Search Results - "Earley, C J"

Profile of altered brain iron acquisition in restless legs syndrome by CONNOR, James R, PONNURU, Padmavathi, WANG, Xin-Sheng, PATTON, Stephanie M, ALLEN, Richard P, EARLEY, Christopher J

“…Restless legs syndrome is a neurological disorder characterized by an urgency to move the legs during periods of rest. Data from a variety of sources provide a…”
Get full text

MRI measurement of brain iron in patients with restless legs syndrome by ALLEN, R. P, BARKER, P. B, WEHRL, F, SONG, H. K, EARLEY, C. J

“…Brain iron insufficiency in the restless legs syndrome (RLS) has been suggested by a prior CSF study. Using a special MRI measurement (R2'), the authors…”
Get full text

Decreased transferrin receptor expression by neuromelanin cells in restless legs syndrome by CONNOR, J. R, WANG, X. S, PATTON, S. M, MENZIES, S. L, TRONCOSO, J. C, EARLEY, C. J, ALLEN, R. P

“…Restless legs syndrome (RLS) is a sensory-movement disorder affecting 5 to 10% of the population. Its etiology is unknown, but MRI analyses and…”
Get full text

Iron deficiency alters expression of dopamine-related genes in the ventral midbrain in mice by Jellen, L.C, Lu, L, Wang, X, Unger, E.L, Earley, C.J, Allen, R.P, Williams, R.W, Jones, B.C

“…Highlights • Inbred mice show differential gene expression in iron deficiency in brain. • Some of these genes are related to dopamine. • Two new iron/dopamine…”
Get full text

Effects of new PLM scoring rules on PLM rate in relation to sleep and resting wake for RLS and healthy controls by Elena, Hughes, Leslie, Bruni, Skeba, P, Wang, A, Earley, CJ, Allen, RP

“…Purpose This study evaluates the differences in periodic leg movement (PLM) rates for Restless Legs Syndrome (RLS) and healthy controls when using the updated…”
Get full text

Effects of IV iron isomaltoside-1000 treatment on regional brain iron status in an iron-deficient animal by Unger, E.L, Earley, C.J, Thomsen, L.L, Jones, B.C, Allen, R.P

“…Highlights • Murine extra-cellular ventral midbrain (VMB)-free iron increases by 50% in circadian light periods. • Iron-deprived (ID) mice VMB-free iron…”
Get full text

Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome by Connor, J R, Boyer, P J, Menzies, S L, Dellinger, B, Allen, R P, Ondo, W G, Earley, C J

“…To assess neuropathology in individuals with restless legs syndrome (RLS). A standard neuropathologic evaluation was performed on seven brains from individuals…”
Get full text

Subclinical sensory neuropathy in late-onset restless legs syndrome by POLYDEFKIS, M, ALLEN, R. P, HAUER, P, EARLEY, C. J, GRIFFIN, J. W, MCARTHUR, J. C

“…To determine the prevalence of different forms of peripheral neuropathy in patients with restless legs syndrome (RLS) and correlate the findings with other…”
Get full text

Diurnal variations in brain iron concentrations in BXD RI mice by Unger, E.L, Jones, B.C, Bianco, L.E, Allen, R.P, Earley, C.J

“…Highlights • Brain-regional-specific diurnal changes in tissue iron were found in across BXD mice. • Total tissue iron concentration in the ventral midbrain…”
Get full text

Augmentation of the restless legs syndrome with carbidopa/levodopa by ALLEN, R. P, EARLEY, C. J

“…Dopaminergic agents and carbidopa/levodopa have become the preferred treatment for both the restless legs (RL) syndrome and for periodic limb movements in…”
Get full text

Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome by EARLEY, C. J, CONNOR, J. R, BEARD, J. L, MALECKI, E. A, EPSTEIN, D. K, ALLEN, R. P

