Search Results - "Eckhard, U."

Isolation of adipose tissue derived regenerative cells from human subcutaneous tissue with or without the use of an enzymatic reagent by Winnier, Glenn E, Valenzuela, Nick, Peters-Hall, Jennifer, Kellner, Joshua, Alt, Christopher, Alt, Eckhard U

“…Freshly isolated, uncultured, autologous adipose derived regenerative cells (ADRCs) have emerged as a promising tool for regenerative cell therapy. The…”
Get full text

Unfolded protein response and angiogenesis in malignancies by Izadpanah, Amin, Willingham, Kurtis, Chandrasekar, Bysani, Alt, Eckhard U., Izadpanah, Reza

“…Cellular stress, arising from accumulation of unfolded proteins, occurs frequently in rapidly proliferating cancer cells. This cellular stress, in turn,…”
Get full text

Molecular characterization of exosome-like vesicles from breast cancer cells by Kruger, Stefan, Abd Elmageed, Zakaria Y, Hawke, David H, Wörner, Philipp M, Jansen, David A, Abdel-Mageed, Asim B, Alt, Eckhard U, Izadpanah, Reza

“…Membrane vesicles released by neoplastic cells into extracellular medium contain potential of carrying arrays of oncogenic molecules including proteins and…”
Get full text

Management of partial-thickness rotator cuff tears with autologous adipose-derived regenerative cells is safe and more effective than injection of corticosteroid by Lundeen, Mark, Hurd, Jason L., Hayes, Matthew, Hayes, Meredith, Facile, Tiffany R., Furia, John P., Maffulli, Nicola, Alt, Christopher, Alt, Eckhard U., Schmitz, Christoph, Pearce, David A.

“…Symptomatic, partial-thickness rotator cuff tears (sPTRCT) are problematic. This study tested the hypothesis that management of sPTRCT with injection of fresh,…”
Get full text

Persistent high glucose concentrations alter the regenerative potential of mesenchymal stem cells by Cramer, Christopher, Freisinger, Eva, Jones, Ryan K, Slakey, Douglas P, Dupin, Charles L, Newsome, Edward R, Alt, Eckhard U, Izadpanah, Reza

“…Type 2 diabetes is associated with numerous long-term complications. This study aims to investigate whether impaired function of tissue-resident multipotent…”
Get more information

Adipose tissue-derived stem cells promote prostate tumor growth by Prantl, Lukas, Muehlberg, Fabian, Navone, Nora M., Song, Yao-Hua, Vykoukal, Jody, Logothetis, Christopher J., Alt, Eckhard U.

“…BACKGROUND Recent evidence indicates that cancer stem cells play an important role in tumor initiation and maintenance. Additionally, the effect of…”
Get full text

Aging alters tissue resident mesenchymal stem cell properties by Alt, Eckhard U, Senst, Christiane, Murthy, Subramanyam N, Slakey, Douglas P, Dupin, Charles L, Chaffin, Abigail E, Kadowitz, Philip J, Izadpanah, Reza

“…Tissue resident mesenchymal stem cells (MSCs) are known to participate in tissue regeneration that follows cell turnover, apoptosis, or necrosis. It has been…”
Get more information

The Circulasome: A Unifying Theory of Flap Vascularity by Izadpanah, Amin, Alt, Eckhard U, Izadpanah, Reza

“…Despite the critical roles of nondominant perforators, choke vessels, and direct and indirect linking vessels in flap vascularity, current models of flap…”
Get full text

Conversion of Unmodified Stem Cells to Pacemaker Cells by Overexpression of Key Developmental Genes by Karimi, Tahereh, Pan, Zhizhong, Potaman, Vladimir N, Alt, Eckhard U

“…Arrhythmias of the heart are currently treated by implanting electronic pacemakers and defibrillators. Unmodified adipose tissue-derived stem cells (ASCs) have…”
Get full text

Biallelic, Selectable, Knock-in Targeting of CCR5 via CRISPR-Cas9 Mediated Homology Directed Repair Inhibits HIV-1 Replication by Scheller, Stefan H, Rashad, Yasmine, Saleh, Fayez M, Willingham, Kurtis A, Reilich, Antonia, Lin, Dong, Izadpanah, Reza, Alt, Eckhard U, Braun, Stephen E

“…Transplanting HIV-1 positive patients with hematopoietic stem cells homozygous for a 32 bp deletion in the chemokine receptor type 5 (CCR5) gene resulted in a…”
Get full text

Safety and efficacy of treating symptomatic, partial-thickness rotator cuff tears with fresh, uncultured, unmodified, autologous adipose-derived regenerative cells (UA-ADRCs) isolated at the point of care: a prospective, randomized, controlled first-in-human pilot study by Hurd, Jason L, Facile, Tiffany R, Weiss, Jennifer, Hayes, Matthew, Hayes, Meredith, Furia, John P, Maffulli, Nicola, Winnier, Glenn E, Alt, Christopher, Schmitz, Christoph, Alt, Eckhard U, Lundeen, Mark

