Search Results - "Ebright, Richard"

Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3) by Lin, Wei, Das, Kalyan, Degen, David, Mazumder, Abhishek, Duchi, Diego, Wang, Dongye, Ebright, Yon W., Ebright, Richard Y., Sineva, Elena, Gigliotti, Matthew, Srivastava, Aashish, Mandal, Sukhendu, Jiang, Yi, Liu, Yu, Yin, Ruiheng, Zhang, Zhening, Eng, Edward T., Thomas, Dennis, Donadio, Stefano, Zhang, Haibo, Zhang, Changsheng, Kapanidis, Achillefs N., Ebright, Richard H.

“…Fidaxomicin is an antibacterial drug in clinical use for treatment of Clostridium difficile diarrhea. The active ingredient of fidaxomicin, lipiarmycin A3…”
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Structural basis of Rho-dependent transcription termination by Molodtsov, Vadim, Wang, Chengyuan, Firlar, Emre, Kaelber, Jason T., Ebright, Richard H.

“…Rho is a ring-shaped hexameric ATP-dependent molecular motor. Together with the transcription elongation factor NusG, Rho mediates factor-dependent…”
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Structural basis of transcription-translation coupling by Wang, Chengyuan, Molodtsov, Vadim, Firlar, Emre, Kaelber, Jason T, Blaha, Gregor, Su, Min, Ebright, Richard H

“…In bacteria, transcription and translation are coupled processes in which the movement of RNA polymerase (RNAP)-synthesizing messenger RNA (mRNA) is…”
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Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer by Ligorio, Matteo, Sil, Srinjoy, Malagon-Lopez, Jose, Nieman, Linda T., Misale, Sandra, Di Pilato, Mauro, Ebright, Richard Y., Karabacak, Murat N., Kulkarni, Anupriya S., Liu, Ann, Vincent Jordan, Nicole, Franses, Joseph W., Philipp, Julia, Kreuzer, Johannes, Desai, Niyati, Arora, Kshitij S., Rajurkar, Mihir, Horwitz, Elad, Neyaz, Azfar, Tai, Eric, Magnus, Neelima K.C., Vo, Kevin D., Yashaswini, Chittampalli N., Marangoni, Francesco, Boukhali, Myriam, Fatherree, Jackson P., Damon, Leah J., Xega, Kristina, Desai, Rushil, Choz, Melissa, Bersani, Francesca, Langenbucher, Adam, Thapar, Vishal, Morris, Robert, Wellner, Ulrich F., Schilling, Oliver, Lawrence, Michael S., Liss, Andrew S., Rivera, Miguel N., Deshpande, Vikram, Benes, Cyril H., Maheswaran, Shyamala, Haber, Daniel A., Fernandez-Del-Castillo, Carlos, Ferrone, Cristina R., Haas, Wilhelm, Aryee, Martin J., Ting, David T.

“…Single-cell technologies have described heterogeneity across tissues, but the spatial distribution and forces that drive single-cell phenotypes have not been…”
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Structural basis of transcription activation by Feng, Yu, Zhang, Yu, Ebright, Richard H.

“…Class II transcription activators function by binding to a DNA site overlapping a core promoter and stimulating isomerization of an initial RNA polymerase…”
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New target for inhibition of bacterial RNA polymerase: ‘switch region’ by Srivastava, Aashish, Talaue, Meliza, Liu, Shuang, Degen, David, Ebright, Richard Y, Sineva, Elena, Chakraborty, Anirban, Druzhinin, Sergey Y, Chatterjee, Sujoy, Mukhopadhyay, Jayanta, Ebright, Yon W, Zozula, Alex, Shen, Juan, Sengupta, Sonali, Niedfeldt, Rui Rong, Xin, Cai, Kaneko, Takushi, Irschik, Herbert, Jansen, Rolf, Donadio, Stefano, Connell, Nancy, Ebright, Richard H

“…Highlights ► Bacterial RNA polymerase is a proven target for antibacterial therapy. ► The ‘switch region’ is a new inhibitor binding site within bacterial RNA…”
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Structural Basis of Transcription Initiation by Zhang, Yu, Feng, Yu, Chatterjee, Sujoy, Tuske, Steve, Ho, Mary X., Arnold, Eddy, Ebright, Richard H.

“…During transcription initiation, RNA polymerase (RNAP) binds and unwinds promoter DNA to form an RNAP-promoter open complex. We have determined crystal…”
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The Initiation Factor TFE and the Elongation Factor Spt4/5 Compete for the RNAP Clamp during Transcription Initiation and Elongation by Grohmann, Dina, Nagy, Julia, Chakraborty, Anirban, Klose, Daniel, Fielden, Daniel, Ebright, Richard H., Michaelis, Jens, Werner, Finn

