Search Results - "Earnshaw, C."

The Centromere: Chromatin Foundation for the Kinetochore Machinery by Fukagawa, Tatsuo, Earnshaw, William C.

“…Since discovery of the centromere-specific histone H3 variant CENP-A, centromeres have come to be defined as chromatin structures that establish the assembly…”
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The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis by Carmena, Mar, Wheelock, Michael, Funabiki, Hironori, Earnshaw, William C.

“…Key Points The chromosomal passenger complex (CPC) is a 'master controller' of cell division that is formed by a kinase module (Aurora B kinase) and a…”
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Chromosomal passengers: conducting cell division by Earnshaw, William C, Ruchaud, Sandrine, Carmena, Mar

“…Mitosis and meiosis are remarkable processes during which cells undergo profound changes in their structure and physiology. These events are orchestrated with…”
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A pathway for mitotic chromosome formation by Gibcus, Johan H, Samejima, Kumiko, Goloborodko, Anton, Samejima, Itaru, Naumova, Natalia, Nuebler, Johannes, Kanemaki, Masato T, Xie, Linfeng, Paulson, James R, Earnshaw, William C, Mirny, Leonid A, Dekker, Job

“…Mitotic chromosomes fold as compact arrays of chromatin loops. To identify the pathway of mitotic chromosome formation, we combined imaging and Hi-C analysis…”
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Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins by Carmena, Mar, Ruchaud, Sandrine, Earnshaw, William C

“…The conserved Aurora family of protein kinases have emerged as crucial regulators of mitosis and cytokinesis. Despite their high degree of homology, Aurora A…”
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Ki-67 and the Chromosome Periphery Compartment in Mitosis by Booth, Daniel G., Earnshaw, William C.

“…The chromosome periphery is a complex network of proteins and RNA molecules (many derived from nucleoli) that covers the outer surface of chromosomes and whose…”
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Reduction in skin cancer diagnosis, and overall cancer referrals, during the COVID‐19 pandemic by Earnshaw, C.H., Hunter, H.J.A., McMullen, E., Griffiths, C.E.M., Warren, R.B.

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An intrinsic S/G2 checkpoint enforced by ATR by Saldivar, Joshua C, Hamperl Stephan, Bocek, Michael J, Chung, Mingyu, Bass, Thomas E, Cisneros-Soberanis Fernanda, Samejima Kumiko, Xie Linfeng, Paulson, James R, Earnshaw, William C, Cortez, David, Meyer, Tobias, Cimprich, Karlene A

“…An additional cell cycle checkpointCell division is controlled by checkpoints that regulate the temporal order of the cell cycle phases, including the G1/S,…”
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The cellular geography of Aurora kinases by Carmena, Mar, Earnshaw, William C

“…Aurora is the name given to a family of highly conserved protein kinases with essential roles in many aspects of cell division. Yeasts have a single Aurora…”
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Kinetochore dynein is sufficient to biorient chromosomes and remodel the outer kinetochore by Prevo, Bram, Cheerambathur, Dhanya K., Earnshaw, William C., Desai, Arshad

“…Multiple microtubule-directed activities concentrate on mitotic chromosomes to ensure their faithful segregation. These include couplers and dynamics…”
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KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation by Ohzeki, Jun-ichirou, Shono, Nobuaki, Otake, Koichiro, Martins, Nuno M.C., Kugou, Kazuto, Kimura, Hiroshi, Nagase, Takahiro, Larionov, Vladimir, Earnshaw, William C., Masumoto, Hiroshi

“…Centromere chromatin containing histone H3 variant CENP-A is required for accurate chromosome segregation as a foundation for kinetochore assembly. Human…”
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Histone H4 Lys 20 Monomethylation of the CENP-A Nucleosome Is Essential for Kinetochore Assembly by Hori, Tetsuya, Shang, Wei-Hao, Toyoda, Atsushi, Misu, Sadahiko, Monma, Norikazu, Ikeo, Kazuho, Molina, Oscar, Vargiu, Giulia, Fujiyama, Asao, Kimura, Hiroshi, Earnshaw, William C., Fukagawa, Tatsuo

