Search Results - "Eckman, Joseph"

Preclinical Experimental and Mathematical Approaches for Assessing Effective Doses of Inhaled Drugs, Using Mometasone to Support Human Dose Predictions by Caniga, Michael, Cabal, Antonio, Mehta, Khamir, Ross, David S, Gil, Malgorzata A, Woodhouse, Janice D, Eckman, Joseph, Naber, John R, Callahan, Marissa K, Goncalves, Luciano, Hill, Susan E, Mcleod, Robbie L, McIntosh, Fraser, Freke, Mark C, Visser, Sandra A G, Johnson, Neil, Salmon, Michael, Cicmil, Milenko

“…Understanding the relationship between dose, lung exposure, and drug efficacy continues to be a challenging aspect of inhaled drug development. An experimental…”
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LBY135, a novel anti-DR5 agonistic antibody induces tumor cell-specific cytotoxic activity in human colon tumor cell lines and xenografts by Li, Jing, Knee, Deborah A., Wang, Youzhen, Zhang, Qingxiu, Johnson, Jennifer A., Cheng, Jane, He, Helen, Miller, Christine, Li, Zhifang, Kowal, Colleen, Eckman III, Joseph, Tang, Betty, Yuan, Jing, Chen, Liqing, Deveraux, Quinn, Nasoff, Marc S., Stover, David

“…TRAIL (TNF‐related apoptosis‐inducing ligand) induces apoptosis on binding to DR4 and DR5 receptors on the surface of tumor cells. These receptors are of…”
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5-Lipoxygenase inhibitors with histamine H1 receptor antagonist activity by LEWIS, Timothy A, BAYLESS, Lynn, WYPIJ, Donna M, ECKMAN, Joseph B, ELLIS, James L, GREWAL, Gurmit, LIBERTINE, Lyn, NICOLAS, Jean Marie, SCANNELL, Ralph T, WELS, Bruce F, WENBERG, Karen

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5-Lipoxygenase inhibition by N-hydroxycarbamates in dual-function compounds by Lewis, Timothy A., Bayless, Lynn, DiPesa, Alan J., Eckman, Joseph B., Gillard, Michel, Libertine, Lyn, Scannell, Ralph T., Wypij, Donna M., Young, Michelle A.

“…A series of N-hydroxycarbamates containing a histaminergic H 1 receptor antagonist pharmacophore was synthesized. The compounds possessed both…”
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Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity by Lewis, Timothy A., Young, Michelle A., Arrington, Mark P., Bayless, Lynn, Cai, Xiong, Collart, Philippe, Eckman, Joseph B., Ellis, James L., Ene, Doina G., Libertine, Lyn, Nicolas, Jean-Marie, Scannell, Ralph T., Wels, Bruce F., Wenberg, Karen, Wypij, Donna M.

“…Three different histaminergic H 1 scaffolds were attached by various linkers to a single 5-LO scaffold. Both activities were observed in vitro. Pharmacokinetic…”
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UCB 62045: pharmacology of a novel, dual-function anti-inflammatory agent with histamine type 1 receptor antagonist and 5-lipoxygenase inhibitor activity by Selig, William M, Bayless, Lynn, Libertine, Lyn, Eckman, Joseph B, Wypij, Donna M, Wels, Bruce F, Eckert, Maria, Young, Michelle A, Nicolas, Jean M, Scannell, Ralph T, Ellis, James L

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Anti-inflammatory actions of Chemoattractant Receptor-homologous molecule expressed on Th2 by the antagonist MK-7246 in a novel rat model of Alternaria alternata elicited pulmonary inflammation by Gil, Malgorzata A., Caniga, Michael, Woodhouse, Janice D., Eckman, Joseph, Lee, Hyun-Hee, Salmon, Michael, Naber, John, Hamilton, Valerie T., Sevilla, Raquel S., Bettano, Kimberly, Klappenbach, Joel, Moy, Lily, Correll, Craig C., Gervais, Francois G., Siliphaivanh, Phieng, Zhang, Weisheng, Zhang-Hoover, Jie, McLeod, Robbie L., Cicmil, Milenko

“…Alternaria alternata is a fungal allergen linked to the development of severe asthma in humans. In view of the clinical relationship between A. alternata and…”
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Alternaria alternata induced inflammatory lung responses: a novel in vivo PK/PD model by Gil, Malgorzata, Caniga, Michael, Eckman, Joseph, McLeod, Robbie, Moy, Lily, Wilhelm, Alan, Woodhouse, Janice, Zhang-Hoover, Jie, Cicmil, Milenko

