Search Results - "Eaton, Colby L."

High Aldehyde Dehydrogenase Activity Identifies Tumor-Initiating and Metastasis-Initiating Cells in Human Prostate Cancer by VAN DEN HOOGEN, Christel, VAN DER HORST, Geertje, PELGER, Rob C. M, VAN DER PLUIJM, Gabri, CHEUNG, Henry, BUIJS, Jeroen T, LIPPITT, Jenny M, GUZMAN-RAMIREZ, Natalia, HAMDY, Freddie C, EATON, Colby L, THALMANN, George N, CECCHINI, Marco G

“…Metastatic progression of advanced prostate cancer is a major clinical problem. Identifying the cell(s) of origin in prostate cancer and its distant metastases…”
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Parathyroid Hormone (PTH) Increases Skeletal Tumour Growth and Alters Tumour Distribution in an In Vivo Model of Breast Cancer by Brown, Hannah K, Allocca, Gloria, Ottewell, Penelope D, Wang, Ning, Brown, Nicola J, Croucher, Peter I, Eaton, Colby L, Holen, Ingunn

“…Breast cancer cells colonize the skeleton by homing to specific niches, but the involvement of osteoblasts in tumour cell seeding, colonization, and…”
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iTRAQ identification of candidate serum biomarkers associated with metastatic progression of human prostate cancer by Rehman, Ishtiaq, Evans, Caroline A, Glen, Adam, Cross, Simon S, Eaton, Colby L, Down, Jenny, Pesce, Giancarlo, Phillips, Joshua T, Yen, Ow Saw, Thalmann, George N, Wright, Phillip C, Hamdy, Freddie C

“…A major challenge in the management of patients with prostate cancer is identifying those individuals at risk of developing metastatic disease, as in most…”
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Evaluation of the frequency of putative prostate cancer stem cells in primary and metastatic prostate cancer by Eaton, Colby L., Colombel, Marc, van der Pluijm, Gabri, Cecchini, Marco, Wetterwald, Antoinette, Lippitt, Jenny, Rehman, Ishtiaq, Hamdy, Freddie, Thalman, George

“…BACKGROUND Tumour cells with a stem cell‐like phenotype have recently been identified in prostate tumors and it has been suggested that this population may be…”
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Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche by Lawson, Michelle A., McDonald, Michelle M., Kovacic, Natasa, Hua Khoo, Weng, Terry, Rachael L., Down, Jenny, Kaplan, Warren, Paton-Hough, Julia, Fellows, Clair, Pettitt, Jessica A., Neil Dear, T., Van Valckenborgh, Els, Baldock, Paul A., Rogers, Michael J., Eaton, Colby L., Vanderkerken, Karin, Pettit, Allison R., Quinn, Julian M. W., Zannettino, Andrew C. W., Phan, Tri Giang, Croucher, Peter I.

“…Multiple myeloma is largely incurable, despite development of therapies that target myeloma cell-intrinsic pathways. Disease relapse is thought to originate…”
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Zoledronic Acid Has Differential Antitumor Activity in the Pre- and Postmenopausal Bone Microenvironment In Vivo by OTTEWELL, Penelope D, NING WANG, BROWN, Hannah K, REEVES, Kimberly J, FOWLES, C. Anne, CROUCHED, Peter I, EATON, Colby L, HOLEN, Ingunn

“…Clinical trials in early breast cancer have suggested that benefits of adjuvant bone-targeted treatments are restricted to women with established menopause. We…”
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Prostate Cancer Cells Preferentially Home to Osteoblast‐rich Areas in the Early Stages of Bone Metastasis: Evidence From In Vivo Models by Wang, Ning, Docherty, Freyja E, Brown, Hannah K, Reeves, Kimberley J, Fowles, Anne CM, Ottewell, Penelope D, Dear, T Neil, Holen, Ingunn, Croucher, Peter I, Eaton, Colby L

“…ABSTRACT It has been suggested that metastasis‐initiating cells gain a foothold in bone by homing to a metastastatic microenvironment (or “niche”). Whereas the…”
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OPG‐Fc inhibits ovariectomy‐induced growth of disseminated breast cancer cells in bone by Ottewell, Penelope D., Wang, Ning, Brown, Hannah K., Fowles, C. Anne, Croucher, Peter I., Eaton, Colby L., Holen, Ingunn

“…Dormant disseminated tumour cells can be detected in the bone marrow of breast cancer patients several years after resection of the primary tumour. The…”
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Mitotic quiescence, but not unique “stemness,” marks the phenotype of bone metastasis‐initiating cells in prostate cancer by Wang, Ning, Docherty, Freyja, Brown, Hannah K., Reeves, Kim, Fowles, Anne, Lawson, Michelle, Ottewell, Penelope D., Holen, Ingunn, Croucher, Peter I., Eaton, Colby L.