“…TFIIE and the archaeal homolog TFE enhance DNA strand separation of eukaryotic RNAPII and the archaeal RNAP during transcription initiation by an unknown…”
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Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis by Ebright, Richard Y, Lee, Sooncheol, Wittner, Ben S, Niederhoffer, Kira L, Nicholson, Benjamin T, Bardia, Aditya, Truesdell, Samuel, Wiley, Devon F, Wesley, Benjamin, Li, Selena, Mai, Andy, Aceto, Nicola, Vincent-Jordan, Nicole, Szabolcs, Annamaria, Chirn, Brian, Kreuzer, Johannes, Comaills, Valentine, Kalinich, Mark, Haas, Wilhelm, Ting, David T, Toner, Mehmet, Vasudevan, Shobha, Haber, Daniel A, Maheswaran, Shyamala, Micalizzi, Douglas S

“…Circulating tumor cells (CTCs) are shed into the bloodstream from primary tumors, but only a small subset of these cells generates metastases. We conducted an…”
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RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription by Li, Lingting, Molodtsov, Vadim, Lin, Wei, Ebright, Richard H., Zhang, Yu

“…All organisms—bacteria, archaea, and eukaryotes—have a transcription initiation factor that contains a structural module that binds within the RNA polymerase…”
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Structural basis of Q-dependent antitermination by Yin, Zhou, Kaelber, Jason T., Ebright, Richard H.

“…Lambdoid bacteriophage Q proteinmediates the switch from middle to late bacteriophage gene expression by enabling RNA polymerase (RNAP) to read through…”
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Closing and opening of the RNA polymerase trigger loop by Mazumder, Abhishek, Lin, Miaoxin, Kapanidis, Achillefs N., Ebright, Richard H.

“…The RNA polymerase (RNAP) trigger loop (TL) is a mobile structural element of the RNAP active center that, based on crystal structures, has been proposed to…”
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Dynamically driven protein allostery by Kalodimos, Charalampos G, Popovych, Nataliya, Sun, Shangjin, Ebright, Richard H

“…Allosteric interactions are typically considered to proceed through a series of discrete changes in bonding interactions that alter the protein conformation…”
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An Interactive Resource to Identify Cancer Genetic and Lineage Dependencies Targeted by Small Molecules by Basu, Amrita, Bodycombe, Nicole E., Cheah, Jaime H., Price, Edmund V., Liu, Ke, Schaefer, Giannina I., Ebright, Richard Y., Stewart, Michelle L., Ito, Daisuke, Wang, Stephanie, Bracha, Abigail L., Liefeld, Ted, Wawer, Mathias, Gilbert, Joshua C., Wilson, Andrew J., Stransky, Nicolas, Kryukov, Gregory V., Dancik, Vlado, Barretina, Jordi, Garraway, Levi A., Hon, C. Suk-Yee, Munoz, Benito, Bittker, Joshua A., Stockwell, Brent R., Khabele, Dineo, Stern, Andrew M., Clemons, Paul A., Shamji, Alykhan F., Schreiber, Stuart L.

“…The high rate of clinical response to protein-kinase-targeting drugs matched to cancer patients with specific genomic alterations has prompted efforts to use…”
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Structural basis of RfaH-mediated transcription-translation coupling by Molodtsov, Vadim, Wang, Chengyuan, Zhang, Jing, Kaelber, Jason T, Blaha, Gregor, Ebright, Richard H

“…The NusG paralog RfaH mediates bacterial transcription-translation coupling in genes that contain a DNA sequence element, termed an ops site, required for…”
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Translational Regulation of Cancer Metastasis by Micalizzi, Douglas S, Ebright, Richard Y, Haber, Daniel A, Maheswaran, Shyamala

“…Deregulation of the mRNA translational process has been observed during tumorigenesis. However, recent findings have shown that deregulation of translation…”
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Antibiotic Production by Myxobacteria Plays a Role in Predation by Xiao, Yao, Wei, Xueming, Ebright, Richard, Wall, Daniel

“…Myxobacteria are predatory and are prolific producers of secondary metabolites. Here, we tested a hypothesized role that secondary metabolite antibiotics…”
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An appeal for an objective, open, and transparent scientific debate about the origin of SARS-CoV-2 by van Helden, Jacques, Butler, Colin D, Achaz, Guillaume, Canard, Bruno, Casane, Didier, Claverie, Jean-Michel, Colombo, Fabien, Courtier, Virginie, Ebright, Richard H, Graner, François, Leitenberg, Milton, Morand, Serge, Petrovsky, Nikolai, Segreto, Rossana, Decroly, Etienne, Halloy, José

“…[...]this argument could literally be reversed. [...]the absence of traces of reverse-engineering systems does not preclude genome editing, which is performed…”
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The Infectious Diseases Society of America’s 10 × ’20 Initiative (10 New Systemic Antibacterial Agents US Food and Drug Administration Approved by 2020): Is 20 × ’20 a Possibility? by Talbot, George H, Jezek, Amanda, Murray, Barbara E, Jones, Ronald N, Ebright, Richard H, Nau, Gerard J, Rodvold, Keith A, Newland, Jason G, Boucher, Helen W

“…Abstract Background Infections caused by antibiotic-resistant bacteria, including carbapenem-resistant Enterobacteriaceae, have increased in frequency,…”
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RNA Polymerase Reaches 60: Transcription Initiation, Elongation, Termination, and Regulation in Prokaryotes by Ebright, Richard H., Werner, Finn, Zhang, Xiaodong

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