Search Results - "Eby, Jonathan"

Effects of ethanol and ethanol metabolites on intrinsic function of mesenteric resistance arteries by Eby, Jonathan M, Majetschak, Matthias

“…Evidence suggests that ethanol-induced hypertension is associated with increased cardiovascular responsiveness to vasopressors in vivo and enhanced reactivity…”
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Episodic alcohol exposure attenuates mesenchymal stem cell chondrogenic differentiation during bone fracture callus formation by Eby, Jonathan M., Sharieh, Farah, Azevedo, Jessica, Callaci, John J.

“…Background During bone fracture repair, mesenchymal stem cells (MSC) differentiate into chondrocytes and osteoblasts to form a fracture callus. Our laboratory…”
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A Quantitative Increase in Regulatory T Cells Controls Development of Vitiligo by Chatterjee, Shilpak, Eby, Jonathan M., Al-Khami, Amir A., Soloshchenko, Myroslawa, Kang, Hee-Kap, Kaur, Navtej, Naga, Osama S., Murali, Anuradha, Nishimura, Michael I., Caroline Le Poole, I., Mehrotra, Shikhar

“…T-cell cytolytic activity targeting epidermal melanocytes is shown to cause progressive depigmentation and autoimmune vitiligo. By using the recently developed…”
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Dietary Alcohol Consumption Elicits Corneal Toxicity Through the Generation of Cellular Oxidative Stress by Ghosh, Anita K, Čėsna, Robertas, Neverauskas, Donatas, Žiniauskaitė, Agnė, Iqbal, Sana, Eby, Jonathan M, Ragauskas, Symantas, Kaja, Simon

“…Clinical data suggest that alcohol use is associated with the development of signs and symptoms of dry eye disease. However, preclinical data investigating…”
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Effects of cognate, non-cognate and synthetic CXCR4 and ACKR3 ligands on human lung endothelial cell barrier function by Cheng, You-Hong, Eby, Jonathan M, LaPorte, Heather M, Volkman, Brian F, Majetschak, Matthias

“…Recent evidence suggests that chemokine CXCL12, the cognate agonist of chemokine receptors CXCR4 and ACKR3, reduces thrombin-mediated impairment of endothelial…”
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Ethanol Inhibits Mesenchymal Stem Cell Osteochondral Lineage Differentiation Due in Part to an Activation of Forkhead Box Protein O‐Specific Signaling by Sharieh, Farah, Eby, Jonathan M., Roper, Philip M., Callaci, John J.

“…Background During bone fracture repair, resident mesenchymal stem cells (MSCs) differentiate into chondrocytes, to form a cartilaginous fracture callus, and…”
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Antigen Specificity Enhances Disease Control by Tregs in Vitiligo by Mukhatayev, Zhussipbek, Dellacecca, Emilia R, Cosgrove, Cormac, Shivde, Rohan, Jaishankar, Dinesh, Pontarolo-Maag, Katherine, Eby, Jonathan M, Henning, Steven W, Ostapchuk, Yekaterina O, Cedercreutz, Kettil, Issanov, Alpamys, Mehrotra, Shikhar, Overbeck, Andreas, Junghans, Richard P, Leventhal, Joseph R, Le Poole, I Caroline

“…Vitiligo is an autoimmune skin disease characterized by melanocyte destruction. Regulatory T cells (Tregs) are greatly reduced in vitiligo skin, and…”
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CCL22 to Activate Treg Migration and Suppress Depigmentation in Vitiligo by Eby, Jonathan M., Kang, Hee-Kap, Tully, Sean T., Bindeman, Wendy E., Peiffer, Daniel S., Chatterjee, Shilpak, Mehrotra, Shikhar, Caroline Le Poole, I.

“…In vitiligo, gradual cutaneous depigmentation and cytotoxic T-cell activity against melanocytes are accompanied by a paucity of regulatory T cells (Tregs) in…”
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Biased antagonism of CXCR4 avoids antagonist tolerance by Hitchinson, Ben, Eby, Jonathan M, Gao, Xianlong, Guite-Vinet, Francois, Ziarek, Joshua J, Abdelkarim, Hazem, Lee, Youngshim, Okamoto, Yukari, Shikano, Sojin, Majetschak, Matthias, Heveker, Nikolaus, Volkman, Brian F, Tarasova, Nadya I, Gaponenko, Vadim

“…Repeated dosing of drugs targeting G protein-coupled receptors can stimulate antagonist tolerance, which reduces their efficacy; thus, strategies to avoid…”
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Alcohol induces oxidative stress and barrier damage to corneal epithelial cells in vitro and ocular surface damage in vivo by Ghosh, Anita K., Cesna, Robertas, Žiniauskaitė, Agne, Neverauskas, Donatas, Eby, Jonathan M., Ragauskas, Symantas, Kaja, Simon

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Functional and structural consequences of chemokine (C-X-C motif) receptor 4 activation with cognate and non-cognate agonists by Eby, Jonathan M., Abdelkarim, Hazem, Albee, Lauren J., Tripathi, Abhishek, Gao, Xianlong, Volkman, Brian F., Gaponenko, Vadim, Majetschak, Matthias

“…Chemokine (C-X-C motif) receptor 4 (CXCR4) regulates cell trafficking and plays important roles in the immune system. Ubiquitin has recently been identified as…”
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Ccl22 Diverts T Regulatory Cells and Controls the Growth of Melanoma by Klarquist, Jared, Tobin, Kristen, Farhangi Oskuei, Peyman, Henning, Steven W, Fernandez, Manuel F, Dellacecca, Emilia R, Navarro, Flor C, Eby, Jonathan M, Chatterjee, Shilpak, Mehrotra, Shikhar, Clark, Joseph I, Le Poole, I Caroline

“…T regulatory cells (Treg) avert autoimmunity, but their increased levels in melanoma confer a poor prognosis. To explore the basis for Treg accumulation in…”
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Impact of Alcohol on Bone Health, Homeostasis, and Fracture Repair by Eby, Jonathan M., Sharieh, Farah, Callaci, John J.

