Search Results - "Ebot, Ericka M."

The association of diabetes with risk of prostate cancer defined by clinical and molecular features by Feng, Xiaoshuang, Song, Mingyang, Preston, Mark A., Ma, Wenjie, Hu, Yang, Pernar, Claire H., Stopsack, Konrad H., Ebot, Ericka M., Fu, Benjamin C., Zhang, Yiwen, Li, Ni, Dai, Min, Liu, Lydia, Giovannucci, Edward L., Mucci, Lorelei A.

“…Background To prospectively examine the association between diabetes and risk of prostate cancer defined by clinical and molecular features. Methods A total of…”
Get full text

A Prospective Investigation of PTEN Loss and ERG Expression in Lethal Prostate Cancer by Ahearn, Thomas U, Pettersson, Andreas, Ebot, Ericka M, Gerke, Travis, Graff, Rebecca E, Morais, Carlos L, Hicks, Jessica L, Wilson, Kathryn M, Rider, Jennifer R, Sesso, Howard D, Fiorentino, Michelangelo, Flavin, Richard, Finn, Stephen, Giovannucci, Edward L, Loda, Massimo, Stampfer, Meir J, De Marzo, Angelo M, Mucci, Lorelei A, Lotan, Tamara L

“…PTEN is a tumor suppressor frequently deleted in prostate cancer that may be a useful prognostic biomarker. However, the association of PTEN loss with lethal…”
Get full text

Transcriptional landscape of PTEN loss in primary prostate cancer by Imada, Eddie Luidy, Sanchez, Diego Fernando, Dinalankara, Wikum, Vidotto, Thiago, Ebot, Ericka M, Tyekucheva, Svitlana, Franco, Gloria Regina, Mucci, Lorelei Ann, Loda, Massimo, Schaeffer, Edward Matthew, Lotan, Tamara, Marchionni, Luigi

“…PTEN is the most frequently lost tumor suppressor in primary prostate cancer (PCa) and its loss is associated with aggressive disease. However, the…”
Get full text

Expression of IGF/insulin receptor in prostate cancer tissue and progression to lethal disease by Ahearn, Thomas U, Peisch, Sam, Pettersson, Andreas, Ebot, Ericka M, Zhou, Cindy Ke, Graff, Rebecca E, Sinnott, Jennifer A, Fazli, Ladan, Judson, Gregory L, Bismar, Tarek A, Rider, Jennifer R, Gerke, Travis, Chan, June M, Fiorentino, Michelangelo, Flavin, Richard, Sesso, Howard D, Finn, Stephen, Giovannucci, Edward L, Gleave, Martin, Loda, Massimo, Li, Zhe, Pollak, Michael, Mucci, Lorelei A

“…Abstract Circulating insulin-like growth factor-1 (IGF-1) is consistently associated with prostate cancer risk. IGF-1 binds to IGF-1 receptor (IGF1R) and…”
Get full text

Deletions on 9p21 are associated with worse outcomes after anti-PD-1/PD-L1 monotherapy but not chemoimmunotherapy by Ebot, Ericka M., Duncan, Daniel L., Tolba, Khaled, Fabrizio, David, Frampton, Garrett M., Comment, Leah A., Albacker, Lee A.

“…NCCN guidelines for first-line treatment of advanced non-squamous non-small-cell lung cancer (NSCLC) patients without targetable driver alterations includes…”
Get full text

Height, Obesity, and the Risk of TMPRSS2:ERG -Defined Prostate Cancer by Graff, Rebecca E, Ahearn, Thomas U, Pettersson, Andreas, Ebot, Ericka M, Gerke, Travis, Penney, Kathryn L, Wilson, Kathryn M, Markt, Sarah C, Pernar, Claire H, Gonzalez-Feliciano, Amparo G, Song, Mingyang, Lis, Rosina T, Schmidt, Daniel R, Vander Heiden, Matthew G, Fiorentino, Michelangelo, Giovannucci, Edward L, Loda, Massimo, Mucci, Lorelei A

“…The largest molecular subtype of primary prostate cancer is defined by the gene fusion. Few studies, however, have investigated etiologic differences by…”
Get full text

Evaluation of tissue- and plasma-derived tumor mutational burden (TMB) and genomic alterations of interest in CheckMate 848, a study of nivolumab combined with ipilimumab and nivolumab alone in patients with advanced or metastatic solid tumors with high TMB by He, Jie, Kalinava, Natallia, Doshi, Parul, Pavlick, Dean C, Albacker, Lee A, Ebot, Ericka M, Tukachinsky, Hanna, Pratt, James, Fusaro, Gina, Oxnard, Geoffrey R, Green, George, Fabrizio, David, Baden, Jonathan

