Search Results - "Eckhardt, Manon"

Mass spectrometry‐based protein–protein interaction networks for the study of human diseases by Richards, Alicia L, Eckhardt, Manon, Krogan, Nevan J

“…A better understanding of the molecular mechanisms underlying disease is key for expediting the development of novel therapeutic interventions. Disease…”
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A systems approach to infectious disease by Eckhardt, Manon, Hultquist, Judd F., Kaake, Robyn M., Hüttenhain, Ruth, Krogan, Nevan J.

“…Ongoing social, political and ecological changes in the 21st century have placed more people at risk of life-threatening acute and chronic infections than ever…”
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Multiple Routes to Oncogenesis Are Promoted by the Human Papillomavirus-Host Protein Network by Eckhardt, Manon, Zhang, Wei, Gross, Andrew M, Von Dollen, John, Johnson, Jeffrey R, Franks-Skiba, Kathleen E, Swaney, Danielle L, Johnson, Tasha L, Jang, Gwendolyn M, Shah, Priya S, Brand, Toni M, Archambault, Jacques, Kreisberg, Jason F, Grandis, Jennifer R, Ideker, Trey, Krogan, Nevan J

“…We have mapped a global network of virus-host protein interactions by purification of the complete set of human papillomavirus (HPV) proteins in multiple cell…”
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A proximity proteomics pipeline with improved reproducibility and throughput by Zhong, Xiaofang, Li, Qiongyu, Polacco, Benjamin J, Patil, Trupti, Marley, Aaron, Foussard, Helene, Khare, Prachi, Vartak, Rasika, Xu, Jiewei, DiBerto, Jeffrey F, Roth, Bryan L, Eckhardt, Manon, von Zastrow, Mark, Krogan, Nevan J, Hüttenhain, Ruth

“…Proximity labeling (PL) via biotinylation coupled with mass spectrometry (MS) captures spatial proteomes in cells. Large-scale processing requires a workflow…”
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Comparative mapping of host–pathogen protein–protein interactions by Shah, Priya S, Wojcechowskyj, Jason A, Eckhardt, Manon, Krogan, Nevan J

“…Graphical abstract…”
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Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3 by Peters, Christine E., Schulze-Gahmen, Ursula, Eckhardt, Manon, Jang, Gwendolyn M., Xu, Jiewei, Pulido, Ernst H., Bardine, Conner, Craik, Charles S., Ott, Melanie, Gozani, Or, Verba, Kliment A., Hüttenhain, Ruth, Carette, Jan E., Krogan, Nevan J.

“…Enteroviruses cause a number of medically relevant and widespread human diseases with no approved antiviral therapies currently available. Host-directed…”
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CD317/Tetherin Is Enriched in the HIV-1 Envelope and Downregulated from the Plasma Membrane upon Virus Infection by HABERMANN, Anja, KRIJNSE-LOCKER, Jacomine, OBERWINKLER, Heike, ECKHARDT, Manon, HOMANN, Stefanie, ANDREW, Amy, STREBEL, Klaus, KRÄUSSLICH, Hans-Georg

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A SNAP-tagged derivative of HIV-1--a versatile tool to study virus-cell interactions by Eckhardt, Manon, Anders, Maria, Muranyi, Walter, Heilemann, Mike, Krijnse-Locker, Jacomine, Müller, Barbara

“…Fluorescently labeled human immunodeficiency virus (HIV) derivatives, combined with the use of advanced fluorescence microscopy techniques, allow the direct…”
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CRISPR-Cas9 screen of E3 ubiquitin ligases identifies TRAF2 and UHRF1 as regulators of HIV latency in primary human T cells by Rathore, Ujjwal, Haas, Paige, Easwar Kumar, Vigneshwari, Hiatt, Joseph, Haas, Kelsey M, Bouhaddou, Mehdi, Swaney, Danielle L, Stevenson, Erica, Zuliani-Alvarez, Lorena, McGregor, Michael J, Turner-Groth, Autumn, Ochieng' Olwal, Charles, Bediako, Yaw, Braberg, Hannes, Soucheray, Margaret, Ott, Melanie, Eckhardt, Manon, Hultquist, Judd F, Marson, Alexander, Kaake, Robyn M, Krogan, Nevan J

