Search Results - "Ebiloma, Godwin U."

Alternative oxidase inhibitors: Mitochondrion‐targeting as a strategy for new drugs against pathogenic parasites and fungi by Ebiloma, Godwin U., Balogun, Emmanuel O., Cueto‐Díaz, Eduardo J., Koning, Harry P., Dardonville, Christophe

“…The alternative oxidase (AOX) is a ubiquitous terminal oxidase of plants and many fungi, catalyzing the four‐electron reduction of oxygen to water alongside…”
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Activity of Compounds from Temperate Propolis against Trypanosoma brucei and Leishmania mexicana by Alotaibi, Adullah, Ebiloma, Godwin U., Williams, Roderick, Alfayez, Ibrahim A., Natto, Manal J., Alenezi, Sameah, Siheri, Weam, AlQarni, Malik, Igoli, John O., Fearnley, James, De Koning, Harry P., Watson, David G.

“…Ethanolic extracts of samples of temperate zone propolis, four from the UK and one from Poland, were tested against three Trypanosoma brucei strains and…”
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The Strong Anti-Kinetoplastid Properties of Bee Propolis: Composition and Identification of the Active Agents and Their Biochemical Targets by Ebiloma, Godwin U, Ichoron, Nahandoo, Siheri, Weam, Watson, David G, Igoli, John O, De Koning, Harry P

“…The kinetoplastids are protozoa characterized by the presence of a distinctive organelle, called the kinetoplast, which contains a large amount of DNA…”
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The Chemical Characterization of Nigerian Propolis samples and Their Activity Against Trypanosoma brucei by Omar, Ruwida, Igoli, John O., Zhang, Tong, Gray, Alexander I., Ebiloma, Godwin U., Clements, Carol J., Fearnley, James, Edrada Ebel, RuAngeli, Paget, Tim, de Koning, Harry P., Watson, David G.

“…Profiling of extracts from twelve propolis samples collected from eight regions in Nigeria was carried out using high performance liquid chromatography (LC)…”
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The Activity of Red Nigerian Propolis and Some of Its Components against Trypanosoma brucei and Trypanosoma congolense by Alenezi, Samya S, Alenezi, Naif D, Ebiloma, Godwin U, Natto, Manal J, Ungogo, Marzuq A, Igoli, John O, Ferro, Valerie A, Gray, Alexander I, Fearnley, James, Koning, Harry P de, Watson, David G

“…Propolis is a resin that is gathered by bees from exudates produced by various plants. Its exact chemical composition depends on the plants available near the…”
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Isolation of a Novel Flavanonol and an Alkylresorcinol with Highly Potent Anti-Trypanosomal Activity from Libyan propolis by Siheri, Weam, Ebiloma, Godwin U, Igoli, John O, Gray, Alexander I, Biddau, Marco, Akrachalanont, Pilaslak, Alenezi, Samya, Alwashih, Mohammad A, Edrada-Ebel, RuAngelie, Muller, Sylke, Lawrence, Catherine E, Fearnley, James, Watson, David G, De Koning, Harry P

“…Twelve propolis samples from different parts of Libya were investigated for their phytochemical constituents. Ethanol extracts of the samples and some purified…”
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Conjugates of 2,4-Dihydroxybenzoate and Salicylhydroxamate and Lipocations Display Potent Antiparasite Effects by Efficiently Targeting the Trypanosoma brucei and Trypanosoma congolense Mitochondrion by Fueyo González, Francisco José, Ebiloma, Godwin U, Izquierdo García, Carolina, Bruggeman, Victor, Sánchez Villamañán, José María, Donachie, Anne, Balogun, Emmanuel Oluwadare, Inaoka, Daniel Ken, Shiba, Tomoo, Harada, Shigeharu, Kita, Kiyoshi, de Koning, Harry P, Dardonville, Christophe

“…We investigated a chemical strategy to boost the trypanocidal activity of 2,4-dihydroxybenzoic acid (2,4-DHBA)- and salicylhydroxamic acid (SHAM)-based…”
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The Antiprotozoal Activity of Papua New Guinea Propolis and Its Triterpenes by Alenezi, Samya S, Alenezi, Naif D, Ebiloma, Godwin U, Natto, Manal J, Ungogo, Marzuq A, Igoli, John O, Ferro, Valerie A, Gray, Alexander I, Fearnley, James, de Koning, Harry P, Watson, David G

“…Profiling a propolis sample from Papua New Guinea (PNG) using high-resolution mass spectrometry indicated that it contained several triterpenoids. Further…”
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Potent Antitrypanosomal Activities of 3-Aminosteroids against African Trypanosomes: Investigation of Cellular Effects and of Cross-Resistance with Existing Drugs by Nnadi, Charles O, Ebiloma, Godwin U, Black, Jennifer A, Nwodo, Ngozi J, Lemgruber, Leandro, Schmidt, Thomas J, de Koning, Harry P

“…Treatment of animal African trypanosomiasis (AAT) requires urgent need for safe, potent and affordable drugs and this has necessitated this study. We…”
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Genetic polymorphisms in malaria vaccine candidate Plasmodium falciparum reticulocyte-binding protein homologue-5 among populations in Lagos, Nigeria by Ajibaye, Olusola, Osuntoki, Akinniyi A, Balogun, Emmanuel O, Olukosi, Yetunde A, Iwalokun, Bamidele A, Oyebola, Kolapo M, Hikosaka, Kenji, Watanabe, Yoh-Ichi, Ebiloma, Godwin U, Kita, Kiyoshi, Amambua-Ngwa, Alfred

