Search Results - "Ebetino, Frank H."

The relationship between the chemistry and biological activity of the bisphosphonates by Ebetino, Frank H, Hogan, Anne-Marie L, Sun, Shuting, Tsoumpra, Maria K, Duan, Xuchen, Triffitt, James T, Kwaasi, Aaron A, Dunford, James E, Barnett, Bobby L, Oppermann, Udo, Lundy, Mark W, Boyde, Alan, Kashemirov, Boris A, McKenna, Charles E, Russell, R. Graham G

“…Abstract The ability of bisphosphonates ((HO)2 P(O)CR1 R2 P(O)(OH)2 ) to inhibit bone resorption has been known since the 1960s, but it is only recently that a…”
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Real-Time Impedance-Based Monitoring of the Growth and Inhibition of Osteomyelitis Biofilm Pathogen Staphylococcus aureus Treated with Novel Bisphosphonate-Fluoroquinolone Antimicrobial Conjugates by Sedghizadeh, Parish P, Cherian, Philip, Roshandel, Sahar, Tjokro, Natalia, Chen, Casey, Junka, Adam F, Hu, Eric, Neighbors, Jeffrey, Pawlak, Jacek, Russell, R Graham G, McKenna, Charles E, Ebetino, Frank H, Sun, Shuting, Sodagar, Esmat

“…Osteomyelitis is a limb- and life-threatening orthopedic infection predominantly caused by biofilms. Bone infections are extremely challenging to treat…”
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The Molecular Mechanism of Nitrogen-Containing Bisphosphonates as Antiosteoporosis Drugs by Kavanagh, Kathryn L., Guo, Kunde, Dunford, James E., Wu, Xiaoqiu, Knapp, Stefan, Ebetino, Frank H., Rogers, Michael J., Russell, Graham G., Oppermann, Udo

“…Osteoporosis and low bone mass are currently estimated to be a major public health risk affecting > 50% of the female population over the age of 50. Because of…”
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Rescue bisphosphonate treatment of alveolar bone improves extraction socket healing and reduces osteonecrosis in zoledronate-treated mice by Hokugo, Akishige, Kanayama, Keiichi, Sun, Shuting, Morinaga, Kenzo, Sun, Yujie, Wu, QingQing, Sasaki, Hodaka, Okawa, Hiroko, Evans, Courtney, Ebetino, Frank H., Lundy, Mark W., Sadrerafi, Keivan, McKenna, Charles E., Nishimura, Ichiro

“…Bisphosphonate (BP)-related osteonecrosis of the jaw, previously known as BRONJ, now referred to more broadly as medication-related osteonecrosis of the jaw…”
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Influence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo by Roelofs, Anke J, Stewart, Charlotte A, Sun, Shuting, Błażewska, Katarzyna M, Kashemirov, Boris A, McKenna, Charles E, Russell, R Graham G, Rogers, Michael J, Lundy, Mark W, Ebetino, Frank H, Coxon, Fraser P

“…Bisphosphonates are widely used antiresorptive drugs that bind to calcium. It has become evident that these drugs have differing affinities for bone mineral;…”
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Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages by Munoz, Marcia A, Fletcher, Emma K, Skinner, Oliver P, Jurczyluk, Julie, Kristianto, Esther, Hodson, Mark P, Sun, Shuting, Ebetino, Frank H, Croucher, David R, Hansbro, Philip M, Center, Jacqueline R, Rogers, Michael J

“…Bisphosphonates drugs target the skeleton and are used globally for the treatment of common bone disorders. Nitrogen-containing bisphosphonates act by…”
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Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects by Yao, Zhenqiang, Ayoub, Akram, Srinivasan, Venkatesan, Wu, Jun, Tang, Churou, Duan, Rong, Milosavljevic, Aleksa, Xing, Lianping, Ebetino, Frank H, Frontier, Alison J, Boyce, Brendan F

“…Osteoporosis remains incurable. The most widely used antiresorptive agents, bisphosphonates (BPs), also inhibit bone formation, while the anabolic agent,…”
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Fluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine by Sun, Shuting, Błażewska, Katarzyna M, Kadina, Anastasia P, Kashemirov, Boris A, Duan, Xuchen, Triffitt, James T, Dunford, James E, Russell, R. Graham G, Ebetino, Frank H, Roelofs, Anke J, Coxon, Fraser P, Lundy, Mark W, McKenna, Charles E

“…A bone imaging toolkit of 21 fluorescent probes with variable spectroscopic properties, bone mineral binding affinities, and antiprenylation activities has…”
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Bisphosphonate use in the horse: what is good and what is not? by Mitchell, Alexis, Watts, Ashlee E, Ebetino, Frank H, Suva, Larry J

“…Bisphosphonates (BPs) are a family of molecules characterized by two key properties: their ability to bind strongly to bone mineral and their inhibitory…”
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Efficacy of Bisphosphonate-Conjugated Sitafloxacin in a Murine Model of S. aureus Osteomyelitis: Evidence of "Target & Release" Kinetics and Killing of Bacteria Within Canaliculi by Ren, Youliang, Xue, Thomas, Rainbolt, Joshua, Bentley, Karen L de Mesy, Galloway, Chad A, Liu, Yuting, Cherian, Philip, Neighbors, Jeffrey, Hofstee, Marloes I, Ebetino, Frank H, Moriarty, Thomas Fintan, Sun, Shuting, Schwarz, Edward M, Xie, Chao

