Search Results - "Ebert, Peter"

MAP Kinase Inhibition Promotes T Cell and Anti-tumor Activity in Combination with PD-L1 Checkpoint Blockade by Ebert, Peter J.R., Cheung, Jeanne, Yang, Yagai, McNamara, Erin, Hong, Rebecca, Moskalenko, Marina, Gould, Stephen E., Maecker, Heather, Irving, Bryan A., Kim, Jeong M., Belvin, Marcia, Mellman, Ira

“…Targeted inhibition of mitogen-activated protein kinase (MAPK) kinase (MEK) can induce regression of tumors bearing activating mutations in the Ras pathway but…”
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Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8+ T Lymphocytes by Yu, Wong, Jiang, Ning, Ebert, Peter J.R., Kidd, Brian A., Müller, Sabina, Lund, Peder J., Juang, Jeremy, Adachi, Keishi, Tse, Tiffany, Birnbaum, Michael E., Newell, Evan W., Wilson, Darrell M., Grotenbreg, Gijsbert M., Valitutti, Salvatore, Quake, Stephen R., Davis, Mark M.

“…It has long been thought that clonal deletion efficiently removes almost all self-specific T cells from the peripheral repertoire. We found that self-peptide…”
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An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a by Li, Qi-Jing, Davis, Mark M, Ebert, Peter J R, Jiang, Shan, Xie, Jianming

“…Endogenous peptides that positively select major histocompatibility complex class II-restricted T cell receptors have not yet been identified. Groups led by…”
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Systematic discovery of neoepitope–HLA pairs for neoantigens shared among patients and tumor types by Gurung, Hem R., Heidersbach, Amy J., Darwish, Martine, Chan, Pamela Pui Fung, Li, Jenny, Beresini, Maureen, Zill, Oliver A., Wallace, Andrew, Tong, Ann-Jay, Hascall, Dan, Torres, Eric, Chang, Andy, Lou, Kenny ‘Hei-Wai’, Abdolazimi, Yassan, Hammer, Christian, Xavier-Magalhães, Ana, Marcu, Ana, Vaidya, Samir, Le, Daniel D., Akhmetzyanova, Ilseyar, Oh, Soyoung A., Moore, Amanda J., Uche, Uzodinma N., Laur, Melanie B., Notturno, Richard J., Ebert, Peter J. R., Blanchette, Craig, Haley, Benjamin, Rose, Christopher M.

“…The broad application of precision cancer immunotherapies is limited by the number of validated neoepitopes that are common among patients or tumor types. To…”
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miR-181a Is an Intrinsic Modulator of T Cell Sensitivity and Selection by Li, Qi-Jing, Chau, Jacqueline, Ebert, Peter J.R., Sylvester, Giselle, Min, Hyeyoung, Liu, Gwen, Braich, Ravi, Manoharan, Muthiah, Soutschek, Juergen, Skare, Petra, Klein, Lawrence O., Davis, Mark M., Chen, Chang-Zheng