“…CSF and serum were obtained from 16 patients with idiopathic restless legs syndrome (RLS) and 8 age-matched healthy control subjects. Patients with RLS had…”
Get full text

Increased CSF hypocretin-1 (orexin-A) in restless legs syndrome by ALLEN, R. P, MIGNOT, E, RIPLEY, B, NISHINO, S, EARLEY, C. J

“…Hypocretin-1 levels were increased in evening CSF samples from subjects with restless legs syndrome, indicating altered hypocretin transmission in this sleep…”
Get full text

Pregnancy and the Risk of Stroke by Kittner, Steven J, Stern, Barney J, Feeser, Barbara R, Hebel, J. Richard, Nagey, David A, Buchholz, David W, Earley, Christopher J, Johnson, Constance J, Macko, Richard F, Sloan, Michael A, Wityk, Robert J, Wozniak, Marcella A

“…Although it is widely believed that pregnancy and the period shortly after pregnancy are associated with an increased risk of stroke, quantitative data…”
Get full text

Stroke in children and sickle-cell disease: Baltimore-Washington Cooperative Young Stroke Study by EARLEY, C. J, KITTNER, S. J, JOHNSON, C, SLOAN, M. A, BUCHHOLZ, D, FEESER, B. R, GARDNER, J, EPSTEIN, A, WOZNIAK, M. A, WITYK, R, STERN, B. J, PRICE, T. R, MACKO, R. F

“…The Baltimore-Washington Cooperative Young Stroke Study is the largest biracial urban-suburban population-based study to examine the etiology of strokes in…”
Get full text

Iron and the restless legs syndrome by SUN, E. R, CHEN, C. A, HO, G, EARLEY, C. J, ALLEN, R. P

“…Using blinded procedures, determine the relation between serum ferritin levels and severity of subjective and objective symptoms of the restless legs syndrome…”
Get full text

Cerebral infarction in young adults : The Baltimore-Washington Cooperative Young Stroke Study by KITTNER, S. J, STERN, B. J, SHERWIN, R, SLOAN, M. A, WITYK, R. J, WOZNIAK, M, BUCHHOLZ, D. W, EARLEY, C. J, FEESER, B. R, JOHNSON, C. J, MACKO, R. F, MCCARTER, R. J, PRICE, T. R

“…Few reports on stroke in young adults have included cases from all community and referral hospitals in a defined geographic region. At 46 hospitals in…”
Get full text

Altered dopaminergic profile in the putamen and substantia nigra in restless leg syndrome by Connor, James R., Wang, Xin-Sheng, Allen, Richard P., Beard, John L., Wiesinger, Jason A., Felt, Barbara T., Earley, Christopher J.

“…Restless leg syndrome (RLS) is a sensorimotor disorder. Clinical studies have implicated the dopaminergic system in RLS, while others have suggested that it is…”
Get full text

Increased carotid artery intimal-medial thickness in asymptomatic older subjects with exercise-induced myocardial ischemia by NAGAI, Y, METTER, E. J, EARLEY, C. J, KEMPER, M. K, BECKER, L. C, LAKATTA, E. G, FLEG, J. L

“…Previous studies have shown an association between symptomatic coronary artery disease (CAD) and increased intimal-medial thickness of the common carotid…”
Get full text

Pergolide and carbidopa/levodopa treatment of the restless legs syndrome and periodic leg movements in sleep in a consecutive series of patients by EARLEY, C. J, ALLEN, R. P

“…Carbidopa/levodopa has become accepted as a primary treatment for both the restless legs (RL) syndrome and periodic leg movements in sleep (PLMS). It, however,…”
Get full text

Randomized, double-blind, placebo-controlled trial of pergolide in restless legs syndrome by EARLEY, C. J, YAFFEE, J. B, ALLEN, R. P

“…To assess the efficacy of pergolide in the treatment of restless legs syndrome (RLS). A randomized, double-blind, parallel-treatment evaluation of pergolide…”
Get full text