Search Results - "Eckert, GP"

Statin effects on cholesterol micro-domains in brain plasma membranes by Kirsch, Christopher, Eckert, Gunter P, Mueller, Walter E

“…Recent epidemiological studies revealed inhibitors of the hydroxymethylglutaryl-coenzyme A reductase, so-called statins, to be effective in lowering the…”
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Omega-3 polyunsaturated fatty acids improve mitochondrial dysfunction in brain aging – Impact of Bcl-2 and NPD-1 like metabolites by Afshordel, Sarah, Hagl, Stephanie, Werner, Deborah, Röhner, Nelli, Kögel, Donat, Bazan, Nicolas G, Eckert, Gunter P

“…Abstract The present study investigated the effects of orally administered long chain omega-3 polyunsaturated fatty acids (PUFA) on mitochondrial function and…”
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Tocotrienols: constitutional effects in aging and disease by Schaffer, Sebastian, Müller, Walter E, Eckert, Gunter P

“…Tocotrienols, a class of vitamin E analogs, modulate several mechanisms associated with the aging process and aging-related diseases. Most studies compare the…”
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Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex by Johnson-Anuna, Leslie N, Eckert, Gunter P, Keller, Jan H, Igbavboa, Urule, Franke, Cornelia, Fechner, Thomas, Schubert-Zsilavecz, Manfred, Karas, Michael, Müller, Walter E, Wood, W Gibson

“…Statins have been reported to lower the risk of developing Alzheimer's disease; however, the mechanism of this potentially important neuroprotective action is…”
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Amyloid beta-protein interactions with membranes and cholesterol: causes or casualties of Alzheimer's disease by Gibson Wood, W., Eckert, Gunter P., Igbavboa, Urule, Müller, Walter E.

“…Amyloid beta-protein (Aβ) is thought to be one of the primary factors causing neurodegeneration in Alzheimer's disease (AD). This protein is an amphipathic…”
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Understanding local Mediterranean diets: A multidisciplinary pharmacological and ethnobotanical approach

“…Epidemiological data indicate a beneficial effect of Mediterranean diets on human health, especially on the prevalence of cardiovascular disease. These…”
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Statins: drugs for Alzheimer's disease? by Eckert, G P, Wood, W G, Müller, W E

“…Evidences from cell culture experiments and animal studies suggest a strong link between cholesterol and Alzheimer's disease (AD). This relationship is…”
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P06 Olesoxime improves specific features of the HD pathology by Clemens, LE, Wlodkowski, TT, Eckmann, J, Eckert, S, Michaud, M, Yu, L, Portal, E, Bordet, T, Pruss, R, Eckert, GP, Riess, O, Nguyen, HP

“…BackgroundOlesoxime, a cholesterol-oxime, is a neuroprotective compound initially developed for the treatment of ALS (Bordet et al 2007). It interacts with…”
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Lipid rafts of purified mouse brain synaptosomes prepared with or without detergent reveal different lipid and protein domains by Eckert, Gunter P, Igbavboa, Urule, Müller, Walter E, Wood, W.Gibson

“…Lipid rafts have been proposed to be important in a variety of functions including lipid transport, signal transduction and cell growth. There is increasing…”
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Brain cholesterol, statins and Alzheimer's Disease by Kirsch, C, Eckert, G P, Koudinov, A R, Müller, W E

“…Growing evidence suggests that cellular cholesterol homeostasis is causally involved in different steps leading to pathological events in the brain of…”
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Membrane-disordering effects of beta-amyloid peptides by Müller, W E, Kirsch, C, Eckert, G P

“…beta-Amyloid (Abeta) protein is the major constituent of senile plaques and cerebrovascular deposits characteristic of Alzheimer's disease (AD). The causal…”
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Cholesterol modulates the membrane-disordering effects of beta-amyloid peptides in the hippocampus: specific changes in Alzheimer's disease by Eckert, G P, Cairns, N J, Maras, A, Gattaz, W F, Müller, W E

“…Cholesterol represents an important determinant of the physical state of biological membranes. In Alzheimer's disease (AD) brains, specific changes in the…”
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Differential effects of lovastatin treatment on brain cholesterol levels in normal and ApoE-deficient mice by Eckert, Gunter P, Kirsch, Christopher, Mueller, Walter E

“…Growing evidence indicates that membrane cholesterol is involved in the development of Alzheimer's disease. Therefore, the availability of pharmacological…”
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Cholesterol modulates amyloid beta-peptide's membrane interactions by Eckert, Gunter P, Kirsch, Christopher, Leutz, Steffen, Wood, W Gibson, Müller, Walter E

“…The causal relationship between amyloid beta-peptide (Abeta) deposition and Alzheimer's disease (AD)-specific neuropathological lesions such as…”
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Hyperforin modifies neuronal membrane properties in vivo by Eckert, Gunter P., Keller, Jan-Henning, Jourdan, Claudia, Karas, Michael, Volmer, Dietrich A., Schubert-Zsilavecz, Manfred, Müller, Walter E.

“…Hyperforin, the major active constituent of St. John Wort (SJW) extract, affects several neurotransmitter systems in the brain putatively by modulation of the…”
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Determination of Hyperforin in Mouse Brain by High-Performance Liquid Chromatography/Tandem Mass Spectrometry by Keller, Jan-Henning, Karas, Michael, Müller, Walter E, Volmer, Dietrich A, Eckert, Gunter P, Tawab, Mona Abdel, Blume, Henning H, Dingermann, Theodor, Schubert-Zsilavecz, Manfred

“…Hyperforin is one of the essential active ingredients of St. John's wort extract, which is used as an antidepressant for mild to moderately severe depressions…”
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Is hypercholesterolemia a risk factor for Alzheimer's disease? by Wood, W Gibson, Igbavboa, Urule, Eckert, Gunter P, Johnson-Anuna, Leslie N, Müller, Walter E

“…There is considerable attention being given to the association of Alzheimer's disease and cholesterol homeostasis. To that end, some have suggested that…”
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Hypochlorous acid scavenging properties of local Mediterranean plant foods by Schaffer, S, Eckert, G.P, Muller, W.E, Llorach, R, Rivera, D, Grande, S, Galli, C, Visioli, F

“…Oxidative modification of low density lipoprotein (LDL) is involved in the pathogenesis of atherosclerosis and coronary heart disease, which are low in the…”
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Murine synaptosomal lipid raft protein and lipid composition are altered by expression of human apoE 3 and 4 and by increasing age by Igbavboa, U., Eckert, G.P., Malo, T.M., Studniski, A.E., Johnson, L.N.A., Yamamoto, N., Kobayashi, M., Fujita, S.C., Appel, T.R., Müller, W.E., Wood, W.G., Yanagisawa, K.

“…Apolipoprotein E (apoE) 4 and aging are risk factors for Alzheimer's disease (AD). Mice expressing human apoE4 and aged wild-type mice show a similarity in the…”
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Piracetam: novelty in a unique mode of action by Müller, W E, Eckert, G P, Eckert, A

“…Extensive research of the recent years has demonstrated that piracetam is effective in the treatment of cognitive decline in aging and dementia. It is usually…”
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