Search Results - "Ear, Po Hien"

Universal strategies in research and drug discovery based on protein-fragment complementation assays by Remy, Ingrid, Stefan, Eduard, Manderson, Emily N, Ear, Po Hien, Michnick, Stephen W

“…Changes in the interactions among proteins that participate in a biochemical pathway can reflect the immediate regulatory responses to intrinsic or extrinsic…”
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Nicotinamide phosphoribosyltransferase expression and clinical outcome of resected stage I/II pancreatic ductal adenocarcinoma by Davis, Katelynn, Dunseth, Craig D, Mott, Sarah L, Cramer-Morales, Kimberly L, Miller, Ann M, Ear, Po Hien, Mezhir, James J, Bellizzi, Andrew M, Chan, Carlos H F

“…Nicotinamide phosphoribosyltransferase (NAMPT) plays a key role in the biosynthesis of nicotinamide adenine dinucleotide (NAD+), which is a vital cofactor in…”
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Purification and characterization of recombinant microsomal prostaglandin E synthase-1 by Ouellet, Marc, Falgueyret, Jean-Pierre, Hien Ear, Po, Pen, Ally, Mancini, Joseph A, Riendeau, Denis, David Percival, M

“…Recombinant human microsomal prostaglandin E 2 synthase-1 (mPGES-1) was expressed in a baculovirus-Sf9 cell system. The mPGES-1 was solubilized from Sf9 cell…”
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Establishment of Novel Neuroendocrine Carcinoma Patient-Derived Xenograft Models for Receptor Peptide-Targeted Therapy by Tran, Catherine G, Borbon, Luis C, Mudd, Jacqueline L, Abusada, Ellen, AghaAmiri, Solmaz, Ghosh, Sukhen C, Vargas, Servando Hernandez, Li, Guiying, Beyer, Gabriella V, McDonough, Mary, Li, Rachel, Chan, Carlos H F, Walsh, Susan A, Wadas, Thaddeus J, O'Dorisio, Thomas, O'Dorisio, M Sue, Govindan, Ramaswamy, Cliften, Paul F, Azhdarinia, Ali, Bellizzi, Andrew M, Fields, Ryan C, Howe, James R, Ear, Po Hien

“…Gastroenteropancreatic neuroendocrine neoplasms (GEP NENs) are rare cancers consisting of neuroendocrine carcinomas (NECs) and neuroendocrine tumors (NETs),…”
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Dissection of Cdk1–cyclin complexes in vivo by Ear, Po Hien, Booth, Michael J., Abd-Rabbo, Diala, Moreno, Jacqueline Kowarzyk, Hall, Conrad, Chen, Daici, Vogel, Jackie, Michnick, Stephen W.

“…Cyclin-dependent kinases (Cdks) are regulatory enzymes with temporal and spatial selectivity for their protein substrates that are governed by cell…”
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A toolkit of protein-fragment complementation assays for studying and dissecting large-scale and dynamic protein-protein interactions in living cells by Michnick, Stephen W, Ear, Po Hien, Landry, Christian, Malleshaiah, Mohan K, Messier, Vincent

“…Protein-fragment complementation assays (PCAs) are a family of assays for detecting protein-protein interactions (PPIs) that have been developed to provide…”
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Fr386 SCREENING FOR NEW THERAPEUTIC AGENTS FOR CHOLANGIOCARCINOMA by Zakharia, Kais, Roberts, Lewis R., Chan, Carlos H., Ear, Po Hien

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A luminescent sensor for investigating serotonin metabolism in neuroendocrine cancer by Tow, Dane H, Chan, Carlos HF, Howe, James R, Ear, Po Hien

“…Serotonin is emerging as a promising therapeutic target in tryptophan hydroxylase 1–positive tumors, but further mechanistic studies are needed to effectively…”
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Gastroenteropancreatic neuroendocrine carcinoma tumor spheroid drug screen reveals vulnerability to tyrosyl-DNA phosphodiesterase 1 inhibitors by Beyer, Gabriella V., Hueser, Sophia, Li, Rachel, Manika, Deeraj, Lee, Minhyuk, Chan, Carlos H.F., Howe, James R., Ear, Po Hien

“…Gastroenteropancreatic neuroendocrine carcinomas are rare neoplasms with no effective treatments and poor prognosis. Few reliable preclinical models exist for…”
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Association Between Female Sex and Better Survival in Gastroenteropancreatic Neuroendocrine Tumors by Chang, Jeremy, Suraju, Mohammed O., Tran, Catherine G., Chan, Carlos H.F., Ear, Po Hien, Howe, James R., Sherman, Scott K.

