Search Results - "Ebbels, Timothy M."

Integrated pathway-level analysis of transcriptomics and metabolomics data with IMPaLA by Kamburov, Atanas, Cavill, Rachel, Ebbels, Timothy M. D., Herwig, Ralf, Keun, Hector C.

“…Pathway-level analysis is a powerful approach enabling interpretation of post-genomic data at a higher level than that of individual biomolecules. Yet, it is…”
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Multiple-testing correction in metabolome-wide association studies by Peluso, Alina, Glen, Robert, Ebbels, Timothy M D

“…The search for statistically significant relationships between molecular markers and outcomes is challenging when dealing with high-dimensional, noisy and…”
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Bayesian deconvolution and quantification of metabolites in complex 1D NMR spectra using BATMAN by Hao, Jie, Liebeke, Manuel, Astle, William, De Iorio, Maria, Bundy, Jacob G, Ebbels, Timothy M D

“…BATMAN is an R package developed to analyze one-dimensional NMR spectra of complex metabolite mixtures using a user-defined template library. Data processing…”
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Reliability of plasma polar metabolite concentrations in a large-scale cohort study using capillary electrophoresis-mass spectrometry by Harada, Sei, Hirayama, Akiyoshi, Chan, Queenie, Kurihara, Ayako, Fukai, Kota, Iida, Miho, Kato, Suzuka, Sugiyama, Daisuke, Kuwabara, Kazuyo, Takeuchi, Ayano, Akiyama, Miki, Okamura, Tomonori, Ebbels, Timothy M D, Elliott, Paul, Tomita, Masaru, Sato, Asako, Suzuki, Chizuru, Sugimoto, Masahiro, Soga, Tomoyoshi, Takebayashi, Toru

“…Cohort studies with metabolomics data are becoming more widespread, however, large-scale studies involving 10,000s of participants are still limited,…”
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Power Analysis and Sample Size Determination in Metabolic Phenotyping by Blaise, Benjamin J, Correia, Gonçalo, Tin, Adrienne, Young, J. Hunter, Vergnaud, Anne-Claire, Lewis, Matthew, Pearce, Jake T. M, Elliott, Paul, Nicholson, Jeremy K, Holmes, Elaine, Ebbels, Timothy M. D

“…Estimation of statistical power and sample size is a key aspect of experimental design. However, in metabolic phenotyping, there is currently no accepted…”
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BATMAN—an R package for the automated quantification of metabolites from nuclear magnetic resonance spectra using a Bayesian model by JIE HAO, ASTLE, William, DE LORIO, Maria, EBBELS, Timothy M. D

“…Nuclear Magnetic Resonance (NMR) spectra are widely used in metabolomics to obtain metabolite profiles in complex biological mixtures. Common methods used to…”
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Urinary metabolic signatures of human adiposity by Elliott, Paul, Posma, Joram M, Chan, Queenie, Garcia-Perez, Isabel, Wijeyesekera, Anisha, Bictash, Magda, Ebbels, Timothy M D, Ueshima, Hirotsugu, Zhao, Liancheng, van Horn, Linda, Daviglus, Martha, Stamler, Jeremiah, Holmes, Elaine, Nicholson, Jeremy K

“…Obesity is a major public health problem worldwide. We used 24-hour urinary metabolic profiling by proton ((1)H) nuclear magnetic resonance (NMR) spectroscopy…”
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Correction of mass calibration gaps in liquid chromatography–mass spectrometry metabolomics data by Benton, H. Paul, Want, Elizabeth J., Ebbels, Timothy M. D.

“…Motivation: High mass accuracy is an important goal in liquid chromatography–mass spectrometry experiments. Some manufacturers employ a mass calibration system…”
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Design and Analysis of Metabolomics Studies in Epidemiologic Research: A Primer on -Omic Technologies by TZOULAKI, Loanna, EBBELS, Timothy M. D, VALDES, Ana, ELLIOTT, Paul, IOANNIDIS, John P. A

“…Metabolomics is the field of "-omics" research concerned with the comprehensive characterization of the small low-molecular-weight metabolites in biological…”
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Single sample pathway analysis in metabolomics: performance evaluation and application by Wieder, Cecilia, Lai, Rachel P J, Ebbels, Timothy M D

