Search Results - "Ebus, Marli E"

Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells by Molenaar, Jan J, Ebus, Marli E, Geerts, Dirk, Koster, Jan, Lamers, Fieke, Valentijn, Linda J, Westerhout, Ellen M, Versteeg, Rogier, Caron, Huib N

“…Two genes have a synthetically lethal relationship when the silencing or inhibiting of 1 gene is only lethal in the context of a mutation or activation of the…”
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Enhancer of zeste homologue 2 plays an important role in neuroblastoma cell survival independent of its histone methyltransferase activity by Bate-Eya, Laurel T, Gierman, Hinco J, Ebus, Marli E, Koster, Jan, Caron, Huib N, Versteeg, Rogier, Dolman, M. Emmy M, Molenaar, Jan J

“…Abstract Neuroblastoma is predominantly characterised by chromosomal rearrangements. Next to V-Myc Avian Myelocytomatosis Viral Oncogene Neuroblastoma Derived…”
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Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma by Molenaar, Jan J, Ebus, Marli E, Koster, Jan, van Sluis, Peter, van Noesel, Carel J M, Versteeg, Rogier, Caron, Huib N

“…Genomic aberrations of Cyclin D1 (CCND1), CDK4, and CDK6 in neuroblastoma indicate that dysregulation of the G(1) entry checkpoint is an important cell cycle…”
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Knockdown of survivin (BIRC5) causes apoptosis in neuroblastoma via mitotic catastrophe by Lamers, Fieke, van der Ploeg, Ida, Schild, Linda, Ebus, Marli E, Koster, Jan, Hansen, Bo R, Koch, Troels, Versteeg, Rogier, Caron, Huib N, Molenaar, Jan J

“…BIRC5 (survivin) is one of the genes located on chromosome arm 17q in the region that is often gained in neuroblastoma. BIRC5 is a protein in the intrinsic…”
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MEK inhibition causes BIM stabilization and increased sensitivity to BCL-2 family member inhibitors in RAS-MAPK-mutated neuroblastoma by Eleveld, Thomas F, Vernooij, Lindy, Schild, Linda, Koopmans, Bianca, Alles, Lindy K, Ebus, Marli E, Dandis, Rana, van Tinteren, Harm, Caron, Huib N, Koster, Jan, van Noesel, Max M, Tytgat, Godelieve A M, Eising, Selma, Versteeg, Rogier, Dolman, M Emmy M, Molenaar, Jan J

“…Mutations affecting the RAS-MAPK pathway occur frequently in relapsed neuroblastoma tumors and are associated with response to MEK inhibition . However, these…”
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Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes by Molenaar, Jan J., Koster, Jan, Zwijnenburg, Danny A., van Sluis, Peter, Valentijn, Linda J., van der Ploeg, Ida, Hamdi, Mohamed, van Nes, Johan, Westerman, Bart A., van Arkel, Jennemiek, Ebus, Marli E., Haneveld, Franciska, Lakeman, Arjan, Schild, Linda, Molenaar, Piet, Stroeken, Peter, van Noesel, Max M., Øra, Ingrid, Santo, Evan E., Caron, Huib N., Westerhout, Ellen M., Versteeg, Rogier

“…Whole-genome sequencing of neuroblastoma, a childhood tumour of the nervous system, shows that chromothripsis (a local shredding of chromosomes) and mutations…”
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LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression by Molenaar, Jan J, Domingo-Fernández, Raquel, Ebus, Marli E, Lindner, Sven, Koster, Jan, Drabek, Ksenija, Mestdagh, Pieter, van Sluis, Peter, Valentijn, Linda J, van Nes, Johan, Broekmans, Marloes, Haneveld, Franciska, Volckmann, Richard, Bray, Isabella, Heukamp, Lukas, Sprüssel, Annika, Thor, Theresa, Kieckbusch, Kristina, Klein-Hitpass, Ludger, Fischer, Matthias, Vandesompele, Jo, Schramm, Alexander, van Noesel, Max M, Varesio, Luigi, Speleman, Frank, Eggert, Angelika, Stallings, Raymond L, Caron, Huib N, Versteeg, Rogier, Schulte, Johannes H

“…Jan Molenaar and colleagues show that LIN28B is overexpressed and amplified in human neuroblastomas and that LIN28B regulates let-7 family miRNAs and MYCN…”
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RAS-MAPK pathway-driven tumor progression is associated with loss of CIC and other genomic aberrations in neuroblastoma by Eleveld, Thomas F, Schild, Linda, Koster, Jan, Zwijnenburg, Danny A, Alles, Lindy K, Ebus, Marli E, Volckmann, Richard, Tytgat, Godelieve A M, van Sluis, Peter, Versteeg, Rogier, Molenaar, Jan J

