Search Results - "Eckhardt, Laurel A"

Chromatin Architecture near a Potential 3′ End of the Igh Locus Involves Modular Regulation of Histone Modifications during B-Cell Development and In Vivo Occupancy at CTCF Sites by Garrett, Francine E., Emelyanov, Alexander V., Sepulveda, Manuel A., Flanagan, Patrick, Volpi, Sabrina, Li, Fubin, Loukinov, Dmitry, Eckhardt, Laurel A., Lobanenkov, Victor V., Birshtein, Barbara K.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Role of the Igh intronic enhancer Eμ in clonal selection at the pre-B to immature B cell transition by Peng, Cheng, Eckhardt, Laurel A

“…We previously described a checkpoint for allelic exclusion that occurs at the pre-B cell to immature B cell transition and is dependent upon the IgH intronic…”
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Critical Role for the Oct-2/OCA-B Partnership in Ig-Secreting Cells by Salas, Mabel, Eckhardt, Laurel A

“…B and T lymphocytes arise from a common precursor in the bone marrow, but ultimately acquire very different functions. The difference in function is largely…”
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A role for the IgH intronic enhancer E mu in enforcing allelic exclusion by Li, Fubin, Eckhardt, Laurel A

“…The intronic enhancer (E mu) of the immunoglobulin heavy chain (IgH) locus is critical for V region gene assembly. To determine E mu's subsequent functions, we…”
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Comparison of identical and functional Igh alleles reveals a nonessential role for Eμ in somatic hypermutation and class-switch recombination by Li, Fubin, Yan, Yi, Pieretti, Joyce, Feldman, Danielle A, Eckhardt, Laurel A

“…Somatic hypermutation (SHM), coupled with Ag selection, provides a mechanism for generating Abs with high affinity for invading pathogens. Class-switch…”
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Homologous Elements hs3a and hs3b in the 3′ Regulatory Region of the Murine Immunoglobulin Heavy Chain (Igh) Locus Are Both Dispensable for Class-switch Recombination by Yan, Yi, Pieretti, Joyce, Ju, Zhongliang, Wei, Shiniu, Christin, John R., Bah, Fatmata, Birshtein, Barbara K., Eckhardt, Laurel A.

“…Immunoglobulin heavy chain (IgH) genes are formed, tested, and modified to yield diverse, specific, and high affinity antibody responses to antigen. The…”
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In a model of immunoglobulin heavy-chain (IGH)/MYC translocation, the Igh 3′ regulatory region induces MYC expression at the immature stage of B cell development by Yan, Yi, Park, Sung Sup, Janz, Siegfried, Eckhardt, Laurel A.

“…Reciprocal translocations involving the immunoglobulin loci and the cellular oncogene MYC are hallmark mutations of the human postgerminal center B cell…”
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Transcription of a productively rearranged Ig VDJC alpha does not require the presence of HS4 in the IgH 3' regulatory region by Zhang, Buyi, Alaie-Petrillo, Adrienne, Kon, Maria, Li, Fubin, Eckhardt, Laurel A

“…V gene assembly, class switch recombination, and somatic hypermutation are gene-modifying processes essential to the development of an effective Ab response…”
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Role of OCA-B in 3'-IgH Enhancer Function by Stevens, Sean, Ong, Jane, Kim, Unkyu, Eckhardt, Laurel A, Roeder, Robert G

“…OCA-B (alternately called Bob1 and OBF-1) is a B cell-specific coactivator that interacts with the ubiquitously expressed Oct-1 and the B cell-restricted Oct-2…”
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Deletional analyses reveal an essential role for the hs3b/hs4 IgH 3′ enhancer pair in an Ig-secreting but not an earlier-stage B cell line by Shi, Xuerong, Eckhardt, Laurel A.

“…The Ig heavy chain (IgH) locus is controlled by multiple regulatory sequences mapping both within the IgH transcription unit (Eμ) and downstream (3′) of IgH…”
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3' IgH Enhancer Elements Shift Synergistic Interactions During B Cell Development by Ong, Jane, Stevens, Sean, Roeder, Robert G, Eckhardt, Laurel A

“…IgH gene expression is tightly controlled over the course of B cell development, B cell activation, and the subsequent differentiation of these cells into…”
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Changes in Replication, Nuclear Location, and Expression of the Igh Locus after Fusion of a Pre-B Cell Line with a T Cell Line by Zhou, Jie, Saleque, Shireen, Ermakova, Olga, Sepulveda, Manuel A, Yang, Qiaoxin, Eckhardt, Laurel A, Schildkraut, Carl L, Birshtein, Barbara K

“…We have previously observed that replication and nuclear location of the murine Igh locus are developmentally regulated during B cell differentiation. In…”
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Role of the IgH Intronic Enhancer Eμ in Clonal Selection at the Pre-B to Immature B Cell Transition1 by Peng, Cheng, Eckhardt, Laurel A.

“…We previously described a check-point for allelic exclusion that occurs at the pre-B to immature B cell transition and is dependent upon IgH intronic enhancer,…”
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Unique Function for Carboxyl-Terminal Domain of Oct-2 in Ig-Secreting Cells by Sharif, M. Nusrat, Radomska, Hanna S, Miller, David M, Eckhardt, Laurel A

“…The activity of Ig gene promoters and enhancers is regulated by two related transcription factors, Oct-1 (ubiquitous) and Oct-2 (B lineage specific), which…”
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IgH intronic enhancer, Eμ, and associated matrix attachment regions are required for efficient somatic hypermutation (35.1) by Li, Fubin, Eckhardt, Laurel A

“…Abstract Somatic hypermutation is a critical mechanism for generating antibody with high affinity. Although the enzyme critical to this process, AID, has been…”
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Homologous elements hs3a and hs3b in the 3′ regulatory region of the murine immunoglobulin heavy chain (Igh) locus are both dispensable for class-switch recombination by Yan, Yi, Pieretti, Joyce, Ju, Zhongliang, Wei, Shiniu, Christin, John R., Bah, Fatmata, Birshtein, Barbara K., Eckhardt, Laurel A.

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Comparison of Identical and Functional Igh Alleles Reveals a Nonessential Role for Ek in Somatic Hypermutation and Class-Switch Recombination by Li, Fubin, Yan, Yi, Pieretti, Joyce, Feldman, Danielle A, Eckhardt, Laurel A

“…Somatic hypermutation (SHM), coupled with Ag selection, provides a mechanism for generating Abs with high affinity for invading pathogens. Class-switch…”
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Response to Guglielmi et al., "The 3′IgH regulatory region is active at immature stages of B-cell development" by Eckhardt, Laurel A., Yan, Yi, Janz, Siegfried

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Immunoglobulin Heavy-Chain Enhancer Is Required To Maintain Transfected γ2A Gene Expression in a Pre-B-Cell Line by Porton, Barbara, Zaller, Dennis M., Lieberson, Rebecca, A. Eckhardt, Laurel

“…The immunoglobulin heavy-chain (IgH) enhancer serves to activate efficient and accurate transcription of cloned IgH genes when introduced into B lymphomas or…”
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In a model of immunoglobulin heavy-chain (IGH)/MYC translocation, the Igh 3'regulatory region induces MYC expression at the immature stage of B cell development by Yan, Yi, Park, Sung Sup, Janz, Siegfried, Eckhardt, Laurel A

“…Reciprocal translocations involving the immunoglobulin loci and the cellular oncogene MYC are hallmark mutations of the human postgerminal center B cell…”
Get full text