Olive extract supplement decreases pain and improves daily activities in adults with osteoarthritis and decreases plasma homocysteine in those with rheumatoid arthritis

Abstract The aim of this study was to determine the effects of a polyphenolic-rich olive extract on pain, inflammation, loss of mobility, and patients' general quality of life associated with osteoarthritis (OA) and rheumatoid arthritis (RA). In this double-blind, randomized, placebo-controlled...

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Published in:	Nutrition research (New York, N.Y.) Vol. 27; no. 8; pp. 470 - 477
Main Authors:	Bitler, Catherine M, Matt, Kathleen, Irving, Mary, Hook, Ginger, Yusen, Joseph, Eagar, Forrest, Kirschner, Ken, Walker, Brian, Crea, Roberto
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-08-2007 Elsevier Science
Subjects:	adults analgesic effect anti-inflammatory activity Biological and medical sciences blood serum dietary supplements elderly Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Gastroenterology and Hepatology Homocysteine Human intervention Inflammation nutritional intervention Olea europaea Olive extract olives Osteoarthritis physical activity plant extracts rheumatoid arthritis Vertebrates: anatomy and physiology, studies on body, several organs or systems Human intervention Inflammation Homocysteine Olive extract Osteoarthritis Human Immunopathology Diseases of the osteoarticular system Autoimmune disease Inflammatory joint disease Extract Blood plasma Vertebrata Chronic Daily Pain Mammalia Decrease Homocystein Rheumatoid arthritis Arthropathy Adult Degenerative disease
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Summary:	Abstract The aim of this study was to determine the effects of a polyphenolic-rich olive extract on pain, inflammation, loss of mobility, and patients' general quality of life associated with osteoarthritis (OA) and rheumatoid arthritis (RA). In this double-blind, randomized, placebo-controlled study, the efficacy of freeze-dried olive vegetation water (OVW) on subjects with a diagnosis of OA or RA was evaluated. The treatment group received 400 mg of freeze-dried OVW per day for 8 weeks. Subjects were assessed using the Health Assessment Questionnaire–Disability Index. In addition, the Disease Activity Score With 28-Joint Count was used to evaluate joint pain and inflammation, and the Profile of Moods State questionnaire for overall well-being. During the same time intervals, serum samples were taken for clinical and biochemical tests. The RA subjects in the OVW treatment group showed significant decreases in serum homocysteine levels after 8 weeks of treatment. There was no significant change in any other clinical marker, including markers of kidney and liver function, at any time during the study, suggesting that the supplement was safe. There was significant improvement by treatment group for the Health Assessment Questionnaire–Disability Index. Subjects with OA in the OVW treatment group showed significant improvement in the Disease Activity Score With 28-Joint Count index. Thus, after a relatively short treatment with OVW, subjects with OA and RA reported decreased pain and improvement in activities of daily living. In addition, subjects with RA had a statistically significant decrease in serum homocysteine. High homocysteine levels in patients with RA have been associated with higher rates of mortality from cardiovascular events.
Bibliography:	http://dx.doi.org/10.1016/j.nutres.2007.06.003
ISSN:	0271-5317 1879-0739
DOI:	10.1016/j.nutres.2007.06.003