Search Results - "Eckers, Christine"

Accurate Mass Liquid Chromatography/Mass Spectrometry on Quadrupole Orthogonal Acceleration Time-of-Flight Mass Analyzers Using Switching between Separate Sample and Reference Sprays. 2. Applications Using the Dual-Electrospray Ion Source by Wolff, Jean-Claude, Eckers, Christine, Sage, Ashley B, Giles, Kevin, Bateman, Robert

“…A new electrospray dual sprayer, LockSpray, was developed for accurate mass measurements on a quadrupole orthogonal acceleration time-of-flight mass…”
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“In-source” fragmentation of an isobaric impurity of lamotrigine for its measurement by liquid chromatography tandem mass spectrometry after pre-concentration using solid phase extraction by Carrier, Dan J., Eckers, Christine, Wolff, Jean-Claude

“…An analytical method has been developed for trace analysis (i.e. sub-ppm levels) of a key synthetic impurity, 14W80 ((…”
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Accurate Mass Liquid Chromatography/Mass Spectrometry on Orthogonal Acceleration Time-of-Flight Mass Analyzers Using Switching between Separate Sample and Reference Sprays. 1. Proof of Concept by Eckers, Christine, Wolff, Jean-Claude, Haskins, Neville J, Sage, Ashley B, Giles, Kevin, Bateman, Robert

“…This paper describes the use of two separate electrosprays for introducing sample and reference for accurate mass liquid chromatography/mass spectrometry…”
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37th British Mass Spectrometry Society annual meeting by Wright, Patricia, Eckers, Christine

“…The 37th British Mass Spectrometry Society (BMSS) annual meeting took place over a brilliantly sunny 3 days by the sea in the historic Eastbourne Winter…”
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The effect of drift gas on the separation of active pharmaceutical ingredients and impurities by ion mobility–mass spectrometry by Howdle, Mark D., Eckers, Christine, Laures, Alice M.-F., Creaser, Colin S.

“…The effect of drift gas and binary gas mixtures on the separation of active pharmaceutical ingredients and related compounds has been investigated using ion…”
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Evaluating the utility of ion mobility separation in combination with high-pressure liquid chromatography/mass spectrometry to facilitate detection of trace impurities in formulated drug products by Eckers, Christine, Laures, Alice M.-F., Giles, Kevin, Major, Hilary, Pringle, Steve

“…Many formulated products contain complex polymeric excipients such as polyethylene glycols (PEGs). Such excipients can be readily ionized by electrospray and…”
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The Use of Shift Reagents in Ion Mobility-Mass Spectrometry: Studies on the Complexation of an Active Pharmaceutical Ingredient with Polyethylene Glycol Excipients by Howdle, Mark D., Eckers, Christine, Laures, Alice M.-F., Creaser, Colin S.

“…Gas-phase ion mobility studies of mixtures containing polyethylene glycols (PEG) and an active pharmaceutical ingredient (API), lamivudine, have been carried…”
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Polydeoxycholate in human and hamster feces : a major product of cholate metabolism by BENSON, G. M, HASKINS, N. J, ECKERS, C, MOORE, P. J, REID, D. G, MITCHELL, R. C, SUNIL WAGHMARE, SUCKLING, K. E

“…Fecal bile acid excretion is one of the two major routes by which cholesterol is eliminated from the body, fecal cholesterol being the other. During their…”
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Finding key impurities in different manufacturing routes of a drug substance using liquid chromatography/mass spectrometry followed by principal components analysis by Carrier, Dan, Eckers, Christine, Arnoult, Tiffanie, Thurston, Thomas, Major, Hilary

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Development, validation and transfer into a factory environment of a liquid chromatography tandem mass spectrometry assay for the highly neurotoxic impurity FMTP (4-(4-fluorophenyl)-1-methyl-1,2,3,6-tetrahydropyridine) in paroxetine active pharmaceutical ingredient (API) by Borman, Phil J., Chatfield, Marion J., Crowley, Elizabeth L., Eckers, Christine, Elder, David P., Francey, Scott W., Laures, Alice M.-F., Wolff, Jean-Claude

“…This work describes the development of a liquid chromatography tandem mass spectrometry (LC–MS/MS) assay for a highly toxic impurity, FMTP…”
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Investigation into the factors affecting accuracy of mass measurements on a time-of-flight mass spectrometer using Design of Experiment by Laures, Alice M.-F., Wolff, Jean-Claude, Eckers, Christine, Borman, Phil J., Chatfield, Marion J.

