Search Results - "Eble, J A"

Jararhagin disruption of endothelial cell anchorage is enhanced in collagen enriched matrices by Baldo, C., Lopes, D.S., Faquim-Mauro, E.L., Jacysyn, J.F., Niland, S., Eble, J.A., Clissa, P.B., Moura-da-Silva, A.M.

“…Hemorrhage is one of the most striking effects of bites by viper snakes resulting in fast bleeding and ischemia in affected tissues. Snake venom…”
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The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC‐2 signaling in platelets by SPALTON, J. C., MORI, J., POLLITT, A. Y., HUGHES, C. E., EBLE, J. A., WATSON, S. P.

“…Background: Syk is a key mediator of signaling pathways downstream of several platelet surface receptors including GPVI/FcRγ collagen receptor, the C‐type…”
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Targeting of C‐type lectin‐like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides by Delierneux, C., Donis, N., Servais, L., Wéra, O., Lecut, C., Vandereyken, M., Musumeci, L., Rahmouni, S., Schneider, J., Eble, J. A., Lancellotti, P., Oury, C.

“…Essentials CpG oligodeoxynucleotide (ODN) immuotherapeutics cause undesired platelet activating effects. It is crucial to understand the mechanisms of these…”
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The molecular basis of integrin-extracellular matrix interactions by Eble, J A

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CLEC‐2‐dependent activation of mouse platelets is weakly inhibited by cAMP but not by cGMP by Borgognone, A., Navarro‐Núñez, L., Correia, J. N., Pollitt, A. Y., Thomas, S. G., Eble, J. A., Pulcinelli, F. M., Madhani, M., Watson, S. P.

“…Summary Background The activation of platelet CLEC‐2 by podoplanin on lymphatic endothelial cells (LECs) has a critical role in prevention of mixing of…”
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Escaping paradise: larval export from Hawaii in an Indo-Pacific reef fish, the yellow tang Zebrasoma flavescens by Eble, JA, Toonen, RJ, Sorenson, L, Basch, LV, Papastamatiou, YP, Bowen, BW

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High genetic connectivity across the Indian and Pacific Oceans in the reef fish Myripristis berndti (Holocentridae) by Craig, MT, Eble, JA, Bowen, BW, Robertson, DR

“…To assess patterns of connectivity among populations of an Indo-Pacific reef fish, we surveyed mtDNA of the bigscale soldierfish Myripristis berndti…”
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Collagen binding is a key factor for the hemorrhagic activity of snake venom metalloproteinases by Moura-da-Silva, A.M., Ramos, O.H.P., Baldo, C., Niland, S., Hansen, U., Ventura, J.S., Furlan, S., Butera, D., Della-Casa, M.S., Tanjoni, I., Clissa, P.B., Fernandes, I., Chudzinski-Tavassi, A.M., Eble, J.A.

“…Snake venom metalloproteinases (SVMPs) are multifunctional enzymes involved in several symptoms following snakebite, such as severe local hemorrhage…”
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Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC‐2 by HUGHES, C. E., AUGER, J. M., McGLADE, J., EBLE, J. A., PEARCE, A. C., WATSON, S. P.

“…Background: The adapter proteins SLP‐76 and LAT have been shown to play critical roles in the activation of PLCγ2 in platelets downstream of GPVI/FcRγ and the…”
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The α1β1 integrin recognition site of the basement membrane collagen molecule [α1(IV)]2α2(IV) by EBLE, J. A, GOLBIK, R, MANN, K, KÜHN, K

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Contraction-Dependent Apoptosis of Normal Dermal Fibroblasts by Niland, Stephan, Cremer, Anja, Fluck, Juliane, Krieg, Thomas, Sollberg, Stephan, Eble, Johannes A.

“…The mechanisms underlying the contraction-dependent apoptosis of primary fibroblasts are of prime importance in understanding anchorage-dependent…”
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A multi-domain protein for β1 integrin-targeted DNA delivery by FORTUNATI, E, EHLERT, E, VAN LOO, N-D, WYMAN, C, EBLE, J. A, GROSVELD, F, SCHOLTE, B. J

“…The development of effective receptor-targeted nonviral vectors for use in vivo is complicated by a number of technical problems. One of these is the low…”
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Differential Effects of Integrin α Chain Mutations on Invasin and Natural Ligand Interaction by Krukonis, Eric S., Dersch, Petra, Eble, Johannes A., Isberg, Ralph R.

“…To determine if recognition of the Yersinia pseudotuberculosis invasin protein and natural substrates requires identical integrin residues, a region of the…”
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Targeting of C-type lectin-like receptorￂ 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides by Delierneux, C, Donis, N, Servais, L, Wera, O, Lecut, C, Vandereyken, M, Musumeci, L, Rahmouni, S, Schneider, J, Eble, J A, Lancellotti, P, Oury, C

“…Essentials CpG oligodeoxynucleotide (ODN) immuotherapeutics cause undesired platelet activating effects. It is crucial to understand the mechanisms of these…”
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Collagen XVII Is Destabilized by a Glycine Substitution Mutation in the Cell Adhesion Domain Col15 by Tasanen, Kaisa, Eble, Johannes A., Aumailley, Monique, Schumann, Hauke, Baetge, Jens, Tu, Hongmin, Bruckner, Peter, Bruckner-Tuderman, Leena

“…Collagen XVII is a hemidesmosomal transmembrane molecule important for epithelial adhesion in the skin. It exists in two forms, as a full-length protein and as…”
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Urokinase Receptors Promote β1 Integrin Function through Interactions with Integrin α3β1 by Wei, Ying, Eble, Johannes A., Wang, Zemin, Kreidberg, Jordan A., Chapman, Harold A.

“…The urokinase receptor (uPAR) is linked to cellular migration through its capacity to promote pericellular proteolysis, regulate integrin function, and mediate…”
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A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2 by Suzuki-Inoue, Katsue, Fuller, Gemma L.J., García, Ángel, Eble, Johannes A., Pöhlmann, Stefan, Inoue, Osamu, Gartner, T. Kent, Hughan, Sascha C., Pearce, Andrew C., Laing, Gavin D., Theakston, R. David G., Schweighoffer, Edina, Zitzmann, Nicole, Morita, Takashi, Tybulewicz, Victor L.J., Ozaki, Yukio, Watson, Steve P.

“…The snake venom rhodocytin has been reported to bind to integrin α2β1 and glycoprotein (GP) Ibα on platelets, but it is also able to induce activation…”
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Migration of human melanoma cells depends on extracellular pH and Na+/H+ exchange by Stock, Christian, Gassner, Birgit, Hauck, Christof R., Arnold, Hannelore, Mally, Sabine, Eble, Johannes A., Dieterich, Peter, Schwab, Albrecht

“…Their glycolytic metabolism imposes an increased acid load upon tumour cells. The surplus protons are extruded by the Na + /H + exchanger (NHE) which causes an…”
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Integrins in cancer treatment by Eble, Johannes A, Haier, Jörg

“…Anchorage-independent growth, anoikis resistance, and most steps of metastasis formation are integrin-mediated or -dependent processes, which are…”
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Tumour necrosis factor alpha confers an invasive, transformed phenotype on mammary epithelial cells by Montesano, Roberto, Soulié, Priscilla, Eble, Johannes A, Carrozzino, Fabio

“…Although loss of cell-cell adhesion and gain of invasive properties play a crucial role in the malignant progression of epithelial tumours, the molecular…”
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