“…T cell sensitivity to antigen is intrinsically regulated during maturation to ensure proper development of immunity and tolerance, but how this is accomplished…”
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The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery by Adams, David, Altucci, Lucia, Amit, Ido, Aparicio, Samuel, Arima, Takahiro, Asnafi, Vahid, Bae, Jae-Bum, Bassler, Kevin, Bilenky, Mikhail, Boehm, Bernhard, Bourque, Guillaume, Brors, Benedikt, Bussemakers, Marion J., Chadwick, Lisa, Chen, Wei, Cheung, Tom H., Choi, Nak Hyen, Chung, Ho-Ryun, Clarke, Laura, Dermitzakis, Manolis, Dylag, Tomasz, Eaves, Connie J., Ebert, Peter, Eils, Jürgen, Enver, Tariq, Ferguson-Smith, Anne, Fitzgibbon, Jude, Flicek, Paul, Fraser, Peter, Gasparoni, Nina, Gasparoni, Gilles, Heath, Simon, Helin, Kristian, Hitz, Benjamin C., Horsthemke, Bernhard, Ip, Nancy Y., Ito, Takashi, Jenuwein, Thomas, Joly, Yann, Kanai, Yae, Kang, Hee Gyung, Kiemer, Alexandra K., Kim, Song Cheol, Kim, Bong-Jo, Lehrach, Hans, Leitão, Elsa, Lengauer, Thomas, Lernmark, Åke, Leung, Gilberto K.K., Leung, Danny, Ma, Yussanne, Martin-Subero, Jose Ignacio, Maschke, Karen, Merten, Christoph, Minucci, Saverio, Mitsuyama, Totai, Moore, Richard A., Nordström, Karl, Norstedt, Irene, Ouellette, Francis, Pap, Thomas, Pelicci, Pier Giuseppe, Phillips, Anthony G., Polansky, Julia, Pospisilik, J. Andrew, Prabhakar, Shyam, Procaccini, Dena C., Radbruch, Andreas, Rajewsky, Nikolaus, Rakyan, Vardham, Richardson, David, Rothstein, Mark, Sasaki, Hiroyuki, Sauer, Sascha, Schmidt, Florian, Schultze, Joachim L., Schulyer, Ronald P., Schulz, Marcel, Siebert, Reiner, Sinha, Anupam, Soranzo, Nicole, Spivakov, Mikhail, Steidl, Christian, Suzuki, Narumi, Torrents, David, Tyson, Frederick L., Ullrich, Sebastian, Ushijima, Toshikazu, Valencia, Alfonso, Wallace, Chris, Weber, Stephanie, Weiler, Nina, Weng, Andrew, Wilder, Steven, Yamashita, Yasuhiro, Yap, Desmond Y., Yip, Kevin Y., Yip, Stephen, Zerbino, Daniel, Zipprich, Gideon

“…The International Human Epigenome Consortium (IHEC) coordinates the generation of a catalog of high-resolution reference epigenomes of major primary human cell…”
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Clonal Deletion Prunes but Does Not Eliminate Self-Specific alpha beta CD8+ T Lymphocytes by Yu, Wong, Jiang, Ning, Ebert, Peter JR, Kidd, Brian A, Mueller, Sabina, Lund, Peder J, Juang, Jeremy, Adachi, Keishi, Tse, Tiffany, Birnbaum, Michael E, Newell, Evan W, Wilson, Darrell M, Grotenbreg, Gijsbert M, Valitutti, Salvatore, Quake, Stephen R, Davis, Mark M

“…It has long been thought that clonal deletion efficiently removes almost all self-specific T cells from the peripheral repertoire. We found that self-peptide…”
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T Cell Receptor (TCR) and Transforming Growth Factor β (TGF-β) Signaling Converge on DNA (Cytosine-5)-methyltransferase to Control forkhead box protein 3 (foxp3) Locus Methylation and Inducible Regulatory T Cell Differentiation by Li, Chaoran, Ebert, Peter J.R., Li, Qi-Jing

“…Naïve T cells can be induced to differentiate into Foxp3+ regulatory T cells (iTregs) upon suboptimal T cell receptor (TCR) stimulus or TCR stimulus in…”
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DNA Methylation Dynamics of Human Hematopoietic Stem Cell Differentiation by Farlik, Matthias, Halbritter, Florian, Müller, Fabian, Choudry, Fizzah A., Ebert, Peter, Klughammer, Johanna, Farrow, Samantha, Santoro, Antonella, Ciaurro, Valerio, Mathur, Anthony, Uppal, Rakesh, Stunnenberg, Hendrik G., Ouwehand, Willem H., Laurenti, Elisa, Lengauer, Thomas, Frontini, Mattia, Bock, Christoph

“…Hematopoietic stem cells give rise to all blood cells in a differentiation process that involves widespread epigenome remodeling. Here we present genome-wide…”
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Photocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be 'preferentially' transported to the cSMAC by Xie, Jianming, Huppa, Johannes B, Newell, Evan W, Huang, Jun, Ebert, Peter J R, Li, Qi-Jing, Davis, Mark M

“…Tetramers of peptide and major histocompatibility complex (pMHC) are very useful for the detection of specific T cell antigen receptors; however, they have…”
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Development and Evaluation of an Improved Apparatus for Measuring the Emissivity at High Temperatures by Arduini, Mariacarla, Manara, Jochen, Stark, Thomas, Ebert, Hans-Peter, Hartmann, Jürgen

