercellular communication system facilitating the transfer of macromolecules between cells. Delivery of…”
Get full text

Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12 by Lewis, Nuruddeen D, Sia, Chang Ling, Kirwin, Katherine, Haupt, Sonya, Mahimkar, Gauri, Zi, Tong, Xu, Ke, Dooley, Kevin, Jang, Su Chul, Choi, Bryan, Boutin, Adam, Grube, Andrew, McCoy, Christine, Sanchez-Salazar, Jorge, Doherty, Michael, Gaidukov, Leonid, Estes, Scott, Economides, Kyriakos D, Williams, Douglas E, Sathyanarayanan, Sriram

“…The promise of IL12 as a cancer treatment has yet to be fulfilled with multiple tested approaches being limited by unwanted systemic exposure and unpredictable…”
Get full text

A luminal epithelial stem cell that is a cell of origin for prostate cancer by Yu, Hailong, Abate-Shen, Cory, Halili, M. Vivienne, Walker, David, Shen, Michael M, Wang, Xi, Price, Sandy M, Julio, Marianna Kruithof-de, Hu, Ya-Ping, Economides, Kyriakos D

“…In epithelial tissues, the lineage relationship between normal progenitor cells and cell type(s) of origin for cancer has been poorly understood. Here we show…”
Get full text

Design of BET Inhibitor Bottlebrush Prodrugs with Superior Efficacy and Devoid of Systemic Toxicities by Vohidov, Farrukh, Andersen, Jannik N, Economides, Kyriakos D, Shipitsin, Michail V, Burenkova, Olga, Ackley, James C, Vangamudi, Bhavatarini, Nguyen, Hung V.-T, Gallagher, Nolan M, Shieh, Peyton, Golder, Matthew R, Liu, Jenny, Dahlberg, William K, Ehrlich, Deborah J. C, Kim, Julie, Kristufek, Samantha L, Huh, Sung Jin, Neenan, Allison M, Baddour, Joelle, Paramasivan, Sattanathan, de Stanchina, Elisa, KC, Gaurab, Turnquist, David J, Saucier-Sawyer, Jennifer K, Kopesky, Paul W, Brady, Samantha W, Jessel, Michael J, Reiter, Lawrence A, Chickering, Donald E, Johnson, Jeremiah A, Blume-Jensen, Peter

“…Prodrugs engineered for preferential activation in diseased versus normal tissues offer immense potential to improve the therapeutic indexes (TIs) of…”
Get full text

DISC1 regulates N-methyl-D-aspartate receptor dynamics: abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness by Malavasi, Elise L. V., Economides, Kyriakos D., Grünewald, Ellen, Makedonopoulou, Paraskevi, Gautier, Philippe, Mackie, Shaun, Murphy, Laura C., Murdoch, Hannah, Crummie, Darragh, Ogawa, Fumiaki, McCartney, Daniel L., O’Sullivan, Shane T., Burr, Karen, Torrance, Helen S., Phillips, Jonathan, Bonneau, Marion, Anderson, Susan M., Perry, Paul, Pearson, Matthew, Constantinides, Costas, Davidson-Smith, Hazel, Kabiri, Mostafa, Duff, Barbara, Johnstone, Mandy, Polites, H. Greg, Lawrie, Stephen M., Blackwood, Douglas H., Semple, Colin A., Evans, Kathryn L., Didier, Michel, Chandran, Siddharthan, McIntosh, Andrew M., Price, David J., Houslay, Miles D., Porteous, David J., Millar, J. Kirsty

“…The neuromodulatory gene DISC1 is disrupted by a t(1;11) translocation that is highly penetrant for schizophrenia and affective disorders, but how this…”
Get full text

Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastases by ABATE-SHEN, Cory, BANACH-PETROSKY, Whitney A, XIAOHUI SUN, ECONOMIDES, Kyriakos D, DESAI, Nishita, GREGG, Jeffery P, BOROWSKY, Alexander D, CARDIFF, Robert D, SHEN, Michael M

“…Recent studies have shown that several loss-of-function mouse models of prostate carcinogenesis can develop a spectrum of precancerous lesions that resemble…”
Get full text

The Central Cannabinoid CB1 Receptor Is Required for Diet-Induced Obesity and Rimonabant's Antiobesity Effects in Mice by Pang, Zhen, Wu, Nancy N., Zhao, Weiguang, Chain, David C., Schaffer, Erica, Zhang, Xin, Yamdagni, Preeti, Palejwala, Vaseem A., Fan, Chunpeng, Favara, Sarah G., Dressler, Holly M., Economides, Kyriakos D., Weinstock, Daniel, Cavallo, Jean S., Naimi, Souad, Galzin, Anne‐Marie, Guillot, Etienne, Pruniaux, Marie‐Pierre, Tocci, Michael J., Polites, H. Greg

