Search Results - "Easley, Charles A"

Energy metabolism in human pluripotent stem cells and their differentiated counterparts by Varum, Sandra, Rodrigues, Ana S, Moura, Michelle B, Momcilovic, Olga, Easley, 4th, Charles A, Ramalho-Santos, João, Van Houten, Bennett, Schatten, Gerald

“…Human pluripotent stem cells have the ability to generate all cell types present in the adult organism, therefore harboring great potential for the in vitro…”
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Direct Differentiation of Human Pluripotent Stem Cells into Haploid Spermatogenic Cells by Easley, Charles A., Phillips, Bart T., McGuire, Megan M., Barringer, Jennifer M., Valli, Hanna, Hermann, Brian P., Simerly, Calvin R., Rajkovic, Aleksander, Miki, Toshio, Orwig, Kyle E., Schatten, Gerald P.

“…Human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) have been shown to differentiate into primordial germ cells (PGCs) but not into…”
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Implications of testicular ACE2 and the renin–angiotensin system for SARS-CoV-2 on testis function by Edenfield, R. Clayton, Easley, Charles A.

“…Although many studies have focused on SARS-CoV-2 infection in the lungs, comparatively little is known about the potential effects of the virus on male…”
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Spermatozoan Metabolism as a Non-Traditional Model for the Study of Huntington’s Disease by Lawlor, Meghan, Zigo, Michal, Kerns, Karl, Cho, In Ki, Easley IV, Charles A., Sutovsky, Peter

“…Huntington’s Disease (HD) is a fatal autosomal dominant neurodegenerative disease manifested through motor dysfunction and cognitive deficits. Decreased…”
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The dynamic expression of YAP is essential for the development of male germ cells derived from human embryonic stem cells by Khampang, Sujittra, Lorthongpanich, Chanchao, Laowtammathron, Chuti, Klaihmon, Phatchanat, Meesa, Sukanya, Suksomboon, Wichuda, Jiamvoraphong, Nittaya, Kheolamai, Pakpoom, Luanpitpong, Sudjit, Easley, Charles A., Mahyari, Eisa, Issaragrisil, Surapol

“…YAP plays a vital role in controlling growth and differentiation in various cell lineages. Although the expression of YAP in mice testicular and spermatogenic…”
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Recent Developments in In Vitro Spermatogenesis and Future Directions by Cho, In Ki, Easley, Charles A.

“…Recent developments in stem cell technologies have made significant advancements in the field of in vitro gametogenesis. In vitro gametogenesis (IVG) is a…”
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Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia by Holler, Christopher J, Taylor, Georgia, McEachin, Zachary T, Deng, Qiudong, Watkins, William J, Hudson, Kathryn, Easley, Charles A, Hu, William T, Hales, Chadwick M, Rossoll, Wilfried, Bassell, Gary J, Kukar, Thomas

“…Progranulin (PGRN) is a secreted growth factor important for neuronal survival and may do so, in part, by regulating lysosome homeostasis. Mutations in the…”
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Inheritance of paternal lifestyles and exposures through sperm DNA methylation by Greeson, Katherine W., Crow, Krista M. S., Edenfield, R. Clayton, Easley, Charles A.

“…Many different lifestyle factors and chemicals present in the environment are a threat to the reproductive tracts of humans. The potential for parental…”
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Prenatal delta-9-tetrahydrocannabinol exposure is associated with changes in rhesus macaque DNA methylation enriched for autism genes by Shorey-Kendrick, Lyndsey E, Roberts, Victoria H J, D'Mello, Rahul J, Sullivan, Elinor L, Murphy, Susan K, Mccarty, Owen J T, Schust, Danny J, Hedges, Jason C, Mitchell, A J, Terrobias, Jose Juanito D, Easley, 4th, Charles A, Spindel, Eliot R, Lo, Jamie O

“…With the growing availability of cannabis and the popularization of additional routes of cannabis use beyond smoking, including edibles, the prevalence of…”
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Detrimental effects of flame retardant, PBB153, exposure on sperm and future generations by Greeson, Katherine Watkins, Fowler, Kristen L., Estave, Paige M., Kate Thompson, S., Wagner, Chelsea, Clayton Edenfield, R., Symosko, Krista M., Steves, Alyse N., Marder, Elizabeth M., Terrell, Metrecia L., Barton, Hillary, Koval, Michael, Marcus, Michele, Easley, Charles A.

“…In 1973, the Velsicol Chemical Company, which manufactured FireMaster, a brominated flame retardant, and NutriMaster, a nutritional supplement, mistakenly…”
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Chronic exposure to delta-9-tetrahydrocannabinol impacts testicular volume and male reproductive health in rhesus macaques by Hedges, Jason C., Hanna, Carol B., Bash, Jasper C., Boniface, Emily R., Burch, Fernanda C., Mahalingaiah, Shruthi, Roberts, Victoria H.J., Terrobias, Juanito Jose D., Mishler, Emily C., Jensen, Jared V., Easley, Charles A., Lo, Jamie O.