“…Purpose of Review Alcohol use continues to rise globally. We review the current literature on the effect of alcohol on bone health, homeostasis, and fracture…”
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A central role for inducible heat-shock protein 70 in autoimmune vitiligo by Mosenson, Jeffrey A., Eby, Jonathan M., Hernandez, Claudia, Le Poole, I. Caroline

“…Inducible heat‐shock protein 70 (HSP70i) is a protein regulated by stress that protects cells from undergoing apoptosis. Such proteins are marvellously well…”
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α1‐Adrenergic Receptors Function Within Hetero‐Oligomeric Complexes With Atypical Chemokine Receptor 3 and Chemokine (C‐X‐C motif) Receptor 4 in Vascular Smooth Muscle Cells by Albee, Lauren J., Eby, Jonathan M., Tripathi, Abhishek, LaPorte, Heather M., Gao, Xianlong, Volkman, Brian F., Gaponenko, Vadim, Majetschak, Matthias

“…Background Recently, we provided evidence that α1‐adrenergic receptors (ARs) in vascular smooth muscle are regulated by chemokine (C‐X‐C motif) receptor (CXCR)…”
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Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells by Moore, Tamson, Wagner, Courtney Regan, Scurti, Gina M., Hutchens, Kelli A., Godellas, Constantine, Clark, Ann Lau, Kolawole, Elizabeth Motunrayo, Hellman, Lance M., Singh, Nishant K., Huyke, Fernando A., Wang, Siao-Yi, Calabrese, Kelly M., Embree, Heather D., Orentas, Rimas, Shirai, Keisuke, Dellacecca, Emilia, Garrett-Mayer, Elizabeth, Li, Mingli, Eby, Jonathan M., Stiff, Patrick J., Evavold, Brian D., Baker, Brian M., Le Poole, I. Caroline, Dropulic, Boro, Clark, Joseph I., Nishimura, Michael I.

“…Malignant melanoma incidence has been increasing for over 30 years, and despite promising new therapies, metastatic disease remains difficult to treat. We…”
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Mutant HSP70 reverses autoimmune depigmentation in vitiligo by Mosenson, Jeffrey A, Zloza, Andrew, Nieland, John D, Garrett-Mayer, Elizabeth, Eby, Jonathan M, Huelsmann, Erica J, Kumar, Previn, Denman, Cecele J, Lacek, Andrew T, Kohlhapp, Frederick J, Alamiri, Ahmad, Hughes, Tasha, Bines, Steven D, Kaufman, Howard L, Overbeck, Andreas, Mehrotra, Shikhar, Hernandez, Claudia, Nishimura, Michael I, Guevara-Patino, Jose A, Le Poole, I Caroline

“…Vitiligo is an autoimmune disease characterized by destruction of melanocytes, leaving 0.5% of the population with progressive depigmentation. Current…”
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Preferential secretion of inducible HSP70 by vitiligo melanocytes under stress by Mosenson, Jeffrey A., Flood, Kelsey, Klarquist, Jared, Eby, Jonathan M., Koshoffer, Amy, Boissy, Raymond E., Overbeck, Andreas, Tung, Rebecca C., Le Poole, I. Caroline

“…Summary Inducible HSP70 (HSP70i) chaperones peptides from stressed cells, protecting them from apoptosis. Upon extracellular release, HSP70i serves an adjuvant…”
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Identification and functional characterization of arginine vasopressin receptor 1A : atypical chemokine receptor 3 heteromers in vascular smooth muscle by Albee, Lauren J., LaPorte, Heather M., Gao, Xianlong, Eby, Jonathan M., Cheng, You-Hong, Nevins, Amanda M., Volkman, Brian F., Gaponenko, Vadim, Majetschak, Matthias

“…Recent observations suggest that atypical chemokine receptor (ACKR)3 and chemokine (C-X-C motif) receptor (CXCR)4 regulate human vascular smooth muscle…”
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Molecular properties of gp100‐reactive T‐cell receptors drive the cytokine profile and antitumor efficacy of transgenic host T cells by Eby, Jonathan M., Smith, Angela R., Riley, Timothy P., Cosgrove, Cormac, Ankney, Christian M., Henning, Steven W., Paulos, Chrystal M., Garrett‐Mayer, Elizabeth, Luiten, Rosalie M., Nishimura, Michael I., Baker, Brian M., Le Poole, I. Caroline

“…To study the contribution of T‐cell receptors (TCR) to resulting T‐cell responses, we studied three different human αβ TCRs, reactive to the same gp100‐derived…”
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