“…In vertebrate cells, centromeres are specified epigenetically through the deposition of the centromere-specific histone CENP-A. Following CENP-A deposition,…”
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CENP-B creates alternative epigenetic chromatin states permissive for CENP-A or heterochromatin assembly by Otake, Koichiro, Ohzeki, Jun-Ichirou, Shono, Nobuaki, Kugou, Kazuto, Okazaki, Koei, Nagase, Takahiro, Yamakawa, Hisashi, Kouprina, Natalay, Larionov, Vladimir, Kimura, Hiroshi, Earnshaw, William C, Masumoto, Hiroshi

“…CENP-B binds to CENP-B boxes on centromeric satellite DNAs (known as alphoid DNA in humans). CENP-B maintains kinetochore function through interactions with…”
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Trashing the genome: the role of nucleases during apoptosis by Earnshaw, William C, Samejima, Kumiko

“…Two classes of nucleases degrade the cellular DNA during apoptosis. Cell-autonomous nucleases cleave DNA within the dying cell. They are not essential for…”
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Breaking the HAC Barrier: Histone H3K9 acetyl/methyl balance regulates CENP-A assembly by Ohzeki, Jun-ichirou, Bergmann, Jan H, Kouprina, Natalay, Noskov, Vladimir N, Nakano, Megumi, Kimura, Hiroshi, Earnshaw, William C, Larionov, Vladimir, Masumoto, Hiroshi

“…The kinetochore is responsible for accurate chromosome segregation. However, the mechanism by which kinetochores assemble and are maintained remains unclear…”
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The intrinsically disorderly story of Ki-67 by Remnant, Lucy, Kochanova, Natalia Y, Reid, Caitlin, Cisneros-Soberanis, Fernanda, Earnshaw, William C

“…Ki-67 is one of the most famous marker proteins used by histologists to identify proliferating cells. Indeed, over 30 000 articles referring to Ki-67 are…”
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Common Fragile Sites Are Characterized by Faulty Condensin Loading after Replication Stress by Boteva, Lora, Nozawa, Ryu-Suke, Naughton, Catherine, Samejima, Kumiko, Earnshaw, William C., Gilbert, Nick

“…Cells coordinate interphase-to-mitosis transition, but recurrent cytogenetic lesions appear at common fragile sites (CFSs), termed CFS expression, in a…”
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Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance by Molina, Oscar, Vargiu, Giulia, Abad, Maria Alba, Zhiteneva, Alisa, Jeyaprakash, A. Arockia, Masumoto, Hiroshi, Kouprina, Natalay, Larionov, Vladimir, Earnshaw, William C.

“…Centromeres consist of specialized centrochromatin containing CENP-A nucleosomes intermingled with H3 nucleosomes carrying transcription-associated…”
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Chromosome Engineering Allows the Efficient Isolation of Vertebrate Neocentromeres by Shang, Wei-Hao, Hori, Tetsuya, Martins, Nuno M.C., Toyoda, Atsushi, Misu, Sadahiko, Monma, Norikazu, Hiratani, Ichiro, Maeshima, Kazuhiro, Ikeo, Kazuho, Fujiyama, Asao, Kimura, Hiroshi, Earnshaw, William C., Fukagawa, Tatsuo

“…Centromeres are specified by sequence-independent epigenetic mechanisms in most organisms. Rarely, centromere repositioning results in neocentromere formation…”
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Two Interlinked Bistable Switches Govern Mitotic Control in Mammalian Cells by Rata, Scott, Suarez Peredo Rodriguez, Maria F., Joseph, Stephy, Peter, Nisha, Echegaray Iturra, Fabio, Yang, Fengwei, Madzvamuse, Anotida, Ruppert, Jan G., Samejima, Kumiko, Platani, Melpomeni, Alvarez-Fernandez, Monica, Malumbres, Marcos, Earnshaw, William C., Novak, Bela, Hochegger, Helfrid

“…Distinct protein phosphorylation levels in interphase and M phase require tight regulation of Cdk1 activity [1, 2]. A bistable switch, based on positive…”
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