Search Results - "Eastwood, Paul"

Predicting the distributions of marine organisms at the global scale by Ready, Jonathan, Kaschner, Kristin, South, Andy B., Eastwood, Paul D., Rees, Tony, Rius, Josephine, Agbayani, Eli, Kullander, Sven, Froese, Rainer

“…We present and evaluate AquaMaps, a presence-only species distribution modelling system that allows the incorporation of expert knowledge about habitat usage…”
Get full text

Modelling Species Distributions Using Regression Quantiles by Vaz, Sandrine, Martin, Corinne S., Eastwood, Paul D., Ernande, Bruno, Carpentier, Andre, Meaden, Geoff J., Coppin, Frank

“…1. Species distribution modelling is an important and well-established tool for conservation planning and resource management. Modelling techniques based on…”
Get full text

Structure–activity relationships (SAR) and structure–kinetic relationships (SKR) of pyrrolopiperidinone acetic acids as CRTh2 antagonists by Andrés, Miriam, Buil, Maria Antonia, Calbet, Marta, Casado, Oscar, Castro, Jordi, Eastwood, Paul R., Eichhorn, Peter, Ferrer, Manel, Forns, Pilar, Moreno, Imma, Petit, Silvia, Roberts, Richard S.

“…Pyrrolopiperidinone acetic acids (PPAs) were identified as highly potent CRTh2 receptor antagonists. In addition, many of these compounds displayed…”
Get full text

Developing best practice for using Marxan to locate Marine Protected Areas in European waters by Smith, Robert J., Eastwood, Paul D., Ota, Yoshitaka, Rogers, Stuart I.

“…Smith, R. J., Eastwood, P. D., Ota, Y., and Rogers, S. I. 2009. Developing best practice for using Marxan to locate Marine Protected Areas in European waters…”
Get full text

Application of a phenotypic drug discovery strategy to identify biological and chemical starting points for inhibition of TSLP production in lung epithelial cells by Orellana, Adelina, García-González, Vicente, López, Rosa, Pascual-Guiral, Sonia, Lozoya, Estrella, Díaz, Julia, Casals, Daniel, Barrena, Antolín, Paris, Stephane, Andrés, Miriam, Segarra, Victor, Vilella, Dolors, Malhotra, Rajneesh, Eastwood, Paul, Planagumà, Anna, Miralpeix, Montserrat, Nueda, Arsenio

“…Thymic stromal lymphopoietin (TSLP) is a cytokine released by human lung epithelium in response to external insult. Considered as a master switch in T helper 2…”
Get full text

Structure–activity relationships (SAR) and structure–kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists III: The role of a hydrogen-bond acceptor in long receptor residence times by Alonso, Juan Antonio, Andrés, Miriam, Bravo, Mónica, Buil, Maria Antonia, Calbet, Marta, Castro, Jordi, Eastwood, Paul R., Esteve, Cristina, Ferrer, Manel, Forns, Pilar, Gómez, Elena, González, Jacob, Lozoya, Estrella, Mir, Marta, Moreno, Imma, Petit, Silvia, Roberts, Richard S., Sevilla, Sara, Vidal, Bernat, Vidal, Laura, Vilaseca, Pere

“…The correct positioning and orientation of an hydrogen bond acceptor (HBA) in the tail portion of the biaryl series of CRTh2 antagonists is a requirement for…”
Get full text

Structure–activity relationships (SAR) and structure–kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists I by Alonso, Juan Antonio, Andrés, Miriam, Bravo, Mónica, Buil, Maria Antonia, Calbet, Marta, Castro, Jordi, Eastwood, Paul R., Eichhorn, Peter, Esteve, Cristina, Gómez, Elena, González, Jacob, Mir, Marta, Petit, Silvia, Roberts, Richard S., Vidal, Bernat, Vidal, Laura, Vilaseca, Pere, Zanuy, Miriam

“…A knowledge-based design strategy led to the discovery of several new series of potent and orally bioavailable CRTh2 antagonists where a bicyclic…”
Get full text

Structure–activity relationships (SAR) and structure–kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists II: Lead optimization by Alonso, Juan Antonio, Andrés, Miriam, Bravo, Mónica, Calbet, Marta, Eastwood, Paul R., Eichhorn, Peter, Esteve, Cristina, Ferrer, Manel, Gómez, Elena, González, Jacob, Mir, Marta, Moreno, Imma, Petit, Silvia, Roberts, Richard S., Sevilla, Sara, Vidal, Bernat, Vidal, Laura, Vilaseca, Pere, Zanuy, Miriam

“…Extensive structure–activity relationship (SAR) and structure–kinetic relationship (SKR) studies in the bicyclic heteroaromatic series of CRTh2 antagonists led…”
Get full text