“…Doc number: P10…”
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Efficacy of Panobinostat (LBH589) in Multiple Myeloma Cell Lines and In Vivo Mouse Model: Tumor-Specific Cytotoxicity and Protection of Bone Integrity in Multiple Myeloma by Growney, Joseph D., Atadja, Peter, Shao, Wenlin, Wang, Youzhen, Pu, Minying, Firestone, Brant, Cheng, Jane, Kowal, Colleen, Miller, Christine, Eckman, Joseph, Yao, Yung-Mae, Fawell, Stephen, Spencer, Andrew, Miguel, Jesus F. San, Anderson, Kenneth C.

“…Panobinostat (LBH589) is a highly potent oral pan-deacetylase (DAC) inhibitor currently undergoing clinical development in hematologic and solid malignancies…”
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5-Lipoxygenase inhibitors with histamine H 1 receptor antagonist activity by Lewis, Timothy A, Bayless, Lynn, Eckman, Joseph B, Ellis, James L, Grewal, Gurmit, Libertine, Lyn, Marie Nicolas, Jean, Scannell, Ralph T, Wels, Bruce F, Wenberg, Karen, Wypij, Donna M

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Epibatidine is a nicotinic analgesic by Qian, C, Li, T, Shen, T Y, Libertine-Garahan, L, Eckman, J, Biftu, T, Ip, S

“…Epibatidine, an alkaloid isolated from skin of the poison frog, Epipedobates tricolor, has been shown to be a very potent analgesic with a non-opioid mechanism…”
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Synthesis and screening of a combinatorial library of naphthalene substituted chalcones: inhibitors of leukotriene B 4 by Deshpande, Anil M., Argade, Narshinha P., Natu, Arvind A., Eckman, Joseph

“…A combinatorial mini library of naphthalene substituted chalcones has been prepared by solution phase chemistry. Screening of these mixtures for leukotriene B…”
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Synthesis and screening of a combinatorial library of naphthalene substituted chalcones : Inhibitors of leukotriene B4 by DESHPANDE, A. M, ARGADE, N. P, NATU, A. A, ECKMAN, J

“…A combinatorial mini library of naphthalene substituted chalcones has been prepared by solution phase chemistry. Screening of these mixtures for leukotriene B4…”
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5-lipoxygenase inhibitors with histamine H(1) receptor antagonist activity by Lewis, Timothy A, Bayless, Lynn, Eckman, Joseph B, Ellis, James L, Grewal, Gurmit, Libertine, Lyn, Marie Nicolas, Jean, Scannell, Ralph T, Wels, Bruce F, Wenberg, Karen, Wypij, Donna M

“…A series of novel compounds with both 5-lipoxygenase (5-LO) inhibitory and histamine H(1) receptor antagonist activity were designed for the treatment of…”
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Synthesis and screening of a combinatorial library of naphthalene substituted chalcones: inhibitors of leukotriene B41NCL Communication No. 6453.1 by Deshpande, Anil M., Argade, Narshinha P., Natu, Arvind A., Eckman, Joseph

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(±)-trans-2-[3-Methoxy-4-(4-chlorophenylthioethoxy)-5-(N-methyl-N- hydroxyureidyl)methylphenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran (CMI-392), a Potent Dual 5-Lipoxygenase Inhibitor and Platelet-Activating Factor Receptor Antagonist by Cai, Xiong, Scannell, Ralph T, Yaeger, David, Hussoin, Md. Sajjat, Killian, David B, Qian, Changgeng, Eckman, Joseph, Hwang, San-Bao, Libertine-Garahan, Lynn, Yeh, C. Grace, Ip, Stephen H, Shen, T. Y

“…By incorporating an N-hydroxyurea functionality onto diaryltetrahydrofurans, a novel series of compounds was investigated as dual 5-lipoxygenese (5-LO)…”
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Cmi-206: A potent dual platelet activating factor antagonist and 5-lipoxygenase inhibitor by Sajjat Hussoin, Md, Cai, Xiong, Scannell, Ralph T., Yaeger, David, Killian, David B., Eckman, Joseph, Hwang, San-Bao, Libertine-Garahan, Lynn, Qian, Changgeng, Grace Yen, C., Ip, Stephen

“…CMI-206, trans-2[3-methoxy-4-propoxy-5(N′-butyl-N′-hydroxyureidyl)phenyl]-5-(3,4,5-trimethoxyphenyl) tetrahydrofuran, was synthesized and was found to…”
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