“…BackgroundAn accumulation of somatic mutations in tumors leads to increased neoantigen levels and antitumor immune response. Tumor mutational burden (TMB)…”
Get full text

The Epidemiology of Prostate Cancer by Pernar, Claire H, Ebot, Ericka M, Wilson, Kathryn M, Mucci, Lorelei A

“…Prostate cancer is a major cause of disease and mortality among men, and each year 1.6 million men are diagnosed with and 366,000 men die of prostate cancer…”
Get full text

A Metabolomics Analysis of Adiposity and Advanced Prostate Cancer Risk in the Health Professionals Follow-Up Study by Dickerman, Barbra A, Ebot, Ericka M, Healy, Brian C, Wilson, Kathryn M, Eliassen, A Heather, Ascherio, Alberto, Pernar, Claire H, Zeleznik, Oana A, Vander Heiden, Matthew G, Clish, Clary B, Giovannucci, Edward, Mucci, Lorelei A

“…Obesity is associated with a higher risk of advanced prostate cancer, but men with the same body mass index (BMI) may differ in their underlying metabolic…”
Get full text

Integrative Analysis of a Large Real-World Cohort of Small Cell Lung Cancer Identifies Distinct Genetic Subtypes and Insights into Histologic Transformation by Sivakumar, Smruthy, Moore, Jay A, Montesion, Meagan, Sharaf, Radwa, Lin, Douglas I, Colón, Caterina I, Fleishmann, Zoe, Ebot, Ericka M, Newberg, Justin Y, Mills, Jennifer M, Hegde, Priti S, Pan, Quintin, Dowlati, Afshin, Frampton, Garrett M, Sage, Julien, Lovly, Christine M

“…Small cell lung cancer (SCLC) is a recalcitrant neuroendocrine carcinoma with dismal survival outcomes. A major barrier in the field has been the relative…”
Get more information

High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program by Labbé, David P., Zadra, Giorgia, Yang, Meng, Reyes, Jaime M., Lin, Charles Y., Cacciatore, Stefano, Ebot, Ericka M., Creech, Amanda L., Giunchi, Francesca, Fiorentino, Michelangelo, Elfandy, Habiba, Syamala, Sudeepa, Karoly, Edward D., Alshalalfa, Mohammed, Erho, Nicholas, Ross, Ashley, Schaeffer, Edward M., Gibb, Ewan A., Takhar, Mandeep, Den, Robert B., Lehrer, Jonathan, Karnes, R. Jeffrey, Freedland, Stephen J., Davicioni, Elai, Spratt, Daniel E., Ellis, Leigh, Jaffe, Jacob D., DʼAmico, Anthony V., Kantoff, Philip W., Bradner, James E., Mucci, Lorelei A., Chavarro, Jorge E., Loda, Massimo, Brown, Myles

“…Systemic metabolic alterations associated with increased consumption of saturated fat and obesity are linked with increased risk of prostate cancer progression…”
Get full text

Statin Use Is Associated with Lower Risk of PTEN-Null and Lethal Prostate Cancer by Allott, Emma H, Ebot, Ericka M, Stopsack, Konrad H, Gonzalez-Feliciano, Amparo G, Markt, Sarah C, Wilson, Kathryn M, Ahearn, Thomas U, Gerke, Travis A, Downer, Mary K, Rider, Jennifer R, Freedland, Stephen J, Lotan, Tamara L, Kantoff, Philip W, Platz, Elizabeth A, Loda, Massimo, Stampfer, Meir J, Giovannucci, Edward, Sweeney, Christopher J, Finn, Stephen P, Mucci, Lorelei A

“…Statins are associated with lower risk of aggressive prostate cancer, but lethal prostate cancer is understudied and contributing mechanisms are unclear. We…”
Get full text

Association between Trichomonas vaginalis and prostate cancer mortality by Tsang, Sabrina H., Peisch, Samuel F., Rowan, Brendan, Markt, Sarah C., Gonzalez‐Feliciano, Amparo G., Sutcliffe, Siobhan, Platz, Elizabeth A., Mucci, Lorelei A., Ebot, Ericka M.