“…This study tested the hypothesis that treatment of symptomatic, partial-thickness rotator cuff tears (sPTRCT) with fresh, uncultured, unmodified, autologous…”
Get full text

Perspective: Why and How Ubiquitously Distributed, Vascular-Associated, Pluripotent Stem Cells in the Adult Body (vaPS Cells) Are the Next Generation of Medicine by Alt, Eckhard U, Schmitz, Christoph, Bai, Xiaowen

“…A certain cell type can be isolated from different organs in the adult body that can differentiate into ectoderm, mesoderm, and endoderm, providing significant…”
Get full text

IFATS Collection: Human Adipose‐Derived Stem Cells Seeded on a Silk Fibroin‐Chitosan Scaffold Enhance Wound Repair in a Murine Soft Tissue Injury Model by Altman, Andrew M., Yan, Yasheng, Matthias, Nadine, Bai, Xiaowen, Rios, Carmen, Mathur, Anshu B., Song, Yao‐Hua, Alt, Eckhard U.

“…Soft tissue loss presents an ongoing challenge in reconstructive surgery. Local stem cell application has recently been suggested as a possible novel therapy…”
Get full text

Tissue-resident stem cells promote breast cancer growth and metastasis by Muehlberg, Fabian L., Song, Yao-Hua, Krohn, Alexander, Pinilla, Severin P., Droll, Lilly H., Leng, Xiaohong, Seidensticker, Max, Ricke, Jens, Altman, Andrew M., Devarajan, Eswaran, Liu, Weili, Arlinghaus, Ralph B., Alt, Eckhard U.

“…Mesenchymal stem cells derived from bone marrow have recently been described to localize to breast carcinomas and to integrate into the tumor-associated…”
Get full text

Methodological Flaws in Meta-Analyses of Clinical Studies on the Management of Knee Osteoarthritis with Stem Cells: A Systematic Review by Schmitz, Christoph, Alt, Christopher, Pearce, David A, Furia, John P, Maffulli, Nicola, Alt, Eckhard U

“…(1) Background: Conclusions of meta-analyses of clinical studies may substantially influence opinions of prospective patients and stakeholders in healthcare…”
Get full text

Towards a Comprehensive Understanding of UA-ADRCs (Uncultured, Autologous, Fresh, Unmodified, Adipose Derived Regenerative Cells, Isolated at Point of Care) in Regenerative Medicine by Alt, Eckhard U, Winnier, Glenn, Haenel, Alexander, Rothoerl, Ralf, Solakoglu, Oender, Alt, Christopher, Schmitz, Christoph

“…It has become practically impossible to survey the literature on cells derived from adipose tissue for regenerative medicine. The aim of this paper is to…”
Get full text

Targeting TRAF3IP2 inhibits angiogenesis in glioblastoma by Izadpanah, Amin, Daneshimehr, Fatemeh, Willingham, Kurtis, Barabadi, Zahra, Braun, Stephen E, Dumont, Aaron, Mostany, Ricardo, Chandrasekar, Bysani, Alt, Eckhard U, Izadpanah, Reza

“…Increased vascularization, also known as neoangiogenesis, plays a major role in many cancers, including glioblastoma multiforme (GBM), by contributing to their…”
Get full text

Dermal matrix as a carrier for in vivo delivery of human adipose-derived stem cells by Altman, Andrew M, Matthias, Nadine, Yan, Yasheng, Song, Yao-Hua, Bai, Xiaowen, Chiu, Ernest S, Slakey, Douglas P, Alt, Eckhard U

“…Abstract The aim of the present study was to evaluate the potential of acellular dermal matrix as a carrier for delivery of stem cells to the site of soft…”
Get full text

Breast Tumor Microenvironment Can Transform Naive Mesenchymal Stem Cells into Tumor-Forming Cells in Nude Mice by Wörner, Philipp M, Schächtele, Deborah J, Barabadi, Zahra, Srivastav, Sudesh, Chandrasekar, Bysani, Izadpanah, Reza, Alt, Eckhard U

“…How mesenchymal stem cells (MSCs) interact with tumor cells and promote tumor growth is not well understood. In this study, we demonstrate that when naive MSCs…”
Get more information

Why and how to use the body's own stem cells for regeneration in musculoskeletal disorders: a primer by Furia, John P, Lundeen, Mark A, Hurd, Jason L, Pearce, David A, Alt, Christopher, Alt, Eckhard U, Schmitz, Christoph, Maffulli, Nicola

“…Recently, the management of musculoskeletal disorders with the patients' own stem cells, isolated from the walls of small blood vessels, which can be found in…”
Get full text