Search Results - "Eaton, Megan M."

Multiple Non-Equivalent Interfaces Mediate Direct Activation of GABAA Receptors by Propofol by Eaton, Megan M, Germann, Allison L, Arora, Ruby, Cao, Lily Q, Gao, Xiaoyi, Shin, Daniel J, Wu, Albert, Chiara, David C, Cohen, Jonathan B, Steinbach, Joe Henry, Evers, Alex S, Akk, Gustav

“…Background: Propofol is a sedative agent that at clinical concentrations acts by allosterically activating or potentiating the ?-aminobutyric acid type A…”
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γ-aminobutyric acid type A α4, β2, and δ subunits assemble to produce more than one functionally distinct receptor type by Eaton, Megan M, Bracamontes, John, Shu, Hong-Jin, Li, Ping, Mennerick, Steven, Steinbach, Joe Henry, Akk, Gustav

“…Native γ-aminobutyric acid (GABA)A receptors consisting of α4, β1-3, and δ subunits mediate responses to the low, tonic concentration of GABA present in the…”
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Mutational Analysis of the Putative High-Affinity Propofol Binding Site in Human β3 Homomeric GABAA Receptors by Eaton, Megan M, Cao, Lily Q, Chen, Ziwei, Franks, Nicholas P, Evers, Alex S, Akk, Gustav

“…Propofol is a sedative and anesthetic agent that can both activate GABA(A) receptors and potentiate receptor activation elicited by submaximal concentrations…”
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Modulation of the human ρ1 GABAA receptor by inhibitory steroids by Eaton, Megan M., Lim, You Bin, Covey, Douglas F., Akk, Gustav

“…Rationale Modulators of the ρ1 GABA A receptor may be useful in the treatment of visual, sleep, and cognitive disorders. Neuroactive steroids and analogues…”
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Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes by Shu, Hong-Jin, Bracamontes, John, Taylor, Amanda, Wu, Kyle, Eaton, Megan M, Akk, Gustav, Manion, Brad, Evers, Alex S, Krishnan, Kathiresan, Covey, Douglas F, Zorumski, Charles F, Steinbach, Joe Henry, Mennerick, Steven

“…GABA(A) receptors mediate both synaptic and extrasynaptic actions of GABA. In several neuronal populations, α4 and δ subunits are key components of…”
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Agonist-specific conformational changes in the α1-γ2 subunit interface of the GABA A receptor by Eaton, Megan M, Lim, You Bin, Bracamontes, John, Steinbach, Joe Henry, Akk, Gustav

“…The GABA(A) receptor undergoes conformational changes upon the binding of agonist that lead to the opening of the channel gate and a flow of small anions…”
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The Benzodiazepine Diazepam Potentiates Responses of α1β2γ2L γ-Aminobutyric Acid Type A Receptors Activated by either γ-Aminobutyric Acid or Allosteric Agonists by Li, Ping, Eaton, Megan M, Steinbach, Joe Henry, Akk, Gustav

“…BACKGROUND:The γ-aminobutyric acid (GABA) type A receptor is a target for several anesthetics, anticonvulsants, anxiolytics, and sedatives. Neurosteroids,…”
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11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors by Chen, Zi-Wei, Wang, Cunde, Krishnan, Kathiresan, Manion, Brad D., Hastings, Randy, Bracamontes, John, Taylor, Amanda, Eaton, Megan M., Zorumski, Charles F., Steinbach, Joseph H., Akk, Gustav, Mennerick, Steven, Covey, Douglas F., Evers, Alex S.

