Search Results - "Ebine, Kazumi"

BET bromodomain inhibitors block growth of pancreatic cancer cells in three-dimensional collagen by Sahai, Vaibhav, Kumar, Krishan, Knab, Lawrence M, Chow, Christina R, Raza, Sania S, Bentrem, David J, Ebine, Kazumi, Munshi, Hidayatullah G

“…Pancreatic ductal adenocarcinoma (PDAC) is associated with pronounced fibrosis that contributes to chemoresistance, in part, through increased histone…”
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Three-dimensional collagen I promotes gemcitabine resistance in vitro in pancreatic cancer cells through HMGA2-dependent histone acetyltransferase expression by Dangi-Garimella, Surabhi, Sahai, Vaibhav, Ebine, Kazumi, Kumar, Krishan, Munshi, Hidayatullah G

“…Pancreatic ductal adenocarcinoma (PDAC) is associated with a pronounced collagen-rich stromal reaction that has been shown to contribute to chemo-resistance…”
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Differential Regulation of ZEB1 and EMT by MAPK-Interacting Protein Kinases (MNK) and eIF4E in Pancreatic Cancer by Kumar, Krishan, Chow, Christina R, Ebine, Kazumi, Arslan, Ahmet D, Kwok, Benjamin, Bentrem, David J, Eckerdt, Frank D, Platanias, Leonidas C, Munshi, Hidayatullah G

“…Human pancreatic ductal adenocarcinoma (PDAC) tumors are associated with dysregulation of mRNA translation. In this report, it is demonstrated that PDAC cells…”
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CodY Deletion Enhances In Vivo Virulence of Community-Associated Methicillin-Resistant Staphylococcus aureus Clone USA300 by MONTGOMERY, Christopher P, BOYLE-VAVRA, Susan, ROUX, Agnès, EBINE, Kazumi, SONENSHEIN, Abraham L, DAUM, Robert S

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Cancer Cell Invasion in Three-dimensional Collagen Is Regulated Differentially by Gα13 Protein and Discoidin Domain Receptor 1-Par3 Protein Signaling by Chow, Christina R., Ebine, Kazumi, Knab, Lawrence M., Bentrem, David J., Kumar, Krishan, Munshi, Hidayatullah G.

“…Cancer cells can invade in three-dimensional collagen as single cells or as a cohesive group of cells that require coordination of cell-cell junctions and the…”
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NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity by Nakazawa, Takanobu, Komai, Shoji, Watabe, Ayako M, Kiyama, Yuji, Fukaya, Masahiro, Arima-Yoshida, Fumiko, Horai, Reiko, Sudo, Katsuko, Ebine, Kazumi, Delawary, Mina, Goto, June, Umemori, Hisashi, Tezuka, Tohru, Iwakura, Yoichiro, Watanabe, Masahiko, Yamamoto, Tadashi, Manabe, Toshiya

“…Phosphorylation of neural proteins in response to a diverse array of external stimuli is one of the main mechanisms underlying dynamic changes in neural…”
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BET inhibitors block pancreatic stellate cell collagen I production and attenuate fibrosis in vivo by Kumar, Krishan, DeCant, Brian T, Grippo, Paul J, Hwang, Rosa F, Bentrem, David J, Ebine, Kazumi, Munshi, Hidayatullah G

“…The fibrotic reaction, which can account for over 70%-80% of the tumor mass, is a characteristic feature of human pancreatic ductal adenocarcinoma (PDAC)…”
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Slug inhibits pancreatic cancer initiation by blocking Kras-induced acinar-ductal metaplasia by Ebine, Kazumi, Chow, Christina R., DeCant, Brian T., Hattaway, Holly Z., Grippo, Paul J., Kumar, Krishan, Munshi, Hidayatullah G.

“…Cells in the pancreas that have undergone acinar-ductal metaplasia (ADM) can transform into premalignant cells that can eventually become cancerous. Although…”
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Abstract 2989: BET inhibitors induce Rac1-dependent MNK and eIF4E phosphorylation in cancer cells by Pham, Thao, Decant, Brian T., Kumar, Krishan, Shang, Meng, Matsangou, Maria, Ebine, Kazumi, Munshi, Hidayatullah G.

“…Abstract Patients with recurrent differentiated thyroid cancers (DTCs) have poor prognosis and suffer from multiple complications from progressive symptomatic…”
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Abstract 4500: BET proteins regulate hyaluronan synthases in pancreatic ductal adenocarcinoma by Kumar, Krishan, Ebine, Kazumi, Pham, Thao, Shang, Meng, Munshi, Hidayatullah G.

