Search Results - "Earley, Eric"
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Non-rectangular neurostimulation waveforms elicit varied sensation quality and perceptive fields on the hand
Published in Scientific reports (28-01-2023)“…Electrical stimulation of the nerves is known to elicit distinct sensations perceived in distal parts of the body. The stimulation is typically modulated in…”
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Extra-neural signals from severed nerves enable intrinsic hand movements in transhumeral amputations
Published in Scientific reports (17-06-2022)“…Robotic prostheses controlled by myoelectric signals can restore limited but important hand function in individuals with upper limb amputation. The lack of…”
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Improved control of a prosthetic limb by surgically creating electro-neuromuscular constructs with implanted electrodes
Published in Science translational medicine (12-07-2023)“…Remnant muscles in the residual limb after amputation are the most common source of control signals for prosthetic hands, because myoelectric signals can be…”
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Genetic polymorphisms and expression of Rhesus blood group RHCE are associated with 2,3-bisphosphoglycerate in humans at high altitude
Published in Proceedings of the National Academy of Sciences - PNAS (02-01-2024)“…Red blood cell (RBC) metabolic reprogramming upon exposure to high altitude contributes to physiological human adaptations to hypoxia, a multifaceted process…”
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Wrist speed feedback improves elbow compensation and reaching accuracy for myoelectric transradial prosthesis users in hybrid virtual reaching task
Published in Journal of neuroengineering and rehabilitation (19-01-2023)“…Myoelectric prostheses are a popular choice for restoring motor capability following the loss of a limb, but they do not provide direct feedback to the user…”
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Neurostimulation artifact removal for implantable sensors improves signal clarity and decoding of motor volition
Published in Frontiers in human neuroscience (19-10-2022)“…As the demand for prosthetic limbs with reliable and multi-functional control increases, recent advances in myoelectric pattern recognition and implanted…”
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Cutting Edge Bionics in Highly Impaired Individuals: A Case of Challenges and Opportunities
Published in IEEE transactions on neural systems and rehabilitation engineering (01-01-2024)“…Highly impaired individuals stand to benefit greatly from cutting-edge bionic technology, however concurrent functional deficits may complicate the adaptation…”
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Competitive motivation increased home use and improved prosthesis self-perception after Cybathlon 2020 for neuromusculoskeletal prosthesis user
Published in Journal of neuroengineering and rehabilitation (16-05-2022)“…Assistive technologies, such as arm prostheses, are intended to improve the quality of life of individuals with physical disabilities. However, certain…”
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Extended reality used in the treatment of phantom limb pain: a multicenter, double-blind, randomized controlled trial
Published in Pain (Amsterdam) (05-09-2024)“…Phantom limb pain (PLP) represents a significant challenge after amputation. This study investigated the use of phantom motor execution (PME) and phantom motor…”
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The B7-H3-Targeting Antibody-Drug Conjugate m276-SL-PBD Is Potently Effective Against Pediatric Cancer Preclinical Solid Tumor Models
Published in Clinical cancer research (15-05-2021)“…Patients with relapsed pediatric solid malignancies have few therapeutic options, and many of these patients die of their disease. B7-H3 is an immune…”
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Statistical analysis plan for an international, double-blind, randomized controlled clinical trial on the use of phantom motor execution as a treatment for phantom limb pain
Published in Current controlled trials in cardiovascular medicine (13-02-2022)“…Phantom limb pain (PLP) is a detrimental condition that can greatly diminish the quality of life. Purposeful control over the phantom limb activates the…”
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Joint speed feedback improves myoelectric prosthesis adaptation after perturbed reaches in non amputees
Published in Scientific reports (04-03-2021)“…Accurate control of human limbs involves both feedforward and feedback signals. For prosthetic arms, feedforward control is commonly accomplished by recording…”
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In vivo activity of the dual PI3Kδ and PI3Kγ inhibitor duvelisib against pediatric acute lymphoblastic leukemia xenografts
Published in Pediatric blood & cancer (01-08-2023)“…Background Acute lymphoblastic leukemia (ALL) remains one of the most common causes of cancer‐related mortality in children. Phosphoinositide 3‐kinases (PI3Ks)…”
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A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A
Published in The EMBO journal (02-11-2022)“…Sirtuin 6 (SIRT6) is a deacylase and mono‐ADP ribosyl transferase (mADPr) enzyme involved in multiple cellular pathways implicated in aging and metabolism…”
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Regulation of kynurenine metabolism by blood donor genetics and biology impacts red cell hemolysis in vitro and in vivo
Published in Blood (01-02-2024)“…In the field of transfusion medicine, the clinical relevance of the metabolic markers of the red blood cell (RBC) storage lesion is incompletely understood…”
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A highly integrated bionic hand with neural control and feedback for use in daily life
Published in Science robotics (18-10-2023)“…Restoration of sensorimotor function after amputation has remained challenging because of the lack of human-machine interfaces that provide reliable control,…”
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Genetic regulation of carnitine metabolism controls lipid damage repair and aging RBC hemolysis in vivo and in vitro
Published in Blood (13-06-2024)“…•Carnitine pools in stored human and murine RBCs are regulated by genetic polymorphisms in the SLC22A16 and SLC22A5 transporters.•Carnitine pools fuel the…”
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Biological and genetic determinants of glycolysis: Phosphofructokinase isoforms boost energy status of stored red blood cells and transfusion outcomes
Published in Cell metabolism (03-09-2024)“…Mature red blood cells (RBCs) lack mitochondria and thus exclusively rely on glycolysis to generate adenosine triphosphate (ATP) during aging in vivo or…”
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Comprehensive Surfaceome Profiling to Identify and Validate Novel Cell-Surface Targets in Osteosarcoma
Published in Molecular cancer therapeutics (01-06-2022)“…Immunoconjugates targeting cell-surface antigens have demonstrated clinical activity to enable regulatory approval in several solid and hematologic…”
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