Search Results - "Eapen, V"

PP2C phosphatases promote autophagy by dephosphorylation of the Atg1 complex by Memisoglu, Gonen, Eapen, Vinay V., Yang, Ying, Klionsky, Daniel J., Haber, James E.

“…Macroautophagy is orchestrated by the Atg1-Atg13 complex in budding yeast. Under nutrient-rich conditions, Atg13 is maintained in a hyperphosphorylated state…”
Get full text

Respiratory Supercomplexes Promote Mitochondrial Efficiency and Growth in Severely Hypoxic Pancreatic Cancer by Hollinshead, Kate E.R., Parker, Seth J., Eapen, Vinay V., Encarnacion-Rosado, Joel, Sohn, Albert, Oncu, Tugba, Cammer, Michael, Mancias, Joseph D., Kimmelman, Alec C.

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive fibrosis and hypovascularization, resulting in significant intratumoral hypoxia (low…”
Get full text

The Saccharomyces cerevisiae Chromatin Remodeler Fun30 Regulates DNA End Resection and Checkpoint Deactivation by Eapen, Vinay V., Sugawara, Neal, Tsabar, Michael, Wu, Wei-Hua, Haber, James E.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

An Assessment of the Incidence of Prolonged Postoperative Bleeding After Dental Extraction Among Patients on Uninterrupted Low Dose Aspirin Therapy and to Evaluate the Need to Stop Such Medication Prior to Dental Extractions by Eapen, Brigit. V., Baig, M. F., Avinash, S.

“…Purpose To propose that low dose aspirin therapy need not be withdrawn for routine dental extraction procedure. Aim This study was designed to evaluate the…”
Get full text

Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy by Eapen, Vinay V, Swarup, Sharan, Hoyer, Melissa J, Paulo, Joao A, Harper, J Wade

“…Removal of damaged organelles via the process of selective autophagy constitutes a major form of cellular quality control. Damaged organelles are recognized by…”
Get full text

Functional interplay between the 53BP1-ortholog Rad9 and the Mre11 complex regulates resection, end-tethering and repair of a double-strand break by Ferrari, Matteo, Dibitetto, Diego, De Gregorio, Giuseppe, Eapen, Vinay V, Rawal, Chetan C, Lazzaro, Federico, Tsabar, Michael, Marini, Federica, Haber, James E, Pellicioli, Achille

“…The Mre11-Rad50-Xrs2 nuclease complex, together with Sae2, initiates the 5'-to-3' resection of Double-Strand DNA Breaks (DSBs). Extended 3' single stranded DNA…”
Get full text

Pathogenetic model for Tourette syndrome delineates overlap with related neurodevelopmental disorders including Autism by Clarke, R A, Lee, S, Eapen, V

“…Tourette syndrome (TS) is a highly heritable neuropsychiatric disorder characterised by motor and vocal tics. Despite decades of research, the aetiology of TS…”
Get full text

A pathway of targeted autophagy is induced by DNA damage in budding yeast by Eapen, Vinay V., Waterman, David P., Bernard, Amélie, Schiffmann, Nathan, Sayas, Enrich, Kamber, Roarke, Lemos, Brenda, Memisoglu, Gonen, Ang, Jessie, Mazella, Allison, Chuartzman, Silvia G., Loewith, Robbie J., Schuldiner, Maya, Denic, Vladimir, Klionsky, Daniel J., Haber, James E.

“…Autophagy plays a central role in the DNA damage response (DDR) by controlling the levels of various DNA repair and checkpoint proteins; however, how the DDR…”
Get full text

Live cell monitoring of double strand breaks in S. cerevisiae by Waterman, David P, Zhou, Felix, Li, Kevin, Lee, Cheng-Sheng, Tsabar, Michael, Eapen, Vinay V, Mazzella, Allison, Haber, James E

“…We have used two different live-cell fluorescent protein markers to monitor the formation and localization of double-strand breaks (DSBs) in budding yeast…”
Get full text