“…Mutations affecting the RAS-MAPK pathway frequently occur in relapsed neuroblastoma tumors, which suggests that activation of this pathway is associated with a…”
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Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma by Poon, Evon, Liang, Tong, Jamin, Yann, Walz, Susanne, Kwok, Colin, Hakkert, Anne, Barker, Karen, Urban, Zuzanna, Thway, Khin, Zeid, Rhamy, Hallsworth, Albert, Box, Gary, Ebus, Marli E, Licciardello, Marco P, Sbirkov, Yordan, Lazaro, Glori, Calton, Elizabeth, Costa, Barbara M, Valenti, Melanie, De Haven Brandon, Alexis, Webber, Hannah, Tardif, Nicolas, Almeida, Gilberto S, Christova, Rossitza, Boysen, Gunther, Richards, Mark W, Barone, Giuseppe, Ford, Anthony, Bayliss, Richard, Clarke, Paul A, De Bono, Johann, Gray, Nathanael S, Blagg, Julian, Robinson, Simon P, Eccles, Suzanne A, Zheleva, Daniella, Bradner, James E, Molenaar, Jan, Vivanco, Igor, Eilers, Martin, Workman, Paul, Lin, Charles Y, Chesler, Louis

“…The undruggable nature of oncogenic Myc transcription factors poses a therapeutic challenge in neuroblastoma, a pediatric cancer in which MYCN amplification is…”
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Defects in 8-oxo-guanine repair pathway cause high frequency of C > A substitutions in neuroblastoma by van den Boogaard, Marlinde L., Oka, Rurika, Hakkert, Anne, Schild, Linda, Ebus, Marli E., van Gerven, Michael R., Zwijnenburg, Danny A., Molenaar, Piet, Hoyng, Lieke L., Dolman, M. Emmy M., Essing, Anke H. W., Koopmans, Bianca, Helleday, Thomas, Drost, Jarno, van Boxtel, Ruben, Versteeg, Rogier, Koster, Jan, Molenaar, Jan J.

“…Neuroblastomas are childhood tumors with frequent fatal relapses after induction treatment, which is related to tumor evolution with additional genomic events…”
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Cyclin-Dependent Kinase Inhibitor AT7519 as a Potential Drug for MYCN-Dependent Neuroblastoma by Dolman, M Emmy M, Poon, Evon, Ebus, Marli E, den Hartog, Ilona J M, van Noesel, Carel J M, Jamin, Yann, Hallsworth, Albert, Robinson, Simon P, Petrie, Kevin, Sparidans, Rolf W, Kok, Robbert J, Versteeg, Rogier, Caron, Huib N, Chesler, Louis, Molenaar, Jan J

“…MYCN-dependent neuroblastomas have low cure rates with current multimodal treatment regimens and novel therapeutic drugs are therefore urgently needed. In…”
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Newly-derived neuroblastoma cell lines propagated in serum-free media recapitulate the genotype and phenotype of primary neuroblastoma tumours by Bate-Eya, Laurel T, Ebus, Marli E, Koster, Jan, den Hartog, Ilona J.M, Zwijnenburg, Danny A, Schild, Linda, van der Ploeg, Ida, Dolman, M. Emmy M, Caron, Huib N, Versteeg, Rogier, Molenaar, Jan J

“…Abstract Recently protocols have been devised for the culturing of cell lines from fresh tumours under serum-free conditions in defined neural stem cell…”
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Targeted BCL2 inhibition effectively inhibits neuroblastoma tumour growth by Lamers, Fieke, Schild, Linda, den Hartog, Ilona J.M, Ebus, Marli E, Westerhout, Ellen M, Ora, Ingrid, Koster, Jan, Versteeg, Rogier, Caron, Huib N, Molenaar, Jan J

“…Abstract Genomic aberrations of key regulators of the apoptotic pathway have hardly been identified in neuroblastoma. We detected high BCL2 mRNA and protein…”
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Copy number defects of G1-Cell cycle genes in neuroblastoma are frequent and correlate with high expression of E2F target genes and a poor prognosis by Molenaar, Jan J., Koster, Jan, Ebus, Marli E., van Sluis, Peter, Westerhout, Ellen M., de Preter, Katleen, Gisselsson, David, Øra, Ingrid, Speleman, Frank, Caron, Huib N., Versteeg, Rogier

“…The tightly controlled network of cell cycle genes consists of a core of cyclin dependent kinases (CDKs) that are activated by periodically expressed cyclins…”
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Differential mRNA expression of Ara-C–metabolizing enzymes explains Ara-C sensitivity in MLL gene–rearranged infant acute lymphoblastic leukemia by Stam, Ronald W., den Boer, Monique L., Meijerink, Jules P.P., Ebus, Marli E.G., Peters, Godefridus J., Noordhuis, Paul, Janka-Schaub, Gritta E., Armstrong, Scott A., Korsmeyer, Stanley J., Pieters, Rob

