Search Results - "Eagle, L."

Single-Prolonged Stress: A Review of Two Decades of Progress in a Rodent Model of Post-traumatic Stress Disorder by Lisieski, Michael J, Eagle, Andrew L, Conti, Alana C, Liberzon, Israel, Perrine, Shane A

“…Post-traumatic stress disorder (PTSD) is a common, costly, and often debilitating psychiatric condition. However, the biological mechanisms underlying this…”
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Discovery of GeV Gamma-Ray Emission from Pulsar Wind Nebula Kes 75 and PSR J1846–0258 by Straal, Samayra M., Gelfand, Joseph D., Eagle, Jordan L.

“…Abstract We report the detection of gamma-ray emission from pulsar wind nebula (PWN) Kes 75 and PSR J1846−0258. Through modeling the spectral energy…”
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Single prolonged stress impairs social and object novelty recognition in rats by Eagle, Andrew L., Fitzpatrick, Chris J., Perrine, Shane A.

“…•Avoidance symptoms and negative cognition in posttraumatic stress disorder (PTSD) are poorly understood.•Single prolonged stress (SPS) in rodents models…”
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Exosomal Transport of Hepatocyte‐Derived Drug‐Modified Proteins to the Immune System by Ogese, Monday O., Jenkins, Rosalind E., Adair, Kareena, Tailor, Arun, Meng, Xiaoli, Faulkner, Lee, Enyindah, Bright O., Schofield, Amy, Diaz‐Nieto, Rafael, Ressel, Lorenzo, Eagle, Gina L., Kitteringham, Neil R., Goldring, Chris E., Park, B. Kevin, Naisbitt, Dean J., Betts, Catherine

“…Idiosyncratic drug‐induced liver injury (DILI) is a rare, often difficult‐to‐predict adverse reaction with complex pathomechanisms. However, it is now evident…”
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Circuit-specific hippocampal ΔFosB underlies resilience to stress-induced social avoidance by Eagle, Andrew L., Manning, Claire E., Williams, Elizabeth S., Bastle, Ryan M., Gajewski, Paula A., Garrison, Amber, Wirtz, Alexis J., Akguen, Seda, Brandel-Ankrapp, Katie, Endege, Wilson, Boyce, Frederick M., Ohnishi, Yoshinori N., Mazei-Robison, Michelle, Maze, Ian, Neve, Rachel L., Robison, Alfred J.

“…Chronic stress is a key risk factor for mood disorders like depression, but the stress-induced changes in brain circuit function and gene expression underlying…”
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Hippocampal Subgranular Zone FosB Expression Is Critical for Neurogenesis and Learning by Manning, Claire E., Eagle, Andrew L., Kwiatkowski, Christine C., Achargui, Ridouane, Woodworth, Hillary, Potter, Emily, Ohnishi, Yoshinori, Leinninger, Gina M., Robison, A.J.

“…Neural proliferation in the dentate gyrus (DG) is closely linked with learning and memory, but the transcriptional programming that drives adult proliferation…”
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An excitatory lateral hypothalamic circuit orchestrating pain behaviors in mice by Siemian, Justin N, Arenivar, Miguel A, Sarsfield, Sarah, Borja, Cara B, Erbaugh, Lydia J, Eagle, Andrew L, Robison, Alfred J, Leinninger, Gina, Aponte, Yeka

“…Understanding how neuronal circuits control nociceptive processing will advance the search for novel analgesics. We use functional imaging to demonstrate that…”
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Sex differences in the traumatic stress response: PTSD symptoms in women recapitulated in female rats by Pooley, Apryl E, Benjamin, Rebecca C, Sreedhar, Susheela, Eagle, Andrew L, Robison, Alfred J, Mazei-Robison, Michelle S, Breedlove, S Marc, Jordan, Cynthia L

“…Post-traumatic stress disorder (PTSD) affects men and women differently. Not only are women twice as likely as men to develop PTSD, they experience different…”
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Single prolonged stress enhances hippocampal glucocorticoid receptor and phosphorylated protein kinase B levels by Eagle, Andrew L., Knox, Dayan, Roberts, Megan M., Mulo, Kostika, Liberzon, Israel, Galloway, Matthew P., Perrine, Shane A.

