Search Results - "Echwald, S"

A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage by Andersen, Jannik N., Jansen, Peter G., Echwald, S⊘ren M., Mortensen, Ole H., Fukada, Toshiyuki, Del Vecchio, Robert, Tonks, Nicholas K., M⊘ller, Niels Peter H.

“…ABSTRACT The protein tyrosine phosphatases (PTPs) are now recognized as critical regulators of signal transduction under normal and pathophysiological…”
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Long-term influences of body-weight changes, independent of the attained weight, on risk of impaired glucose tolerance and Type 2 diabetes by Black, E., Holst, C., Astrup, A., Toubro, S., Echwald, S., Pedersen, O., Sørensen, T. I. A.

“…Aim  To investigate if weight gain during adulthood has effects on the risk of developing impaired glucose tolerance (IGT) or Type 2 diabetes beyond effect of…”
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The K121Q variant of the human PC-1 gene is not associated with insulin resistance or type 2 diabetes among Danish Caucasians by RASMUSSEN, S. K, URHAMMER, S. A, PEDERSEN, O, PIZZUTI, A, ECHWALD, S. M, EKSTRØM, C. T, HANSEN, L, HANSEN, T, BORCH-JOHNSEN, K, FRITTITTA, L, TRISCHITTA, V

“…The K121Q variant of the human PC-1 gene is not associated with insulin resistance or type 2 diabetes among Danish Caucasians. S K Rasmussen , S A Urhammer , A…”
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Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus by Almind, K, Bjørbaek, C, Vestergaard, H, Hansen, T, Echwald, S, Pedersen, O

“…Since relative or absolute insulin deficiency and insulin insensitivity are involved in the aetiology of non-insulin-dependent diabetes mellitus (NIDDM), we…”
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The Asn363Ser variant of the glucocorticoid receptor gene is not associated with obesity or weight gain in Danish men by ECHWALD, S. M, SØRENSEN, T. I. A, ANDERSEN, T, PEDERSEN, O

“…Testing association of the Asn363Ser variant of the glucocorticoid gene with measures of obesity and weight gain. 741 obese subjects (BMI > or = 31 kg/m(2) at…”
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Lower-body fat mass as an independent marker of insulin sensitivity-the role of adiponectin by BUEMANN, B, SØRENSEN, T. I. A, PEDERSEN, O, BLACK, E, HOLST, C, TOUBRO, S, ECHWALD, S, HOLST, J. J, RASMUSSEN, C, ASTRUP, A

“…To study the association between lower-body fat and estimates of whole-body insulin sensitivity in middle-aged men with and without a history of juvenile onset…”
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Possible Role of Adiponectin and Insulin Sensitivity in Mediating the Favorable Effects of Lower Body Fat Mass on Blood Lipids by Buemann, B., Astrup, A., Pedersen, O., Black, E., Holst, C., Toubro, S., Echwald, S., Holst, J. J., Rasmussen, C., Sørensen, T. I. A.

“…Aims: The objective of this study was to investigate the role of insulin sensitivity and serum adiponectin concentration as determinants, in middle-aged men,…”
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meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference by Heo, M, Leibel, R.L, Fontaine, K.R, Boyer, B.B, Chung, W.K, Koulu, M, Karvonen, M.K, Pesonen, U, Rissanen, A, Laakso, M, Uusitupa, M.I.J, Chagnon, Y, Bouchard, C, Donohoue, P.A, Burns, T.L, Shuldiner, A.R

“…Methods: We analyzed data pooled from nine studies on the human leptin receptor (LEPR) gene for the association of three alleles (K109R, Q223R and K656N) of…”
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Genetics of human obesity: lessons from mouse models and candidate genes by Echwald, S. M.

“… Echwald SM (Steno Diabetes Centre and Hagedorn Research Institute, Gentofte, Denmark). Genetics of human obesity: lessons from mouse models and candidate…”
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Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene by HANSEN, T, ECHWALD, S. M, AGUILAR-BRYAN, L, PERMUTT, M. A, PEDERSEN, O, HANSEN, L, MØLLER, A. M, AHMIND, K, CLAUSEN, J. O, URHAMMER, S. A, INOUE, H, FERRER, J, BRYAN, J

“…Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene. T Hansen , S M…”
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Insulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1 by Clausen, J O, Hansen, T, Bjørbaek, C, Echwald, S M, Urhammer, S A, Rasmussen, S, Andersen, C B, Hansen, L, Almind, K, Winther, K

“…We previously discovered two aminoacid polymorphisms in codons 513 and 972 of the protein insulin receptor substrate-1 (IRS-1), which is important in cellular…”
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Leptin in obesity by Sorensen, Thorkild Ia, Echwald, Soren M, Holm, Jens-Christian

