Search Results - "Eble, Johannes A"

Neuropilins in the Context of Tumor Vasculature by Niland, Stephan, Eble, Johannes A

“…Neuropilin-1 and Neuropilin-2 form a small family of plasma membrane spanning receptors originally identified by the binding of semaphorin and vascular…”
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Hold on or Cut? Integrin- and MMP-Mediated Cell-Matrix Interactions in the Tumor Microenvironment by Niland, Stephan, Eble, Johannes A

“…The tumor microenvironment (TME) has become the focus of interest in cancer research and treatment. It includes the extracellular matrix (ECM) and…”
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Structurally Robust and Functionally Highly Versatile-C-Type Lectin (-Related) Proteins in Snake Venoms by Eble, Johannes A

“…Snake venoms contain an astounding variety of different proteins. Among them are numerous C-type lectin family members, which are grouped into classical Ca -…”
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Titration ELISA as a Method to Determine the Dissociation Constant of Receptor Ligand Interaction by Eble, Johannes A

“…The dissociation constant describes the interaction between two partners in the binding equilibrium and is a measure of their affinity. It is a crucial…”
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Distinct Pathways Regulate Syk Protein Activation Downstream of Immune Tyrosine Activation Motif (ITAM) and hemITAM Receptors in Platelets by Manne, Bhanu Kanth, Badolia, Rachit, Dangelmaier, Carol, Eble, Johannes A., Ellmeier, Wilfried, Kahn, Mark, Kunapuli, Satya P.

“…Tyrosine kinase pathways are known to play an important role in the activation of platelets. In particular, the GPVI and CLEC-2 receptors are known to activate…”
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Reversible photoregulation of cell-cell adhesions with opto-E-cadherin by Nzigou Mombo, Brice, Bijonowski, Brent M., Raab, Christopher A., Niland, Stephan, Brockhaus, Katrin, Müller, Marc, Eble, Johannes A., Wegner, Seraphine V.

“…E-cadherin-based cell-cell adhesions are dynamically and locally regulated in many essential processes, including embryogenesis, wound healing and tissue…”
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Snake venom components in medicine: From the symbolic rod of Asclepius to tangible medical research and application by Estevão-Costa, Maria-Inacia, Sanz-Soler, Raquel, Johanningmeier, Benjamin, Eble, Johannes A.

“…Both mythologically and logically, snakes have always fascinated man. Snakes have attracted both awe and fear not only because of the elegant movement of their…”
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Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins by Maqsood, Zahra, Clark, Joanne C, Martin, Eleyna M, Cheung, Yam Fung Hilaire, Morán, Luis A, Watson, Sean E T, Pike, Jeremy A, Di, Ying, Poulter, Natalie S, Slater, Alexandre, Lange, Bodo M H, Nieswandt, Bernhard, Eble, Johannes A, Tomlinson, Mike G, Owen, Dylan M, Stegner, David, Bridge, Lloyd J, Wierling, Christoph, Watson, Steve P

“…The clustering of platelet glycoprotein receptors with cytosolic YxxL and YxxM motifs, including GPVI, CLEC-2 and PEAR1, triggers activation via…”
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The Current State-of-the-Art Identification of Unknown Proteins Using Mass Spectrometry Exemplified on De Novo Sequencing of a Venom Protease from Bothrops moojeni by König, Simone, Obermann, Wolfgang M. J., Eble, Johannes A.

“…(1) Background: The amino acid sequence elucidation of peptides from the gas phase fragmentation mass spectra, de novo sequencing, is a valuable method for the…”
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Collateral Damage Intended-Cancer-Associated Fibroblasts and Vasculature Are Potential Targets in Cancer Therapy by Cavaco, Ana, Rezaei, Maryam, Niland, Stephan, Eble, Johannes A

“…After oncogenic transformation, tumor cells rewire their metabolism to obtain sufficient energy and biochemical building blocks for cell proliferation, even…”
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CLEC-2 contributes to hemostasis independently of classical hemITAM signaling in mice by Haining, Elizabeth J., Cherpokova, Deya, Wolf, Karen, Becker, Isabelle C., Beck, Sarah, Eble, Johannes A., Stegner, David, Watson, Steve P., Nieswandt, Bernhard

