Search Results - "Eangoor, Padmanabhan"

A guided approach to preclinical bioanalysis of proteins using immunoassays for pharmacokinetic and pharmacodynamic assessments by Eangoor, Padmanabhan

“…Techniques that are not regularly used but considered for special applications are covered briefly: ultrasensitivity (Single Molecule Counting [SMC™])-based…”
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Evaluation of homogeneous proximity immunoassays for preclinical bioanalysis by Eangoor, Padmanabhan, Das, Sharmistha, Pucci, Vincenzo

“…Drug discovery is moving at a rapid pace and a fast turnaround of bioanalytical data is needed to sustain this pace. This article focuses on the evaluation of…”
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Multiplexed ELISA screening assay for nine paralytic shellfish toxins in human plasma by Eangoor, Padmanabhan, Indapurkar, Amruta Sanjay, Vakkalanka, Mani Deepika, Knaack, Jennifer Sporty

“…Paralytic shellfish poisoning is a lethal syndrome that can develop in humans who consume shellfish contaminated with paralytic shellfish toxins. These toxins…”
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Dihydroergotamine mesylate-loaded dissolving microneedle patch made of polyvinylpyrrolidone for management of acute migraine therapy by Tas, Cetin, Joyce, Jessica C., Nguyen, Hiep X., Eangoor, Padmanabhan, Knaack, Jennifer S., Banga, Ajay K., Prausnitz, Mark R.

“…Migraine is a widespread neurological disease with negative effects on quality of life and productivity. Moderate to severe acute migraine attacks can be…”
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A Method for Diagnosing Organophosphate Pesticide Exposure in Humans Using Liquid Chromatography Coupled to Tandem Mass Spectrometry by Indapurkar, Amruta S, Eangoor, Padmanabhan, Yeh, Jihee Stephanie, Vakkalanka, Manideepika, Cashman, John R, Knaack, Jennifer S

“…Abstract Organophosphate (OP) pesticides are commonly utilized worldwide for agricultural purposes and pose a health threat through air, ground and water…”
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Development of a Rapid, Sensitive and Reliable Clinical Diagnostic Test to Measure Paralytic Shellfish Toxins in Human Matrices by Eangoor, Padmanabhan

“…Paralytic shellfish poisoning is a lethal poisoning caused by the consumption of shellfish like clams, oysters, scallops and mussels that are contaminated with…”
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Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology by Lu, Min, Zhang, Hongjun, Li, Derun, Childers, Matthew, Pu, Qinglin, Palte, Rachel L, Gathiaka, Symon, Lyons, Thomas W, Palani, Anandan, Fan, Peter W, Spacciapoli, Peter, Miller, J. Richard, Cho, Hyelim, Cheng, Mangeng, Chakravarthy, Kalyan, O’Neil, Jennifer, Eangoor, Padmanabhan, Beard, Adam, Kim, Hai-Young, Saurí, Josep, Gunaydin, Hakan, Sloman, David L, Siliphaivanh, Phieng, Cumming, Jared, Fischer, Christian

“…Recent data suggest that the inhibition of arginase (ARG) has therapeutic potential for the treatment of a number of indications ranging from pulmonary and…”
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Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy by Mitcheltree, Matthew J, Li, Derun, Achab, Abdelghani, Beard, Adam, Chakravarthy, Kalyan, Cheng, Mangeng, Cho, Hyelim, Eangoor, Padmanabhan, Fan, Peter, Gathiaka, Symon, Kim, Hai-Young, Lesburg, Charles A, Lyons, Thomas W, Martinot, Theodore A, Miller, J. Richard, McMinn, Spencer, O’Neil, Jennifer, Palani, Anandan, Palte, Rachel L, Saurí, Josep, Sloman, David L, Zhang, Hongjun, Cumming, Jared N, Fischer, Christian

“…The action of arginase, a metalloenzyme responsible for the hydrolysis of arginine to urea and ornithine, is hypothesized to suppress immune-cell activity…”
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