Search Results - "Eckenweber, Florian"

Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO) by Shi, Yuan, Cui, Mochen, Ochs, Katharina, Brendel, Matthias, Strübing, Felix L., Briel, Nils, Eckenweber, Florian, Zou, Chengyu, Banati, Richard B., Liu, Guo-Jun, Middleton, Ryan J., Rupprecht, Rainer, Rudolph, Uwe, Zeilhofer, Hanns Ulrich, Rammes, Gerhard, Herms, Jochen, Dorostkar, Mario M.

“…Benzodiazepines are widely administered drugs to treat anxiety and insomnia. In addition to tolerance development and abuse liability, their chronic use may…”
Get full text

Validity and value of metabolic connectivity in mouse models of β-amyloid and tauopathy by Ruch, François, Gnörich, Johannes, Wind, Karin, Köhler, Mara, Zatcepin, Artem, Wiedemann, Thomas, Gildehaus, Franz-Joseph, Lindner, Simon, Boening, Guido, von Ungern-Sternberg, Barbara, Beyer, Leonie, Herms, Jochen, Bartenstein, Peter, Brendel, Matthias, Eckenweber, Florian

“…Among functional imaging methods, metabolic connectivity (MC) is increasingly used for investigation of regional network changes to examine the pathophysiology…”
Get full text

Towards multicenter β-amyloid PET imaging in mouse models: A triple scanner head-to-head comparison by Gnörich, Johannes, Koehler, Mara, Wind-Mark, Karin, Klaus, Carolin, Zatcepin, Artem, Palumbo, Giovanna, Lalia, Manvir, Monasor, Laura Sebastian, Beyer, Leonie, Eckenweber, Florian, Scheifele, Maximilian, Gildehaus, Franz-Josef, von Ungern-Sternberg, Barbara, Barthel, Henryk, Sabri, Osama, Bartenstein, Peter, Herms, Jochen, Tahirovic, Sabina, Franzmeier, Nicolai, Ziegler, Sibylle, Brendel, Matthias

“…•Three distinct small animal PET scanners show high agreement in Aβ-PET quantification, crucial for multicentric AD research.•Variability in scanner…”
Get full text

Long-Term Pioglitazone Treatment Has No Significant Impact on Microglial Activation and Tau Pathology in P301S Mice by Kunze, Lea Helena, Ruch, François, Biechele, Gloria, Eckenweber, Florian, Wind-Mark, Karin, Dinkel, Lina, Feyen, Paul, Bartenstein, Peter, Ziegler, Sibylle, Paeger, Lars, Tahirovic, Sabina, Herms, Jochen, Brendel, Matthias

“…Neuroinflammation is one disease hallmark on the road to neurodegeneration in primary tauopathies. Thus, immunomodulation might be a suitable treatment…”
Get full text

Feasibility of short imaging protocols for [18F]PI-2620 tau-PET in progressive supranuclear palsy by Song, Mengmeng, Scheifele, Maximilian, Barthel, Henryk, van Eimeren, Thilo, Beyer, Leonie, Marek, Ken, Eckenweber, Florian, Palleis, Carla, Kaiser, Lena, Finze, Anika, Kern, Maike, Nitschmann, Alexander, Biechele, Gloria, Katzdobler, Sabrina, Bischof, Gèrard, Hammes, Jochen, Jessen, Frank, Saur, Dorothee, Schroeter, Matthias L., Rumpf, Jost-Julian, Rullmann, Michael, Schildan, Andreas, Patt, Marianne, Neumaier, Bernd, Stephens, Andrew W., Rauchmann, Boris-Stephan, Perneczky, Robert, Levin, Johannes, Classen, Joseph, Höglinger, Günter U., Bartenstein, Peter, Boening, Guido, Ziegler, Sibylle, Villemagne, Victor, Drzezga, Alexander, Seibyl, John, Sabri, Osama, Brendel, Matthias

“…Purpose Dynamic 60-min positron emission tomography (PET) imaging with the novel tau radiotracer [ 18 F]PI-2620 facilitated accurate discrimination between…”
Get full text