“…infection of bone is difficult to eradicate due to its ability to colonize the osteocyte-lacuno-canalicular network (OLCN), rendering it resistant to…”
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Synthesis of a Bone-Targeted Bortezomib with In Vivo Anti-Myeloma Effects in Mice by Wang, Hua, Xiao, Lifeng, Tao, Jianguo, Srinivasan, Venkat, Boyce, Brendan F, Ebetino, Frank H, Oyajobi, Babatunde O, Boeckman, Jr, Robert K, Xing, Lianping

“…Multiple myeloma (MM) is the most common cancer affecting the bone and bone marrow and remains incurable for most patients; novel therapies are therefore…”
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Inhibition of Protein Prenylation by Bisphosphonates Causes Sustained Activation of Rac, Cdc42, and Rho GTPases by Dunford, James E, Rogers, Michael J, Ebetino, Frank H, Phipps, Roger J, Coxon, Fraser P

“…N‐BPs, which inhibit bone resorption by preventing prenylation of small GTPases, unexpectedly cause the accumulation of GTP‐bound, unprenylated Rho family…”
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How Do Bisphosphonates Inhibit Bone Metastasis In Vivo by Fournier, Pierrick G., Stresing, Verena, Ebetino, Frank H., Clezardin, Philippe

“…Bisphosphonates are potent inhibitors of osteoclast-mediated bone resorption and have demonstrated clinical utility in the treatment of patients with…”
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Evidence of bisphosphonate-conjugated sitafloxacin eradication of established methicillin-resistant S. aureus infection with osseointegration in murine models of implant-associated osteomyelitis by Ren, Youliang, Weeks, Jason, Xue, Thomas, Rainbolt, Joshua, de Mesy Bentley, Karen L, Shu, Ye, Liu, Yuting, Masters, Elysia, Cherian, Philip, McKenna, Charles E, Neighbors, Jeffrey, Ebetino, Frank H, Schwarz, Edward M, Sun, Shuting, Xie, Chao

“…Eradication of MRSA osteomyelitis requires elimination of distinct biofilms. To overcome this, we developed bisphosphonate-conjugated sitafloxacin (BCS,…”
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The Pharmacological Profile of a Novel Highly Potent Bisphosphonate, OX14 (1‐Fluoro‐2‐(Imidazo‐[1,2‐α]Pyridin‐3‐yl)‐Ethyl‐Bisphosphonate) by Lawson, Michelle A, Ebetino, Frank H, Mazur, Adam, Chantry, Andrew D, Paton‐Hough, Julia, Evans, Holly R, Lath, Darren, Tsoumpra, Maria K, Lundy, Mark W, Dobson, Roy LM, Quijano, Michael, Kwaasi, Aaron A, Dunford, James E, Duan, Xuchen, Triffitt, James T, Jeans, Gwyn, Russell, R Graham G

“…ABSTRACT Bisphosphonates are widely used in the treatment of clinical disorders characterized by increased bone resorption, including osteoporosis, Paget's…”
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A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation by Coffman, Abigail A, Basta‐Pljakic, Jelena, Guerra, Rosa M, Ebetino, Frank H, Lundy, Mark W, Majeska, Robert J, Schaffler, Mitchell B

“…ABSTRACT Bisphosphonates (BPs) are a mainstay of osteoporosis treatment; however, concerns about bone health based on oversuppression of remodeling remain…”
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Fluorescent risedronate analogue 800CW-pRIS improves tooth extraction-associated abnormal wound healing in zoledronate-treated mice by Okawa, Hiroko, Kondo, Takeru, Hokugo, Akishige, Cherian, Philip, Sundberg, Oskar, Campagna, Jesus J., Kashemirov, Boris A., John, Varghese, Sun, Shuting, Ebetino, Frank H., McKenna, Charles E., Nishimura, Ichiro

“…Background Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a rare but serious side effect of nitrogen-containing bisphosphonate drugs (N-BPs)…”
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Development of Bisphosphonate-Conjugated Antibiotics to Overcome Pharmacodynamic Limitations of Local Therapy: Initial Results with Carbamate Linked Sitafloxacin and Tedizolid by Adjei-Sowah, Emmanuela, Peng, Yue, Weeks, Jason, Jonason, Jennifer, de Mesy Bentley, Karen, Masters, Elysia, Morita, Yugo, Muthukrishnan, Gowrishankar, Cherian, Philip, Hu, X., McKenna, Charles, Ebetino, Frank, Sun, Shuting, Schwarz, Edward, Xie, Chao

“…The use of local antibiotics to treat bone infections has been questioned due to a lack of clinical efficacy and emerging information about Staphylococcus…”
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Synthesis, Chiral High Performance Liquid Chromatographic Resolution and Enantiospecific Activity of a Potent New Geranylgeranyl Transferase Inhibitor, 2-Hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic Acid by McKenna, Charles E, Kashemirov, Boris A, Błażewska, Katarzyna M, Mallard-Favier, Isabelle, Stewart, Charlotte A, Rojas, Javier, Lundy, Mark W, Ebetino, Frank H, Baron, Rudi A, Dunford, James E, Kirsten, Marie L, Seabra, Miguel C, Bala, Joy L, Marma, Mong S, Rogers, Michael J, Coxon, Fraser P

“…3-(3-Pyridyl)-2-hydroxy-2-phosphonopropanoic acid (3-PEHPC, 1) is a phosphonocarboxylate (PC) analogue of 2-(3-pyridyl)-1-hydroxyethylidenebis(phosphonic acid)…”
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Reply to: A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation by Coffman, Abigail A, Basta‐Pljakic, Jelena, Guerra, Rosa M, Ebetino, Frank H, Lundy, Mark W, Majeska, Robert J, Schaffler, Mitchell B

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