“…Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) is associated with an extensive desmoplasia which is composed of multiple extracellular matrix…”
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Quantitative Method to Track Proteolytic Invasion in 3D Collagen by Ebine, Kazumi, Chow, Christina R, Munshi, Hidayatullah G

“…Since many tumors are associated with a pronounced collagen-rich stromal reaction, there is increasing interest in understanding mechanisms by which cancer…”
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GLI2-dependent c-MYC upregulation mediates resistance of pancreatic cancer cells to the BET bromodomain inhibitor JQ1 by Kumar, Krishan, Raza, Sania S., Knab, Lawrence M., Chow, Christina R., Kwok, Benjamin, Bentrem, David J., Popovic, Relja, Ebine, Kazumi, Licht, Jonathan D., Munshi, Hidayatullah G.

“…JQ1 and I-BET151 are selective inhibitors of BET bromodomain proteins that have efficacy against a number of different cancers. Since the effectiveness of…”
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Abstract 1679: BET inhibitors suppress PD-L1 expression in pancreatic stellate cells by Ebine, Kazumi, DeCant, Brian T., Collier, Katharine A., Pham, Thao N., Kumar, Krishan, Munshi, Hidayatullah G.

“…Abstract Single agent treatment with T-cell checkpoint inhibitors has not been effective in pancreatic ductal adenocarcinoma (PDAC) patients. The PDAC stroma,…”
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Induction of MNK kinases-dependent eIF4E phosphorylation by inhibitors targeting BET proteins limits efficacy of BET inhibitors by Pham, Thao N., Kumar, Krishan, DeCant, Brian T., Shang, Meng, Munshi, Samad Z., Matsangou, Maria, Ebine, Kazumi, Munshi, Hidayatullah G.

“…BET inhibitors (BETis), which target transcription of key oncogenic genes, are currently being evaluated in early-phase clinical trials. However, since BETis…”
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Slfn2 Regulates Type I Interferon Responses by Modulating the NF-κB Pathway by Fischietti, Mariafausta, Arslan, Ahmet D., Sassano, Antonella, Saleiro, Diana, Majchrzak-Kita, Beata, Ebine, Kazumi, Munshi, Hidayatullah G., Fish, Eleanor N., Platanias, Leonidas C.

“…Although members of the Slfn family have been implicated in the regulation of type I interferon (IFN) responses, the mechanisms by which they mediate their…”
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Interplay between interferon regulatory factor 1 and BRD4 in the regulation of PD-L1 in pancreatic stellate cells by Ebine, Kazumi, Kumar, Krishan, Pham, Thao N., Shields, Mario A., Collier, Katharine A., Shang, Meng, DeCant, Brian T., Urrutia, Raul, Hwang, Rosa F., Grimaldo, Sam, Principe, Daniel R., Grippo, Paul J., Bentrem, David J., Munshi, Hidayatullah G.

“…The fibrotic reaction is a characteristic feature of human pancreatic ductal adenocarcinoma (PDAC) tumors. It is associated with activation and proliferation…”
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Induction of MNK Kinase-dependent eIF4E Phosphorylation by Inhibitors Targeting BET Proteins Limits Efficacy of BET Inhibitors by Pham, Thao N D, Kumar, Krishan, DeCant, Brian T, Shang, Meng, Munshi, Samad Z, Matsangou, Maria, Ebine, Kazumi, Munshi, Hidayatullah G

“…BET inhibitors (BETi), which target transcription of key oncogenic genes, are currently being evaluated in early-phase clinical trials. However, because BETis…”
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Abstract B17: BET inhibitors block pancreatic stellate cell collagen production and attenuate fibrosis in vivo by Kumar, Krishan, DeCant, Brian, Hattaway, Hattaway Z., Grippo, Paul J., Bentrem, David J., Ebine, Kazumi, Munshi, Hidayatullah G.

“…Abstract The fibrotic reaction, which can account for over 70% of the tumor mass, is a characteristic feature of the majority of human pancreatic ductal…”
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Abstract 1517: Pancreatic stellate cells and chemoresistant pancreatic cancer cells induce EMT gene expression in normal pancreatic ductal cells by Kumar, Krishan, Sahai, Vaibhav, Ebine, Kazumi, Munshi, Hidayatullah G.

“…Abstract Pancreatic cancer, one of the deadliest of human cancers, is associated with a collagen-rich pronounced stromal reaction. Previously, we showed that…”
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Interaction of tRNA with MEK2 in pancreatic cancer cells by Wang, Xiaoyun, Chow, Christina R., Ebine, Kazumi, Lee, Jiyoung, Rosner, Marsha R., Pan, Tao, Munshi, Hidayatullah G.

“…Although the translational function of tRNA has long been established, extra translational functions of tRNA are still being discovered. We previously…”
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