“…► Single prolonged stress (SPS) enhances hippocampal glucocorticoid receptor (GR) levels. ► SPS increases phosphorylated Akt in the hippocampus coincident with…”
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Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome by Fulton, Sasha L., Wenderski, Wendy, Lepack, Ashley E., Eagle, Andrew L., Fanutza, Tomas, Bastle, Ryan M., Ramakrishnan, Aarthi, Hays, Emma C., Neal, Arianna, Bendl, Jaroslav, Farrelly, Lorna A., Al-Kachak, Amni, Lyu, Yang, Cetin, Bulent, Chan, Jennifer C., Tran, Tina N., Neve, Rachael L., Roper, Randall J., Brennand, Kristen J., Roussos, Panos, Schimenti, John C., Friedman, Allyson K., Shen, Li, Blitzer, Robert D., Robison, Alfred J., Crabtree, Gerald R., Maze, Ian

“…With an incidence of ~1 in 800 births, Down syndrome (DS) is the most common chromosomal condition linked to intellectual disability worldwide. While the…”
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Role of hippocampal activity-induced transcription in memory consolidation by Eagle, Andrew L, Gajewski, Paula A, Robison, Alfred J

“…Experience-dependent changes in the strength of connections between neurons in the hippocampus (HPC) are critical for normal learning and memory consolidation,…”
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Assessing technical and biological variation in SWATH-MS-based proteomic analysis of chronic lymphocytic leukaemia cells by Eagle, Gina L., Herbert, John M. J., Zhuang, Jianguo, Oates, Melanie, Khan, Umair T., Kitteringham, Neil R., Clarke, Kim, Park, B. Kevin, Pettitt, Andrew R., Jenkins, Rosalind E., Falciani, Francesco

“…Chronic lymphocytic leukaemia (CLL) exhibits variable clinical course and response to therapy, but the molecular basis of this variability remains incompletely…”
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Sex differences in the traumatic stress response: the role of adult gonadal hormones by Pooley, Apryl E, Benjamin, Rebecca C, Sreedhar, Susheela, Eagle, Andrew L, Robison, Alfred J, Mazei-Robison, Michelle S, Breedlove, S Marc, Jordan, Cynthia L

“…Our previous study revealed that adult female rats respond differently to trauma than adult males, recapitulating sex differences in symptoms of post-traumatic…”
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Project-Based Inquiry (PBI) Global during a Pandemic: A New Learning Ecology Perspective by Himes, Marie P, Spires, Hiller A, Krupa, Erin E, Borden, Margaret L, Eagle, Jessica L

“…Building on new learning ecology theory and situated in the COVID-19 pandemic context, a qualitative research design was used to examine student and teacher…”
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Partial dopaminergic denervation-induced impairment in stimulus discrimination acquisition in parkinsonian rats: A model for early Parkinson's disease by Eagle, Andrew L., Olumolade, Oluyemi O., Otani, Hajime

“…•Low dose, bilateral 6-hydroxydopamine (6OHDA) was administered to dorsal striatum.•Rats were tested for stimulus discrimination acquisition 1 or 2 weeks…”
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Biomarkers of chemotherapy resistance in breast cancer identified by proteomics: Current status by Hodgkinson, Victoria C, Eagle, Gina L, Drew, Philip J, Lind, Michael J, Cawkwell, Lynn

“…Abstract This review describes and discusses the advantages and limitations of proteomic approaches in the identification of biomarkers associated with…”
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Do Adults Utilizing Intermittent Fasting Improve Lipids More Than Those Following a Restricted-Calorie Diet? A Clin-IQ by Sanford, Mitchell A, Sanford, Tracy S., Campbell, K. F., Davis, Dustin, Tandberg, Tammy, Eagle Road, L. N.

“…With approximately 95 million Americans diagnosed with high cholesterol, and many searching for a nonmedicinal treatment, intermittent fasting as a method to…”
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Sleep and mild cognitive impairment by Cassidy-Eagle, Erin L., Siebern, Allison

“…Older adults frequently suffer from sleep disturbances. In addition, with increasing age such disturbances may accompany mild cognitive changes that are…”
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COX-2 specific inhibitors enhance the cytotoxic effects of pemetrexed in mesothelioma cell lines by O’Kane, Sara L, Eagle, Gina L, Greenman, John, Lind, Michael J, Cawkwell, Lynn

“…Abstract Background Although malignant pleural mesothelioma is a rare tumour, its incidence is increasing. The prognosis remains very poor with an average…”
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Androgen-Dependent Excitability of Mouse Ventral Hippocampal Afferents to Nucleus Accumbens Underlies Sex-Specific Susceptibility to Stress by Williams, Elizabeth S., Manning, Claire E., Eagle, Andrew L., Swift-Gallant, Ashlyn, Duque-Wilckens, Natalia, Chinnusamy, Sadhana, Moeser, Adam, Jordan, Cynthia, Leinninger, Gina, Robison, Alfred Jay

“…Depression affects women nearly twice as often as men, but the neurobiological underpinnings of this discrepancy are unclear. Preclinical studies in male mice…”
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