Search Results - "Eblen, Scott T."

Targeting Chromatin Remodeling for Cancer Therapy by Kaur, Jasmine, Daoud, Abdelkader, Eblen, Scott T

“…Epigenetic alterations comprise key regulatory events that dynamically alter gene expression and their deregulation is commonly linked to the pathogenesis of…”
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Extracellular-Regulated Kinases: Signaling From Ras to ERK Substrates to Control Biological Outcomes by Eblen, Scott T

“…The extracellular-regulated kinases ERK1 and ERK2 are evolutionarily conserved, ubiquitous serine-threonine kinases that are involved in regulating cellular…”
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Regulation of chemoresistance via alternative messenger RNA splicing by Eblen, Scott T.

“…The acquisition of resistance to chemotherapy is a significant problem in the treatment of cancer, greatly increasing patient morbidity and mortality. Tumors…”
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Mitogen-Activated Protein Kinase Phosphorylation of Splicing Factor 45 (SPF45) Regulates SPF45 Alternative Splicing Site Utilization, Proliferation, and Cell Adhesion by Al-Ayoubi, Adnan M., Zheng, Hui, Liu, Yuying, Bai, Tao, Eblen, Scott T.

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Phosphorylation of the alternative mRNA splicing factor 45 (SPF45) by Clk1 regulates its splice site utilization, cell migration and invasion by Liu, Yuying, Conaway, LaShardai, Rutherford Bethard, Jennifer, Al-Ayoubi, Adnan M, Thompson Bradley, Amber, Zheng, Hui, Weed, Scott A, Eblen, Scott T

“…Alternative mRNA splicing is a mechanism to regulate protein isoform expression and is regulated by alternative splicing factors. The alternative splicing…”
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HUNK Phosphorylates Rubicon to Support Autophagy by Zambrano, Joelle N, Eblen, Scott T, Abt, Melissa, Rhett, J Matthew, Muise-Helmericks, Robin, Yeh, Elizabeth S

“…Autophagy is a catabolic cellular recycling pathway that is essential for maintaining intracellular homeostasis. Autophagosome formation is achieved via the…”
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Transcriptional suppression, DNA methylation, and histone deacetylation of the regulator of G-protein signaling 10 (RGS10) gene in ovarian cancer cells by Ali, Mourad W, Cacan, Ercan, Liu, Yuying, Pierce, Jennifer Young, Creasman, William T, Murph, Mandi M, Govindarajan, Rajgopal, Eblen, Scott T, Greer, Susanna F, Hooks, Shelley B

“…RGS10 regulates ovarian cancer cell growth and survival, and RGS10 expression is suppressed in cell models of ovarian cancer chemoresistance. However, the…”
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Stress Kinase Signaling Regulates Androgen Receptor Phosphorylation, Transcription, and Localization by Gioeli, Daniel, Black, Ben E, Gordon, Vicki, Spencer, Adam, Kesler, Cristina T, Eblen, Scott T, Paschal, Bryce M, Weber, Michael J

“…Activation of signal transduction kinase cascades is known to alter androgen receptor (AR) activity, but the molecular mechanisms are still poorly defined…”
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PAK1 Phosphorylation of MEK1 Regulates Fibronectin-Stimulated MAPK Activation by Slack-Davis, Jill K., Eblen, Scott T., Zecevic, Maja, Boerner, Scott A., Tarcsafalvi, Adel, Diaz, H. Bruce, Marshall, Mark S., Weber, Michael J., Parsons, J. Thomas, Catling, Andrew D.

“…Activation of the Ras-MAPK signal transduction pathway is necessary for biological responses both to growth factors and ECM. Here, we provide evidence that…”
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Rac-PAK Signaling Stimulates Extracellular Signal-Regulated Kinase (ERK) Activation by Regulating Formation of MEK1-ERK Complexes by Eblen, Scott T., Slack, Jill K., Weber, Michael J., Catling, Andrew D.

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Mitogen-Activated Protein Kinase Feedback Phosphorylation Regulates MEK1 Complex Formation and Activation during Cellular Adhesion by Eblen, Scott T., Slack-Davis, Jill K., Tarcsafalvi, Adel, Parsons, J. Thomas, Weber, Michael J., Catling, Andrew D.