“…Vaccines are the most reliable alternative to elicit sterile immunity against malaria but their development has been hindered by polymorphisms and…”
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A Review of the Antimalarial, Antitrypanosomal, and Antileishmanial Activities of Natural Compounds Isolated From Nigerian Flora by Ungogo, Marzuq A, Ebiloma, Godwin U, Ichoron, Nahandoo, Igoli, John O, de Koning, Harry P, Balogun, Emmanuel O

“…The West African country Nigeria features highly diverse vegetation and climatic conditions that range from rain forest bordering the Atlantic Ocean in the…”
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SAR of 4‑Alkoxybenzoic Acid Inhibitors of the Trypanosome Alternative Oxidase by Meco-Navas, Alejandro, Ebiloma, Godwin U, Martín-Domínguez, Ana, Martínez-Benayas, Irene, Cueto-Díaz, Eduardo J, Alhejely, Amani Saud, Balogun, Emmanuel O, Saito, Machi, Matsui, Miho, Arai, Natsumi, Shiba, Tomoo, Harada, Shigeharu, de Koning, Harry P, Dardonville, Christophe

“…The SAR of 4-hydroxybenzaldehyde inhibitors of the trypanosome alternative oxidase (TAO), a critical enzyme for the respiration of bloodstream forms of…”
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Sustainable Elimination (Zero Cases) of Sleeping Sickness: How Far Are We from Achieving This Goal? by Akazue, Pearl Ihuoma, Ebiloma, Godwin U, Ajibola, Olumide, Isaac, Clement, Onyekwelu, Kenechukwu, Ezeh, Charles O, Eze, Anthonius Anayochukwu

“…The recent massive reduction in the numbers of fresh Human African Trypanosomiasis (HAT) infection has presented an opportunity for the global elimination of…”
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Design and synthesis of a series of truncated neplanocin fleximers by Zimmermann, Sarah C, O'Neill, Elizaveta, Ebiloma, Godwin U, Wallace, Lynsey J M, De Koning, Harry P, Seley-Radtke, Katherine L

“…In an effort to study the effects of flexibility on enzyme recognition and activity, we have developed several different series of flexible nucleoside…”
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Erratum for Ranjbarian et al., "9-(2'-Deoxy-2'-Fluoro-β-d-Arabinofuranosyl) Adenine Is a Potent Antitrypanosomal Adenosine Analogue That Circumvents Transport-Related Drug Resistance" by Ranjbarian, Farahnaz, Vodnala, Munender, Alzahrani, Khalid J H, Ebiloma, Godwin U, de Koning, Harry P, Hofer, Anders

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Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential by Carruthers, Lauren V., Munday, Jane C., Ebiloma, Godwin U., Steketee, Pieter, Jayaraman, Siddharth, Campagnaro, Gustavo D., Ungogo, Marzuq A., Lemgruber, Leandro, Donachie, Anne‐Marie, Rowan, Tim G., Peter, Rose, Morrison, Liam J., Barrett, Michael P., De Koning, Harry P.

“…Trypanosoma congolense is a principal agent causing livestock trypanosomiasis in Africa, costing developing economies billions of dollars and undermining food…”
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Type I-like metalloproteinase in the venom of the West African saw-scaled carpet viper (Echis ocellatus) has anti-trypanosomal activity against African trypanosomes by Ilu, Ameh, Chia, Mathias A., Cataldi, Thais R., Labate, Carlos A., Ebiloma, Godwin U., Yusuf, Peter O., Shuaibu, Mohammed N., Balogun, Emmanuel O.

“…African trypanosomiasis is an infectious disease caused by hemoparasites of the genus Trypanosoma and remains a major health problem in Africa - killing around…”
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Multi-target mode of action of a Clerodane-type diterpenoid from Polyalthia longifolia targeting African trypanosomes by Ebiloma, Godwin U., Katsoulis, Evangelos, Igoli, John O., Gray, Alexander I., De Koning, Harry P.

“…Natural products have made remarkable contributions to drug discovery and therapy. In this work we exploited various biochemical approaches to investigate the…”
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European propolis is highly active against trypanosomatids including Crithidia fasciculata by Alotaibi, Abdullah, Ebiloma, Godwin U., Williams, Roderick, Alenezi, Samya, Donachie, Anne-Marie, Guillaume, Selome, Igoli, John O., Fearnley, James, de Koning, Harry P., Watson, David G.

“…Extracts of 35 samples of European propolis were tested against wild type and resistant strains of the protozoal pathogens Trypanosoma brucei , Trypanosoma…”
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Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense by Ebiloma, Godwin U., Ayuga, Teresa Díaz, Balogun, Emmanuel O., Gil, Lucía Abad, Donachie, Anne, Kaiser, Marcel, Herraiz, Tomás, Inaoka, Daniel K., Shiba, Tomoo, Harada, Shigeharu, Kita, Kiyoshi, de Koning, Harry P., Dardonville, Christophe

“…African trypanosomiasis is a neglected parasitic disease that is still of great public health relevance, and a severe impediment to agriculture in endemic…”
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