Search Results - "Echeverri, Christophe J"

High-throughput RNAi screening in cultured cells: a user's guide by Echeverri, Christophe J, Perrimon, Norbert

“…RNA interference has re-energized the field of functional genomics by enabling genome-scale loss-of-function screens in cultured cells. Looking back on the…”
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Minimizing the risk of reporting false positives in large-scale RNAi screens by Echeverri, Christophe J, Beachy, Philip A, Baum, Buzz, Boutros, Michael, Buchholz, Frank, Chanda, Sumit K, Downward, Julian, Ellenberg, Jan, Fraser, Andrew G, Hacohen, Nir, Hahn, William C, Jackson, Aimee L, Kiger, Amy, Linsley, Peter S, Lum, Lawrence, Ma, Yong, Mathey-Prévôt, Bernard, Root, David E, Sabatini, David M, Taipale, Jussi, Perrimon, Norbert, Bernards, René

“…Large-scale RNA interference (RNAi)-based analyses, very much as other 'omic' approaches, have inherent rates of false positives and negatives. The variability…”
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Host scavenger receptor SR-BI plays a dual role in the establishment of malaria parasite liver infection by Rodrigues, Cristina D, Hannus, Michael, Prudêncio, Miguel, Martin, Cécilie, Gonçalves, Lígia A, Portugal, Sílvia, Epiphanio, Sabrina, Akinc, Akin, Hadwiger, Philipp, Jahn-Hofmann, Kerstin, Röhl, Ingo, van Gemert, Geert-Jan, Franetich, Jean-François, Luty, Adrian J F, Sauerwein, Robert, Mazier, Dominique, Koteliansky, Victor, Vornlocher, Hans-Peter, Echeverri, Christophe J, Mota, Maria M

“…An obligatory step of malaria parasite infection is Plasmodium sporozoite invasion of host hepatocytes, and host lipoprotein clearance pathways have been…”
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Kinome-wide RNAi screen implicates at least 5 host hepatocyte kinases in Plasmodium sporozoite infection by Prudêncio, Miguel, Rodrigues, Cristina D, Hannus, Michael, Martin, Cécilie, Real, Eliana, Gonçalves, Lígia A, Carret, Céline, Dorkin, Robert, Röhl, Ingo, Jahn-Hoffmann, Kerstin, Luty, Adrian J F, Sauerwein, Robert, Echeverri, Christophe J, Mota, Maria M

“…Plasmodium sporozoites, the causative agent of malaria, are injected into their vertebrate host through the bite of an infected Anopheles mosquito, homing to…”
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Predictive models of molecular machines involved in Caenorhabditis elegans early embryogenesis by Roth, Frederick P, Vidal, Marc, Piano, Fabio, Gunsalus, Kristin C, Ge, Hui, Schetter, Aaron J, Goldberg, Debra S, Han, Jing-Dong J, Hao, Tong, Berriz, Gabriel F, Bertin, Nicolas, Huang, Jerry, Chuang, Ling-Shiang, Li, Ning, Mani, Ramamurthy, Hyman, Anthony A, Sönnichsen, Birte, Echeverri, Christophe J

“…Although numerous fundamental aspects of development have been uncovered through the study of individual genes and proteins, system-level models are still…”
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Overexpression of the Dynamitin (p50) Subunit of the Dynactin Complex Disrupts Dynein-Dependent Maintenance of Membrane Organelle Distribution by Burkhardt, Janis K., Echeverri, Christophe J., Nilsson, Tommy, Vallee, Richard B.

“…Dynactin is a multisubunit complex that plays an accessory role in cytoplasmic dynein function. Overexpression in mammalian cells of one dynactin subunit,…”
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Dynamitin Mutagenesis Reveals Protein-Protein Interactions Important for Dynactin Structure by Maier, Kerstin C, Godfrey, Jamie E, Echeverri, Christophe J, Cheong, Frances K.Y, Schroer, Trina A

“…Dynactin is a highly conserved, multiprotein complex that works in conjunction with microtubule-based motors to power a variety of intracellular motile events…”
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In situ fluorescence analysis demonstrates active siRNA exclusion from the nucleus by Exportin 5 by Ohrt, Thomas, Merkle, Dennis, Birkenfeld, Karin, Echeverri, Christophe J., Schwille, Petra

“…Two types of short double-stranded RNA molecules, namely microRNAs (miRNAs) and short interfering RNAs (siRNAs), have emerged recently as important regulators…”
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A chemical biology approach identified PI3K as a potential therapeutic target for neurofibromatosis type 2 by Petrilli, Alejandra M, Fuse, Marisa A, Donnan, Mathew S, Bott, Marga, Sparrow, Nicklaus A, Tondera, Daniel, Huffziger, Julia, Frenzel, Corina, Malany, C Siobhan, Echeverri, Christophe J, Smith, Layton, Fernández-Valle, Cristina

“…Mutations in the merlin tumor suppressor gene cause Neurofibromatosis type 2 (NF2), which is a disease characterized by development of multiple benign tumors…”
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Molecular Characterization of the 50-kD Subunit of Dynactin Reveals Function for the Complex in Chromosome Alignment and Spindle Organization during Mitosis by Echeverri, Christophe J., Paschal, Bryce M., Vaughan, Kevin T., Vallee, Richard B.

