Search Results - "Eck, Tyler"

A novel series of putative Brugia malayi histone demethylase inhibitors as potential anti-filarial drugs by Kreiss, Tamara, Eck, Tyler, Hart, Brittany, Tummalapalli, Sreedhar, Rotella, David, Siekierka, John

“…Filariasis, caused by a family of parasitic nematodes, affects millions of individuals throughout the tropics and is a major cause of acute and chronic…”
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Crystal structure of dihydrofolate reductase from the filarial nematode W. bancrofti in complex with NADPH and folate by Lange, Keith, Frey, Kathleen M, Eck, Tyler, Janson, Cheryl A, Gubler, Ueli, Goodey, Nina M

“…Lymphatic filariasis is a debilitating illness with an estimated 50 million cases as of 2018. The majority of cases are caused by the parasitic worm W…”
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Expression, purification, and inhibition profile of dihydrofolate reductase from the filarial nematode Wuchereria bancrofti by Tobias, Andrew M, Toska, Dea, Lange, Keith, Eck, Tyler, Bhat, Rohit, Janson, Cheryl A, Rotella, David P, Gubler, Ueli, Goodey, Nina M

“…Filariasis is a tropical disease caused by the parasitic nematodes Wuchereria bancrofti and Brugia malayi. Known inhibitors of dihydrofolate reductase (DHFR)…”
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Effect of Non‐Active Site Amino Acid Residues on Inhibitor Selectivity by Eck, Tyler, Gubler, Ueli, Goodey, Nina

“…Enzyme inhibitors are important in biological processes and as pharmaceutical drugs, the cornerstone of modern medicine. It is necessary to build a…”
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A novel series of putative Brugia malayi histone demethylase inhibitors as potential anti-filarial drugs by Tamara Kreiss, Tyler Eck, Brittany Hart, Sreedhar Tummalapalli, David Rotella, John Siekierka

“…Filariasis, caused by a family of parasitic nematodes, affects millions of individuals throughout the tropics and is a major cause of acute and chronic…”
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Structure–Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials by Gilleran, John A., Ashraf, Kutub, Delvillar, Melvin, Eck, Tyler, Fondekar, Raheel, Miller, Edward B., Hutchinson, Ashley, Dong, Aiping, Seitova, Alma, De Souza, Mariana Laureano, Augeri, David, Halabelian, Levon, Siekierka, John, Rotella, David P., Gordon, John, Childers, Wayne E., Grier, Mark C., Staker, Bart L., Roberge, Jacques Y., Bhanot, Purnima

“…Controlling malaria requires new drugs against Plasmodium falciparum. The P. falciparum cGMP-dependent protein kinase (PfPKG) is a validated target whose…”
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Correction to “Structure–Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials” by Gilleran, John A., Ashraf, Kutub, Delvillar, Melvin, Eck, Tyler, Fondekar, Raheel, Miller, Edward B., Hutchinson, Ashley, Dong, Aiping, Seitova, Alma, De Souza, Mariana Laureano, Augeri, David, Halabelian, Levon, Siekierka, John, Rotella, David P., Gordon, John, Childers, Wayne E., Grier, Mark C., Staker, Bart L., Roberge, Jacques Y., Bhanot, Purnima

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Characterization of Competitive Inhibitors of P. falciparum cGMP-Dependent Protein Kinase by Eck, Tyler, de Souza, Mariana Laureano, Delvillar, Melvin, Ashraf, Kutub, Bheemanaboina, Rammohan R. Yadav, Chakrasali, Ramappa, Kreiss, Tamara, Siekierka, John J., Rotella, David P., Bhanot, Purnima, Goodey, Nina M.

“…P. falciparum cGMP-dependent protein kinase (PfPKG) is an enticing anti-malarial drug target. Novel chemotypes are needed because existing inhibitors have…”
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Mutational analysis confirms the presence of distal inhibitor-selectivity determining residues in B. stearothermophilus dihydrofolate reductase by Eck, Tyler, Patel, Seema, Candela, Thomas, Leon H, Katherine, Little, Michael, Reis, Natalia E., Liyanagunawardana, Uththara, Gubler, Ueli, Janson, Cheryl A., Catalano, Jaclyn, Goodey, Nina M.

“…Many antibacterial and antiparasitic drugs work by competitively inhibiting dihydrofolate reductase (DHFR), a vital enzyme in folate metabolism. The…”
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Characterization of Competitive Inhibitors of Plasmodium falciparum cGMP‐Dependent Protein Kinase by Eck, Tyler, Laureano de Souza, Mariana, Delvillar, Melvin, Ashraf, Kutub, Yadav Bheemanaboina, Rammohan R., Chakrasali, Ramappa, Kreiss, Tamara, Siekierka, John J., Rotella, David P., Bhanot, Purnima, Goodey, Nina M.

“…Plasmodium falciparum cGMP‐dependent protein kinase (PfPKG) is an enticing antimalarial drug target. Novel chemotypes are needed because existing inhibitors…”
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Discovery of Imidazole-Based Inhibitors of Plasmodium falciparum cGMP-Dependent Protein Kinase by Bheemanaboina, Rammohan R. Yadav, de Souza, Mariana Laureano, Gonzalez, Mariana Lozano, Mahmood, Shams Ul, Eck, Tyler, Kreiss, Tamara, Aylor, Samantha O, Roth, Alison, Lee, Patricia, Pybus, Brandon S, Colussi, Dennis J, Childers, Wayne E, Gordon, John, Siekierka, John J, Bhanot, Purnima, Rotella, David P

“…The discovery of new targets for the treatment of malaria, in particular those aimed at the pre-erythrocytic stage in the life cycle, advanced with the…”
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Discovery of isoxazolyl-based inhibitors of Plasmodium falciparum cGMP-dependent protein kinase by Mahmood, Shams Ul, Cheng, Huimin, Tummalapalli, Sreedhar R, Chakrasali, Ramappa, Yadav Bheemanaboina, Rammohan R, Kreiss, Tamara, Chojnowski, Agnieska, Eck, Tyler, Siekierka, John J, Rotella, David P

“…The cGMP-dependent protein kinase in (PfPKG) plays multiple roles in the life cycle of the parasite. As a result, this enzyme is a potential target for new…”
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Discovery of isoxazolyl-based inhibitors of cGMP-dependent protein kinase by Mahmood, Shams Ul, Cheng, Huimin, Tummalapalli, Sreedhar R, Chakrasali, Ramappa, Yadav Bheemanaboina, Rammohan R, Kreiss, Tamara, Chojnowski, Agnieska, Eck, Tyler, Siekierka, John J, Rotella, David P

“…The cGMP-dependent protein kinase in Plasmodium falciparum (PfPKG) plays multiple roles in the life cycle of the parasite. As a result, this enzyme is a…”
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