“…Cannabinoid receptor CB1 is expressed abundantly in the brain and presumably in the peripheral tissues responsible for energy metabolism. It is unclear if the…”
Get full text

Publisher Correction: Reduction of liver fibrosis by rationally designed macromolecular telmisartan prodrugs by Golder, Matthew R., Liu, Jenny, Andersen, Jannik N., Shipitsin, Michail V., Vohidov, Farrukh, Nguyen, Hung V.-T., Ehrlich, Deborah C., Huh, Sung Jin, Vangamudi, Bhavatarini, Economides, Kyriakos D., Neenan, Allison M., Ackley, James C., Baddour, Joelle, Paramasivan, Sattanathan, Brady, Samantha W., Held, Eric J., Reiter, Lawrence A., Saucier-Sawyer, Jennifer K., Kopesky, Paul W., Chickering, Donald E., Blume-Jensen, Peter, Johnson, Jeremiah A.

“…In the version of this Article originally published, the author Peter Blume-Jensen was not denoted as a corresponding author; this has now been amended and the…”
Get full text

Abstract 2150: engEx: A novel exosome engineering platform enabling targeted transfer of pharmacological molecules by Dooley, Kevin, Xu, Ke, Haupt, Sonya, Lewis, Nuruddeen, Harrison, Rane, Martin, Shelly, McCoy, Christine, Sia, Chang Ling, Jang, Su Chul, Kirwin, Katherine, McConnell, Russell, Choi, Bryan, Boutin, Adam T., Houde, Damian, Sanchez-Salazar, Jorge, Villiger-Oberbek, Agata, Economides, Kyriakos D., Kulman, John D., Sathyanarayanan, Sriram

“…Exosomes are natural and abundant nanoscale vesicles for intercellular communication, capable of transferring biological instructions between neighboring and…”
Get full text

Abstract 944: exoSTING: An engineered exosome therapeutic that selectively delivers STING agonist to the tumor resident antigen-presenting cells resulting in improved tumor antigen-specific adaptive immune response by Jang, Su Chul, Moniz, Raymond J., Sia, Chang Ling, Harrison, Rane A., Houde, Damian, Ross, Nikki, Xu, Ke, Lewis, Nuruddeen, Bourdeau, Raymond, McCoy, Christine, Zi, Tong, Villiger-Oberbek, Agata, Estes, Scott, Sanchez-Salazar, Jorge, Dooley, Kevin, Dahlberg, William K., Sathyanarayanan, Sriram, Economides, Kyriakos D.

“…Background: The Stimulator of Interferon Genes (STING) pathway is an attractive target in immuno-oncology. Selective activation of the STING pathway in antigen…”
Get full text

Abstract LB-062: Development of macromolecular prodrugs of BET-bromodomain inhibitors with superior anti-tumor efficacy that are T-cell sparing and devoid of systemic toxicity by Vohidov, Farrukh, Andersen, Jannik N., Economides, Kyriakos D., Shipitsin, Michail V., Burenkova, Olga, Gallagher, Nolan M., Sheih, Peyton, Golder, Matthew, Liu, Jenny, Dahlberg, William K., Nguyen, Hung V., Ehrlich, Deborah J., Kim, Julie, Huh, Sung Jin, Vangamudi, Bhavatarini, Neenan, Allison M., Ackley, James C., Baddour, Joelle, Paramasivan, Sattanathan, KC, Gaurab, Turnquist, David J., Saucier-Sawyer, Jenny K., Kopesky, Paul W., Brady, Samantha W., Jessel, Michael J., Reiter, Lawrence A., Chickering, Donald E., Johnson, Jeremiah A., Blume-Jensen, Peter

“…Small molecule BET inhibitors are promising anti-cancer agents, but their clinical development has been limited by hematological and gastrointestinal (GI)…”
Get full text

Hoxb13 mutations cause overgrowth of caudal spinal cord and tail vertebrae by Economides, Kyriakos D, Zeltser, Lori, Capecchi, Mario R

“…To address the expression and function of Hoxb13, the 5' most Hox gene in the HoxB cluster, we have generated mice with loss-of-function and beta-galactosidase…”
Get full text

The role of Hoxb13 in caudal axis patterning and prostate development by Economides, Kyriakos D

“…Vertebrate Hox genes encode a family of homeobox transcription factors that regulate developmental programs and determine the embryonic body plan. These…”
Get full text