“…During HIV infection of CD4+ T cells, ubiquitin pathways are essential to viral replication and host innate immune response; however, the role of specific E3…”
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Network modeling suggests HIV infection phenocopies PI3K-AKT pathway mutations to enhance HPV-associated cervical cancer by Olwal, Charles Ochieng', Fabius, Jacqueline M, Zuliani-Alvarez, Lorena, Eckhardt, Manon, Kyei, George Boateng, Quashie, Peter Kojo, Krogan, Nevan J, Bouhaddou, Mehdi, Bediako, Yaw

“…Women coinfected with human immunodeficiency virus type 1 (HIV-1) and human papillomavirus (HPV) are six times as likely to develop invasive cervical carcinoma…”
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Protocol for mapping differential protein-protein interaction networks using affinity purification-mass spectrometry by Kaushal, Prashant, Ummadi, Manisha R., Jang, Gwendolyn M., Delgado, Yennifer, Makanani, Sara K., Alba, Kareem, Winters, Declan M., Blanc, Sophie F., Xu, Jiewei, Polacco, Benjamin, Zhou, Yuan, Stevenson, Erica, Eckhardt, Manon, Zuliani-Alvarez, Lorena, Kaake, Robyn, Swaney, Danielle L., Krogan, Nevan J., Bouhaddou, Mehdi

“…Proteins congregate into complexes to perform diverse cellular functions. Protein complexes are remodeled by protein-coding mutations or cellular signaling…”
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An expanded model of HIV cell entry phenotype based on multi-parameter single-cell data by Bozek, Katarzyna, Eckhardt, Manon, Sierra, Saleta, Anders, Maria, Kaiser, Rolf, Kräusslich, Hans-Georg, Müller, Barbara, Lengauer, Thomas

“…Entry of human immunodeficiency virus type 1 (HIV-1) into the host cell involves interactions between the viral envelope glycoproteins (Env) and the cellular…”
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A SARS-CoV-2 protein interaction map reveals targets for drug repurposing by Gordon, David E., Jang, Gwendolyn M., Bouhaddou, Mehdi, Xu, Jiewei, Obernier, Kirsten, White, Kris M., O’Meara, Matthew J., Rezelj, Veronica V., Guo, Jeffrey Z., Swaney, Danielle L., Tummino, Tia A., Kaake, Robyn M., Richards, Alicia L., Tutuncuoglu, Beril, Foussard, Helene, Haas, Kelsey, Modak, Maya, Haas, Paige, Braberg, Hannes, Fabius, Jacqueline M., Eckhardt, Manon, Bennett, Melanie J., Cakir, Merve, McGregor, Michael J., Li, Qiongyu, Roesch, Ferdinand, Vallet, Thomas, Mac Kain, Alice, Miorin, Lisa, Moreno, Elena, Naing, Zun Zar Chi, Zhou, Yuan, Peng, Shiming, Shi, Ying, Zhang, Ziyang, Shen, Wenqi, Kirby, Ilsa T., Melnyk, James E., Chorba, John S., Lou, Kevin, Dai, Shizhong A., Barrio-Hernandez, Inigo, Memon, Danish, Hernandez-Armenta, Claudia, Perica, Tina, Ganesan, Sai J., Saltzberg, Daniel J., Calviello, Lorenzo, Venkataramanan, Srivats, Lin, Yizhu, Liu, YongFeng, Wankowicz, Stephanie A., Bohn, Markus, Safari, Maliheh, Ugur, Fatima S., Koh, Cassandra, Savar, Nastaran Sadat, Tran, Quang Dinh, Fletcher, Sabrina J., Cai, Yiming, Chang, Jason C. J., Broadhurst, David J., Klippsten, Saker, Sharp, Phillip P., Kuzuoglu-Ozturk, Duygu, Wang, Hao-Yuan, Trenker, Raphael, Cavero, Devin A., Hiatt, Joseph, Roth, Theodore L., Rathore, Ujjwal, Subramanian, Advait, Noack, Julia, Hubert, Mathieu, Stroud, Robert M., Frankel, Alan D., Verba, Kliment A., Agard, David A., Emerman, Michael, Jura, Natalia, von Zastrow, Mark, Verdin, Eric, Ashworth, Alan, Schwartz, Olivier, Mukherjee, Shaeri, Jacobson, Matt, Fujimori, Danica G., Ideker, Trey, Craik, Charles S., Floor, Stephen N., Fraser, James S., Gross, John D., Roth, Bryan L., Ruggero, Davide, Taunton, Jack, Beltrao, Pedro, Vignuzzi, Marco, Shokat, Kevan M., Shoichet, Brian K., Krogan, Nevan J.

