Search Results - "Eccles, Wendy"

Identification of benzofuran central cores for the inhibition of leukotriene A4 hydrolase by Eccles, Wendy, Blevitt, Jonathan M., Booker, Jamila N., Chrovian, Christa C., Crawford, Shelby, de Leon, Aimee Rose, Deng, Xiaohu, Fourie, Anne M., Grice, Cheryl A., Herman, Krystal, Karlsson, Lars, Kearney, Aaron M., Lee-Dutra, Alice, Liang, Jimmy, Luna, Rosa, Pippel, Dan, Rao, Navin, Riley, Jason P., Santillán, Alejandro, Savall, Brad, Tanis, Virginia M., Xue, Xiaohua, Young, Arlene L.

“…Leukotrienes (LT’s) are known to play a physiological role in inflammatory immune response. Leukotriene A4 hydrolase (LTA4H) is a cystolic enzyme that…”
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Loss of sodium modulation of plasma kinins in human hypertension by Murphey, Laine J, Eccles, Wendy K, Williams, Gordon H, Brown, Nancy J

“…We studied the effect of salt intake and hypertension on the systemic kallikrein-kinin system (KKS), as measured by bradykinin (BK) 1-5, a stable circulating…”
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Polypharmacology of Small-Molecule Modulators of the 5-Lipoxygenase Activating Protein (FLAP) Observed via a High-throughput Lipidomics Platform by Song, Jiao, Liu, Xuejun, Zhu, Jian, Tootoonchi, Mandana, Keith, John M, Meduna, Steven P, Dvorak, Curt A, Eccles, Wendy, Krawczuk, Paul J, Blevitt, Jonathan M, Wu, Jiejun, Rao, Navin L, Lebsack, Alec D, Milla, Marcos E

“…Leukotrienes (LTs) and related species are proinflammatory lipid mediators derived from arachidonic acid (AA) that have pathological roles in autoimmune and…”
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Reactivity of 13,13-Dibromo-2,4,9,11-tetraoxadispiro[5.0.5.1]tridecane toward Organolithiums: Remarkable Resistance to the DMS Rearrangement by Eccles, Wendy, Jasinski, Marcin, Kaszynski, Piotr, Zienkiewicz, Katarzyna, Stulgies, Baldur, Jankowiak, Aleksandra

“…Reactions of dibromocyclopropane 2a, containing two spiro-fused 1,3-dioxane rings, with MeLi gave only the methylation products 8 and 9 even at elevated…”
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Synthesis and structure–activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with a heterocyclic ring constraint by Hudson, Sarah, Kiankarimi, Mehrak, Eccles, Wendy, Mostofi, Yalda S., Genicot, Marc J., Dwight, Wesley, Fleck, Beth A., Gogas, Kathleen, Wade, Warren S.

“…A series of heterocyclic ring-constrained norepinephrine reuptake inhibitors have activities as racemates equivalent to atomoxetine (IC 50’s < 10 nM). The…”
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Identification of benzofuran central cores for the inhibition of leukotriene A(4) hydrolase by Eccles, Wendy, Blevitt, Jonathan M, Booker, Jamila N, Chrovian, Christa C, Crawford, Shelby, de Leon, Aimee Rose, Deng, Xiaohu, Fourie, Anne M, Grice, Cheryl A, Herman, Krystal, Karlsson, Lars, Kearney, Aaron M, Lee-Dutra, Alice, Liang, Jimmy, Luna, Rosa, Pippel, Dan, Rao, Navin, Riley, Jason P, Santillán, Alejandro, Savall, Brad, Tanis, Virginia M, Xue, Xiaohua, Young, Arlene L

“…Leukotrienes (LT's) are known to play a physiological role in inflammatory immune response. Leukotriene A(4) hydrolase (LTA(4)H) is a cystolic enzyme that…”
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Structure–activity relationships of chiral selective norepinephrine reuptake inhibitors (sNRI) with increased oxidative stability by Hudson, Sarah, Kiankarimi, Mehrak, Eccles, Wendy, Dwight, Wesley, Mostofi, Yalda S., Genicot, Marc J., Fleck, Beth A., Gogas, Kathleen, Aparicio, Anna, Wang, Hua, Wen, Jenny, Wade, Warren S.

“…A series of chiral ring-constrained norepinephrine reuptake inhibitors equivalent to atomoxetine in potency, selectivity, and inhibition of CYP2D6 but more…”
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