Glial activation is moderated by sex in response to amyloidosis but not to tau pathology in mouse models of neurodegenerative diseases by Biechele, Gloria, Franzmeier, Nicolai, Blume, Tanja, Ewers, Michael, Luque, Jose Medina, Eckenweber, Florian, Sacher, Christian, Beyer, Leonie, Ruch-Rubinstein, Francois, Lindner, Simon, Gildehaus, Franz-Josef, von Ungern-Sternberg, Barbara, Cumming, Paul, Bartenstein, Peter, Rominger, Axel, Höglinger, Günter U, Herms, Jochen, Brendel, Matthias

“…In vivo assessment of neuroinflammation by 18-kDa translocator protein positron-emission-tomography (TSPO-PET) ligands receives growing interest in preclinical…”
Get full text

[ 18 F]F-DED PET imaging of reactive astrogliosis in neurodegenerative diseases: preclinical proof of concept and first-in-human data by Ballweg, Anna, Klaus, Carolin, Vogler, Letizia, Katzdobler, Sabrina, Wind, Karin, Zatcepin, Artem, Ziegler, Sibylle I, Secgin, Birkan, Eckenweber, Florian, Bohr, Bernd, Bernhardt, Alexander, Fietzek, Urban, Rauchmann, Boris-Stephan, Stoecklein, Sophia, Quach, Stefanie, Beyer, Leonie, Scheifele, Maximilian, Simmet, Marcel, Joseph, Emanuel, Lindner, Simon, Berg, Isabella, Koglin, Norman, Mueller, Andre, Stephens, Andrew W, Bartenstein, Peter, Tonn, Joerg C, Albert, Nathalie L, Kümpfel, Tania, Kerschensteiner, Martin, Perneczky, Robert, Levin, Johannes, Paeger, Lars, Herms, Jochen, Brendel, Matthias

“…Reactive gliosis is a common pathological hallmark of CNS pathology resulting from neurodegeneration and neuroinflammation. In this study we investigate the…”
Get full text

Microglial activation in the right amygdala-entorhinal-hippocampal complex is associated with preserved spatial learning in AppNL-G-F mice by Biechele, Gloria, Wind, Karin, Blume, Tanja, Sacher, Christian, Beyer, Leonie, Eckenweber, Florian, Franzmeier, Nicolai, Ewers, Michael, Zott, Benedikt, Lindner, Simon, Gildehaus, Franz-Josef, von Ungern-Sternberg, Barbara, Tahirovic, Sabina, Willem, Michael, Bartenstein, Peter, Cumming, Paul, Rominger, Axel, Herms, Jochen, Brendel, Matthias

“…[Display omitted] In Alzheimer`s disease (AD), regional heterogeneity of β-amyloid burden and microglial activation of individual patients is a well-known…”
Get full text

Longitudinal TSPO expression in tau transgenic P301S mice predicts increased tau accumulation and deteriorated spatial learning by Eckenweber, Florian, Medina-Luque, Jose, Blume, Tanja, Sacher, Christian, Biechele, Gloria, Wind, Karin, Deussing, Maximilian, Briel, Nils, Lindner, Simon, Boening, Guido, von Ungern-Sternberg, Barbara, Unterrainer, Marcus, Albert, Nathalie L, Zwergal, Andreas, Levin, Johannes, Bartenstein, Peter, Cumming, Paul, Rominger, Axel, Höglinger, Günter U, Herms, Jochen, Brendel, Matthias

“…P301S tau transgenic mice show age-dependent accumulation of neurofibrillary tangles in the brainstem, hippocampus, and neocortex, leading to neuronal loss and…”
Get full text

Depletion and activation of microglia impact metabolic connectivity of the mouse brain by Gnörich, Johannes, Reifschneider, Anika, Wind, Karin, Zatcepin, Artem, Kunte, Sebastian T, Beumers, Philipp, Bartos, Laura M, Wiedemann, Thomas, Grosch, Maximilian, Xiang, Xianyuan, Fard, Maryam K, Ruch, Francois, Werner, Georg, Koehler, Mara, Slemann, Luna, Hummel, Selina, Briel, Nils, Blume, Tanja, Shi, Yuan, Biechele, Gloria, Beyer, Leonie, Eckenweber, Florian, Scheifele, Maximilian, Bartenstein, Peter, Albert, Nathalie L, Herms, Jochen, Tahirovic, Sabina, Haass, Christian, Capell, Anja, Ziegler, Sibylle, Brendel, Matthias

“…We aimed to investigate the impact of microglial activity and microglial FDG uptake on metabolic connectivity, since microglial activation states determine…”
Get full text