“…Dynactin is a multi-subunit complex which has been implicated in cytoplasmic dynein function, though its mechanism of action is unknown. In this study, we have…”
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Cytoplasmic Dynein and Dynactin Are Required for the Transport of Microtubules into the Axon by Ahmad, Fridoon J., Echeverri, Christophe J., Vallee, Richard B., Baas, Peter W.

“…Previous work from our laboratory suggested that microtubules are released from the neuronal centrosome and then transported into the axon (Ahmad, F.J., and…”
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High-throughput RNA interference strategies for target discovery and validation by using synthetic short interfering RNAs: functional genomics investigations of biological pathways by Sachse, Christoph, Krausz, Eberhard, Krönke, Andrea, Hannus, Michael, Walsh, Andrew, Grabner, Anne, Ovcharenko, Dmitriy, Dorris, David, Trudel, Claude, Sönnichsen, Birte, Echeverri, Christophe J

“…During the past five years, RNA interference (RNAi) has emerged as arguably the best functional genomics tool available to date, providing direct, causal links…”
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Oncology studies using siRNA libraries: the dawn of RNAi-based genomics by Sachse, Christoph, Echeverri, Christophe J

“…High-throughput, human cell-based applications of RNA-mediated interference (RNAi) have emerged in recent years as perhaps the most powerful of a 'second wave'…”
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Oncology studies using siRNA libraries: the dawn of RNAi-based genomics: RNA interference-based functional genomics in cancer research by SACHSE, Christoph, ECHEVERRI, Christophe J

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Colocalization of cytoplasmic dynein with dynactin and CLIP-170 at microtubule distal ends by Vaughan, K T, Tynan, S H, Faulkner, N E, Echeverri, C J, Vallee, R B

“…Cytoplasmic dynein is a minus end-directed microtubule motor responsible for centripetal organelle movement and several aspects of chromosome segregation. Our…”
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Kinome-Wide RNAi Screen Implicates at Least 5 Host Hepatocyte Kinases in Plasmodium Sporozoite Infection: e1000201 by Prudêncio, Miguel, Rodrigues, Cristina D, Hannus, Michael, Martin, Cécilie, Real, Eliana, Gonçalves, Lígia A, Carret, Céline, Dorkin, Robert, Röhl, Ingo, Jahn-Hoffmann, Kerstin, Luty, Adrian JF, Sauerwein, Robert, Echeverri, Christophe J, Mota, Maria M

“…Plasmodium sporozoites, the causative agent of malaria, are injected into their vertebrate host through the bite of an infected Anopheles mosquito, homing to…”
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Localization of Motor-Related Proteins and Associated Complexes to Active, but Not Inactive, Centromeres by Faulkner, Nicole E., Vig, Baldev, Echeverri, Christophe J., Wordeman, Linda, Vallee, Richard B.

“…Multicentric chromosomes are often found in tumor cells and certain cell lines. How they are generated is not fully understood, though their stability suggests…”
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Multiple Mouse Chromosomal Loci for Dynein-Based Motility by Vaughan, Kevin T., Mikami, Atsushi, Paschal, Bryce M., Holzbaur, Erika L.F., Hughes, Sharon M., Echeverri, Christophe J., Moore, Karen J., Gilbert, Debra J., Copeland, Neal G., Jenkins, Nancy A., Vallee, Richard B.

“…Dyneins are multisubunit mechanochemical enzymes capable of interacting with microtubules to generate force. Axonemal dyneins produce the motive force for…”
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Differential sorting of beta tubulin isotypes into colchicine-stable microtubules during neuronal and muscle differentiation of embryonal carcinoma cells by Falconer, M M, Echeverri, C J, Brown, D L

“…Pluripotent P19 embryonal carcinoma (EC) cells were differentiated along the neuronal and muscle pathways. Comparisons of class I, II, III, and IV beta tubulin…”
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Monoclonal antibodies to Gliocladium roseum, a potential biological control fungus of sap-staining fungi in wood by Breuil, Colette, Luck, Brian T, Rossignol, Lynne, Little, Judy, Echeverri, Christophe J, Banerjee, Srabani, Brown, David L

“…1 Forest Products Biotechnology, Faculty of Forestry, University of British Columbia, 2357 Main Mall, Vancouver, Canada V6T1Z4 2 Department of Biology,…”
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