“…An editorial discusses the obese gene in rodents, which encodes a protein called leptin. Leptin is thought to be a bloodborne signal from the adipose tissue…”
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Genetic variability of the SUR1 promoter in relation to beta-cell function and Type II diabetes mellitus by HANSEN, T, AMBYE, L, GRARUP, N, HANSEN, L, ECHWALD, S. M, FERRER, J, PEDERSEN, O

“…We aimed to examine the promoter of SUR1 for genetic variation and to determine if variants were associated with Type II (non-insulin-dependent) diabetes…”
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Mutational analysis of the proopiomelanocortin gene in Caucasians with early onset obesity by ECHWALD, S. M, SØRENSEN, T. I. A, ANDERSEN, T, TYBJAERG-HANSEN, A, CLAUSEN, J. O, PEDERSEN, O

“…Mutations in the human gene encoding the polyhormone peptide proopiomelanocortin (POMC) are associated with obesity in rare cases and the gene co-localizes…”
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Discovery of amino acid variants in the human glucose-dependent insulinotropic polypeptide (GIP) receptor : the impact on the pancreatic beta cell responses and functional expression studies in Chinese hamster fibroblast cells by ALMIND, K, AMBYE, L, URHAMMER, S. A, HANSEN, T, ECHWALD, S. M, HOLST, J. J, GROMADA, J, THORENS, B, PEDERSEN, O

“…The two incretins, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), are insulinotropic factors released from the small…”
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Organisation of the coding exons and mutational screening of the uncoupling protein 3 gene in subjects with juvenile-onset obesity by URHAMMER, S. A, DALGAARD, L. T, SØRENSEN, T. I. A, TYBJAERG-HANSEN, A, ECHWALD, S. M, ANDERSEN, T, CLAUSEN, J. O, PEDERSEN, O

“…Uncoupling proteins (UCPs) are mitochondrial transporters that uncouple the cellular respiration releasing stored energy as heat. Recently a third member of…”
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Studies of the variability of the genes encoding the insulin-like growth factor I receptor and its ligand in relation to type 2 diabetes mellitus by RASMUSSEN, S. K, LAUTIER, C, PEDERSEN, O, HANSEN, L, ECHWALD, S. M, HANSEN, T, EKSTRØM, C. T, URHAMMER, S. A, BORCH-JOHNSEN, K, GRIGORESCU, F, SMITH, R. J

“…Insulin-like growth factor I (IGF-I) is an important regulator of many aspects of growth, differentiation, and development, and as low birth weight has been…”
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Pooling Analysis of Genetic Data: The Association of Leptin Receptor (LEPR) Polymorphisms With Variables Related to Human Adiposity by Heo, M, Leibel, R. L, Boyer, B. B, Chung, W. K, Koulu, M, Karvonen, M. K, Pesonen, U, Rissanen, A, Laakso, M, Uusitupa, M. I. J, Chagnon, Y, Bouchard, C, Donohoue, P. A, Burns, T. L, Shuldiner, A. R, Silver, K, Andersen, R. E, Pedersen, O, Echwald, S, Sorensen, T. I. A, Behn, P, Permutt, M. A, Jacobs, K. B, Elston, R. C, Hoffman, D. J, Allison, D. B

“…Analysis of raw pooled data from distinct studies of a single question generates a single statistical conclusion with greater power and precision than…”
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Amino acid polymorphisms in the ATP-regulatable inward rectifier Kir6.2 and their relationships to glucose- and tolbutamide-induced insulin secretion, the insulin sensitivity index, and NIDDM by Hansen, L., Echwald, S. M., Hansen, T., Urhammer, S. A., Clausen, J. O., Pedersen, O.

“…Amino acid polymorphisms in the ATP-regulatable inward rectifier Kir6.2 and their relationships to glucose- and tolbutamide-induced insulin secretion, the…”
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Association Studies between Microsatellite Markers within the Gene Encoding Human 11β-Hydroxysteroid Dehydrogenase Type 1 and Body Mass Index, Waist to Hip Ratio, and Glucocorticoid Metabolism by Draper, N., Echwald, S. M., Lavery, G. G., Walker, E. A., Fraser, R., Davies, E., Sørensen, T. I. A., Astrup, A., Adamski, J., Hewison, M., Connell, J. M., Pedersen, O., Stewart, P. M.

“…Two isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD) interconvert active cortisol (F) and inactive cortisone (E). 11β-HSD1 is an oxo-reductase (E to F)…”
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