Search Results - "Eaton, K."

Turbulent Dispersed Multiphase Flow by BALACHANDAR, S, EATON, John K

“…Turbulent dispersed multiphase flows are common in many engineering and environmental applications. The stochastic nature of both the carrier-phase turbulence…”
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Copper induces cell death by targeting lipoylated TCA cycle proteins by Tsvetkov, Peter, Coy, Shannon, Petrova, Boryana, Dreishpoon, Margaret, Verma, Ana, Abdusamad, Mai, Rossen, Jordan, Joesch-Cohen, Lena, Humeidi, Ranad, Spangler, Ryan D, Eaton, John K, Frenkel, Evgeni, Kocak, Mustafa, Corsello, Steven M, Lutsenko, Svetlana, Kanarek, Naama, Santagata, Sandro, Golub, Todd R

“…Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations exceed a threshold maintained by evolutionarily conserved…”
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Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition by Hangauer, Matthew J., Viswanathan, Vasanthi S., Ryan, Matthew J., Bole, Dhruv, Eaton, John K., Matov, Alexandre, Galeas, Jacqueline, Dhruv, Harshil D., Berens, Michael E., Schreiber, Stuart L., McCormick, Frank, McManus, Michael T.

“…Cancer persister cells, which survive cytotoxic treatments, are shown to be sensitive to inhibition of the lipid hydroperoxidase GPX4. Reservoir of resistance…”
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Plasticity of ether lipids promotes ferroptosis susceptibility and evasion by Zou, Yilong, Henry, Whitney S., Ricq, Emily L., Graham, Emily T., Phadnis, Vaishnavi V., Maretich, Pema, Paradkar, Sateja, Boehnke, Natalie, Deik, Amy A., Reinhardt, Ferenc, Eaton, John K., Ferguson, Bryan, Wang, Wenyu, Fairman, Joshua, Keys, Heather R., Dančík, Vlado, Clish, Clary B., Clemons, Paul A., Hammond, Paula T., Boyer, Laurie A., Weinberg, Robert A., Schreiber, Stuart L.

“…Ferroptosis—an iron-dependent, non-apoptotic cell death process—is involved in various degenerative diseases and represents a targetable susceptibility in…”
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A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis by Zou, Yilong, Palte, Michael J., Deik, Amy A., Li, Haoxin, Eaton, John K., Wang, Wenyu, Tseng, Yuen-Yi, Deasy, Rebecca, Kost-Alimova, Maria, Dančík, Vlado, Leshchiner, Elizaveta S., Viswanathan, Vasanthi S., Signoretti, Sabina, Choueiri, Toni K., Boehm, Jesse S., Wagner, Bridget K., Doench, John G., Clish, Clary B., Clemons, Paul A., Schreiber, Stuart L.

“…Clear-cell carcinomas (CCCs) are a histological group of highly aggressive malignancies commonly originating in the kidney and ovary. CCCs are distinguished by…”
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Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles by Eaton, John K., Furst, Laura, Ruberto, Richard A., Moosmayer, Dieter, Hilpmann, André, Ryan, Matthew J., Zimmermann, Katja, Cai, Luke L., Niehues, Michael, Badock, Volker, Kramm, Anneke, Chen, Sixun, Hillig, Roman C., Clemons, Paul A., Gradl, Stefan, Montagnon, Claire, Lazarski, Kiel E., Christian, Sven, Bajrami, Besnik, Neuhaus, Roland, Eheim, Ashley L., Viswanathan, Vasanthi S., Schreiber, Stuart L.

“…We recently described glutathione peroxidase 4 (GPX4) as a promising target for killing therapy-resistant cancer cells via ferroptosis. The onset of therapy…”
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Structure–activity relationships of GPX4 inhibitor warheads by Eaton, John K., Furst, Laura, Cai, Luke L., Viswanathan, Vasanthi S., Schreiber, Stuart L.

“…Direct inhibition of GPX4 requires covalent modification of the active-site selenocysteine. While phenotypic screening has revealed that activated alkyl…”
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A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering by To, Tsz-Leung, Cuadros, Alejandro M., Shah, Hardik, Hung, Wendy H.W., Li, Yang, Kim, Sharon H., Rubin, Daniel H.F., Boe, Ryan H., Rath, Sneha, Eaton, John K., Piccioni, Federica, Goodale, Amy, Kalani, Zohra, Doench, John G., Root, David E., Schreiber, Stuart L., Vafai, Scott B., Mootha, Vamsi K.

