Characterization of novel polydiacetylene gel dosimeter for radiotherapy

Polymer gel dosimeters are instrumental for clinical and research applications in radiotherapy. These dosimeters possess the unique ability to record dose distribution in three dimensions. A Polymer gel dosimeter is composed of organic molecules in a gel matrix, which upon irradiation polymerize to...

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Bibliographic Details
Published in:	Biomedical physics & engineering express Vol. 6; no. 5; p. 055017
Main Authors:	Walg, Y Peleg, Silveira, M A, Eafergan, N, Krutman, Y, Baffa, O, Berman, A, Orion, I
Format:	Journal Article
Language:	English
Published:	England 01-09-2020
Subjects:	Gels - chemistry Humans Polyacetylene Polymer - chemistry Polymers - chemistry Radiation Dosimeters - statistics & numerical data Radiometry - instrumentation Radiotherapy Dosage
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Summary:	Polymer gel dosimeters are instrumental for clinical and research applications in radiotherapy. These dosimeters possess the unique ability to record dose distribution in three dimensions. A Polymer gel dosimeter is composed of organic molecules in a gel matrix, which upon irradiation polymerize to form a conjugated polymer with optical absorbance proportional to the irradiated dose. Other required characteristics of a radiotherapy clinical dosimeter are soft-tissue equivalency, linear dose-response in a range of clinical treatments, and long term stability for the duration of the analysis. The dosimeter presented in this paper is based on diacetylene bearing fatty acid aggregates embedded in a soft-tissue equivalent gel matrix, Phytagel™, which upon irradiation polymerize to form a blue phase polydiacetylene with a strong optical absorption. Initial characterization showed that PDA-gel irradiated with 160 kV x-ray responded linearly to the irradiated dose, and the calculated diffusion coefficient is [Formula: see text] what is very low. It was also found that the percentage depth dose (PDD) curve of the PDA-gel in a 4 × 4 cm field, irradiated with 6 MV x-rays, was with good agreement with the literature. PDA-gel has the potential to detect absorbed dose in a range of clinical radiological irradiation regimes.
ISSN:	2057-1976
DOI:	10.1088/2057-1976/aba638