Search Results - "Early, Julie V"
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A rapid, low pH, nutrient stress, assay to determine the bactericidal activity of compounds against non-replicating Mycobacterium tuberculosis
Published in PloS one (07-10-2019)“…There is an urgent need for new anti-tubercular agents which can lead to a shortened treatment time by targeting persistent or non-replicating bacilli. In…”
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Journal Article -
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Synthesis and Evaluation of the 2-Aminothiazoles as Anti-Tubercular Agents
Published in PloS one (12-05-2016)“…The 2-aminothiazole series has anti-bacterial activity against the important global pathogen Mycobacterium tuberculosis. We explored the nature of the activity…”
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Journal Article -
3
Virulence Phenotypes of Legionella pneumophila Associated with Noncoding RNA lpr0035
Published in Infection and Immunity (01-12-2012)“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Journal Article -
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Novel Trifluoromethyl Pyrimidinone Compounds With Activity Against Mycobacterium tuberculosis
Published in Frontiers in chemistry (29-04-2021)“…The identification and development of new anti-tubercular agents are a priority research area. We identified the trifluoromethyl pyrimidinone series of…”
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Journal Article -
5
In Vitro Evaluation of Novel Nitazoxanide Derivatives against Mycobacterium tuberculosis
Published in ACS omega (30-09-2017)“…Nitazoxanide has antiparasitic and antibiotic activities including activity against Mycobacterium tuberculosis. We prepared and evaluated a set of its…”
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Journal Article -
6
The relevance of persisters in tuberculosis drug discovery
Published in Microbiology (Society for General Microbiology) (01-05-2019)“…Bacterial persisters are a subpopulation of cells that exhibit phenotypic resistance during exposure to a lethal dose of antibiotics. They are difficult to…”
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Correction for Shelton et al., “Deletion of Rv2571c Confers Resistance to Arylamide Compounds in Mycobacterium tuberculosis”
Published in Antimicrobial agents and chemotherapy (16-08-2022)Get full text
Journal Article -
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Deletion of Rv2571c confers resistance to arylamide compounds in Mycobacterium tuberculosis
Published in Antimicrobial agents and chemotherapy (19-04-2021)“…Tuberculosis, caused by , is an urgent global health problem requiring new drugs, new drug targets and an increased understanding of antibiotic resistance. We…”
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Journal Article -
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Imidazopyridine Compounds Inhibit Mycobacterial Growth by Depleting ATP Levels
Published in Antimicrobial agents and chemotherapy (01-06-2018)“…The imidazopyridines are a promising new class of antitubercular agents with potent activity and We isolated mutants of resistant to a representative…”
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Journal Article -
10
8‐Hydroxyquinolines are bactericidal against Mycobacterium tuberculosis
Published in Drug development research (01-08-2019)“…ABSTRACT There is an urgent need for new treatments effective against Mycobacterium tuberculosis, the causative agent of tuberculosis. The 8‐hydroxyquinoline…”
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Journal Article -
11
Identification of Phenoxyalkylbenzimidazoles with Antitubercular Activity
Published in Journal of medicinal chemistry (24-09-2015)“…We conducted an evaluation of the phenoxyalkylbenzimidazole series based on the exemplar 2-ethyl-1-(3-phenoxypropyl)-1H-benzo[d]imidazole for its…”
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Journal Article -
12
Oxadiazoles Have Butyrate-Specific Conditional Activity against Mycobacterium tuberculosis
Published in Antimicrobial agents and chemotherapy (01-06-2016)“…Mycobacterium tuberculosis is a global pathogen of huge importance which can adapt to several host niche environments in which carbon source availability is…”
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Journal Article -
13
Mycobacterium tuberculosis Rv0560c is not essential for growth in vitro or in macrophages
Published in Tuberculosis (Edinburgh, Scotland) (01-01-2017)“…Abstract Mycobacterium tuberculosis Rv0560c, a putative benzoquinone methyl transferase, is heavily induced in response to salicylate exposure. It has some…”
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Journal Article -
14
Synthesis and biological evaluation of aryl-oxadiazoles as inhibitors of Mycobacterium tuberculosis
Published in Bioorganic & medicinal chemistry letters (01-06-2018)“…[Display omitted] •We conducted SAR for the aryl-oxadiazole series with anti-bacterial activity against Mycobacterium tuberculosis.•Improved compounds have…”
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Journal Article -
15
Molecular and cellular characterization of the intracellular phenotype of Mycobacterium avium
Published 01-01-2009“…Mycobacterium avium cause disseminated disease in immunocompromised people such as AIDS patients. Subsequent to crossing the intestinal epithelium, M. avium…”
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Dissertation -
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Molecular and cellular characterization of the intracellular phenotype of Mycobacterium avium
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Dissertation