“…Mitochondrial dysfunction is associated with a spectrum of human conditions, ranging from rare, inborn errors of metabolism to the aging process. To identify…”
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Classification of turbulence modification by dispersed spheres using a novel dimensionless number by Tanaka, Tomohiko, Eaton, John K

“…A novel dimensionless parameter, the particle moment number Pa, was derived using dimensional analysis of the particle-laden Navier-Stokes equations, in order…”
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Milk Containing A2 β-Casein ONLY, as a Single Meal, Causes Fewer Symptoms of Lactose Intolerance than Milk Containing A1 and A2 β-Caseins in Subjects with Lactose Maldigestion and Intolerance: A Randomized, Double-Blind, Crossover Trial by Ramakrishnan, Monica, Eaton, Tracy K, Sermet, Omer M, Savaiano, Dennis A

“…Acute-feeding and multiple-day studies have demonstrated that milk containing A2 β-casein only causes fewer symptoms of lactose intolerance (LI) than milk…”
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A phase III study of belagenpumatucel-L, an allogeneic tumour cell vaccine, as maintenance therapy for non-small cell lung cancer by Giaccone, G, Bazhenova, L.A, Nemunaitis, J, Tan, M, Juhász, E, Ramlau, R, van den Heuvel, M.M, Lal, R, Kloecker, G.H, Eaton, K.D, Chu, Q, Dunlop, D.J, Jain, M, Garon, E.B, Davis, C.S, Carrier, E, Moses, S.C, Shawler, D.L, Fakhrai, H

“…Abstract Background Treatment options after first-line chemotherapy are limited in non-small cell lung cancer (NSCLC). Belagenpumatucel-L is a therapeutic…”
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Two-way coupled turbulence simulations of gas-particle flows using point-particle tracking by Eaton, John K.

“…This paper addresses computational models for dilute gas-particle multiphase flow in which the three dimensional, time-dependent fluid motion is calculated in…”
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Prevalence of Insufficient, Borderline, and Optimal Hours of Sleep Among High School Students – United States, 2007 by Eaton, Danice K., Ph.D, McKnight-Eily, Lela R., Ph.D, Lowry, Richard, M.D, Perry, Geraldine S., Dr.P.H, Presley-Cantrell, Letitia, Ph.D, Croft, Janet B., Ph.D

“…Abstract We describe the prevalence of insufficient, borderline, and optimal sleep hours among U.S. high school students on an average school night. Most…”
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The healthcare system and the provision of oral healthcare in European Union member states: Part 5: Romania by Oancea, R., Amariei, C., Eaton, K. A., Widström, E.

“…Key Points Demonstrates that over 90% of oral healthcare in Romania is funded privately – some public support is available for children. Suggests there has…”
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Sequential Treatment Application Robot (STAR) for high-replication marine experimentation by Enochs, I.C., Soderberg, N., Palacio-Castro, A.M., Eaton, K.

“…[Display omitted] Marine organisms are often subject to numerous anthropogenic stressors, resulting in widespread ecosystem degradation. Physiological…”
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The healthcare system and the provision of oral healthcare in European Union member states. Part 8: Italy by Bindi, M., Paganelli, C., Eaton, K. A., Widström, E.

“…Key Points Shows that although there is a well-developed publicly funded health service in Italy, well over 90% of dentistry is provided under private…”
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Prevalence and Correlates of Missing Meals Among High School Students—United States, 2010 by Demissie, Zewditu, Eaton, Danice K., Lowry, Richard, Nihiser, Allison J., Foltz, Jennifer L.

“…Purpose: To determine the prevalence and correlates of missing meals among adolescents. Design: The 2010 National Youth Physical Activity and Nutrition Study,…”
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A correction method for measuring turbulence kinetic energy dissipation rate by PIV by Tanaka, Tomohiko, Eaton, John K

“…The accuracy of turbulent kinetic energy (TKE) dissipation rate measured by PIV is studied. The critical issue for PIV-based dissipation measurements is the…”
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Sufficient Sleep, Physical Activity, and Sedentary Behaviors by Foti, Kathryn E., MPH, Eaton, Danice K., PhD, Lowry, Richard, MD, MS, McKnight-Ely, Lela R., PhD

“…Background Insufficient sleep among adolescents is common and has adverse health and behavior consequences. Understanding associations of physical activity and…”
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Different Demands, Same Goal: Promoting Transition Readiness in Adolescents and Young Adults With and Without Medical Conditions by Eaton, Cyd K., M.S, Davis, Molly F., M.S, Gutierrez-Colina, Ana M., M.S, LaMotte, Julia, M.S, Blount, Ronald L., Ph.D, Suveg, Cynthia, Ph.D

“…Abstract Purpose This study aimed to examine differences in transition readiness, self-involvement and parental involvement in completing medical tasks, and…”
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