“…We previously observed a positive association between seropositivity for the parasite Trichomonas vaginalis and risk of clinically significant prostate cancer…”
Get full text

SLCO1B3 and SLCO2B1 genotypes, androgen deprivation therapy, and prostate cancer outcomes: a prospective cohort study and meta-analysis by Rajanala, Sai Harisha, Plym, Anna, Vaselkiv, Jane B, Ebot, Ericka M, Matsoukas, Konstantina, Lin, Zhike, Chakraborty, Goutam, Markt, Sarah C, Penney, Kathryn L, Lee, Gwo-Shu M, Mucci, Lorelei A, Kantoff, Philip W, Stopsack, Konrad H

“…Abstract Solute carrier organic anion (SLCO) transporters (OATP transporters) are involved in cellular uptake of drugs and hormones. Germline variants in…”
Get full text

Prostate tumor DNA methylation is associated with cigarette smoking and adverse prostate cancer outcomes by Shui, Irene M., Wong, Chao‐Jen, Zhao, Shanshan, Kolb, Suzanne, Ebot, Ericka M., Geybels, Milan S., Rubicz, Rohina, Wright, Jonathan L., Lin, Daniel W., Klotzle, Brandy, Bibikova, Marina, Fan, Jian‐Bing, Ostrander, Elaine A., Feng, Ziding, Stanford, Janet L.

“…BACKGROUND DNA methylation has been hypothesized as a mechanism for explaining the association between smoking and adverse prostate cancer (PCa) outcomes. This…”
Get full text

A Prospective Study of Intraprostatic Inflammation, Focal Atrophy, and Progression to Lethal Prostate Cancer by Zhang, Yiwen, Zhou, Cindy Ke, Rencsok, Emily M, Fall, Katja, Lotan, Tamara L, Loda, Massimo, Giunchi, Francesca, Platz, Elizabeth A, De Marzo, Angelo M, Mucci, Lorelei A, Fiorentino, Michelangelo, Ebot, Ericka M

“…Inflammation and focal atrophy are common features adjacent to prostate tumors. Limited evidence exists on whether these features have prognostic significance…”
Get full text

A Prospective Study of the Association between Physical Activity and Risk of Prostate Cancer Defined by Clinical Features and TMPRSS2:ERG by Pernar, Claire H., Ebot, Ericka M., Pettersson, Andreas, Graff, Rebecca E., Giunchi, Francesca, Ahearn, Thomas U., Gonzalez-Feliciano, Amparo G., Markt, Sarah C., Wilson, Kathryn M., Stopsack, Konrad H., Gazeeva, Elizaveta, Lis, Rosina T., Parmigiani, Giovanni, Rimm, Eric B., Finn, Stephen P., Giovannucci, Edward L., Fiorentino, Michelangelo, Mucci, Lorelei A.

“…Growing evidence shows that clinical and molecular subtypes of prostate cancer (PCa) have specific risk factors. Observational studies suggest that physical…”
Get full text

Transcriptomes of Prostate Cancer with TMPRSS2:ERG and Other ETS Fusions by Stopsack, Konrad H, Su, Xiaofeng A, Vaselkiv, J Bailey, Graff, Rebecca E, Ebot, Ericka M, Pettersson, Andreas, Lis, Rosina T, Fiorentino, Michelangelo, Loda, Massimo, Penney, Kathryn L, Lotan, Tamara L, Mucci, Lorelei A

“…The most common somatic event in primary prostate cancer is a fusion between the androgen-related TMPRSS2 gene and the ERG oncogene. Tumors with these fusions,…”
Get full text

Gene Expression Pathways in Prostate Tissue Associated with Vigorous Physical Activity in Prostate Cancer by Pernar, Claire H, Parmigiani, Giovanni, Giovannucci, Edward L, Rimm, Eric B, Tyekucheva, Svitlana, Loda, Massimo, Finn, Stephen P, Vander Heiden, Matthew G, Fiorentino, Michelangelo, Ebot, Ericka M, Mucci, Lorelei A

“…Men engaged in high physical activity have lower risks of advanced and fatal prostate cancer. Mechanisms underlying this association are not well understood…”
Get full text

Association of Prediagnostic Blood Metabolomics with Prostate Cancer Defined by ERG or PTEN Molecular Subtypes by Feng, Xiaoshuang, Zhou, Cindy Ke, Clish, Clary B, Wilson, Kathryn M, Pernar, Claire H, Dickerman, Barbra A, Loda, Massimo, Finn, Stephen P, Penney, Kathryn L, Schmidt, Daniel R, Vander Heiden, Matthew G, Giovannucci, Edward L, Ebot, Ericka M, Mucci, Lorelei A

“…The gene fusion and loss are two of the most common somatic molecular alterations in prostate cancer. Here, we investigated the association of…”
Get full text