Search Results - "Eastman, Richard T"

Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria by Eastman, Richard T, Fidock, David A

“…Key Points Malaria has devastating consequences: it strikes over 250 million people worldwide and kills approximately 1 million people each year, many of whom…”
Get full text

Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19 by Eastman, Richard T, Roth, Jacob S, Brimacombe, Kyle R, Simeonov, Anton, Shen, Min, Patnaik, Samarjit, Hall, Matthew D

“…The global pandemic of SARS-CoV-2, the causative viral pathogen of COVID-19, has driven the biomedical community to actionto uncover and develop antiviral…”
Get full text

Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue by Adjalley, Sophie H., Johnston, Geoffrey L., Li, Tao, Eastman, Richard T., Ekland, Eric H., Eappen, Abraham G., Richman, Adam, Sim, B. Kim Lee, Lee, Marcus C. S., Hoffman, Stephen L., Fidock, David A.

“…Clinical studies and mathematical models predict that, to achieve malaria elimination, combination therapies will need to incorporate drugs that block the…”
Get full text

Supergenomic Network Compression and the Discovery of EXP1 as a Glutathione Transferase Inhibited by Artesunate by Lisewski, Andreas Martin, Quiros, Joel P., Ng, Caroline L., Adikesavan, Anbu Karani, Miura, Kazutoyo, Putluri, Nagireddy, Eastman, Richard T., Scanfeld, Daniel, Regenbogen, Sam J., Altenhofen, Lindsey, Llinás, Manuel, Sreekumar, Arun, Long, Carole, Fidock, David A., Lichtarge, Olivier

“…A central problem in biology is to identify gene function. One approach is to infer function in large supergenomic networks of interactions and ancestral…”
Get full text

Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2 by Chen, Catherine Z, Shinn, Paul, Itkin, Zina, Eastman, Richard T, Bostwick, Robert, Rasmussen, Lynn, Huang, Ruili, Shen, Min, Hu, Xin, Wilson, Kelli M, Brooks, Brianna M, Guo, Hui, Zhao, Tongan, Klump-Thomas, Carleen, Simeonov, Anton, Michael, Samuel G, Lo, Donald C, Hall, Matthew D, Zheng, Wei

“…Drug repurposing is a rapid approach to identify therapeutics for the treatment of emerging infectious diseases such as COVID-19. To address the urgent need…”
Get full text

Piperaquine Resistance Is Associated with a Copy Number Variation on Chromosome 5 in Drug-Pressured Plasmodium falciparum Parasites by EASTMAN, Richard T, DHARIA, Neekesh V, WINZELER, Elizabeth A, FIDOCK, David A

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

A systematic and prospectively validated approach for identifying synergistic drug combinations against malaria by KalantarMotamedi, Yasaman, Eastman, Richard T, Guha, Rajarshi, Bender, Andreas

“…Nearly half of the world's population (3.2 billion people) were at risk of malaria in 2015, and resistance to current therapies is a major concern. While the…”
Get full text

A platform of assays for the discovery of anti-Zika small-molecules with activity in a 3D-bioprinted outer-blood-retina model by Dorjsuren, Dorjbal, Eastman, Richard T, Song, Min Jae, Yasgar, Adam, Chen, Yuchi, Bharti, Kapil, Zakharov, Alexey V, Jadhav, Ajit, Ferrer, Marc, Shi, Pei-Yong, Simeonov, Anton

“…The global health emergency posed by the outbreak of Zika virus (ZIKV), an arthropod-borne flavivirus causing severe neonatal neurological conditions, has…”
Get full text

High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations by Mott, Bryan T., Eastman, Richard T., Guha, Rajarshi, Sherlach, Katy S., Siriwardana, Amila, Shinn, Paul, McKnight, Crystal, Michael, Sam, Lacerda-Queiroz, Norinne, Patel, Paresma R., Khine, Pwint, Sun, Hongmao, Kasbekar, Monica, Aghdam, Nima, Fontaine, Shaun D., Liu, Dongbo, Mierzwa, Tim, Mathews-Griner, Lesley A., Ferrer, Marc, Renslo, Adam R., Inglese, James, Yuan, Jing, Roepe, Paul D., Su, Xin-zhuan, Thomas, Craig J.

