Search Results - "Ebert, Gregor"

Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2 by Klemm, Theresa, Ebert, Gregor, Calleja, Dale J, Allison, Cody C, Richardson, Lachlan W, Bernardini, Jonathan P, Lu, Bernadine GC, Kuchel, Nathan W, Grohmann, Christoph, Shibata, Yuri, Gan, Zhong Yan, Cooney, James P, Doerflinger, Marcel, Au, Amanda E, Blackmore, Timothy R, van der Heden van Noort, Gerbrand J, Geurink, Paul P, Ovaa, Huib, Newman, Janet, Riboldi‐Tunnicliffe, Alan, Czabotar, Peter E, Mitchell, Jeffrey P, Feltham, Rebecca, Lechtenberg, Bernhard C, Lowes, Kym N, Dewson, Grant, Pellegrini, Marc, Lessene, Guillaume, Komander, David

“…The SARS‐CoV‐2 coronavirus encodes an essential papain‐like protease domain as part of its non‐structural protein (nsp)‐3, namely SARS2 PLpro, that cleaves the…”
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Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection by Doerflinger, Marcel, Deng, Yexuan, Whitney, Paul, Salvamoser, Ranja, Engel, Sven, Kueh, Andrew J., Tai, Lin, Bachem, Annabell, Gressier, Elise, Geoghegan, Niall D., Wilcox, Stephen, Rogers, Kelly L., Garnham, Alexandra L., Dengler, Michael A., Bader, Stefanie M., Ebert, Gregor, Pearson, Jaclyn S., De Nardo, Dominic, Wang, Nancy, Yang, Chenying, Pereira, Milton, Bryant, Clare E., Strugnell, Richard A., Vince, James E., Pellegrini, Marc, Strasser, Andreas, Bedoui, Sammy, Herold, Marco J.

“…Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necroptosis, and apoptosis during…”
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Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis by Ebert, Gregor, Allison, Cody, Preston, Simon, Cooney, James, Toe, Jesse G., Stutz, Michael D., Ojaimi, Samar, Baschuk, Nikola, Nachbur, Ueli, Torresi, Joseph, Silke, John, Begley, C. Glenn, Pellegrini, Marc

“…We have shown that cellular inhibitor of apoptosis proteins (cIAPs) impair clearance of hepatitis B virus (HBV) infection by preventing TNF-mediated…”
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The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation by Vijayaraj, Swarna L., Feltham, Rebecca, Rashidi, Maryam, Frank, Daniel, Liu, Zhengyang, Simpson, Daniel S., Ebert, Gregor, Vince, Angelina, Herold, Marco J., Kueh, Andrew, Pearson, Jaclyn S., Dagley, Laura F., Murphy, James M., Webb, Andrew I., Lawlor, Kate E., Vince, James E.

“…Interleukin-1β (IL-1β) is activated by inflammasome-associated caspase-1 in rare autoinflammatory conditions and in a variety of other inflammatory diseases…”
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Multi-omics characterization of the monkeypox virus infection by Huang, Yiqi, Bergant, Valter, Grass, Vincent, Emslander, Quirin, Hamad, M. Sabri, Hubel, Philipp, Mergner, Julia, Piras, Antonio, Krey, Karsten, Henrici, Alexander, Öllinger, Rupert, Tesfamariam, Yonas M., Dalla Rosa, Ilaria, Bunse, Till, Sutter, Gerd, Ebert, Gregor, Schmidt, Florian I., Way, Michael, Rad, Roland, Bowie, Andrew G., Protzer, Ulrike, Pichlmair, Andreas

“…Multiple omics analyzes of Vaccinia virus (VACV) infection have defined molecular characteristics of poxvirus biology. However, little is known about the…”
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Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus by Ebert, Gregor, Preston, Simon, Allison, Cody, Cooney, James, Toe, Jesse G., Stutz, Michael D., Ojaimi, Samar, Scott, Hamish W., Baschuk, Nikola, Nachbur, Ueli, Torresi, Joseph, Chin, Ruth, Colledge, Danielle, Li, Xin, Warner, Nadia, Revill, Peter, Bowden, Scott, Silke, John, Begley, C. Glenn, Pellegrini, Marc

