Search Results - "Eaton, Brett P."
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Sangivamycin is highly effective against SARS-CoV-2 in vitro and has favorable drug properties
Published in JCI insight (11-01-2022)“…Sangivamycin is a nucleoside analog that is well tolerated by humans and broadly active against phylogenetically distinct viruses, including arenaviruses,…”
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Proteomic Analysis of Non-human Primate Peripheral Blood Mononuclear Cells During Burkholderia mallei Infection Reveals a Role of Ezrin in Glanders Pathogenesis
Published in Frontiers in microbiology (22-04-2021)“…, the causative agent of glanders, is a gram-negative intracellular bacterium. Depending on different routes of infection, the disease is manifested by…”
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Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430
Published in Nature (London) (17-04-2014)“…A broad-spectrum antiviral small molecule is reported to act as an inhibitor of viral polymerase activity and is shown to be effective in protecting non-human…”
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Recent successes in therapeutics for Ebola virus disease: no time for complacency
Published in The Lancet infectious diseases (01-09-2020)“…The PALM trial in the Democratic Republic of the Congo identified a statistically significant survival benefit for two monoclonal antibody-based therapeutics…”
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IK1 Heterogeneity Affects Genesis and Stability of Spiral Waves in Cardiac Myocyte Monolayers
Published in Circulation research (13-02-2009)“…Previous studies have postulated an important role for the inwardly rectifying potassium current (IK1) in controlling the dynamics of electrophysiological…”
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A high-content imaging assay for the quantification of the Burkholderia pseudomallei induced multinucleated giant cell (MNGC) phenotype in murine macrophages
Published in BMC microbiology (22-04-2014)“…Burkholderia pseudomallei (Bp), a Gram-negative, motile, facultative intracellular bacterium is the causative agent of melioidosis in humans and animals. The…”
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I K1 Heterogeneity Affects Genesis and Stability of Spiral Waves in Cardiac Myocyte Monolayers
Published in Circulation research (13-02-2009)“…Previous studies have postulated an important role for the inwardly rectifying potassium current ( I K1 ) in controlling the dynamics of electrophysiological…”
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Abstract 1349: Overexpression And Dominant-negative Suppression Of Inwardly Rectifying Potassium Channel Protein (Kir2.1) Alters Electrophysiology And Spiral Wave Dynamics Of An In Vitro Model Of Cardiac Myocytes
Published in Circulation (New York, N.Y.) (16-10-2007)“…Abstract only Introduction : An important role for the inwardly rectifying potassium current (I K1 ) has been postulated in controlling the stability and…”
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