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Identification of Novel ERK2 Substrates through Use of an Engineered Kinase and ATP Analogs by Eblen, Scott T., Kumar, N. Vinay, Shah, Kavita, Henderson, Michelle J., Watts, Colin K.W., Shokat, Kevan M., Weber, Michael J.

“…The mitogen-activated protein kinases are key regulators of cellular organization and function. To understand the mechanisms(s) by which these ubiquitous…”
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Rapid Renal Regulation of Peroxisome Proliferator-activated Receptor γ Coactivator-1α by Extracellular Signal-Regulated Kinase 1/2 in Physiological and Pathological Conditions by Collier, Justin B., Whitaker, Ryan M., Eblen, Scott T., Schnellmann, Rick G.

“…Previous studies have shown that extracellular signal-regulated kinase 1/2 (ERK1/2) directly inhibits mitochondrial function during cellular injury. We…”
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HUNK phosphorylates EGFR to regulate breast cancer metastasis by Williams, Carly B., Phelps-Polirer, Kendall, Dingle, Ivan P., Williams, Christina J., Rhett, Matthew J., Eblen, Scott T., Armeson, Kent, Hill, Elizabeth G., Yeh, Elizabeth S.

“…Epidermal growth factor receptor (EGFR) is commonly over-expressed in metastatic breast cancer yet metastatic breast cancer is generally resistant to anti-EGFR…”
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Identifying mitigating strategies for endothelial cell dysfunction and hypertension in response to VEGF receptor inhibitors by Camarda, Nicholas D, Lu, Qing, Meola, Dawn M, Man, Joshua J, Song, Zeyuan, Travers, Richard J, Lopez, Katherine E, Powers, Sarah N, Papanastasiou, Malvina, DeRuff, Katherine C, Mullahoo, James, Egri, Shawn B, Davison, Desiree, Sebastiani, Paola, Eblen, Scott T, Buchsbaum, Rachel, Huggins, Gordon S, London, Cheryl A, Jaffe, Jacob D, Upshaw, Jenica N, Yang, Vicky K, Jaffe, Iris Z

“…Vascular endothelial growth factor receptor inhibitors (VEGFRis) improve cancer survival but are associated with treatment-limiting hypertension, often…”
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Correction: HUNK phosphorylates EGFR to regulate breast cancer metastasis by Williams, Carly B., Phelps-Polirer, Kendall, Dingle, Ivan P., Williams, Christina J., Rhett, Matthew J., Eblen, Scott T., Armeson, Kent, Hill, Elizabeth G., Yeh, Elizabeth S.

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Staurosporine, an inhibitor of hormonally up-regulated neu-associated kinase by Zambrano, Joelle N, Williams, Christina J, Williams, Carly Bess, Hedgepeth, Lonzie, Burger, Pieter, Dilday, Tinslee, Eblen, Scott T, Armeson, Kent, Hill, Elizabeth G, Yeh, Elizabeth S

“…HUNK is a protein kinase that is implicated in HER2-positive (HER2+) breast cancer progression and resistance to HER2 inhibitors. Though prior studies suggest…”
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EDD enhances cell survival and cisplatin resistance and is a therapeutic target for epithelial ovarian cancer by Bradley, Amber, Zheng, Hui, Ziebarth, Angela, Sakati, Wayne, Branham-O’Connor, Melissa, Blumer, Joe B., Liu, Yuying, Kistner-Griffin, Emily, Rodriguez-Aguayo, Cristian, Lopez-Berestein, Gabriel, Sood, Anil K., Landen, Charles N., Eblen, Scott T.

“…Summary We show that the E3 ubiquitin ligase EDD/UBR5 regulates both survival and cisplatin resistance in ovarian cancer cells and is a novel therapeutic…”
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MOAP-1, UBR5 and cisplatin resistance in ovarian cancer by Eblen, Scott T., Bradley, Amber

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Oncogenic K-Ras Regulates Bioactive Sphingolipids in a Sphingosine Kinase 1-dependent Manner by Gault, Christopher R., Eblen, Scott T., Neumann, Carola A., Hannun, Yusuf A., Obeid, Lina M.

“…Sphingosine kinase 1 (SK1) is an important enzyme involved in the production of the bioactive lipid sphingosine 1-phosphate (S1P). SK1 is overexpressed in many…”
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