Search Results - "Earl, Patricia L."

Intranasal inoculation of an MVA-based vaccine induces IgA and protects the respiratory tract of hACE2 mice from SARS-CoV-2 infection by Americo, Jeffrey L, Cotter, Catherine A, Earl, Patricia L, Liu, Ruikang, Moss, Bernard

“…Current vaccines have greatly diminished the severity of the COVID-19 pandemic, even though they do not entirely prevent infection and transmission, likely due…”
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Natural killer cells expanded in vivo or ex vivo with IL-15 overcomes the inherent susceptibility of CAST mice to lethal infection with orthopoxviruses by Earl, Patricia L, Americo, Jeffrey L, Moss, Bernard

“…The wild-derived inbred CAST/EiJ mouse, one of eight founder strains in the Collaborative Cross panel, is an exceptional model for studying monkeypox virus…”
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One or two injections of MVA-vectored vaccine shields hACE2 transgenic mice from SARS-CoV-2 upper and lower respiratory tract infection by Liu, Ruikang, Americo, Jeffrey L., Cotter, Catherine A., Earl, Patricia L., Erez, Noam, Peng, Chen, Moss, Bernard

“…Modified vaccinia virus Ankara (MVA) is a replication-restricted smallpox vaccine, and numerous clinical studies of recombinant MVAs (rMVAs) as vectors for…”
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Protective Efficacy of a Global HIV-1 Mosaic Vaccine against Heterologous SHIV Challenges in Rhesus Monkeys by Barouch, Dan H., Stephenson, Kathryn E., Borducchi, Erica N., Smith, Kaitlin, Stanley, Kelly, McNally, Anna G., Liu, Jinyan, Abbink, Peter, Maxfield, Lori F., Seaman, Michael S., Dugast, Anne-Sophie, Alter, Galit, Ferguson, Melissa, Li, Wenjun, Earl, Patricia L., Moss, Bernard, Giorgi, Elena E., Szinger, James J., Eller, Leigh Anne, Billings, Erik A., Rao, Mangala, Tovanabutra, Sodsai, Sanders-Buell, Eric, Weijtens, Mo, Pau, Maria G., Schuitemaker, Hanneke, Robb, Merlin L., Kim, Jerome H., Korber, Bette T., Michael, Nelson L.

“…The global diversity of HIV-1 represents a critical challenge facing HIV-1 vaccine development. HIV-1 mosaic antigens are bioinformatically optimized…”
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Lethal Monkeypox Virus Infection of CAST/EiJ Mice Is Associated with a Deficient Gamma Interferon Response by EARL, Patricia L, AMERICO, Jeffrey L, MOSS, Bernard

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Identification of Wild-Derived Inbred Mouse Strains Highly Susceptible to Monkeypox Virus Infection for Use as Small Animal Models by Americo, Jeffrey L, Moss, Bernard, Earl, Patricia L

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Interferon α/β Decoy Receptor Encoded by a Variant in the Dryvax Smallpox Vaccine Contributes to Virulence and Correlates with Severe Vaccine Side Effects by Liu, Ruikang, Americo, Jeffrey L, Earl, Patricia L, Villani, Jack, Cotter, Catherine A, Moss, Bernard

“…Although providing long-lasting immunity, smallpox vaccination was associated with local and systemic reactions and rarely with severe complications, including…”
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Virulence differences of mpox (monkeypox) virus clades I, IIa, and IIb.1 in a small animal model by Americo, Jeffrey L, Earl, Patricia L, Moss, Bernard

“…Human mpox (monkeypox), a disease with similarities to smallpox, is endemic in Africa where it has persisted as a zoonosis with limited human-to-human spread…”
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Protection from SARS-CoV-2 Variants by MVAs expressing matched or mismatched S administered intranasally to mice by Cotter, Catherine A., Americo, Jeffrey L., Earl, Patricia L., Moss, Bernard

“…SARS-CoV-2 vaccines prevent severe disease but are less efficient in averting infection and transmission of variant strains, making it imperative to explore…”
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HIV-DNA Given with or without Intradermal Electroporation Is Safe and Highly Immunogenic in Healthy Swedish HIV-1 DNA/MVA Vaccinees: A Phase I Randomized Trial by Nilsson, Charlotta, Hejdeman, Bo, Godoy-Ramirez, Karina, Tecleab, Teghesti, Scarlatti, Gabriella, Bråve, Andreas, Earl, Patricia L, Stout, Richard R, Robb, Merlin L, Shattock, Robin J, Biberfeld, Gunnel, Sandström, Eric, Wahren, Britta