Caffeine impairs resection during DNA break repair by reducing the levels of nucleases Sae2 and Dna2 by Tsabar, Michael, Eapen, Vinay V, Mason, Jennifer M, Memisoglu, Gonen, Waterman, David P, Long, Marcus J, Bishop, Douglas K, Haber, James E

“…In response to chromosomal double-strand breaks (DSBs), eukaryotic cells activate the DNA damage checkpoint, which is orchestrated by the PI3 kinase-like…”
Get full text

“Watch Me Grow- Electronic (WMG-E)” surveillance approach to identify and address child development, parental mental health, and psychosocial needs: study protocol by Eapen, V, Woolfenden, S, Schmied, V, Jalaludin, B, Lawson, K, Liaw, S. T, Lingam, R, Page, A, Cibralic, S, Winata, T, Mendoza Diaz, A, Lam-Cassettari, C, Burley, J, Boydell, K, Lin, P, Masi, A, Katz, I, Dadich, A, Preddy, J, Bruce, J, Raman, S, Kohlhoff, J, Descallar, J, Karlov, L, Kaplun, C, Arora, A, Di Mento, B, Smead, M, Doyle, K, Grace, R, McClean, T, Blight, V, Wood, A, Raine, K. Hazell

“…Abstract Background The COVID-19 pandemic and the associated economic recession has increased parental psychosocial stress and mental health challenges. This…”
Get full text

DNA damage checkpoint triggers autophagy to regulate the initiation of anaphase by Dotiwala, Farokh, Eapen, Vinay V, Harrison, Jacob C, Arbel-Eden, Ayelet, Ranade, Vikram, Yoshida, Satoshi, Haber, James E

“…Budding yeast cells suffering a single unrepaired double-strand break (DSB) trigger the Mec1 (ATR)-dependent DNA damage response that causes them to arrest…”
Get full text

Sgs1 and exo1 redundantly inhibit break-induced replication and de novo telomere addition at broken chromosome ends by Lydeard, John R, Lipkin-Moore, Zachary, Jain, Suvi, Eapen, Vinay V, Haber, James E

“…In budding yeast, an HO endonuclease-inducible double-strand break (DSB) is efficiently repaired by several homologous recombination (HR) pathways. In contrast…”
Get full text

Predictors of developmental surveillance completion at six months of age in south western Sydney by Overs, B. J., Woolfenden, S., Williams, K., Jalaludin, B., Axelsson, E. L., Dissanayake, C., Descallar, J., Harvey, S., Beasley, D., Murphy, E., Eapen, V.

“…Background While developmental surveillance programs promote early identification of child developmental problems, evidence has indicated suboptimal uptake…”
Get full text

Developmental vulnerability - don't investigate without a model in mind by Woolfenden, S., Williams, K., Eapen, V., Mensah, F., Hayen, A., Siddiqi, A., Kemp, L.

“…Children who are developmentally vulnerable are at risk of a difficult start to school, and ongoing educational challenges which may adversely impact on long…”
Get full text

S14-01 Understanding Developmental Trajectory: Implications for Early Intervention by Eapen, V

Get full text

IS03 Understanding Brain Connectivity in Autism: Implications for Early Intervention by Eapen, V

Get full text

Clinical features and associated psychopathology in a Tourette syndrome cohort by Eapen, V., Fox-Hiley, P., Banerjee, S., Robertson, M.

“…Objective – This study explored in detail the association between tic symptomatology, related clinical variables, and psychopathology in 91 consecutive adult…”
Get full text

Gilles de la Tourette syndrome in a cohort of deaf people by Robertson, M.M, Roberts, S, Pillai, S, Eapen, V

“…Highlights • Tourette syndrome (GTS) in deaf have similar phenomenology and co-morbid disorders. • The “signing phonic tics” are akin to phonic tics in GTS. •…”
Get full text

SP4-26 Burden of toxic metal exposure among school-aged children in United Arab Emirates by Yousef, S, Adem, A, Eapen, V, Zoubeidi, T, Kosanovic, M, Mabrouk, A A

“…BackgroundEnvironmental toxic metal exposure may adversely affect children's development and behaviour. Data are lacking about heavy metal exposure in children…”
Get full text