“…This study aimed to identify subpopulations of prostate cancer cells that are responsible for the initiation of bone metastases. Using rapidly dividing human…”
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Castration-induced bone loss triggers growth of disseminated prostate cancer cells in bone by Ottewell, Penelope D, Wang, Ning, Meek, Joshua, Fowles, C Anne, Croucher, Peter I, Eaton, Colby L, Holen, Ingunn

“…Up to 90% of patients with castrate-resistant prostate cancer develop bone metastases, and the majority of these men have received androgen deprivation therapy…”
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Increased expression of putative cancer stem cell markers in primary prostate cancer is associated with progression of bone metastases by Colombel, Marc, Eaton, Colby L., Hamdy, Freddy, Ricci, Estelle, van der Pluijm, Gabri, Cecchini, Marco, Mege-Lechevallier, Florence, Clezardin, Philippe, Thalmann, George

“…BACKGROUND A number of putative stem cell markers have been associated with aggressiveness of prostate cancer, including alpha 2 and alpha 6 integrin and…”
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Increased expression of putative cancer stem cell markers in the bone marrow of prostate cancer patients is associated with bone metastasis progression by Ricci, Estelle, Mattei, Eve, Dumontet, Charles, Eaton, Colby L., Hamdy, Freddy, van der Pluije, Gabri, Cecchini, Marco, Thalmann, George, Clezardin, Philippe, Colombel, Marc

“…BACKGROUND The number of cells positive for the α‐6 and α‐2 integrin subunits and the c‐Met receptor in primary tumors and bone biopsies from prostate cancer…”
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The frequency of osteolytic bone metastasis is determined by conditions of the soil, not the number of seeds; evidence from in vivo models of breast and prostate cancer by Wang, Ning, Reeves, Kimberley J, Brown, Hannah K, Fowles, Anne C M, Docherty, Freyja E, Ottewell, Penelope D, Croucher, Peter I, Holen, Ingunn, Eaton, Colby L

“…While both preclinical and clinical studies suggest that the frequency of growing skeletal metastases is elevated in individuals with higher bone turnover, it…”
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Osteoprotegerin (OPG) is a survival factor for human prostate cancer cells by HOLEN, Ingunn, CROUCHER, Peter I, HAMDY, Freddie C, EATON, Colby L

“…Factors that aid survival of prostate cancer cells in the presence of the various categories of cytotoxic cytokines present in tumors in vivo are largely…”
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iTRAQ-Facilitated Proteomic Analysis of Human Prostate Cancer Cells Identifies Proteins Associated with Progression by Glen, Adam, Gan, Chee S, Hamdy, Freddie C, Eaton, Colby L, Cross, Simon S, Catto, James W. F, Wright, Phillip C, Rehman, Ishtiaq

“…The unpredictable behavior of prostate cancer presents a major clinical challenge during patient management. In order to gain an insight into the molecular…”
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Prostate cancer cells home to bone using a novel in vivo model: Modulation by the integrin antagonist GLPG0187 by Reeves, Kimberley J., Hurrell, Jack E., Cecchini, Marco, van der Pluijm, Gabri, Down, Jenny M., Eaton, Colby L., Hamdy, Freddie, Clement‐Lacroix, Philippe, Brown, Nicola J.

“…Micrometastasis is a barrier to the development of effective cancer therapies for prostate cancer metastasis to bone. The mechanisms remain incompletely…”
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The BMP antagonist Noggin is produced by osteoblasts in response to the presence of prostate cancer cells by AlShaibi, Huda F., Ahmed, Farid, Buckle, Clive, Fowles, Ann C.M., Awlia, Jalaluddin, Cecchini, Marco G., Eaton, Colby L.

“…Bone metastasis is a key event responsible for morbidity in prostate cancer patients. Interactions between prostate cancer cells and the bone microenvironment…”
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Eight-plex iTRAQ analysis of variant metastatic human prostate cancer cells identifies candidate biomarkers of progression: An exploratory study by Glen, Adam, Evans, Caroline A., Gan, Chee S., Cross, Simon S., Hamdy, Freddie C., Gibbins, Jonathan, Lippitt, Jenny, Eaton, Colby L., Noirel, Josselin, Wright, Phillip C., Rehman, Ishtiaq

“…BACKGROUND Due to the heterogeneity in the biological behavior of prostate cancer, biomarkers that can reliably distinguish indolent from aggressive disease…”
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Osteoprotegerin (OPG) expression by breast cancer cells in vitro and breast tumours in vivo : a role in tumour cell survival? by HOLEN, Ingunn, CROSS, Simon S, NEVILLE-WEBBE, Helen L, CROSS, Neil A, BALASUBRAMANIAN, Sabapathy P, CROUCHER, Peter I, EVANS, C. Alyson, LIPPITT, Jennifer M, COLEMAN, Robert E, EATON, Colby L

“…In addition to its role in bone turnover, osteoprotegerin (OPG) has been reported to bind to and inhibit Tumour necrosis factor-related apoptosis inducing…”
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Human Bone Marrow Stromal Cells Protect Prostate Cancer Cells From TRAIL‐Induced Apoptosis by Nyambo, Rachel, Cross, Neil, Lippitt, Jenny, Holen, Ingunn, Bryden, Gorden, Hamdy, Freddie C, Eaton, Colby L

“…Tumor‐derived OPG has recently been shown to protect prostate cancer cells from apoptosis. This study has confirmed that bone marrow stromal cell‐derived OPG…”
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