A versatile synthesis of 4-aryl tetrahydropyridines via palladium mediated Suzuki cross-coupling with cyclic vinyl boronates by Eastwood, Paul R

“…A simple preparation of cyclic vinyl boronates derived from the vinyl triflates of N-protected tetrahydropyridines is described. Suzuki coupling of the…”
Get full text

Modelling spatial variations in spawning habitat suitability for the sole Solea solea using regression quantiles and GIS procedures by EASTWOOD, Paul D, MEADEN, Geoff J, GRIOCHE, Alain

“…In order to quantify spatial variations in spawning habitat suitability for the sole Solea solea, spatial models were developed within a Geographical…”
Get full text

Estimating limits to the spatial extent and suitability of sole ( Solea solea) nursery grounds in the Dover Strait by Eastwood, Paul D, Meaden, Geoff J, Carpentier, André, Rogers, Stuart I

“…There is a growing need for accurate and interpretable maps that describe the spatial extent and suitability of flatfish habitats. A common approach to…”
Get full text

Discovery of LAS101057: A Potent, Selective, and Orally Efficacious A2B Adenosine Receptor Antagonist by Eastwood, Paul, Esteve, Cristina, González, Jacob, Fonquerna, Silvia, Aiguadé, Josep, Carranco, Inés, Doménech, Teresa, Aparici, Mònica, Miralpeix, Montserrat, Albertí, Joan, Córdoba, Mónica, Fernández, Raquel, Pont, Mercè, Godessart, Núria, Prats, Neus, Loza, María Isabel, Cadavid, María Isabel, Nueda, Arsenio, Vidal, Bernat

“…The structure−activity relationships for a series of pyrazine-based A2B adenosine receptor antagonists are described. From this work, LAS101057 (17), a potent,…”
Get full text

Mindful Maturation Matters: The V‐Model as a passport to engagement by Beasley, Richard, Woodcock, Hazel, Eastwood, Paul

“…The purpose of this paper is to explore how awareness and insight from the information associated with a system (requirements, analysis, solution,…”
Get full text

Total Synthesis of (+)-Dactylol via a Novel [3 + 5] Annulation Approach by Molander, Gary A, Eastwood, Paul R

Get full text

[3 + 4] and [3 + 5] Annulation Reactions of .alpha.-(Phenylthio)Dicarbonyl Electrophiles with Bis(trimethylsilyl) Enol Ethers: Synthesis of Highly Functionalized Medium Ring Carbocycles by Molander, Gary A, Eastwood, Paul R

Get full text

Identification of 2‑Imidazopyridine and 2‑Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases by Bach, Jordi, Eastwood, Paul, González, Jacob, Gómez, Elena, Alonso, Juan Antonio, Fonquerna, Silvia, Lozoya, Estrella, Orellana, Adela, Maldonado, Mónica, Calaf, Elena, Albertí, Joan, Pérez, Juan, Andrés, Ana, Prats, Neus, Carreño, Cristina, Calama, Elena, De Alba, Jorge, Calbet, Marta, Miralpeix, Montserrat, Ramis, Isabel

“…Janus kinases (JAKs) have a key role in regulating the expression and function of relevant inflammatory cytokines involved in asthma and chronic obstructive…”
Get full text

Synthesis of Cyclic Bis(trimethysilyl) Enol Ethers and Their [3 + 4] and [3 + 5] Annulation Reactions with Dicarbonyl Electrophiles. Access to Highly Functionalized Tricyclic Ethers Possessing Trans Intrabridgehead Stereochemistry by Molander, Gary A, Bessières, Bernard, Eastwood, Paul R, Noll, Bruce C

“…The synthesis of cyclic bis(trimethylsilyl) enol ethers from cycloalkanone carboxylates is described. The [3 + 4] and [3 + 5] annulation reactions of these…”
Get full text

Chelation and Nonchelation Control in the [3 + 4] and [3 + 5] Annulation Reactions of Benzyloxy-Substituted Dicarbonyl Electrophiles with Bis(trimethylsilyl) Enol Ethers by Molander, Gary A, Eastwood, Paul R

Get full text

Estimating high resolution trawl fishing effort from satellite-based vessel monitoring system data by Mills, Craig M., Townsend, Sunny E., Jennings, Simon, Eastwood, Paul D., Houghton, Carla A.

“…Mills, C. M., Townsend, S. E., Jennings, S., Eastwood, P. D., and Houghton, C. A. 2007. Estimating high resolution trawl fishing effort from satellite-based…”
Get full text

Discovery of N-(5,6-diarylpyridin-2-yl)amide derivatives as potent and selective A2B adenosine receptor antagonists by EASTWOOD, Paul, GONZALEZ, Jacob, PAREDES, Sergio, NUEDA, Arsenio, DOMENECH, Teresa, ALBERTI, Joan, VIDAL, Bernat

Get full text