Search Results - "Eckhardt, A L"

Abnormal brain structure in youth who commit homicide by Cope, L M, Ermer, E, Gaudet, L M, Steele, V R, Eckhardt, A L, Arbabshirani, M R, Caldwell, M F, Calhoun, V D, Kiehl, K A

“…Violence that leads to homicide results in an extreme financial and emotional burden on society. Juveniles who commit homicide are often tried in adult court…”
Get full text

E47 activates the Ig‐heavy chain and TdT loci in non‐B cells by Choi, J. K., Shen, C. P., Radomska, H. S., Eckhardt, L. A., Kadesch, T.

“…The E2A proteins, E12 and E47, are basic helix‐loop‐helix (bHLH) proteins essential for the B‐cell lineage. Initially identified as immunoglobulin…”
Get full text

Immunoglobulin gene transcription ceases upon deletion of a distant enhancer by Lieberson, R., Ong, J., Shi, X., Eckhardt, L. A.

“…The tissue‐specific E mu enhancer within the immunoglobulin heavy chain (IgH) locus has recently been shown to be essential for efficient V region gene…”
Get full text

Unique Function for Carboxyl-Terminal Domain of Oct-2 in Ig-Secreting Cells by Sharif, M. Nusrat, Radomska, Hanna S, Miller, David M, Eckhardt, Laurel A

“…The activity of Ig gene promoters and enhancers is regulated by two related transcription factors, Oct-1 (ubiquitous) and Oct-2 (B lineage specific), which…”
Get full text

An enhancer at the 3' end of the mouse immunoglobulin heavy chain locus by LIEBERSON, R, GIANNINI, S. L, BIRSHTEIN, B. K, ECKHARDT, L. A

“…A tissue-specific enhancer (E mu) lies between the joining (JH) and mu constant region (C mu) gene segments of the immunoglobulin heavy chain (IgH) locus…”
Get full text

Deletion of a B-Cell-Specific Enhancer Affects Transfected, but not Endogenous, Immunoglobulin Heavy-Chain Gene Expression by Zaller, Dennis M., Eckhardt, Laurel A.

“…A transcriptional enhancer has recently been identified between the variable and constant region coding segments of an assembled immunoglobulin heavy-chain…”
Get full text

Independent immunoglobulin class-switch events occurring in a single myeloma cell line by ECKHARDT, L. A, BIRSHTEIN, B. K

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Genes activated in the presence of an immunoglobulin enhancer or promoter are negatively regulated by a T-lymphoma cell line by ZALLER, D. M, HUA YU, ECKHARDT, L. A

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Mammalian cell fusion in an electroporation device by Radomska, Hanna S., Eckhardt, Laurel A.

“…We and others have been interested in the phenomenon of gene ‘extinction’ in somatic cell hybrids, reasoning that the study of this process is likely to reveal…”
Get full text

Transcription factor effects on chromosome constitution of cell hybrids by Hines, M D, Radomska, H S, Eckhardt, L A

“…When immunoglobulin (Ig)-secreting plasmacytomas are fused to a T-cell lymphoma, Ig gene expression ceases in greater than 95% of the resulting hybrids. In the…”
Get more information

Role of the octamer motif in hybrid cell extinction of immunoglobulin gene expression: extinction is dominant in a two enhancer system by Yu, H, Porton, B, Shen, L Y, Eckhardt, L A

“…We have shown previously that genes activated by the immunoglobulin heavy chain (IgH) enhancer or promoter in mouse myeloma cells are extinguished upon fusion…”
Get more information

Immunoglobulin gene expression only in the right cells at the right time by Eckhardt, L A

“…Study of immunoglobulin gene transcriptional control has disclosed a complexity that rivals that of the antibody repertoire itself. Although some DNA sequences…”
Get more information

The octamer/mu E4 region of the immunoglobulin heavy-chain enhancer mediates gene repression in myeloma x T-lymphoma hybrids by Shen, L, Lieberman, S, Eckhardt, L A

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

DNA rearrangement causes a high rate of spontaneous mutation at the immunoglobulin heavy-chain locus of a mouse myeloma cell line by Yu, H, Eckhardt, L A

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Changes in gene position are accompanied by a change in time of replication by Calza, R E, Eckhardt, L A, DelGiudice, T, Schildkraut, C L

“…The globin and immunoglobulin multigene families have been used to study the effect of chromosomal organization on the time of gene replication. Some of the…”
Get more information

Role of OCA-B in 3'-IgH Enhancer Function by Stevens, Sean, Ong, Jane, Kim, Unkyu, Eckhardt, Laurel A, Roeder, Robert G

“…OCA-B (alternately called Bob1 and OBF-1) is a B cell-specific coactivator that interacts with the ubiquitously expressed Oct-1 and the B cell-restricted Oct-2…”
Get full text

Products of a Reciprocal Chromosome Translocation Involving the c-myc Gene in a Murine Plasmacytoma by Stanton, Lawrence W., Yang, Jian-Qing, Eckhardt, Laurel A., Harris, Linda J., Birshtein, Barbara K., Marcu, Kenneth B.

“…The structures of the rearranged c-myc gene products derived from a rcp T(12;15) have been investigated in the MPC-11 (IgG2bκ ) plasmacytoma. The rcp T(12;15)…”
Get full text

Immunoglobulin heavy-chain enhancer is required to maintain transfected gamma 2A gene expression in a pre-B-cell line by Porton, B, Zaller, D M, Lieberson, R, Eckhardt, L A

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Deletional analyses reveal an essential role for the hs3b/hs4 IgH 3′ enhancer pair in an Ig-secreting but not an earlier-stage B cell line by Shi, Xuerong, Eckhardt, Laurel A.

“…The Ig heavy chain (IgH) locus is controlled by multiple regulatory sequences mapping both within the IgH transcription unit (Eμ) and downstream (3′) of IgH…”
Get full text

T cell recognition of endogenous IgG2a expressed in B lymphoma cells by Bikoff, E K, Yu, H, Eckhardt, L A

“…We recently characterized a panel of C57BL/6J T cell clones specific for IgG2a of the a allotype in association with I-Ab. Several of the clones gave…”
Get more information