“…A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of coronavirus disease 2019…”
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A SARS-CoV-2 protein interaction map reveals targets for drug repurposing by Gordon, David E, Jang, Gwendolyn M, Bouhaddou, Mehdi, Xu, Jiewei, Obernier, Kirsten, White, Kris M, O'Meara, Matthew J, Rezelj, Veronica V, Guo, Jeffrey Z, Swaney, Danielle L, Tummino, Tia A, Hüttenhain, Ruth, Kaake, Robyn M, Richards, Alicia L, Tutuncuoglu, Beril, Foussard, Helene, Batra, Jyoti, Haas, Kelsey, Modak, Maya, Kim, Minkyu, Haas, Paige, Polacco, Benjamin J, Braberg, Hannes, Fabius, Jacqueline M, Eckhardt, Manon, Soucheray, Margaret, Bennett, Melanie J, Cakir, Merve, McGregor, Michael J, Li, Qiongyu, Meyer, Bjoern, Roesch, Ferdinand, Vallet, Thomas, Mac Kain, Alice, Miorin, Lisa, Moreno, Elena, Naing, Zun Zar Chi, Zhou, Yuan, Peng, Shiming, Shi, Ying, Zhang, Ziyang, Shen, Wenqi, Kirby, Ilsa T, Melnyk, James E, Chorba, John S, Lou, Kevin, Dai, Shizhong A, Barrio-Hernandez, Inigo, Memon, Danish, Hernandez-Armenta, Claudia, Lyu, Jiankun, Mathy, Christopher J P, Perica, Tina, Pilla, Kala Bharath, Ganesan, Sai J, Saltzberg, Daniel J, Rakesh, Ramachandran, Liu, Xi, Rosenthal, Sara B, Calviello, Lorenzo, Venkataramanan, Srivats, Liboy-Lugo, Jose, Lin, Yizhu, Huang, Xi-Ping, Liu, YongFeng, Wankowicz, Stephanie A, Bohn, Markus, Safari, Maliheh, Ugur, Fatima S, Koh, Cassandra, Savar, Nastaran Sadat, Tran, Quang Dinh, Shengjuler, Djoshkun, Fletcher, Sabrina J, O'Neal, Michael C, Cai, Yiming, Chang, Jason C J, Broadhurst, David J, Klippsten, Saker, Sharp, Phillip P, Wenzell, Nicole A, Kuzuoglu-Ozturk, Duygu, Wang, Hao-Yuan, Trenker, Raphael, Young, Janet M, Cavero, Devin A, Hiatt, Joseph, Roth, Theodore L, Rathore, Ujjwal, Subramanian, Advait, Noack, Julia, Hubert, Mathieu, Stroud, Robert M, Frankel, Alan D, Rosenberg, Oren S, Verba, Kliment A, Agard, David A, Ott, Melanie, Emerman, Michael, Jura, Natalia

“…A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of coronavirus disease 2019…”
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The Landscape of Human Cancer Proteins Targeted by SARS-CoV-2 by Tutuncuoglu, Beril, Cakir, Merve, Batra, Jyoti, Bouhaddou, Mehdi, Eckhardt, Manon, Gordon, David E, Krogan, Nevan J

“…The mapping of SARS-CoV-2 human protein-protein interactions by Gordon and colleagues revealed druggable targets that are hijacked by the virus. Here, we…”
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SARS-CoV-2 variants evolve convergent strategies to remodel the host response by Bouhaddou, Mehdi, Reuschl, Ann-Kathrin, Polacco, Benjamin J., Thorne, Lucy G., Ummadi, Manisha R., Ye, Chengjin, Rosales, Romel, Pelin, Adrian, Batra, Jyoti, Jang, Gwendolyn M., Xu, Jiewei, Moen, Jack M., Richards, Alicia L., Zhou, Yuan, Harjai, Bhavya, Stevenson, Erica, Rojc, Ajda, Ragazzini, Roberta, Whelan, Matthew V.X., Furnon, Wilhelm, De Lorenzo, Giuditta, Cowton, Vanessa, Syed, Abdullah M., Ciling, Alison, Deutsch, Noa, Pirak, Daniel, Dowgier, Giulia, Mesner, Dejan, Turner, Jane L., McGovern, Briana L., Rodriguez, M. Luis, Leiva-Rebollo, Rocio, Dunham, Alistair S., Zhong, Xiaofang, Eckhardt, Manon, Fossati, Andrea, Liotta, Nicholas F., Kehrer, Thomas, Cupic, Anastasija, Rutkowska, Magdalena, Mena, Ignacio, Aslam, Sadaf, Hoffert, Alyssa, Foussard, Helene, Olwal, Charles Ochieng’, Huang, Weiqing, Zwaka, Thomas, Pham, John, Lyons, Molly, Donohue, Laura, Griffin, Aliesha, Nugent, Rebecca, Holden, Kevin, Deans, Robert, Aviles, Pablo, Lopez-Martin, Jose A., Jimeno, Jose M., Obernier, Kirsten, Fabius, Jacqueline M., Soucheray, Margaret, Hüttenhain, Ruth, Jungreis, Irwin, Kellis, Manolis, Echeverria, Ignacia, Verba, Kliment, Bonfanti, Paola, Beltrao, Pedro, Sharan, Roded, Doudna, Jennifer A., Martinez-Sobrido, Luis, Patel, Arvind H., Palmarini, Massimo, Miorin, Lisa, White, Kris, Swaney, Danielle L., Garcia-Sastre, Adolfo, Jolly, Clare, Zuliani-Alvarez, Lorena, Towers, Greg J., Krogan, Nevan J.