“…Significance Hepatitis B virus (HBV) causes substantial morbidity and mortality. A large proportion of infected individuals controls infection but does not…”
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Combinatorial Treatment of Birinapant and Zosuquidar Enhances Effective Control of HBV Replication In Vivo by Morrish, Emma, Mackiewicz, Liana, Silke, Natasha, Pellegrini, Marc, Silke, John, Brumatti, Gabriela, Ebert, Gregor

“…Chronic hepatitis B virus (HBV) infection remains a global health threat and affects hundreds of millions worldwide. Small molecule compounds that mimic…”
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5′ Triphosphorylated Small Interfering RNAs Control Replication of Hepatitis B Virus and Induce an Interferon Response in Human Liver Cells and Mice by Ebert, Gregor, Poeck, Hendrik, Lucifora, Julie, Baschuk, Nikola, Esser, Knud, Esposito, Irene, Hartmann, Gunther, Protzer, Ulrike

“…Background & Aims Approved therapies for chronic hepatitis B include systemic administration of interferon (IFN)-alfa and inhibitors of hepatitis B virus (HBV)…”
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A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation by Garnish, Sarah E., Martin, Katherine R., Kauppi, Maria, Jackson, Victoria E., Ambrose, Rebecca, Eng, Vik Ven, Chiou, Shene, Meng, Yanxiang, Frank, Daniel, Tovey Crutchfield, Emma C., Patel, Komal M., Jacobsen, Annette V., Atkin-Smith, Georgia K., Di Rago, Ladina, Doerflinger, Marcel, Horne, Christopher R., Hall, Cathrine, Young, Samuel N., Cook, Matthew, Athanasopoulos, Vicki, Vinuesa, Carola G., Lawlor, Kate E., Wicks, Ian P., Ebert, Gregor, Ng, Ashley P., Slade, Charlotte A., Pearson, Jaclyn S., Samson, André L., Silke, John, Murphy, James M., Hildebrand, Joanne M.

“…Across the globe, 2-3% of humans carry the p.Ser132Pro single nucleotide polymorphism in MLKL , the terminal effector protein of the inflammatory form of…”
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Is Receptor-Interacting Protein Kinase 3 a Viable Therapeutic Target for Mycobacterium tuberculosis Infection? by Stutz, Michael D, Ojaimi, Samar, Ebert, Gregor, Pellegrini, Marc

“…The dwindling list of antimicrobial agents exhibiting broad efficacy against clinical strains of (Mtb) has forced the medical community to redefine current…”
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Targeting the Extrinsic Pathway of Hepatocyte Apoptosis Promotes Clearance of Plasmodium Liver Infection by Ebert, Gregor, Lopaticki, Sash, O’Neill, Matthew T., Steel, Ryan W.J., Doerflinger, Marcel, Rajasekaran, Pravin, Yang, Annie S.P., Erickson, Sara, Ioannidis, Lisa, Arandjelovic, Philip, Mackiewicz, Liana, Allison, Cody, Silke, John, Pellegrini, Marc, Boddey, Justin A.

“…Plasmodium sporozoites infect the liver and develop into exoerythrocytic merozoites that initiate blood-stage disease. The hepatocyte molecular pathways that…”
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A fully humanized IgG-like bispecific antibody for effective dual targeting of CXCR3 and CCR6 by Robert, Remy, Juglair, Laurent, Lim, Ee X, Ang, Caroline, Wang, Carl J H, Ebert, Gregor, Dolezal, Olan, Mackay, Charles R

“…Chemokines and their receptors are pivotal for the trafficking of leukocytes during immune responses, and host defense. However, immune cell migration also…”
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Virology Downunder, a meeting commentary from the 2019 Lorne Infection and Immunity Conference, Australia by Ebert, Gregor, Paradkar, Prasad N, Londrigan, Sarah L

“…The aim of this article is to summarise the virology content presented at the 9th Lorne Infection and Immunity Conference, Australia, in February 2019. The…”
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Clinical stage drugs targeting inhibitor of apoptosis proteins purge episomal Hepatitis B viral genome in preclinical models by Clark, Michelle P., Huynh, Thao, Rao, Shringar, Mackiewicz, Liana, Mason, Hugh, Romal, Shahla, Stutz, Michael D., Ahn, Sang H., Earnest, Linda, Sozzi, Vitina, Littlejohn, Margaret, Tran, Bang M., Wiedemann, Norbert, Vincan, Elizabeth, Torresi, Joseph, Netter, Hans J., Mahmoudi, Tokameh, Revill, Peter, Pellegrini, Marc, Ebert, Gregor