“…We compared safety and immunogenicity of intradermal (ID) vaccination with and without electroporation (EP) in a phase I randomized placebo-controlled trial of…”
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Novel Nonreplicating Vaccinia Virus Vector Enhances Expression of Heterologous Genes and Suppresses Synthesis of Endogenous Viral Proteins by Wyatt, Linda S, Xiao, Wei, Americo, Jeffrey L, Earl, Patricia L, Moss, Bernard

“…Viruses are used as expression vectors for protein synthesis, immunology research, vaccines, and therapeutics. Advantages of poxvirus vectors include the…”
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Rapid protection in a monkeypox model by a single injection of a replication-deficient vaccinia virus by Earl, Patricia L, Americo, Jeffrey L, Wyatt, Linda S, Espenshade, Ondraya, Bassler, Jocelyn, Gong, Kathy, Lin, Shuling, Peters, Elizabeth, Rhodes, Lowrey Jr, Spano, Yvette Edghill, Silvera, Peter M, Moss, Bernard

“…The success of the World Health Organization smallpox eradication program three decades ago resulted in termination of routine vaccination and consequent…”
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Highly Attenuated Smallpox Vaccine Protects Mice with and without Immune Deficiencies against Pathogenic Vaccinia Virus Challenge by Wyatt, Linda S., Earl, Patricia L., Eller, Leigh Anne, Moss, Bernard

“…Modified vaccinia virus Ankara (MVA), developed > 30 years ago as a highly attenuated candidate smallpox vaccine, was recloned from a 1974 passage and…”
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Immunogenicity of a highly attenuated MVA smallpox vaccine and protection against monkeypox by Moss, Bernard, Earl, Patricia L, Americo, Jeffrey L, Wyatt, Linda S, Eller, Leigh Anne, Whitbeck, J. Charles, Cohen, Gary H, Eisenberg, Roselyn J, Hartmann, Christopher J, Jackson, David L, Kulesh, David A, Martinez, Mark J, Miller, David M, Mucker, Eric M, Shamblin, Joshua D, Zwiers, Susan H, Huggins, John W, Jahrling, Peter B

“…The potential use of smallpox as a biological weapon has led to the production and stockpiling of smallpox vaccine and the immunization of some healthcare…”
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Antibody Profiling by Proteome Microarray Reveals the Immunogenicity of the Attenuated Smallpox Vaccine Modified Vaccinia Virus Ankara Is Comparable to That of Dryvax by DAVIES, D. Huw, WYATT, Linda S, FELGNER, Philip L, NEWMAN, Frances K, EARL, Patricia L, CHUN, Sookhee, HERNANDEZ, Jenny E, MOLINA, Douglas M, HIRST, Siddiqua, MOSS, Bernard, FREY, Sharon E

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Elucidating and Minimizing the Loss by Recombinant Vaccinia Virus of Human Immunodeficiency Virus Gene Expression Resulting from Spontaneous Mutations and Positive Selection by WYATT, Linda S, EARL, Patricia L, WEI XIAO, AMERICO, Jeffrey L, COTTER, Catherine A, VOGT, Jennifer, MOSS, Bernard

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Heterologous prime-boost regimens using rAd35 and rMVA vectors elicit stronger cellular immune responses to HIV proteins than homologous regimens by Ratto-Kim, Silvia, Currier, Jeffrey R, Cox, Josephine H, Excler, Jean-Louis, Valencia-Micolta, Anais, Thelian, Doris, Lo, Vicky, Sayeed, Eddy, Polonis, Victoria R, Earl, Patricia L, Moss, Bernard, Robb, Merlin L, Michael, Nelson L, Kim, Jerome H, Marovich, Mary A

“…We characterized prime-boost vaccine regimens using heterologous and homologous vector and gene inserts. Heterologous regimens offer a promising approach that…”
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Generation of Recombinant Vaccinia Viruses by Wyatt, Linda S, Earl, Patricia L, Moss, Bernard

“…This unit describes how to infect cells with vaccinia virus and then transfect them with a plasmid-transfer vector or PCR fragment to generate a recombinant…”
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Cryptic Nature of a Conserved, CD4-Inducible V3 Loop Neutralization Epitope in the Native Envelope Glycoprotein Oligomer of CCR5-Restricted, but Not CXCR4-Using, Primary Human Immunodeficiency Virus Type 1 Strains by LUSSO, Paolo, EARL, Patricia L, SIRONI, Francesca, SANTORO, Fabio, RIPAMONTI, Chiara, SCARLATTI, Gabriella, LONGHI, Renato, BERGER, Edward A, BURASTERO, Samuele E

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Development and Use of a Vaccinia Virus Neutralization Assay Based on Flow Cytometric Detection of Green Fluorescent Protein by Earl, Patricia L, Americo, Jeffrey L, Moss, Bernard

“…Erratum ( vol. 77 , p. 12930 ) Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious…”
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