Chronic PPARγ Stimulation Shifts Amyloidosis to Higher Fibrillarity but Improves Cognition by Blume, Tanja, Deussing, Maximilian, Biechele, Gloria, Peters, Finn, Zott, Benedikt, Schmidt, Claudio, Franzmeier, Nicolai, Wind, Karin, Eckenweber, Florian, Sacher, Christian, Shi, Yuan, Ochs, Katharina, Kleinberger, Gernot, Xiang, Xianyuan, Focke, Carola, Lindner, Simon, Gildehaus, Franz-Josef, Beyer, Leonie, von Ungern-Sternberg, Barbara, Bartenstein, Peter, Baumann, Karlheinz, Adelsberger, Helmuth, Rominger, Axel, Cumming, Paul, Willem, Michael, Dorostkar, Mario M, Herms, Jochen, Brendel, Matthias

“…We undertook longitudinal β-amyloid positron emission tomography (Aβ-PET) imaging as a translational tool for monitoring of chronic treatment with the…”
Get full text

Impact of TSPO Receptor Polymorphism on [18F]GE-180 Binding in Healthy Brain and Pseudo-Reference Regions of Neurooncological and Neurodegenerative Disorders by Vettermann, Franziska J., Harris, Stefanie, Schmitt, Julia, Unterrainer, Marcus, Lindner, Simon, Rauchmann, Boris-Stephan, Palleis, Carla, Weidinger, Endy, Beyer, Leonie, Eckenweber, Florian, Schuster, Sebastian, Biechele, Gloria, Ferschmann, Christian, Milenkovic, Vladimir M., Wetzel, Christian H., Rupprecht, Rainer, Janowitz, Daniel, Buerger, Katharina, Perneczky, Robert, Höglinger, Günter U., Levin, Johannes, Haass, Christian, Tonn, Joerg C., Niyazi, Maximilian, Bartenstein, Peter, Albert, Nathalie L., Brendel, Matthias

“…TSPO-PET tracers are sensitive to a single-nucleotide polymorphism (rs6971-SNP), resulting in low-, medium- and high-affinity binders (LABs, MABs and HABS),…”
Get full text

Stereological Investigation of Regional Brain Volumes after Acute and Chronic Cuprizone-Induced Demyelination by Hochstrasser, Tanja, Rühling, Sebastian, Hecher, Kerstin, Fabisch, Kai H, Chrzanowski, Uta, Brendel, Matthias, Eckenweber, Florian, Sacher, Christian, Schmitz, Christoph, Kipp, Markus

“…Brain volume measurement is one of the most frequently used biomarkers to establish neuroprotective effects during pre-clinical multiple sclerosis (MS)…”
Get full text

Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO) by Shi, Yuan, Cui, Mochen, Ochs, Katharina, Brendel, Matthias, Strübing, Felix L., Briel, Nils, Eckenweber, Florian, Zou, Chengyu, Banati, Richard B., Liu, Guo-Jun, Middleton, Ryan J., Rupprecht, Rainer, Rudolph, Uwe, Zeilhofer, Hanns Ulrich, Rammes, Gerhard, Herms, Jochen, Dorostkar, Mario M.

Get full text

Microglial Activation and Connectivity in Alzheimer Disease and Aging by Rauchmann, Boris‐Stephan, Brendel, Matthias, Franzmeier, Nicolai, Trappmann, Lena, Zaganjori, Mirlind, Ersoezlue, Ersin, Morenas‐Rodriguez, Estrella, Guersel, Selim, Burow, Lena, Kurz, Carolin, Haeckert, Jan, Tatò, Maia, Utecht, Julia, Papazov, Boris, Pogarell, Oliver, Janowitz, Daniel, Buerger, Katharina, Ewers, Michael, Palleis, Carla, Weidinger, Endy, Biechele, Gloria, Schuster, Sebastian, Finze, Anika, Eckenweber, Florian, Rupprecht, Rainer, Rominger, Axel, Goldhardt, Oliver, Grimmer, Timo, Keeser, Daniel, Stoecklein, Sophia, Dietrich, Olaf, Bartenstein, Peter, Levin, Johannes, Höglinger, Günter, Perneczky, Robert

“…Objective Alzheimer disease (AD) is characterized by amyloid β (Aβ) plaques and neurofibrillary tau tangles, but increasing evidence suggests that…”
Get full text