“…C-type lectin-like receptor 2 (CLEC-2) is a platelet receptor that is critical during development in blood-lymph separation and implicated in thrombus…”
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Low-dose Btk inhibitors selectively block platelet activation by CLEC-2 by Nicolson, Phillip L R, Nock, Sophie H, Hinds, Joshua, Garcia-Quintanilla, Lourdes, Smith, Christopher W, Campos, Joana, Brill, Alexander, Pike, Jeremy A, Khan, Abdullah O, Poulter, Natalie S, Kavanagh, Diedre M, Watson, Stephanie, Watson, Callum N, Clifford, Hayley, Huissoon, Aarnoud P, Pollitt, Alice Y, Eble, Johannes A, Pratt, Guy, Watson, Steve P, Hughes, Craig E

“…Inhibitors of the tyrosine kinase Btk have been proposed as novel antiplatelet agents. In this study we show that low concentrations of the Btk inhibitor…”
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The extracellular matrix in tumor progression and metastasis by Eble, Johannes A., Niland, Stephan

“…The extracellular matrix (ECM) constitutes the scaffold of tissues and organs. It is a complex network of extracellular proteins, proteoglycans and…”
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A novel flow cytometry–based platelet aggregation assay by De Cuyper, Iris M., Meinders, Marjolein, van de Vijver, Edith, de Korte, Dirk, Porcelijn, Leendert, de Haas, Masja, Eble, Johannes A., Seeger, Karl, Rutella, Sergio, Pagliara, Daria, Kuijpers, Taco W., Verhoeven, Arthur J., van den Berg, Timo K., Gutiérrez, Laura

“…The main function of platelets is to maintain normal hemostasis. Inefficient platelet production and/or defective platelet function results in bleeding…”
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Dramatic and concerted conformational changes enable rhodocetin to block α2β1 integrin selectively by Eble, Johannes A, McDougall, Matthew, Orriss, George L, Niland, Stephan, Johanningmeier, Benjamin, Pohlentz, Gottfried, Meier, Markus, Karrasch, Simone, Estevão-Costa, Maria Inacia, Martins Lima, Augusto, Stetefeld, Jörg

“…The collagen binding integrin α2β1 plays a crucial role in hemostasis, fibrosis, and cancer progression amongst others. It is specifically inhibited by…”
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Correction for Niemann et al., "More Is Not Always Better-the Double-Headed Role of Fibronectin in Staphylococcus aureus Host Cell Invasion" by Niemann, Silke, Nguyen, Minh-Thu, Eble, Johannes A, Chasan, Achmet I, Mrakovcic, Maria, Preissner, Klaus T, Roßlenbroich, Steffen, Peters, Georg, Herrmann, Mathias

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The binding capacity of α1β1-, α2β1- and α10β1-integrins depends on non-collagenous surface macromolecules rather than the collagens in cartilage fibrils by Woltersdorf, Christian, Bonk, Melanie, Leitinger, Birgit, Huhtala, Mikko, Käpylä, Jarmo, Heino, Jyrki, Gil Girol, Christian, Niland, Stephan, Eble, Johannes A., Bruckner, Peter, Dreier, Rita, Hansen, Uwe

“…Interactions of cells with supramolecular aggregates of the extracellular matrix (ECM) are mediated, in part, by cell surface receptors of the integrin family…”
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More Is Not Always Better-the Double-Headed Role of Fibronectin in Staphylococcus aureus Host Cell Invasion by Niemann, Silke, Nguyen, Minh-Thu, Eble, Johannes A, Chasan, Achmet I, Mrakovcic, Maria, Böttcher, Ralph T, Preissner, Klaus T, Roßlenbroich, Steffen, Peters, Georg, Herrmann, Mathias

“…While Staphylococcus aureus has classically been considered an extracellular pathogen, these bacteria are also capable of being taken up by host cells,…”
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The Interaction between Laminin-332 and α3β1 Integrin Determines Differentiation and Maintenance of CAFs, and Supports Invasion of Pancreatic Duct Adenocarcinoma Cells by Cavaco, Ana C Martins, Rezaei, Maryam, Caliandro, Michele F, Lima, Augusto Martins, Stehling, Martin, Dhayat, Sameer A, Haier, Jörg, Brakebusch, Cord, Eble, Johannes A

“…Ranking among the most lethal tumour entities, pancreatic duct adenocarcinoma cells invade neighbouring tissue resulting in high incidence of metastasis. They…”
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Role of Integrins α1β1 and α2β1 in Wound and Tumor Angiogenesis in Mice by Ghatak, Sushmita, Niland, Stephan, Schulz, Jan-Niklas, Wang, Fang, Eble, Johannes A, Leitges, Michael, Mauch, Cornelia, Krieg, Thomas, Zigrino, Paola, Eckes, Beate

“…Integrins are transmembrane receptors composed of one α subunit and one β subunit and involved in cellular growth, differentiation, and apoptosis. The…”
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