Search Results - "Echevarria, David J."
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Zebrafish models in neuropsychopharmacology and CNS drug discovery
Published in British journal of pharmacology (01-07-2017)“…Despite the high prevalence of neuropsychiatric disorders, their aetiology and molecular mechanisms remain poorly understood. The zebrafish (Danio rerio) is…”
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Zebrafish neurobehavioral phenomics for aquatic neuropharmacology and toxicology research
Published in Aquatic toxicology (01-01-2016)“…•Zebrafish are an important model organism for aquatic neuropharmacology and toxicology.•Zebrafish behavioral complexity enables a detailed dissection of…”
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Zebrafish and conditioned place preference: A translational model of drug reward
Published in Progress in neuro-psychopharmacology & biological psychiatry (03-12-2014)“…Addiction and substance abuse are found ubiquitously throughout human society. In the United States, these disorders are responsible for amassing hundreds of…”
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Role of brain norepinephrine in the behavioral response to stress
Published in Progress in neuro-psychopharmacology & biological psychiatry (01-12-2005)“…The brain noradrenergic system is activated by acute stress. The post-synaptic effects of norepinephrine (NE), exerted at a cellular or neural circuit level,…”
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Gaining translational momentum: More zebrafish models for neuroscience research
Published in Progress in neuro-psychopharmacology & biological psychiatry (03-12-2014)“…Zebrafish (Danio rerio) are rapidly becoming a popular model organism in translational neuroscience and biological psychiatry research. Here we discuss…”
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Memory facilitation by methylene blue: Dose-dependent effect on behavior and brain oxygen consumption
Published in European journal of pharmacology (28-03-2005)“…Methylene blue administered post-training improves memory retention in avoidance and appetitive tasks, and restores spatial memory impaired by an inhibitor of…”
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Zebrafish models of autism spectrum disorder
Published in Experimental neurology (01-01-2018)“…Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by motor, social and cognitive deficits that develop early during…”
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Comparative Analyses of Zebrafish Anxiety-Like Behavior Using Conflict-Based Novelty Tests
Published in Zebrafish (01-06-2017)“…Modeling of stress and anxiety in adult zebrafish (Danio rerio) is increasingly utilized in neuroscience research and central nervous system (CNS) drug…”
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Modeling consequences of prolonged strong unpredictable stress in zebrafish: Complex effects on behavior and physiology
Published in Progress in neuro-psychopharmacology & biological psychiatry (02-02-2018)“…Chronic stress is the major pathogenetic factor of human anxiety and depression. Zebrafish (Danio rerio) have become a novel popular model species for…”
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Anxiogenic-like effects of chronic nicotine exposure in zebrafish
Published in Pharmacology, biochemistry and behavior (01-12-2015)“…Nicotine is one of the most widely used and abused legal drugs. Although its pharmacological profile has been extensively investigated in humans and rodents,…”
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Alzheimer’s disease in the zebrafish: where can we take it?
Published in Behavioural pharmacology (01-04-2017)“…With the ever-growing geriatric population, research on brain diseases such as dementia is more imperative now than ever. The most prevalent of all dementias…”
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Aquatic toxicology of fluoxetine: Understanding the knowns and the unknowns
Published in Aquatic toxicology (01-11-2014)“…Fluoxetine is one of the most prescribed psychotropic medications, and is an agent of increasing interest for environmental toxicology. Fish and other aquatic…”
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Back to basics: searching for a comprehensive framework for exploring individual differences in zebrafish (Danio rerio) behavior
Published in Zebrafish (01-08-2014)“…Individual differences (IDs) in behavior among nonhuman animals have been documented in a wide range of taxa. Although traditionally considered noise around an…”
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Understanding zebrafish cognition
Published in Behavioural processes (01-08-2017)“…•Zebrafish are rapidly becoming a popular model organism in cognitive neuroscience research.•Zebrafish continue to increase our understanding of brain…”
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Modeling PTSD in the zebrafish: are we there yet?
Published in Behavioural brain research (01-01-2015)“…Post-traumatic stress disorder is an anxiety disorder that can develop following one or more traumatic events that threaten one's safety or make the victim…”
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Legal aspects of zebrafish neuropharmacology and neurotoxicology research
Published in Regulatory toxicology and pharmacology (01-02-2019)“…Despite the growing emphasis on translational neuropharmacology and drug discovery research, the legality underlying these fields are seldom considered. The…”
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The utility of the zebrafish model in conditioned place preference to assess the rewarding effects of drugs
Published in Behavioural pharmacology (01-09-2013)“…Substance abuse is a significant public health concern both domestically and worldwide. The persistent use of substances regardless of aversive consequences…”
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Alcohol-induced behavior change in zebrafish models
Published in Reviews in the neurosciences (01-02-2011)“…Zebrafish are at the forefront of neurobiological research and have been gaining popularity as a viable and valid behavioral model in a variety of research…”
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Methylene Blue Facilitates Memory Retention in Zebrafish in a Dose-Dependent Manner
Published in Zebrafish (01-12-2016)“…Methylene blue (MB) is an FDA-grandfathered drug with memory-enhancing effects at low doses, but opposite effects at high doses. We investigated the effects of…”
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The failure of anxiolytic therapies in early clinical trials: what needs to be done
Published in Expert opinion on investigational drugs (01-04-2015)“…Anxiety spectrum disorders (ASDs) are highly prevalent psychiatric illnesses that affect millions of people worldwide. Strongly associated with stress, common…”
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