“…The results of an investigation of the parameters which have the most significant effect on the accuracy of mass measurements on a quadrupole orthogonal…”
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Identification of the 'wrong' active pharmaceutical ingredient in a counterfeit Halfan™ drug product using accurate mass electrospray ionisation mass spectrometry, accurate mass tandem mass spectrometry and liquid chromatography/mass spectrometry by Wolff, Jean-Claude, Thomson, Linda A., Eckers, Christine

“…Methodology is presented for identifying an unknown active (pharmaceutical) ingredient (AI) in a counterfeit drug product. A range of mass spectrometric…”
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The use of liquid chromatography combined with a quadrupole time-of-flight analyser for the identification of trace impurities in drug substance by Eckers, Christine, Haskins, Neville, Langridge, James

“…This paper shows the use of a quadrupole time‐of‐flight mass spectrometer combined with a liquid chromatograph for the identification of trace impurities in a…”
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Sulfur-Specific Detection of Impurities in Cimetidine Drug Substance Using Liquid Chromatography Coupled to High Resolution Inductively Coupled Plasma Mass Spectrometry and Electrospray Mass Spectrometry by Evans, E. Hywel, Wolff, Jean-Claude, Eckers, Christine

“…The use of liquid chromatography coupled to sector field inductively coupled plasma mass spectrometry (SF-ICP-MS) for the specific detection of…”
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Development, validation and transfer into a factory environment of a liquid chromatography tandem mass spectrometry assay for the highly neurotoxic impurity FMTP (4-(4-fluorophenyl)-1-methyl-1.2,3,6-tetrahydropyridine) in paroxetine active pharmaceutical ingredient (API) by BARMAN, Phil J, CHATFIELD, Marion J, CROWLEY, Elizabeth L, ECKERS, Christine, ELDER, David P, FRANCEY, Scott W, LAURES, Alice M.-F, WOLFF, Jean-Claude

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Discrimination between tablet production methods using pyrolysis-gas chromatography-mass spectrometry and pattern recognition by Shen, Hailin, Carter, James F, Brereton, Richard G, Eckers, Christine

“…Wet granulation and direct compression are two processes employed in tablet preparation. In this paper, pyrolysis-gas chromatography-mass spectrometry…”
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Sulfur-specific detection of impurities in cimetidine drug substance using liquid chromatography coupled to high resolution inductively by Evans, E Hywel, Wolff, Jean-Claude, Eckers, Christine

“…The use of liquid chromatography coupled to sector field inductively coupled plasma mass spectrometry (SF-ICP-MS) for the specific detection of…”
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Fragmentation of Trimethoprim and other Compounds Containing Alkoxy-Phenyl Groups in Electrospray Ionisation Tandem Mass Spectrometry by Eckers, Christine, Monaghan, John J., Wolff, Jean-Claude

“…This work describes electrospray ionisation tandem mass spectrometry studies of trimethoprim and a series of structurally similar compounds containing…”
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Accurate mass liquid chromatography/mass spectrometry on quadrupole orthogonal accleration time-of-flight mass analyzers by Wolff, Jean-Claude, Eckers, Christine, Sage, Ashley B, Giles, Kevin, Bateman, Robert

“…A new electrospray dual sprayer, LockSpray, was developed for accurate mass measurements on a quadrupole orthogonal acceleration time-of-flight mass…”
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Accurate mass liquid chromatography/mass spectrometry on orthogonal acceleration time-of-flight mass analyzers using switching between separate sample and reference sprays by Eckers, Christine, Wolff, Jean-Claude, Haskins, Neville J, Sage, Ashley B

“…This paper describes the use of two separate electrosprays for introducing sample and reference for accurate mass liquid chromatography/mass spectrometry…”
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