“…Infant acute lymphoblastic leukemia (ALL) is characterized by a high incidence of mixed lineage leukemia (MLL) gene rearrangements, a poor outcome, and…”
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Neuroblastoma is composed of two super-enhancer-associated differentiation states by van Groningen, Tim, Koster, Jan, Valentijn, Linda J, Zwijnenburg, Danny A, Akogul, Nurdan, Hasselt, Nancy E, Broekmans, Marloes, Haneveld, Franciska, Nowakowska, Natalia E, Bras, Johannes, van Noesel, Carel J M, Jongejan, Aldo, van Kampen, Antoine H, Koster, Linda, Baas, Frank, van Dijk-Kerkhoven, Lianne, Huizer-Smit, Margriet, Lecca, Maria C, Chan, Alvin, Lakeman, Arjan, Molenaar, Piet, Volckmann, Richard, Westerhout, Ellen M, Hamdi, Mohamed, van Sluis, Peter G, Ebus, Marli E, Molenaar, Jan J, Tytgat, Godelieve A, Westerman, Bart A, van Nes, Johan, Versteeg, Rogier

“…Rogier Versteeg, Johan van Nes and colleagues report that neuroblastomas comprise two cell types, mesenchymal and adrenergic, that have different responses to…”
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Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations by Eleveld, Thomas F, Oldridge, Derek A, Bernard, Virginie, Koster, Jan, Daage, Leo Colmet, Diskin, Sharon J, Schild, Linda, Bentahar, Nadia Bessoltane, Bellini, Angela, Chicard, Mathieu, Lapouble, Eve, Combaret, Valérie, Legoix-Né, Patricia, Michon, Jean, Pugh, Trevor J, Hart, Lori S, Rader, JulieAnn, Attiyeh, Edward F, Wei, Jun S, Zhang, Shile, Naranjo, Arlene, Gastier-Foster, Julie M, Hogarty, Michael D, Asgharzadeh, Shahab, Smith, Malcolm A, Guidry Auvil, Jaime M, Watkins, Thomas B K, Zwijnenburg, Danny A, Ebus, Marli E, van Sluis, Peter, Hakkert, Anne, van Wezel, Esther, van der Schoot, C Ellen, Westerhout, Ellen M, Schulte, Johannes H, Tytgat, Godelieve A, Dolman, M Emmy M, Janoueix-Lerosey, Isabelle, Gerhard, Daniela S, Caron, Huib N, Delattre, Olivier, Khan, Javed, Versteeg, Rogier, Schleiermacher, Gudrun, Molenaar, Jan J, Maris, John M

“…John Maris, Jan Molenaar, Gudrun Schleiermacher and colleagues performed whole-genome sequencing of 23 paired diagnostic and relapsed neuroblastomas, showing…”
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Abstract A26: High frequency of Cytosine to Adenine mutations in neuroblastoma correlates with genomic aberrations in 8-Oxo-Guanine repair pathway by Hakkert, Anne, Ebus, Marli E., Versteeg, Rogier, Huib, Caron N., Koster, Jan, Molenaar, Jan J.

“…Abstract Background: Somatic mutations can be grouped into 96 tri-nucleotide patterns, termed mutational signatures. These signatures can provide insights into…”
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Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma by Poon, Evon, Liang, Tong, Jamin, Yann, Walz, Susanne, Kwok, Colin, Hakkert, Anne, Barker, Karen, Urban, Zuzanna, Thway, Khin, Zeid, Rhamy, Hallsworth, Albert, Box, Gary, Ebus, Marli E, Licciardello, Marco P, Sbirkov, Yordan, Lazaro, Glori, Calton, Elizabeth, Costa, Barbara M, Valenti, Melanie, Brandon, Alexis De Haven, Webber, Hannah, Tardif, Nicolas, Almeida, Gilberto S, Christova, Rossitza, Boysen, Gunther, Richards, Mark W, Barone, Giuseppe, d, Anthony, Bayliss, Richard, Clarke, Paul A, DE BONO, Johann, Gray, Nathanael S, Blagg, Julian, Robinson, Simon P, Eccles, Suzanne A, Zheleva, Daniella, Bradner, James E, Molenaar, Jan, Vivanco, Igor, Eilers, Martin, Workman, Paul, Lin, Charles Y, Chesler, Louis

“…The undruggable nature of oncogenic Myc transcription factors poses a therapeutic challenge in neuroblastoma, a pediatric cancer in which MYCN amplification is…”
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Abstract B41: Whole genome sequencing identifies tumor evolution events in relapse neuroblastoma by Eleveld, Thomas F., Schild, Linda, Koster, Jan, Zwijnenburg, Danny, Ebus, Marli E., van, Peter Sluis, Schulte, Johannes H., Caron, Huib N., Versteeg, Rogier, Molenaar, Jan J.

“…Abstract Treatment of primary neuroblastoma tumors tends to initially cause tumor regression, but relapse occurs in 50-60% of patients with high-risk tumors…”
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