“…An improved apparatus for measuring the spectral directional emissivity in the wavelength range between 1 µm and 20 µm at temperatures up to 2400 K is…”
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A comprehensive analysis of 195 DNA methylomes reveals shared and cell-specific features of partially methylated domains by Salhab, Abdulrahman, Nordström, Karl, Gasparoni, Gilles, Kattler, Kathrin, Ebert, Peter, Ramirez, Fidel, Arrigoni, Laura, Müller, Fabian, Polansky, Julia K, Cadenas, Cristina, G Hengstler, Jan, Lengauer, Thomas, Manke, Thomas, Walter, Jörn

“…Partially methylated domains are extended regions in the genome exhibiting a reduced average DNA methylation level. They cover gene-poor and transcriptionally…”
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Graphasing: phasing diploid genome assembly graphs with single-cell strand sequencing by Henglin, Mir, Ghareghani, Maryam, Harvey, William T, Porubsky, David, Koren, Sergey, Eichler, Evan E, Ebert, Peter, Marschall, Tobias

“…Haplotype information is crucial for biomedical and population genetics research. However, current strategies to produce de novo haplotype-resolved assemblies…”
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Volumetric Disentanglement for 3D Scene Manipulation by Benaim, Sagie, Warburg, Frederik, Christensen, Peter Ebert, Belongie, Serge

“…Recently, advances in differential volumetric rendering enabled significant breakthroughs in the photo-realistic and fine-detailed reconstruction of complex 3D…”
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Assessing Neural Network Robustness via Adversarial Pivotal Tuning by Christensen, Peter Ebert, Snabjarnarson, Vesteinn, Dittadi, Andrea, Belongie, Serge, Benaim, Sagie

“…The robustness of image classifiers is essential to their deployment in the real world. The ability to assess this resilience to manipulations or deviations…”
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Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection by Juang, Jeremy, Ebert, Peter J R, Feng, Dan, Garcia, K Christopher, Krogsgaard, Michelle, Davis, Mark M

“…T cell selection and maturation in the thymus depends on the interactions between T cell receptors (TCRs) and different self-peptide-major histocompatibility…”
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Ten Simple Rules for Developing Usable Software in Computational Biology by List, Markus, Ebert, Peter, Albrecht, Felipe

“…[...]scientific software is often poorly documented, non-intuitive, non-robust with regards to input data and parameters, and hard to install. Usable software…”
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Low Ligand Requirement for Deletion and Lack of Synapses in Positive Selection Enforce the Gauntlet of Thymic T Cell Maturation by Ebert, Peter J.R., Ehrlich, Lauren I. Richie, Davis, Mark M.

“…Immature double-positive (CD4+CD8+) thymocytes respond to negatively selecting peptide-MHC ligands by forming an immune synapse that sustains contact with the…”
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Dynamics of p56lck Translocation to the T Cell Immunological Synapse following Agonist and Antagonist Stimulation by Ehrlich, Lauren I.Richie, Ebert, Peter J.R., Krummel, Matthew F., Weiss, Arthur, Davis, Mark M.

“…To study the spatio/temporal recruitment of lck during immunological synapse formation, we utilize high-speed time-lapse microscopy to visualize green…”
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Alterations in the hepatocyte epigenetic landscape in steatosis by Maji, Ranjan Kumar, Czepukojc, Beate, Scherer, Michael, Tierling, Sascha, Cadenas, Cristina, Gianmoena, Kathrin, Gasparoni, Nina, Nordström, Karl, Gasparoni, Gilles, Laggai, Stephan, Yang, Xinyi, Sinha, Anupam, Ebert, Peter, Falk-Paulsen, Maren, Kinkley, Sarah, Hoppstädter, Jessica, Chung, Ho-Ryun, Rosenstiel, Philip, Hengstler, Jan G, Walter, Jörn, Schulz, Marcel H, Kessler, Sonja M, Kiemer, Alexandra K

“…Fatty liver disease or the accumulation of fat in the liver, has been reported to affect the global population. This comes with an increased risk for the…”
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