Search Results - "Ebbinghaus, Charles F"

Concentration-dependent modulation of amyloid-beta in vivo and in vitro using the gamma-secretase inhibitor, LY-450139 by Lanz, Thomas A, Karmilowicz, Michael J, Wood, Kathleen M, Pozdnyakov, Nikolay, Du, Ping, Piotrowski, Mary A, Brown, Tracy M, Nolan, Charles E, Richter, Karl E G, Finley, James E, Fei, Qing, Ebbinghaus, Charles F, Chen, Yuhpyng L, Spracklin, Douglas K, Tate, Barbara, Geoghegan, Kieran F, Lau, Lit-Fui, Auperin, David D, Schachter, Joel B

“…LY-450139 is a gamma-secretase inhibitor shown to have efficacy in multiple cellular and animal models. Paradoxically, robust elevations of plasma amyloid-beta…”
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Thiazole-diamides as potent γ-secretase inhibitors by Chen, Yuhpyng L., Cherry, Kevin, Corman, Michael L., Ebbinghaus, Charles F., Gamlath, Chandra B., Liston, Dane, Martin, Barbara-Anne, Oborski, Christine E., Sahagan, Barbara G.

“…The thiazole-diamide series has been identified as highly potent γ-secretase inhibitors. Several representative compounds showed IC 50 values of <0.3 nM. The…”
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Rearrangement of 2-diazoceph-3-em 1.beta.-oxides: migration of oxygen from sulfur to carbon by Ebbinghaus, Charles F, Morrissey, Peter, Rosati, Robert L

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Discovery and Preclinical Pharmacology of a Novel, Potent, Nonsteroidal Estrogen Receptor Agonist/Antagonist, CP-336156, a Diaryltetrahydronaphthalene by Rosati, Robert L, Da Silva Jardine, Paul, Cameron, Kimberly O, Thompson, David D, Ke, Hua Zhu, Toler, Steven M, Brown, Thomas A, Pan, Lydia C, Ebbinghaus, Charles F, Reinhold, Anthony R, Elliott, Nancy C, Newhouse, Bradley N, Tjoa, Christina M, Sweetnam, Paul M, Cole, Mark J, Arriola, Mark W, Gauthier, Jeffrey W, Crawford, D. Todd, Nickerson, David F, Pirie, Christine M, Qi, Hong, Simmons, Hollis A, Tkalcevic, George T

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