Search Results - "Ebner, Lynn J A"

Single-cell RNA sequencing of the retina in a model of retinitis pigmentosa reveals early responses to degeneration in rods and cones by Karademir, Duygu, Todorova, Vyara, Ebner, Lynn J A, Samardzija, Marijana, Grimm, Christian

“…In inherited retinal disorders such as retinitis pigmentosa (RP), rod photoreceptor-specific mutations cause primary rod degeneration that is followed by…”
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HBEGF-TNF induce a complex outer retinal pathology with photoreceptor cell extrusion in human organoids by Völkner, Manuela, Wagner, Felix, Steinheuer, Lisa Maria, Carido, Madalena, Kurth, Thomas, Yazbeck, Ali, Schor, Jana, Wieneke, Stephanie, Ebner, Lynn J. A., Del Toro Runzer, Claudia, Taborsky, David, Zoschke, Katja, Vogt, Marlen, Canzler, Sebastian, Hermann, Andreas, Khattak, Shahryar, Hackermüller, Jörg, Karl, Mike O.

“…Human organoids could facilitate research of complex and currently incurable neuropathologies, such as age-related macular degeneration (AMD) which causes…”
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Retinal Layer Separation (ReLayS) method enables the molecular analysis of photoreceptor segments and cell bodies, as well as the inner retina by Todorova, Vyara, Merolla, Luca, Karademir, Duygu, Wögenstein, Gabriele M., Behr, Julian, Ebner, Lynn J. A., Samardzija, Marijana, Grimm, Christian

“…Understanding the physiology of the retina, and especially of the highly polarized photoreceptors, is essential not only to broaden our knowledge of the…”
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Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activation by Todorova, Vyara, Stauffacher, Mia Fee, Ravotto, Luca, Nötzli, Sarah, Karademir, Duygu, Ebner, Lynn J A, Imsand, Cornelia, Merolla, Luca, Hauck, Stefanie M, Samardzija, Marijana, Saab, Aiman S, Barros, L Felipe, Weber, Bruno, Grimm, Christian

“…Major retinal degenerative diseases, including age-related macular degeneration, diabetic retinopathy and retinal detachment, are associated with a local…”
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AAV Serotypes and Their Suitability for Retinal Gene Therapy by Ebner, Lynn J A, Grimm, Christian

“…Throughout the last 25 years, exceptional progress in retinal gene therapy was achieved. The major breakthrough was realized in 2017 when the FDA approved the…”
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Regulation of ABCA1 by AMD-Associated Genetic Variants and Hypoxia in iPSC-RPE by Peters, Florian, Ebner, Lynn J A, Atac, David, Maggi, Jordi, Berger, Wolfgang, den Hollander, Anneke I, Grimm, Christian

“…Age-related macular degeneration (AMD) is a progressive disease of the macula characterized by atrophy of the retinal pigment epithelium (RPE) and…”
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Modeling inducible neuropathologies of the retina with differential phenotypes in organoids by Völkner, Manuela, Wagner, Felix, Kurth, Thomas, Sykes, Alex M, Del Toro Runzer, Claudia, Ebner, Lynn J A, Kavak, Cagri, Alexaki, Vasileia Ismini, Cimalla, Peter, Mehner, Mirko, Koch, Edmund, Karl, Mike O

“…Neurodegenerative diseases remain incompletely understood and therapies are needed. Stem cell-derived organoid models facilitate fundamental and translational…”
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Mouse Retinal Organoid Growth and Maintenance in Longer-Term Culture by Völkner, Manuela, Kurth, Thomas, Schor, Jana, Ebner, Lynn J A, Bardtke, Lara, Kavak, Cagri, Hackermüller, Jörg, Karl, Mike O

“…Using retinal organoid systems, organ-like 3D tissues, relies implicitly on their robustness. However, essential key parameters, particularly retinal growth…”
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HIF1 and DROSHA are involved in MMACHC repression in hypoxia by Kiessling, Eva, Peters, Florian, Ebner, Lynn J.A., Merolla, Luca, Samardzija, Marijana, Baumgartner, Matthias R., Grimm, Christian, Froese, D. Sean

“…The MMACHC gene encodes for an enzyme involved in intracellular vitamin B12 metabolism, and autosomal recessive defects in MMACHC represent the most common…”
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