Longitudinal PET Monitoring of Amyloidosis and Microglial Activation in a Second Generation Amyloid-beta Mouse Model by Sacher, Christian, Blume, Tanja, Beyer, Leonie, Peters, Finn, Eckenweber, Florian, Sgobio, Carmelo, Deussing, Maximilian, Albert, Nathalie Lisa, Unterrainer, Marcus, Lindner, Simon, Gildehaus, Franz-Josef, von Ungern-Sternberg, Barbara, Brzak, Irena, Neumann, Ulf, Saito, Takashi, Saido, Takaomi C, Bartenstein, Peter, Rominger, Axel, Herms, Jochen, Brendel, Matthias

“…Non-physiological overexpression of β-amyloid (Aβ) precursor protein in common transgenic Aβ mouse models of Alzheimer's disease (AD) likely hampers their…”
Get full text

In Vivo Assessment of Neuroinflammation in 4‐Repeat Tauopathies by Palleis, Carla, Sauerbeck, Julia, Beyer, Leonie, Harris, Stefanie, Schmitt, Julia, Morenas‐Rodriguez, Estrella, Finze, Anika, Nitschmann, Alexander, Ruch‐Rubinstein, Francois, Eckenweber, Florian, Biechele, Gloria, Blume, Tanja, Shi, Yuan, Weidinger, Endy, Prix, Catharina, Bötzel, Kai, Danek, Adrian, Rauchmann, Boris‐Stephan, Stöcklein, Sophia, Lindner, Simon, Unterrainer, Marcus, Albert, Nathalie L., Wetzel, Christian, Rupprecht, Rainer, Rominger, Axel, Bartenstein, Peter, Herms, Jochen, Perneczky, Robert, Haass, Christian, Levin, Johannes, Höglinger, Günter U., Brendel, Matthias

“…ABSTRACT Background Neuroinflammation has received growing interest as a therapeutic target in neurodegenerative disorders, including 4‐repeat tauopathies…”
Get full text

Asymmetry of Fibrillar Plaque Burden in Amyloid Mouse Models by Sacher, Christian, Blume, Tanja, Beyer, Leonie, Biechele, Gloria, Sauerbeck, Julia, Eckenweber, Florian, Deussing, Maximilian, Focke, Carola, Parhizkar, Samira, Lindner, Simon, Gildehaus, Franz-Josef, von Ungern-Sternberg, Barbara, Baumann, Karlheinz, Tahirovic, Sabina, Kleinberger, Gernot, Willem, Michael, Haass, Christian, Bartenstein, Peter, Cumming, Paul, Rominger, Axel, Herms, Jochen, Brendel, Matthias

“…Asymmetries of amyloid-β (Aβ) burden are well known in Alzheimer disease (AD) but did not receive attention in Aβ mouse models of Alzheimer disease. Therefore,…”
Get full text

Assessment of perfusion deficit with early phases of [18F]PI-2620 tau-PET versus [18F]flutemetamol-amyloid-PET recordings by Völter, Friederike, Beyer, Leonie, Eckenweber, Florian, Scheifele, Maximilian, Bui, Ngoc, Patt, Marianne, Barthel, Henryk, Katzdobler, Sabrina, Palleis, Carla, Franzmeier, Nicolai, Levin, Johannes, Perneczky, Robert, Rauchmann, Boris-Stephan, Sabri, Osama, Hong, Jimin, Cumming, Paul, Rominger, Axel, Shi, Kuangyu, Bartenstein, Peter, Brendel, Matthias

“…Purpose Characteristic features of amyloid-PET (A), tau-PET (T), and FDG-PET (N) can serve for the A/T/N classification of neurodegenerative diseases. Recent…”
Get full text

Microglial activation in the right amygdala-entorhinal-hippocampal complex is associated with preserved spatial learning in App mice by Biechele, Gloria, Wind, Karin, Blume, Tanja, Sacher, Christian, Beyer, Leonie, Eckenweber, Florian, Franzmeier, Nicolai, Ewers, Michael, Zott, Benedikt, Lindner, Simon, Gildehaus, Franz-Josef, von Ungern-Sternberg, Barbara, Tahirovic, Sabina, Willem, Michael, Bartenstein, Peter, Cumming, Paul, Rominger, Axel, Herms, Jochen, Brendel, Matthias

Get full text