“…Rationale While neurosteroids are well-described positive allosteric modulators of gamma-aminobutyric acid type A (GABA A ) receptors, the binding sites that…”
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The benzodiazepine diazepam potentiates responses of α1β2γ2 γ-aminobutyric acid type A receptors activated by either γ-aminobutyric acid or allosteric agonists by Li, Ping, Eaton, Megan M., Steinbach, Joe Henry, Akk, Gustav

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Modulation of the human [rho]1 GABA^sub A^ receptor by inhibitory steroids by Eaton, Megan M, Lim, You Bin, Covey, Douglas F, Akk, Gustav

“…Issue Title: Neuroactive Steroids in the CNS in Memory of Robert H. Purdy' Modulators of the [rho]1 GABA^sub A^ receptor may be useful in the treatment of…”
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Modulation of the human ρ1 [GABA.sub.A] receptor by inhibitory steroids by Eaton, Megan M, Lim, You Bin, Covey, Douglas F, Akk, Gustav

“…Rationale Modulators of the ρ1 [GABA.sub.A] receptor may be useful in the treatment of visual, sleep, and cognitive disorders. Neuroactive steroids and…”
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Modulation of the human Ie1 GABA sub(A) receptor by inhibitory steroids by Eaton, Megan M, Lim, You Bin, Covey, Douglas F, Akk, Gustav

“…Rationale: Modulators of the Ie1 GABA sub(A) receptor may be useful in the treatment of visual, sleep, and cognitive disorders. Neuroactive steroids and…”
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11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for [GABA.sub.A] receptors by Chen, Zi-Wei, Wang, Cunde, Krishnan, Kathiresan, Manion, Brad D, Hastings, Randy, Bracamontes, John, Taylor, Amanda, Eaton, Megan M, Zorumski, Charles F, Steinbach, Joseph H, Akk, Gustav, Mennerick, Steven, Covey, Douglas F, Evers, Alex S

“…Rationale While neurosteroids are well-described positive allosteric modulators of gamma-aminobutyric acid type A ([GABA.sub.A]) receptors, the binding sites…”
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11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABA^sub A^ receptors by Chen, Zi-wei, Wang, Cunde, Krishnan, Kathiresan, Manion, Brad D, Hastings, Randy, Bracamontes, John, Taylor, Amanda, Eaton, Megan M, Zorumski, Charles F, Steinbach, Joseph H, Akk, Gustav, Mennerick, Steven, Covey, Douglas F, Evers, Alex S

“…Issue Title: Neuroactive Steroids in the CNS in Memory of Robert H. Purdy' While neurosteroids are well-described positive allosteric modulators of…”
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Characteristics of concatemeric GABAA receptors containing α4/δ subunits expressed in Xenopus oocytes by Shu, Hong‐Jin, Bracamontes, John, Taylor, Amanda, Wu, Kyle, Eaton, Megan M, Akk, Gustav, Manion, Brad, Evers, Alex S, Krishnan, Kathiresan, Covey, Douglas F, Zorumski, Charles F, Steinbach, Joe Henry, Mennerick, Steven

“…BACKGROUND AND PURPOSE GABAA receptors mediate both synaptic and extrasynaptic actions of GABA. In several neuronal populations, α4 and δ subunits are key…”
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Characteristics of concatemeric GABA sub(A) receptors containing alpha 4/[delta] subunits expressed in Xenopus oocytes by Shu, Hong-Jin, Bracamontes, John, Taylor, Amanda, Wu, Kyle, Eaton, Megan M, Akk, Gustav, Manion, Brad, Evers, Alex S, Krishnan, Kathiresan, Covey, Douglas F, Zorumski, Charles F, Steinbach, Joe Henry, Mennerick, Steven

“…BACKGROUND AND PURPOSE GABA sub(A) receptors mediate both synaptic and extrasynaptic actions of GABA. In several neuronal populations, alpha 4 and [delta]…”
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Characteristics of concatemeric GABAA receptors containing [alpha]4/[delta] subunits expressed in Xenopus oocytes by Shu, Hong-Jin, Bracamontes, John, Taylor, Amanda, Wu, Kyle, Eaton, Megan M, Akk, Gustav, Manion, Brad, Evers, Alex S, Krishnan, Kathiresan, Covey, Douglas F, Zorumski, Charles F, Steinbach, Joe Henry, Mennerick, Steven

“…BACKGROUND AND PURPOSE GABAA receptors mediate both synaptic and extrasynaptic actions of GABA. In several neuronal populations, [alpha]4 and [delta] subunits…”
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