“…To determine the dose-dependent effect of delta-9-tetrahydrocannabinol (THC) exposure on male testes and reproductive health in a nonhuman primate model…”
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Stem cell therapeutic possibilities: future therapeutic options for male-factor and female-factor infertility? by Easley, Charles A, Simerly, Calvin R, Schatten, Gerald

“…Abstract Recent advances in assisted reproduction treatment have enabled some couples with severe infertility issues to conceive, but the methods are not…”
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Influence of substance use on male reproductive health and offspring outcomes by Lo, Jamie O., Hedges, Jason C., Chou, Wesley H., Tager, Kylie R., Bachli, Ian D., Hagen, Olivia L., Murphy, Susan K., Hanna, Carol B., Easley, Charles A.

“…The prevalence of substance use globally is rising and is highest among men of reproductive age. In Africa, and South and Central America, cannabis use…”
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Cannabis and Pregnancy: A Review by Hayer, Sarena, Mandelbaum, Ava D., Watch, Lester, Ryan, Kimberly S., Hedges, Madeline A., Manuzak, Jennifer A., Easley, Charles A., Schust, Danny J., Lo, Jamie O.

“…Prenatal cannabis use is rising and is a major public health issue. Cannabis use in pregnancy and during lactation has been associated with increased maternal…”
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Cannabis alters DNA methylation at maternally imprinted and autism candidate genes in spermatogenic cells by Schrott, Rose, Greeson, Katherine W., King, Dillon, Symosko Crow, Krista M., Easley, Charles A., Murphy, Susan K.

“…Cannabis use in the United States is increasing, with highest consumption among men at their peak reproductive years. We previously demonstrated widespread…”
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Microscale Generation of Cardiospheres Promotes Robust Enrichment of Cardiomyocytes Derived from Human Pluripotent Stem Cells by Nguyen, Doan C., Hookway, Tracy A., Wu, Qingling, Jha, Rajneesh, Preininger, Marcela K., Chen, Xuemin, Easley, Charles A., Spearman, Paul, Deshpande, Shriprasad R., Maher, Kevin, Wagner, Mary B., McDevitt, Todd C., Xu, Chunhui

“…Cardiomyocytes derived from human pluripotent stem cells (hPSCs) are a promising cell source for regenerative medicine, disease modeling, and drug discovery,…”
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Suppression of trinucleotide repeat expansion in spermatogenic cells in Huntington’s disease by Cho, In K., Easley, Charles A., Chan, Anthony W. S.

“…Trinucleotide repeats (TNRs) are dispersed throughout the human genome. About 20 loci are related to human diseases, such as Huntington’s disease (HD). A…”
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Cessation of chronic delta-9-tetrahydrocannabinol use partially reverses impacts on male fertility and the sperm epigenome in rhesus macaques by Hedges, Jason C., Hanna, Carol B., Shorey-Kendrick, Lyndsey E., Boniface, Emily R., Bash, Jasper C., Rice-Stitt, Travis L., Burch, Fernanda C., D’Mello, Rahul, Morgan, Terry K., Lima, Ana Cristina, Terrobias, Juanito Jose D., Graham, Jason A., Mishler, Emily C., Jensen, Jared V., Hagen, Olivia L., Urian, J. Wes, Spindel, Eliot R., Easley, Charles A., Murphy, Susan K., Lo, Jamie O.

“…To determine whether discontinuation of delta-9-tetrahydrocannabinol (THC) use mitigates THC-associated changes in male reproductive health using a rhesus…”
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Chronic alcohol use primes bronchial cells for altered inflammatory response and barrier dysfunction during SARS-CoV-2 infection by Easley, Kristen F, Edenfield, R Clayton, Lott, Megan E J, Reed, Ryan C, Das Sarma, Jayasri, Mehta, Ashish J, Staitieh, Bashar S, Lipp, Erin K, Cho, In Ki, Johnson, Scott K, Jones, Cheryl A, Bebin-Blackwell, Anne-Gaelle, Levy, Joshua M, Tompkins, S Mark, Easley, 4th, Charles A, Koval, Michael

“…Alcohol use disorder (AUD) is a significant public health concern and people with AUD are more likely to develop severe acute respiratory distress syndrome…”
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mTOR-mediated activation of p70 S6K induces differentiation of pluripotent human embryonic stem cells by Easley, 4th, Charles A, Ben-Yehudah, Ahmi, Redinger, Carrie J, Oliver, Stacie L, Varum, Sandra T, Eisinger, Vonya M, Carlisle, Diane L, Donovan, Peter J, Schatten, Gerald P

“…Deciding to exit pluripotency and undergo differentiation is of singular importance for pluripotent cells, including embryonic stem cells (ESCs). The molecular…”
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