“…SARS-CoV-2 variants of concern (VOCs) emerged during the COVID-19 pandemic. Here, we used unbiased systems approaches to study the host-selective forces…”
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Mapping the protein–protein and genetic interactions of cancer to guide precision medicine by Bouhaddou, Mehdi, Eckhardt, Manon, Chi Naing, Zun Zar, Kim, Minkyu, Ideker, Trey, Krogan, Nevan J

“…Massive efforts to sequence cancer genomes have compiled an impressive catalogue of cancer mutations, revealing the recurrent exploitation of a handful of…”
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HIV-1 entry in SupT1-R5, CEM-ss, and primary CD4+ T cells occurs at the plasma membrane and does not require endocytosis by Herold, Nikolas, Anders-Ößwein, Maria, Glass, Bärbel, Eckhardt, Manon, Müller, Barbara, Kräusslich, Hans-Georg

“…Cytoplasmic entry of HIV-1 requires binding of the viral glycoproteins to the cellular receptor and coreceptor, leading to fusion of viral and cellular…”
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Quantitative Proteomic Analysis Reveals apoE4-Dependent Phosphorylation of the Actin-Regulating Protein VASP by Cakir, Zeynep, Lord, Samuel J., Zhou, Yuan, Jang, Gwendolyn M., Polacco, Benjamin J., Eckhardt, Manon, Jimenez-Morales, David, Newton, Billy W., Orr, Adam L., Johnson, Jeffrey R., da Cruz, Alexandre, Mullins, R. Dyche, Krogan, Nevan J., Mahley, Robert W., Swaney, Danielle L.

“…Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer’s disease. While neurons generally produce a minority of the apoE in the central nervous…”
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Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets by Haas, Kelsey M., McGregor, Michael J., Bouhaddou, Mehdi, Polacco, Benjamin J., Kim, Eun-Young, Nguyen, Thong T., Newton, Billy W., Urbanowski, Matthew, Kim, Heejin, Williams, Michael A. P., Rezelj, Veronica V., Hardy, Alexandra, Fossati, Andrea, Stevenson, Erica J., Sukerman, Ellie, Kim, Tiffany, Penugonda, Sudhir, Moreno, Elena, Braberg, Hannes, Zhou, Yuan, Metreveli, Giorgi, Harjai, Bhavya, Tummino, Tia A., Melnyk, James E., Soucheray, Margaret, Batra, Jyoti, Pache, Lars, Martin-Sancho, Laura, Carlson-Stevermer, Jared, Jureka, Alexander S., Basler, Christopher F., Shokat, Kevan M., Shoichet, Brian K., Shriver, Leah P., Johnson, Jeffrey R., Shaw, Megan L., Chanda, Sumit K., Roden, Dan M., Carter, Tonia C., Kottyan, Leah C., Chisholm, Rex L., Pacheco, Jennifer A., Smith, Maureen E., Schrodi, Steven J., Albrecht, Randy A., Vignuzzi, Marco, Zuliani-Alvarez, Lorena, Swaney, Danielle L., Eckhardt, Manon, Wolinsky, Steven M., White, Kris M., Hultquist, Judd F., Kaake, Robyn M., García-Sastre, Adolfo, Krogan, Nevan J.

“…Influenza A Virus (IAV) is a recurring respiratory virus with limited availability of antiviral therapies. Understanding host proteins essential for IAV…”
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