“…A major unmet clinical need is a therapeutic capable of removing hepatitis B virus (HBV) genome from the liver of infected individuals to reduce their risk of…”
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Engineered, nucleocytoplasmic shuttling Cas13d enables highly efficient cytosolic RNA targeting by Gruber, Christoph, Krautner, Lea, Bergant, Valter, Grass, Vincent, Ma, Zhe, Rheinemann, Lara, Krus, Ariane, Reinhardt, Friederike, Mazneykova, Lyupka, Rocha-Hasler, Marianne, Truong, Dong-Jiunn Jeffery, Westmeyer, Gil Gregor, Pichlmair, Andreas, Ebert, Gregor, Giesert, Florian, Wurst, Wolfgang

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Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death by Frank, Daniel, Garnish, Sarah E., Sandow, Jarrod J., Weir, Ashley, Liu, Lin, Clayer, Elise, Meza, Lizeth, Rashidi, Maryam, Cobbold, Simon A., Scutts, Simon R., Doerflinger, Marcel, Anderton, Holly, Lawlor, Kate E., Lalaoui, Najoua, Kueh, Andrew J., Eng, Vik Ven, Ambrose, Rebecca L., Herold, Marco J., Samson, Andre L., Feltham, Rebecca, Murphy, James M., Ebert, Gregor, Pearson, Jaclyn S., Vince, James E.

“…Pathogen recognition and TNF receptors signal via receptor interacting serine/threonine kinase-3 (RIPK3) to cause cell death, including MLKL-mediated…”
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Targeted protein degradation at the host–pathogen interface by Grohmann, Christoph, Marapana, Danushka S., Ebert, Gregor

“…Infectious diseases remain a major burden to global health. Despite the implementation of successful vaccination campaigns and efficient drugs, the increasing…”
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Major open questions in the hepatitis B and D field – Proceedings of the inaugural International emerging hepatitis B and hepatitis D researchers workshop by Tu, Thomas, Wettengel, Jochen, Xia, Yuchen, Testoni, Barbara, Littlejohn, Margaret, Le Bert, Nina, Ebert, Gregor, Verrier, Eloi R., Tavis, John E., Cohen, Chari

“…The early and mid-career researchers (EMCRs) of scientific communities represent the forefront of research and the future direction in which a field takes. The…”
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Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors by Falke, Sven, Lieske, Julia, Herrmann, Alexander, Loboda, Jure, Karničar, Katarina, Günther, Sebastian, Reinke, Patrick Y. A., Ewert, Wiebke, Usenik, Aleksandra, Lindič, Nataša, Sekirnik, Andreja, Dretnik, Klemen, Tsuge, Hideaki, Turk, Vito, Chapman, Henry N., Hinrichs, Winfried, Ebert, Gregor, Turk, Dušan, Meents, Alke

“…Emerging RNA viruses, including SARS-CoV-2, continue to be a major threat. Cell entry of SARS-CoV-2 particles via the endosomal pathway involves cysteine…”
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Light-Induced Transformation of Virus-Like Particles on TiO 2 by Kohantorabi, Mona, Ugolotti, Aldo, Sochor, Benedikt, Roessler, Johannes, Wagstaffe, Michael, Meinhardt, Alexander, Beck, E Erik, Dolling, Daniel Silvan, Garcia, Miguel Blanco, Creutzburg, Marcus, Keller, Thomas F, Schwartzkopf, Matthias, Vayalil, Sarathlal Koyiloth, Thuenauer, Roland, Guédez, Gabriela, Löw, Christian, Ebert, Gregor, Protzer, Ulrike, Hammerschmidt, Wolfgang, Zeidler, Reinhard, Roth, Stephan V, Di Valentin, Cristiana, Stierle, Andreas, Noei, Heshmat

“…Titanium dioxide (TiO ) shows significant potential as a self-cleaning material to inactivate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and…”
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