“…Studies conflict on whether sex influences survival in gastroenteropancreatic neuroendocrine tumors (GEP-NETs). GEP-NETs express receptors and genes responsive…”
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Pancreatic Neuroendocrine Tumors: Molecular Mechanisms and Therapeutic Targets by Maharjan, Chandra K, Ear, Po Hien, Tran, Catherine G, Howe, James R, Chandrasekharan, Chandrikha, Quelle, Dawn E

“…Pancreatic neuroendocrine tumors (pNETs) are unique, slow-growing malignancies whose molecular pathogenesis is incompletely understood. With rising incidence…”
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Gene Expression Signatures Identify Novel Therapeutics for Metastatic Pancreatic Neuroendocrine Tumors by Scott, Aaron T, Weitz, Michelle, Breheny, Patrick J, Ear, Po Hien, Darbro, Benjamin, Brown, Bart J, Braun, Terry A, Li, Guiying, Umesalma, Shaikamjad, Kaemmer, Courtney A, Maharjan, Chandra K, Quelle, Dawn E, Bellizzi, Andrew M, Chandrasekharan, Chandrikha, Dillon, Joseph S, O'Dorisio, Thomas M, Howe, James R

“…Pancreatic neuroendocrine tumors (pNETs) are uncommon malignancies noted for their propensity to metastasize and comparatively favorable prognosis. Although…”
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Abstract 5953: DUSP6 is a novel target in neuroendocrine tumors by Momeny, Majid, Khalaj, Vahid, AghaAmiri, Solmaz, Ear, Po Hien, Vargas, Servando Hernandez, Ghosh, Sukhen, Azhdarinia, Ali

“…Abstract Background: Neuroendocrine tumors (NETs) are rare malignancies derived from enterochromaffin cells of the diffuse neuroendocrine system and most…”
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Is There a Role for Surgical Resection of Grade 3 Neuroendocrine Neoplasms? by Borbon, Luis C., Tran, Catherine G., Sherman, Scott K., Ear, Po Hien, Chandrasekharan, Chandrikha, Bellizzi, Andrew M., Dillon, Joseph S., O’Dorisio, Thomas M., Howe, James R.

“…Background Grade 3 (G3) gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs) are aggressive tumors with poor survival outcomes for which medical…”
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Effect of bacterial contamination in bile on pancreatic cancer cell survival by Shrader, Hannah R., Miller, Ann M., Tomanek-Chalkley, Ann, McCarthy, Ashley, Coleman, Kristen L., Ear, Po Hien, Mangalam, Ashutosh K., Salem, Aliasger K., Chan, Carlos H.F.

“…Introduction of gut flora into the biliary system is common owing to biliary stenting in patients with obstructing pancreatic head cancer. We hypothesize that…”
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Metastatic pancreatic neuroendocrine tumors have decreased somatostatin expression and increased Akt signaling by Tran, Catherine G., Scott, Aaron T., Li, Guiying, Sherman, Scott K., Ear, Po Hien, Howe, James R.

“…Patients with pancreatic neuroendocrine tumors often present with metastases, which reduce survival. Molecular features associated with pancreatic…”
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It Is Time to Rethink Biomarkers for Surveillance of Small Bowel Neuroendocrine Tumors by Tran, Catherine G., Sherman, Scott K., Scott, Aaron T., Ear, Po Hien, Chandrasekharan, Chandrikha, Bellizzi, Andrew M., Dillon, Joseph S., O’Dorisio, Thomas M., Howe, James R.

“…Background Tumor biomarkers (TBMs) reflect disease burden and correlate with survival for small bowel neuroendocrine tumors (SBNETs). This study sought to…”
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Management of Duodenal Neuroendocrine Tumors: Surgical versus Endoscopic Mucosal Resection by Tran, Catherine G., Sherman, Scott K., Suraju, Mohammed O., Nayyar, Apoorve, Gerke, Henning, Abiad, Rami G. El, Chandrasekharan, Chandrikha, Ear, Po Hien, O’Dorisio, Thomas M., Dillon, Joseph S., Bellizzi, Andrew M., Howe, James R.

“…Background Management of duodenal neuroendocrine tumors (DNETs) is not standardized, with smaller lesions (< 1–2 cm) generally treated by endoscopic mucosal…”
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Expression, purification and characterization of recombinant human microsomal PGE2 synthase-1 by Ouellet, Marc, Pen, Ally, Ear, Po-Hien, Falgueyret, Jean-Pierre, LeRiche, Tammy G, Mancini, Joseph A, Riendeau, Denis, Percival, M David

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ASO Visual Abstract: Is There a Role for Surgical Resection of Grade 3 Neuroendocrine Neoplasms? by Borbon, Luis C., Tran, Catherine G., Sherman, Scott K., Ear, Po Hien, Chandrasekharan, Chandrikha, Bellizzi, Andrew M., Dillon, Joseph S., O’Dorisio, Thomas M., Howe, James R.

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