“…Single sample pathway analysis (ssPA) transforms molecular level omics data to the pathway level, enabling the discovery of patient-specific pathway…”
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Integrative analysis of time course metabolic data and biomarker discovery by Jendoubi, Takoua, Ebbels, Timothy M D

“…Metabolomics time-course experiments provide the opportunity to understand the changes to an organism by observing the evolution of metabolic profiles in…”
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Predictive modelling using pathway scores: robustness and significance of pathway collections by Segura-Lepe, Marcelo P, Keun, Hector C, Ebbels, Timothy M D

“…Transcriptomic data is often used to build statistical models which are predictive of a given phenotype, such as disease status. Genes work together in…”
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Problems, principles and progress in computational annotation of NMR metabolomics data by Judge, Michael T., Ebbels, Timothy M. D.

“…Background Compound identification remains a critical bottleneck in the process of exploiting Nuclear Magnetic Resonance (NMR) metabolomics data, especially…”
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Statistical analysis in metabolic phenotyping by Blaise, Benjamin J., Correia, Gonçalo D. S., Haggart, Gordon A., Surowiec, Izabella, Sands, Caroline, Lewis, Matthew R., Pearce, Jake T. M., Trygg, Johan, Nicholson, Jeremy K., Holmes, Elaine, Ebbels, Timothy M. D.

“…Metabolic phenotyping is an important tool in translational biomedical research. The advanced analytical technologies commonly used for phenotyping, including…”
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Optimizing the Use of Quality Control Samples for Signal Drift Correction in Large-Scale Urine Metabolic Profiling Studies by Kamleh, Muhammad Anas, Ebbels, Timothy M. D, Spagou, Konstantina, Masson, Perrine, Want, Elizabeth J

“…The evident importance of metabolic profiling for biomarker discovery and hypothesis generation has led to interest in incorporating this technique into…”
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Optimization and Evaluation of Metabolite Extraction Protocols for Untargeted Metabolic Profiling of Liver Samples by UPLC-MS by Masson, Perrine, Alves, Alexessander Couto, Ebbels, Timothy M. D, Nicholson, Jeremy K, Want, Elizabeth J

“…A series of six protocols were evaluated for UPLC-MS based untargeted metabolic profiling of liver extracts in terms of reproducibility and number of…”
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Optimized Preprocessing of Ultra-Performance Liquid Chromatography/Mass Spectrometry Urinary Metabolic Profiles for Improved Information Recovery by Veselkov, Kirill A, Vingara, Lisa K, Masson, Perrine, Robinette, Steven L, Want, Elizabeth, Li, Jia V, Barton, Richard H, Boursier-Neyret, Claire, Walther, Bernard, Ebbels, Timothy M, Pelczer, István, Holmes, Elaine, Lindon, John C, Nicholson, Jeremy K

“…Ultra-performance liquid chromatography coupled to mass spectrometry (UPLC/MS) has been used increasingly for measuring changes of low molecular weight…”
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Use cases, best practice and reporting standards for metabolomics in regulatory toxicology by Viant, Mark R., Ebbels, Timothy M. D., Beger, Richard D., Ekman, Drew R., Epps, David J. T., Kamp, Hennicke, Leonards, Pim E. G., Loizou, George D., MacRae, James I., van Ravenzwaay, Bennard, Rocca-Serra, Philippe, Salek, Reza M., Walk, Tilmann, Weber, Ralf J. M.

“…Metabolomics is a widely used technology in academic research, yet its application to regulatory science has been limited. The most commonly cited barrier to…”
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Statistical Correlations between NMR Spectroscopy and Direct Infusion FT-ICR Mass Spectrometry Aid Annotation of Unknowns in Metabolomics by Hao, Jie, Liebeke, Manuel, Sommer, Ulf, Viant, Mark R, Bundy, Jacob G, Ebbels, Timothy M. D

“…NMR spectroscopy and mass spectrometry are the two major analytical platforms for metabolomics, and both generate substantial data with hundreds to thousands…”
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Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts by Nicholson, Jeremy K, Beckonert, Olaf, Keun, Hector C, Ebbels, Timothy M D, Bundy, Jacob, Holmes, Elaine, Lindon, John C

“…Metabolic profiling, metabolomic and metabonomic studies mainly involve the multicomponent analysis of biological fluids, tissue and cell extracts using NMR…”
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