Search Results - "Eckert, G P"

Sex-associated differences in mitochondrial function in human peripheral blood mononuclear cells (PBMCs) and brain by Silaidos, C, Pilatus, U, Grewal, R, Matura, S, Lienerth, B, Pantel, J, Eckert, G P

“…Alzheimer's disease (AD) is the most common form of dementia, and it affects more women than men. Mitochondrial dysfunction (MD) plays a key role in AD, and it…”
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Cholesterol modulates the membrane-disordering effects of beta-amyloid peptides in the hippocampus: specific changes in Alzheimer's disease by Eckert, G P, Cairns, N J, Maras, A, Gattaz, W F, Müller, W E

“…Cholesterol represents an important determinant of the physical state of biological membranes. In Alzheimer's disease (AD) brains, specific changes in the…”
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Statins: drugs for Alzheimer's disease? by Eckert, G P, Wood, W G, Müller, W E

“…Evidences from cell culture experiments and animal studies suggest a strong link between cholesterol and Alzheimer's disease (AD). This relationship is…”
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Time-dependent melatonin secretion is associated with mitochondrial function in peripheral blood mononuclear cells (PBMC) of male volunteers by Silaidos, C., Grube, J., Muley, C., Eckert, G.P.

“…•Evaluation of mitochondrial function in PBMC at different time points.•Sex differences in mitochondrial function and serum melatonin…”
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Brain cholesterol, statins and Alzheimer's Disease by Kirsch, C, Eckert, G P, Koudinov, A R, Müller, W E

“…Growing evidence suggests that cellular cholesterol homeostasis is causally involved in different steps leading to pathological events in the brain of…”
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Membrane-disordering effects of beta-amyloid peptides by Müller, W E, Kirsch, C, Eckert, G P

“…beta-Amyloid (Abeta) protein is the major constituent of senile plaques and cerebrovascular deposits characteristic of Alzheimer's disease (AD). The causal…”
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Effects of aging and β-amyloid on the properties of brain synaptic and mitochondrial membranes by ECKERT, G. P, WOOD, W. G, MÜLLER, W. E

“…The effects of aging and of different amyloid beta-peptides (A beta) on the properties of purified synaptosomal plasma and mitochondrial membranes were studied…”
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Differential effects of lovastatin treatment on brain cholesterol levels in normal and ApoE-deficient mice by Eckert, Gunter P, Kirsch, Christopher, Mueller, Walter E

“…Growing evidence indicates that membrane cholesterol is involved in the development of Alzheimer's disease. Therefore, the availability of pharmacological…”
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Isoquercitrin provides better bioavailability than quercetin: comparison of quercetin metabolites in body tissue and brain sections after six days administration of isoquercitrin and quercetin by Paulke, A, Eckert, G P, Schubert-Zsilavecz, M, Wurglics, M

“…In the present study, over a period of 8 days 12 mg/kg/d quercetin aglycone and 18 mg/kg/d isoquercitrin were orally given to rats, respectively. Four hours…”
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Alterations of brain membranes in schizophrenia: impact of phospholipase A(2) by Schaeffer, E L, Gattaz, W F, Eckert, G P

“…Physiological enzymatic cleavage of membrane phospholipids by phospholipase A2 (PLA2) results in normal levels of phosphomonoester and phosphodiester, by which…”
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Lipid membranes and beta-amyloid: a harmful connection by Eckert, G P, Wood, W G, Müller, W E

“…Gradual changes in steady-state levels of beta amyloid peptides (Abeta) in the brain are considered as initial step in the amyloid cascade hypothesis of…”
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Murine synaptosomal lipid raft protein and lipid composition are altered by expression of human apoE 3 and 4 and by increasing age by Igbavboa, U., Eckert, G.P., Malo, T.M., Studniski, A.E., Johnson, L.N.A., Yamamoto, N., Kobayashi, M., Fujita, S.C., Appel, T.R., Müller, W.E., Wood, W.G., Yanagisawa, K.

“…Apolipoprotein E (apoE) 4 and aging are risk factors for Alzheimer's disease (AD). Mice expressing human apoE4 and aged wild-type mice show a similarity in the…”
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Effects of hyperforin on the fluidity of brain membranes by Eckert, G P, Müller, W E

“…Hyperforin, an acylphloroglucinol derivative isolated from Hypericum perforatum (St. John's wort, SJW), affects several ionic conductance mechanisms in brain…”
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Pharmacokinetic properties of MH84, a γ-secretase modulator with PPARγ agonistic activity by Pellowska, M., Stein, C., Pohland, M., Merk, D., Klein, J., Eckert, G.P., Schubert-Zsilavecz, M., Wurglics, M.

“…•MH84 was identified as γ-secretase modulator and PPARγ agonist (Alzheimer's disease).•We developed and validated a sensitive LC–MS method for MH84.•A…”
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Neuroprotection by bilobalide in ischemia: improvement of mitochondrial function by Schwarzkopf, T M, Hagl, S, Eckert, G P, Klein, J

“…Bilobalide, an active constituent of Ginkgo biloba, is known to have neuroprotective properties, but its mode of action remains unclear. In this study,…”
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Increased brain membrane fluidity in schizophrenia by Eckert, G P, Schaeffer, E L, Schmitt, A, Maras, A, Gattaz, W F

“…Recent findings showing significant correlations between phospholipase A2 (PLA2) activity and structural changes in schizophrenic brains contribute to the…”
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Simvastatin alters membrane cholesterol distribution and beta-amyloid levels in brains of female APP751SL mice by Eckert, G P, Reik, C, Müller, W E

“…Statins (HMG-CoA reductase or CSE-inhibitors) strongly reduce the cellular amyloid-beta protein production by modulating the processing of amyloid precursor…”
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The effects of extracts from St. John's Wort and Kava Kava on brain neurotransmitter levels in the mouse by Serdarevic, N, Eckert, G P, Müller, W E

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Piracetam reverses hippocampal membrane alterations in Alzheimer's disease by ECKERT, G. P, CAIRNS, N. J, MÜLLER, W. E

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P06 Olesoxime improves specific features of the HD pathology by Clemens, LE, Wlodkowski, TT, Eckmann, J, Eckert, S, Michaud, M, Yu, L, Portal, E, Bordet, T, Pruss, R, Eckert, GP, Riess, O, Nguyen, HP

“…BackgroundOlesoxime, a cholesterol-oxime, is a neuroprotective compound initially developed for the treatment of ALS (Bordet et al 2007). It interacts with…”
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