“…Drug resistance in Plasmodium parasites is a constant threat. Novel therapeutics, especially new drug combinations, must be identified at a faster rate. In…”
Get full text

Using Machine Learning to Predict Synergistic Antimalarial Compound Combinations With Novel Structures by Mason, Daniel J, Eastman, Richard T, Lewis, Richard P I, Stott, Ian P, Guha, Rajarshi, Bender, Andreas

“…The parasite is the most lethal species of Plasmodium to cause serious malaria infection in humans, and with resistance developing rapidly novel treatment…”
Get full text

PfCRT and PfMDR1 modulate interactions of artemisinin derivatives and ion channel blockers by Eastman, Richard T., Khine, Pwint, Huang, Ruili, Thomas, Craig J., Su, Xin-zhuan

“…Treatment of the symptomatic asexual stage of Plasmodium falciparum relies almost exclusively on artemisinin (ART) combination therapies (ACTs) in endemic…”
Get full text

Mechanism of splenic cell death and host mortality in a Plasmodium yoelii malaria model by Lacerda-Queiroz, Norinne, Riteau, Nicolas, Eastman, Richard T., Bock, Kevin W., Orandle, Marlene S., Moore, Ian N., Sher, Alan, Long, Carole A., Jankovic, Dragana, Su, Xin-zhuan

“…Malaria is a fatal disease that displays a spectrum of symptoms and severity, which are determined by complex host-parasite interactions. It has been difficult…”
Get full text

Rapid-response RNA-fluorescence in situ hybridization (FISH) assay platform for coronavirus antiviral high-throughput screening by Chan, Ryan, Mugisha, Christian Shema, Chuenchob, Vorada, Moquin, Stephanie A., Manjunatha, Ujjini H., Jarrousse, Nadine, Menachery, Vineet D., Xie, Xuping, Flannery, Erika L., Eastman, Richard T.

“…Over the past 25 years, the global community has faced challenges posed by three distinct outbreaks of coronaviruses including severe acute respiratory…”
Get full text

A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence by Nair, Sethu C., Xu, Ruixue, Pattaradilokrat, Sittiporn, Wu, Jian, Qi, Yanwei, Zilversmit, Martine, Ganesan, Sundar, Nagarajan, Vijayaraj, Eastman, Richard T., Orandle, Marlene S., Tan, John C., Myers, Timothy G., Liu, Shengfa, Long, Carole A., Li, Jian, Su, Xin-zhuan

“…Infection of mice with strains of Plasmodium yoelii parasites can result in different pathology, but molecular mechanisms to explain this variation are…”
Get full text

Recent highlights in antimalarial drug resistance and chemotherapy research by Fidock, David A, Eastman, Richard T, Ward, Stephen A, Meshnick, Steven R

“…This review summarizes recent investigations into antimalarial drug resistance and chemotherapy, including reports of some of the many exciting talks and…”
Get full text

Ex Vivo Susceptibility of Plasmodium falciparum to Antimalarial Drugs in Western, Northern, and Eastern Cambodia, 2011-2012: Association with Molecular Markers by LIM, Pharath, DEK, Dalin, ASHLEY, Elizabeth A, MIOTTO, Olivo, DONDORP, Arjen M, WHITE, Nicholas J, SU, Xin-Zhuan, MENG CHUOR CHAR, ANDERSON, Jennifer M, AMARATUNGA, Chanaki, MENARD, Didier, FAIRHURST, Rick M, TRY, Vorleak, EASTMAN, Richard T, CHY, Sophy, SRENG, Sokunthea, SUON, Seila, MAO, Sivanna, SOPHA, Chantha, SAM, Baramey

“…OA  Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

A Class of Tricyclic Compounds Blocking Malaria Parasite Oocyst Development and Transmission by EASTMAN, Richard T, PATTARADILOKRAT, Sittiporn, RUILI HUANG, WILLIAMSON, Kim C, LAMBERT, Lynn E, LONG, Carole, AUSTIN, Christopher P, YIMIN WU, SU, Xin-Zhuan, RAJ, Dipak K, DIXIT, Saurabh, BINGBING DENG, MIURA, Kazutoyo, JING YUAN, TANAKA, Takeshi Q, JOHNSON, Ronald L, HONGYING JIANG

“…OA  Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Deep learning identifies synergistic drug combinations for treating COVID-19 by Jin, Wengong, Stokes, Jonathan M., Eastman, Richard T., Itkin, Zina, Zakharov, Alexey V., Collins, James J., Jaakkola, Tommi S., Barzilay, Regina

“…Effective treatments for COVID-19 are urgently needed. However, discovering single-agent therapies with activity against severe acute respiratory syndrome…”
Get full text

Correction to Remdesivir: A Review of Its Discovery and Development Leading to Human Clinical Trials for Treatment of COVID-19 by Eastman, Richard T, Roth, Jacob S, Brimacombe, Kyle R, Simeonov, Anton, Shen, Min, Patnaik, Samarjit, Hall, Matthew D

Get full text

Regulation of Plasmodium yoelii oocyst development by strain- and stage-specific small-subunit rRNA by Qi, Yanwei, Zhu, Feng, Eastman, Richard T, Fu, Young, Zilversmit, Martine, Pattaradilokrat, Sittiporn, Hong, Lingxian, Liu, Shengfa, McCutchan, Thomas F, Pan, Weiqing, Xu, Wenyue, Li, Jian, Huang, Fusheng, Su, Xin-zhuan

“…One unique feature of malaria parasites is the differential transcription of structurally distinct rRNA (rRNA) genes at different developmental stages: the…”
Get full text